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Section 8(e) Substantial Risk Notifications and FYI Submissions Received October 2008

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-1008-16721A (PDF)
(4 pp, 169K)
Fluorinated surfactant salt Confidential 3M Company Final report of a 5-day repeated-dose oral toxicity screening study in rats. (In February of 2007, 3M notified EPA of interim study data received).
8EHQ-1008-17277A (PDF)
(2 pp, 80K)
Crude oil Confidential Confidential Report of a retrospective cohort study of approximately 24,000 employees employed in production or processing for at least 6 months some time between 1946 and 2002. Mortality due to cancers and chronic illnesses (such as heart disease and respiratory disease) were assessed.
8EHQ-1008-17278A (PDF)
(20 pp, 742K)
Ethylene glycol dimethyl ether (EGDME) 110-71-4 Y Clariant Corporation Robust summary reports on a series of repeated-dose, reproductive and developmental toxicity studies in rats and rabbits. The following 5 studies were provided as attachments:
1. 14 d-Inhalation toxicity study in rat (1985), Hoechst Corp., Report No. 1985.0477, GLP/OECD; reliability: 2
2. 14 d-Inhalation toxicity study in rat (1986), Hoechst Corp., Report No. 1986.0002, GLP/OECD; reliability: 1
3. 14 d-Inhalation toxicity study in rabbit (1986), Hoechst Corp., Report No. 1986.0426, GLP/OECD reliability: 1
4. Developmental toxicity study in rabbit (1988, inhalation), Hoechst Corp., Report No. 1988.0003, GLP/OECD; reliability: 1
5. Developmental toxicity study in rat (1988, inhalation), Hoechst Corp., Report No. 1988.0110, GLP/OECD; reliability: 1
8EHQ-1008-17279A (PDF)
(2 pp, 89K)
2-Propenoic acid, 2-methyl, 3,3,4,4,5,5,6,6,7,7,8,8,8- tridecafluorooctyl ester 2144-53-8 N DuPont Haskell Global Centers Results of an in vivo mouse micronucleus and chromosome aberration test.
8EHQ-1008-17280A (PDF)
(1 pg, 60K)
Substituted Pyrazole Confidential Confidential Results of skin irritation and eye irritation tests in rabbits
8EHQ-1008-17281A (PDF)
(2 pp, 84K)
Substituted Benzyl Ether Confidential BASF Corporation Results of an acute toxicity study in freshwater isopod (Asellus aquaticus).
8EHQ-1008-17282A (PDF)
(2 pp, 74K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an Acute Toxicity study in Water Flea (Daphnia magna).
8EHQ-1008-17283A (PDF)
(2 pp, 74K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17284A (PDF)
(2 pp, 78K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17285A (PDF)
(2 pp, 78K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17286A (PDF)
(2 pp, 76K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17287A (PDF)
(2 pp, 75K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17288A (PDF)
(2 pp, 72K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17289A (PDF)
(2 pp, 72K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17290A (PDF)
(2 pp, 79K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17291A (PDF)
(2 pp, 74K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17292A (PDF)
(2 pp, 74K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water fleas (Daphnia magna)
8EHQ-1008-17293A (PDF)
(2 pp, 74K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17294A (PDF)
(2 pp, 75K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17295A (PDF)
(2 pp, 74K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water fleas (Daphnia magna).
8EHQ-1008-17296A (PDF)
(2 pp, 75K)
Substituted Nitrogen Containing Heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in water flea (Daphnia magna).
8EHQ-1008-17297A (PDF)
(7 pp, 251K)
pyrethroid compound *2 Confidential Confidential Results of a two week oral toxicity study in dogs.
8EHQ-1008-17298A (PDF)
(1 pg, 40K)
Substituted Polycyclic Nitrogen Containing Heterocycle Confidential Confidential Results of a Ames test in Salmonella typhimurium TA98.
8EHQ-1008-17299A (PDF)
(2 pp, 116K)
Pyrroline Confidential Bayer CropScience LP Results of aa 28-day toxicity study in the rat by dietary administration.
8EHQ-1008-17300A (PDF)
(2 pp, 120K)
Pyrroline Confidential Bayer CropScience LP Results of a range-finding study with fetal evaluation for developmental toxicity in the rat by gavage.
8EHQ-1008-17301A (PDF)
(1 pg, 49K)
Substituted Isoxazole Confidential Syngenta Crop Protection, Inc. Results of a rat local lymph node assay.
8EHQ-1008-17302A (PDF)
(2 pp, 55K)
Substituted Isoxazole Confidential Syngenta Crop Protection, Inc. Results of a rat local lymph node assay.
8EHQ-1008-17303A (PDF)
(2 pp, 72K)
Substituted Nitrogen Containing Heterocycle Confidential BASF Corporation Results of an acute toxicity test in fathead minnow (Pimephales promelas).
8EHQ-1008-17304A (PDF)
(3 pp, 118K)
Substituted Nitrogen Containing Heterocycle Confidential BASF Corporation Results of a developmental toxicity screening study in rats.
8EHQ-1008-17305A (PDF)
(2 pp, 68K)
2,3,7,8 tetrachlorodibenzofuran (TCDF)

