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Section 8(e) Substantial Risk Notifications and FYI Submissions Received April 2007

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0407-16784A (PDF)
(28 pp, 984K)
Dimethyl 2-Methyl Glutarate *1 14035-94-0 N Rhodia, Inc. Preliminary results from an i.p. micronucleus assay in mice.
8EHQ-0407-16785A (PDF)
(2 pp, 59K)
Polymer dispersion, anionic aqueous acrylate Confidential   Confidential Results of a murine local lymph node assay
8EHQ-0407-16786A (PDF)
(103 pp, 3.87MB)
Perfluorooctanoic acid 335-67-1   E.I. du Pont de Nemours and Company APFO and PFOA results from 7 water samples at Parkersburg Utility (public water supply).
8EHQ-0407-16787A (PDF)
(3 pp, 137K)
Decamethylcyclopentasilox ane *3 541-02-6 Y Silicones Environmental, Health and Safety Council of North America Results from a preliminary screening study on mussels
8EHQ-0407-16788A (PDF)
(3 pp, 134K)
Ortho-toluenediamine

2687-25-4

Y

Ortho-Toluenediamine Consortium Results of an acute toxicity study in Daphnia magna and an acute toxicity study in green algae.
Ortho-toluenediamine 496-72-0 Y
8EHQ-0407-16789A (PDF)
(153 pp, 4.33MB)
Perfluorinated organics None   E.I. du Pont de Nemours and Company Results and information from a human serum analysis, an aqueous sample analysis, and a water analysis from taps/wells of concern.
8EHQ-0407-16790A (PDF)
(1 pg, 51K)
Carboxamide, Substituted Confidential   Confidential Results from an oral developmental toxicity study in rats
8EHQ-0407-16792A (PDF)
(1 pg, 52K)
N-Methyl-2-pyrrolidone *3 872-50-4 Y Lyondell Chemical Company Results from an in-vitro embryotoxicity study (rate whole embryo culture system and BALB/C 3T3 Cytotoxicity Test)
8EHQ-0407-16811A (PDF)
(2 pp, 106K)
C9-13-neo-, cobalt salts 68955-83-9 Y Synthetic Organic Chemical Manufacturers Association (SOCMA) Results from an in vitro mammalian chromosome aberration test
8EHQ-0407-16812A (PDF)
(2 pp, 75K)
1,2-Dibromo-1, 1, 2, 3, 3, 3-hexafluoropropane 661-95-0 N DuPont Haskell Laboratory Results from an in vitro mammalian chromosome aberration test
8EHQ-0407-16813A (PDF)
(1 pg, 40K)
Fluorinated surfactant salt Confidential   3M Company Results from a local lymph node assay in mice.
8EHQ-0407-16814A (PDF)
(1 pg, 56K)
Chemical None   Clorox Services Company Report of unexpected adverse effects from inhalation of product.
8EHQ-0407-16815A (PDF)
(2 pp, 82K)
Chemical None   Clorox Services Company Report of unexpected adverse effects from inhalation of product.
8EHQ-0407-16817A (PDF)
(1 pg, 47K)
Sulfoxime derivative Confidential   Dow Chemical Company Results from a palatability and oral toxicity study in mice.
8EHQ-0407-16818A (PDF)
(21 pp, 770K)
Trimethylolpropane Triacrylate 15625-89-5 Y DuPont Haskell Laboratory Results from an acute oral toxicity study in rats, a primary skin irritation and sensitization test on guinea pigs, one subject human skin test, and 50 subject human patch test
8EHQ-0407-16820A (PDF)
(4 pp, 159K)
Phenol, 4,4'-(1-methylethylidene)bis- 80-05-7 Y American Chemistry Council Results from toxicity study on terrestrial plants; Seedling emergence and seedling growth test.
8EHQ-0407-00394Q (PDF)
(2 pp, 61K)
Perfluorooctanoic acid 335-67-1   DuPont Haskell Laboratory Additional results from a longitudinal study of serum total cholesterol related to serum PFOA measurments in a group of employees.
8EHQ-0407-00394R (PDF)
(2 pp, 73K)
Perfluorooctanoic acid (PFOA) 335-67-1   DuPont Haskell Laboratory Supplemental data from a surveillance study of general health status related to a PFOA serum biomarker of exposure to and a cohort mortality analyses in a polymer production plant.
