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TSCA Section 8(e) Substantial Risk Notifications and FYI Submissions Received April 2006

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0406-16429A (PDF)
(2 pp, 83K)
Urea, substituted and aniline, substituted mixture Confidential BASF Corporation Results of an acute toxicity study in green algae
8EHQ-0406-16431A (PDF)
(3 pp, 145K)
3,7-dimethyl-2,6,octadienenitrile 5146-66-7 Fragrance Materials Association of the United States Results of an in vivo chromosome aberration study in mouse spermatogonial cells
8EHQ-0406-16432A (PDF)
(2 pp, 74K)
Ketoenol derivative Confidential Bayer CropScience LP Results of an 18-month carcinogenicity study in mice (route of exposure not stated)
8EHQ-0406-16435A (PDF)
(3 pp, 250K)
Nitrogen-containing heterocycles, substituted Confidential BASF Corporation Results of two acute toxicity screening tests in fathead minnows
8EHQ-0406-16436A (PDF)
(1 pg, 52K)
Perfluorinated aliphatic carboxylic acid, ammonium salt Confidential N Confidential Results of an acute oral toxicity study in rats
8EHQ-0406-16437A (PDF)
(214 pp, 5.78MB)
Siloxanes and silicones, di-Me, polymers with 3-[(2aminoethyl) amino] propyl Ph silsesquioxanes, methoxy-terminated *1 477725-72-7 N Wacker Chemical Corporation Final report of a 30-day aerosol inhalation toxicity study in rats with a 30-day recovery period.
8EHQ-0406-16438A (PDF)
(2 pp, 113K)
Methylamine hydrochloride 593-51-1 N American Chemistry Council's Amines Panel Results of a combined repeated dose toxicity study with reproductive/developmental toxicity screening test in rats (OECD TG 422)
8EHQ-0406-16439A (PDF)
(84 pp, 2.43MB)
Chemical Confidential   McKenna, Long & Aldridge LLP Final reports of an in vitro chromosome aberration test in Chinese hamster lung cells, an in vivo micronucleus test in mice, and a bacterial reverse mutation test in S. typhimurium and E. coli
8EHQ-0406-16440A (PDF)
(3 pp, 117K)
alpha-Cypermethrin *2 67375-30-8 N BASF Corporation Results of three oral and three contact toxicity studies in the honeybee.
8EHQ-0406-16441A (PDF)
(4 pp, 272K)
Dimethylsilanediol 1066-42-8 N Silicones Environmental, Health and Safety Council of North America Results of an ongoing in vitro mammalian chromosome aberrations assay with Chinese hamster ovary cells
8EHQ-0406-16442A (PDF)
(3 pp, 145K)
Methyltrimethoxysilane 1185-55-3 Y Silicones Environmental, Health and Safety Council of North America Preliminary results of a 14-day repeated dose whole-body inhalation range-finding toxicity study in rats
8EHQ-0406-16443A (PDF)
(2 pp, 66K)
Ketoenol derivative Confidential   Bayer CropScience LP Results of an acute inhalation toxicity study in rats
8EHQ-0406-16444A (PDF)
(2 pp, 64K)
Ketoenol derivative Confidential   Bayer CropScience LP Results of a range-finding reproductive toxicity study in rats
8EHQ-0406-16445A (PDF)
(2 pp, 71K)
Arsenic trioxide *2 1327-53-3 N Dow Chemical Company Results of worker monitoring of urine
8EHQ-0406-16446A (PDF)
(11 pp, 76K)
Perfluorooctanoic acid (PFOA) 335-67-1 N Dupont Haskell Laboratory Results of occupational blood monitoring
8EHQ-0406-16447A (PDF)
(82 pp, 2.23MB)
2-Propenoic acid, 2( phenylthio) ethyl ester 95175-38-5 N General Electric Company Draft report of a 14-day oral gavage range-finding toxicity study in rats
8EHQ-0406-16448A (PDF)
(1 pg, 57K)
Ethanamine, 1,1,2,2tetrafluoro- N,N-dimethyl 1550-50-1 N DuPont Haskell Laboratory Results of an acute inhalation toxicity study in rats
8EHQ-0406-16449A (PDF)
(16 pp, 825K)
Phosphorothiodioate, butyl and isooctyl esters, zinc salt 309919-97-9 N Lubrizol Corporation Draft report of an acute oral gavage toxicity study in rats
8EHQ-0406-16450A (PDF)
(1 pg, 51K)
Chemical Unknown N Syngenta Crop Protection, Inc. Results of an acute oral toxicity study in rats
8EHQ-0406-16451A (PDF)
(42 pp, 1MB)
Irgaphor 1669 (TKP50101) None N Ciba Specialty Chemicals North America Final report of a local lymph node assay in mice
8EHQ-0406-16456A Diethylaminotriethoxysilane 35077-00-0 N UBE America Inc. Final report of an in vitro dermal irritation study using skin discs from rats
8EHQ-0406-00373BS Perfluorochemicals, sulfonate-based and carboxylic-based None N 3M Company Two analytical reports of groundwater monitoring
8EHQ-0406-00374AG Perfluorochemicals, sulfonate-based and carboxylic-based None N 3M Company Two analytical reports of groundwater monitoring
8EHQ-0406-00394K Perfluorochemicals, sulfonate-based and carboxylic-based None N 3M Company Two analytical reports of groundwater monitoring
8EHQ-0406-14591B Hexamethyldisiloxane 107-46-0 Y Dow Corning Corporation Final report of a 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in rats.
8EHQ-0406-15889C Tetrapropenyl phenol 74499-35-7 Y Chevron Corporation Response to EPA request for additional information
8EHQ-0406-16010D Benzenamine, N-phenyl-, reaction products with isobutylene and 2,4,4trimethylpentene 184378-08-3 N American Chemistry Council Draft report of an oral gavage combined repeated dose and reproductive/developmental toxicity screening test in rats (OECD TG 422)
8EHQ-0406-16035B 1,2-Ethanediamine, 1,2disubstituted Confidential Confidential Results of a local lymph node assay in mice.
8EHQ-0406-16197B Butyl acetate *3 123-86-4 Y American Chemistry Council Final report of an inhalation range-finding reproductive toxicity study in rats
8EHQ-0406-16223B Petroleum industry chemicals None ConocoPhillips Company Letter of clarification regarding the current ownership status of a submitter for a 1992 leukemia study.
8EHQ-0406-16265B 1,4-Dichloro-2-butene 764-41-0 Y International Institute of Synthetic Rubber Producers, Inc. Results of an acute toxicity study in daphnia magna.
2,3-Dichloro-1,3-butadiene 1653-19-6 Y
8EHQ-0406-16288C Pyrimidine, substituted *1 Confidential   Confidential Results of a one-generation oral dietary reproductive toxicity study in rats.
8EHQ-0406-16292B Fluorochemicals salt Confidential   3M Company Final report of an acute eye irritation study in rabbits
8EHQ-0406-16293B Fluorinated alcohol Confidential N 3M Company Final report of an acute inhalation toxicity study in rats
8EHQ-0406-16449B (PDF)
(16 pp, 503K)
Phosphorothiodioate, butyl and isooctyl esters, zinc salt 309919-97-9 N Lubrizol Corporation Final report of an acute oral gavage toxicity study in rats
FYI-0406-01378AT Perfluorooctanoic acid (PFOA) 335-67-1 N General Electric Company Final report of a product monitoring study

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A). Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.

FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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