51207-31-9

N

Dow Chemical Company Results of a reproduction/ developmental toxicity study with mink.
2,3,4,7,8 Pentachlorodibenzofuran (4-PeCDF) 57117-31-4 N
2,3,7,8 Tetrachlorodibenzo-pdioxin (TCDD) 1746-01-6 N
8EHQ-1008-17306A (PDF)
(9 pp, 465K)
Cesium Formate 3495-36-1 N Cabot Corporation Results of a 28-day repeated dose oral gavage toxicity study in rats.
8EHQ-1008-17307A (PDF)
(1 pg, 51K)
Substituted Nitrogen Containing Heterocycle Confidential   Confidential Results of an in vivo mouse micronucleus assay.
8EHQ-1008-17308A (PDF)
(1 pg, 70K)
Substituted Nitrogen Containing Heterocycle Confidential   Confidential Results of an in vivo mouse micronucleus assay.
8EHQ-1008-17309A (PDF)
(1 pg, 70K)
Substituted Nitrogen Containing Heterocycle Confidential   Confidential Results of an in vivo mouse micronucleus assay.
8EHQ-1008-17310A (PDF)
(2 pp, 83K)
N-(3-aminopropyl)-Ndodecylpropane-1,3diamine 2372-82-9   Akzo Nobel Results of a one year dietary feeding study in rats.
8EHQ-1008-17311A (PDF)
(2 pp, 99K)
Aminoethylethanolamine (AEEA) *3 111-41-1 Y Ethyleneamines Product Stewardship Discussion Group (EPSDG) Aminoethylethanol amine (AEEA) Testing Consortium Interim results of a preliminary developmental toxicity study to explore the intraperitoneal route of administration of AEEA to rats.
8EHQ-1008-17312A (PDF)
(130 pp, 2.80MB)
Acryloylisocyanate (AOI) Confidential ENVIRON International Corporation Three study reports titled Acryloylisocyanate (AOI) were provided with the following stubtitles:
1. acute toxicity study in fish
2. acute toxicity study in Daphnia magna
3. algal growth inhibition assay.
8EHQ-1008-17313A (PDF)
(1 pg, 53K)
Methyl (E)- a(methoxymethylene)-2-[[[6(trifluoromethyl)-2pyridinyl]oxy]methyl] benzeneacetate 117428-22-5 DuPont Haskell Global Centers Results of an eye irritation test in rabbits.
8EHQ-1008-00373CR (PDF)
(30 pp, 1.15MB)
Perfluorooctanoic acid (PFOA, C8)

335-67-1

N

Taft Stettinius and Hollister LLP Information regarding
1. C-8 Science Panel Status Reports (October 15, 2008); and
2. "Self-reported health effects among community residents exposed to Perfluorooctanoate," Anderson-Mahoney, et al. 18(2) New Solutions 129-143 (2008).
Perfluorooctane sulfonate (PFOS) 2795-39-3 N
8EHQ-1008-16819E (PDF)
(2 pp, 80K)
Halogenated pyridine derivative Confidential Dow Chemical Company Results of an acute neurotoxicity study in rats.
8EHQ-1008-17079C (PDF)
(3 pp, 152K)
Hydrated magnesium silicate

63800-37-30

N Confidential Request by EPA for a copy of the complete report: pulmonary bioassay screening study in rats for Sepiolite (hydrated magnesium silicate) and Sepiolite Nanoclay (organically modified hydrated magnesium silicate). This submission references 8ehq_0208_17079A and 8ehq_0408_17079B. This first pages of these submissons are included as attachments.
Hydrated magnesium silicate, organically modified Confidential
8EHQ-1008-17146B (PDF)
(322 pp, 9.02MB)
tert-butyl acetate 540-88-5 N Lyondell Chemical company Final report of a oral developmental toxicity study in rats.
8EHQ-1008-17177B (PDF)
(944 pp, 21.02MB)
allyl alcohol *3 107-18-6   Lyondell Chemical Company Final report of an acute inhalation toxiciy study in rats.
8EHQ-1008-17197E (PDF)
(2 pp, 60K)
Isoxazole, substituted Confidential   Syngenta Crop Protection Inc. Results of two local lymph node assays in the mouse.
8EHQ-1008-17224E (PDF)
(1 pg, 47K)
Imidazole, substituted Confidential   Syngenta Crop Protection, Inc. Results of a single oral dose acute toxicity study in rats.
8EHQ-1008-17225E (PDF)
(2 pp, 60K)
Pyrazole, substituted Confidential   Syngenta Crop Protection Results of an oral feed two year study in rats.
8EHQ-1008-17227E (PDF)
(1 pg, 47K)
Imidazole, substituted Confidential   Syngenta Crop Protection Results of a rat single oral dose acute toxicity study.
8EHQ-1008-17241C (PDF)
(1 pg, 35K)
Ethanol (< 10%) 64-17-5   Confidential Response to a request by EPA for the generic name/composition for the 8ehq-1008-17241 submission.
Proprietary Solvent ( < 15%) