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Section 8(e) Substantial Risk Notifications and FYI Submissions Received July 2008

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0708-17191A (PDF)
(2 pp, 85K)
alkylazine Confidential   Bayer CropScience LP Results of an acute inhalation study in rats.
8EHQ-0708-17192A (PDF)
(2 pp, 90K)
Arylimine Confidential   Bayer CropScience LP Results of a range-finding oral (gavage) developmental toxicity study in rats.
8EHQ-0708-17193A (PDF)
(2 pp, 85K)
sulfonylurea Confidential   Bayer CropScience LP Results of a range-finding oral (gavage) developmental toxicity study in rabbits.
8EHQ-0708-17194A (PDF)
(2 pp, 86K)
Sulfonylurea Confidential   Bayer CropScience LP Results of a range-finding oral developmental toxicity study in rats.
8EHQ-0708-17195A (PDF)
(2 pp, 87K)
alkykazine Confidential   Bayer CropScience LP Results of an acute oral neurotoxicity study in rats.
8EHQ-0708-17196A (PDF)
(29 pp, 1.05MB)
1,3-diphenyl-1,2,3 propanetrione-2-[O(ethyoxycarbonyl)oxime] 111451-23-1 N Center for Regulatory Services, Inc. Results of an acute immobilization test in water fleas, algae growth inhibition test and fish acute toxicity test.
8EHQ-0708-17197A (PDF)
(1 pg, 45K)
isoxazole, substituted Confidential   Syngenta Crop Protection Inc. Insufficient information to identify study. One animal had to be killed on day 3 for humane reasons.
8EHQ-0708-17198A (PDF)
(51 pp, 867K)
aliphatic, aromatic, unsaturated bicyclic derivative Confidential   Keller and Heckman LLP Preliminary results from a combined 90-day oral (gavage) repeated-dose and a one-generation reproductive toxicity study in rats.
8EHQ-0708-17199A (PDF)
(1 pg, 38K)
Oxime carbamate 7-2A Confidential   CBI Results of an acute oral (gavage) toxicity screen in rats.
8EHQ-0708-17200A (PDF)
(1 pp, 38K)
Oxime carbamate 7-2B Confidential   CBI Results of an acute oral (gavage) toxicity screen in rats.
8EHQ-0708-17201A (PDF)
(1 pg, 37K)
Oxamimidic acid, N[(methylcarbamoyl)
oxy]- 1thio-, propyl ester
24944-50-1 N CBI Results of an acute oral (gavage) toxicity screen in rats.
8EHQ-0708-17202A (PDF)
(1 pg, 36K)
Ethanimidothioic acid, N, N'[dithiobis[(methylimino)car bonyloxy]]bis[2(dimethylamino)- 2-oxo-, dimethyl ester 71066-17-6 N CBI Results of an acute oral (gavage) toxicity screen in rats.
8EHQ-0708-17203A (PDF)
(1 pg, 36K)
Ethanimidothioic acid, N,N'[thiobis[(methylimino)carb onyloxy]]bis[2(dimethylamino)-
2-oxo-, dimethyl ester
63942-44-9 N CBI Results of an acute oral toxicity study in rats.
8EHQ-0708-17204A (PDF)
(1 pg, 35K)
Oxime Carbamate 7-2C Confidential   CBI Results of an acute oral toxicity study in rats.
8EHQ-0708-17205A (PDF)
(4 pp, 210K)
2,3,7,8-tetrachlorodibenzop-
dioxin (TCDD)

2,3,4,7,8 pentachlorodibenzofuran
(4-PeCDF)

2,3,7,8 tetrachlorodibenzofuran (TCDF)
1746-01-6


57117-31-4


51207-31-9
N


N


N
Dow Chemical Company Results of egg injection and CYP1A1 induction studies in chicken and japanese quail.
8EHQ-0708-17206A (PDF)
(2 pp, 85K)
Substituted Cyclopropanecarboxylate Family: Pyrethroide Confidential BASF Corporation Results of an acute eye irritation test in rabbits.
8EHQ-0708-17207A (PDF)
(1 pg, 53K)
5-phenyl-pyrimidine derivative None BASF Chemical Company Results of an acute oral (gavage) toxicity study in rats.
8EHQ-0708-17209A (PDF)
(7 pp, 278K)
experimental pyrethroid insecticide Confidential CBI Results of an acute inhalation toxicity study in rats, a preliminary developmental toxicity study in rats and a micronucleus study in rats.
8EHQ-0708-17212A (PDF)
(285 pp, 7.17MB)
Soybean oil, sulfurized 68152-90-9 N Lubrizol Report of a combined systemic and reproduction repeated-dose oral gavage study in rats.
8EHQ-0708-17213A (PDF)
(2 pp, 80K)
substituted nitrogen containing heterocycle (Substance A) and (Substance B) Confidential BASF Corporation Results of screening tests on acute toxicity in water fleas.
8EHQ-0708-17214A (PDF)
(2 pp, 93K)
Nitrogen Containing Heterocycle *2 Substituted Epoxide *2 Confidential Confidential BASF Corporation Results of the effect on growth of green algae.
8EHQ-0708-17215A (PDF)
(2 pp, 92K)
Nitrogen Containing Heterocycle *2 Confidential BASF Corporation Results of a study on the growth of green algae.
8EHQ-0708-17216A (PDF)
(2 pp, 74K)
Substituted Nitrogen containing heterocycle Confidential BASF Corporation Results of a test on acute toxicity in fathead minnow.
8EHQ-0708-17217A (PDF)
(1 pg, 44K)
imidazole, substituted Confidential Syngenta Crop Protection Inc. Results of an acute oral toxicity study in rats
8EHQ-0708-17218A (PDF)
(1 pg, 43K)
Imidazole, substituted Confidential Syngenta Crop Protection, Inc. Results of an acute oral toxicity study in rats
8EHQ-0708-17219A (PDF)
(2 pp, 85K)
Methylaminoethanol 109-83-1 Y American Chemistry Council Results of an oral gavage developmental toxicity range finding study in rats
8EHQ-0708-17220A (PDF)
(2 pp, 82K)
Alkylazine Confidential Bayer CropScience LP Results of a two generation reproductive toxicity study in rats
8EHQ-0708-17221A (PDF)
(2 pp, 75K)
(2,3,5,6 tetrafluorophenyl)methyl (1R-trans)-3-(2,2 dichloroethenyl)-2,2 dimethylcyclopropanecarbo xylate 118712-89-3 N Bayer CropScience LP Results of a chronic toxicity and carcinogenicity study in rats
8EHQ-0708-17222A (PDF)
(5 pp, 209K)
N,N-dimethylaminoethanol 108-01-0 Y BASF Corporation Results of a modified developmental screening study in rats
8EHQ-0708-17223A (PDF)
(1 pg, 43K)
imidazole, substituted Confidential Syngenta Crop Protection, Inc. Results of an acute oral toxicity study in rats
8EHQ-0708-17224A (PDF)
(1 pg, 46K)
imidazole, substituted Confidential Syngenta Crop Protection, Inc. Results of an acute oral toxicity study in rats
8EHQ-0708-17225A (PDF)
(1 pg, 46K)
pyrazole, substituted Confidential Syngenta Crop Protection Inc. Results of a carcinogenicity study
8EHQ-0708-17226A (PDF)
(2 pp, 103K)
Diamylamine 2050-92-2 Y American Chemistry Council Results of a combined oral repeated dose/reproduction/developmental toxicity screening test in rats
8EHQ-0708-17227A (PDF)
(1 pg, 43K)
imidazole, substituted Confidential Syngenta Crop Protection, Inc Results of an acute oral toxicity study in rats
8EHQ-0708-17228A (PDF)
(6 pp, 329K)
Coke (Petroleum) 64741-79-3 Y American Petroleum Institute Results of an inhalation reproductive/developmental study in rats
8EHQ-0708-15412C (PDF)
(2 pp, 80K)
1-Decanol, 3,3,4,4,5,5,6,6,7,7,8,8,9,9,1 0,10-heptadecafluoro- 678-39-7 N DuPont Haskell Results of an inhalation metabolism study in rats
8EHQ-0708-16105J (PDF)
(2 pp, 78K)
Thiophene derivative, substituted None DuPont Haskell Results of a range-finding study in rats to determine doses for a definitive developmental neurotoxicity study.
8EHQ-0708-16105K (PDF)
(1 pg, 42K)
Thiophene derivative, substituted Confidential Dupont Haskell Results of an acute oral toxicity study in rats.
8EHQ-0708-16105L (PDF)
(2 pp, 90K)
Thiophene derivative, substituted None Dupont Haskell Results of a 4 week immunotoxicity study in mice.
8EHQ-0708-16105M (PDF)
(1 pg, 38K)
Thiophene derivative, substituted confidential DuPont Haskell Laboratory Results of an acute oral toxicity study in rats.
8EHQ-0708-16365B (PDF)
(2 pp, 85K)
N-methyl(amino,chloro,methyl) carbomonocyclic carbamide Confidential CBI Results of an in vivo micronucleus assay in mice.
8EHQ-0708-16630B (PDF)
(1 pg, 63K)
Bisphenol A-diglycidyl ether methacrylate 1565-94-2 N 3M Company Results of an oral repeated-dose toxicity study and a reproductive toxicity study in mice.
8EHQ-0708-16819D (PDF)
(2 pp, 65K)
Halogenated pyridine derivative Confidential Dow Chemical Company Results of an oral developmental toxicity study in rats.
8EHQ-0708-16913C (PDF)
(1 pg, 64K)
Fluorinated Aliphatic Alcohol Confidential CBI Results of a developmental toxicity study in rats.
8EHQ-0708-16913D (PDF)
(1 pg, 52K)
Fluorinated Aliphatic Alcohol Confidential CBI Results of an oral reproductive toxicity study in rats.
8EHQ-0708-16946C (PDF)
(28 pp, 840K)
Polymeric MDI Confidential CBI Results of a modified local lymph node assay in mice.
8EHQ-0708-17045D (PDF)
(1 pg, 60K)
Perfluorinated Aliphatic Carboxylinc Acid Confidential CBI Results of an acute oral toxicity study in rats.
8EHQ-0708-17130B (PDF)
(49 pp, 1.95MB)
1-Chlorododecane 112-52-7 Y Lonza Inc. Final report of an in vitro mammalian chromosome aberration test in chinese hamster ovary cells.
FYI-0708-01611A (PDF)
(63 pp, 5.80MB)
multiwalled carbon nanotubes (MWNT) None Technology Sciences Group Inc. Results of study exposing the mesothelial lining of the body cavity by i.p. injection of mice to MWNT.

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit
number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial
submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report.
Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number
as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.

FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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