8EHQ-0407-14970E (PDF)
(2 pp, 153K)
Confidential Confidential   DuPont Haskell Laboratory Results of an acute toxicity test in sheepshead minnow and acute toxicity in mysid shrimp
8EHQ-0407-15167I (PDF)
(2 pp, 99K)
Aminoethanolamine *3 111-41-1 Y Ethyleneamines Product Stewardship Discussion Group Results of a dermal and oral absorption and limited pharmacokinetic study in rats.
8EHQ-0407-15167J (PDF)
(56 pp, 2.48MB)
Aminoethanolamine *3 111-41-1 Y Ethyleneamines Product Stewardship Discussion Group Final report of a dermal and oral absorption and limited pharmacokinetic study in rats.
8EHQ-0407-16043H (PDF)
(2 pp, 65K)
Lactone, substituted Confidential   Confidential Results of an acute oral toxicity study in rats and an acute inhalation toxicity study in rats
8EHQ-0407-16156B (PDF)
(2 pp, 96K)
Tert-Butyl Acetate 540-88-5 N Lyondell Chemical Company Final report of a two-week range-finding inhalation toxicity study in mice
8EHQ-0407-16399B (PDF)
(1 pg, 63K)
Confidential Confidential   Confidential Supplement data from a 90-day oral toxicity study in rats
8EHQ-0407-16440B (PDF)
(87 pp, 2.95MB)
Dimethylsilanediol 1066-42-8 N Silicones Environmental, Health and Safety Council of North America Supplemental data from an in vitro chromosomal aberration assay in mammalian cells
8EHQ-0407-16452C (PDF)
(5 pp, 302K)
Perfluorocarboxylate salt Confidential   Confidential Results of a 90-day oral repeated-dose toxicity study with one-generation reproduction study in rats
8EHQ-0407-16486C (PDF)
(1 pg, 59K)
Hydrofluorocarbon Confidential   Confidential Results of a inhalation developmental toxicity study in rats
8EHQ-0407-16523C (PDF)
(2 pp, 93K)
tert-Butyl acetate 540-88-5 N Lyondell Chemical Company Final report of a 13-week inhalation toxicity study in mice
8EHQ-0407-16533B (PDF)
(599 pp, 19.79MB)
Confidential Confidential   McKenna, Long & Aldridge LLP Reports of chromosomal aberration and mutagenicity studies in mammalian cells, acute oral toxicity studies in rats, and a 28-day oral repeated-dose toxicity study in rats
8EHQ-0407-16567C (PDF)
(2 pp, 94K)
tert-Butyl acetate 540-88-5 N Lyondell Chemical Company Final report of a 13-week subchronic inhalation toxicity study in rats
8EHQ-0407-16721D (PDF)
(1 pg, 42K)
Fluorinated surfactant salt Confidential   3M Company Draft results from a mouse local lymph node assay.
8EHQ-0407-16749B (PDF)
(48 pp, 1.90MB)
1,2-Diaminocyclohexane 694-83-7 Y Confidential Supplemental data from an oral repeated-dose toxicity with reproductive and developmental screening study in rats
FYI-0407-01568A (PDF)
(5 pp, 240K)
Chloroprene Dimers None   International Institute of Synthetic Rubber Producers, Inc. Results from workplace air monitoring and extraction study on polychloroprene examination and surgical gloves.
FYI-0407-01569A (PDF)
(30 pp, 958K)
Decamethylcyclopentasilox ane *3 541-02-6 Y Dow Corning Corporation Results from an oral metabolite identification study in rats.
FYI-0407-01570A (PDF)
(203 pp, 6.96MB)
Hexamethyldisiloxane 107-46-0 Y Dow Corning Corporation Results from a 14-day inhalation toxicity study (vapor) in rats.
FYI-0407-01539B (PDF)
(4 pp, 179K)
Perfluorooctanoic acid 335-67-1 N Ahlstrom Additional results from employee blood tests/screening for PFOA.

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit
number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial
submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report.
Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number
as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.

FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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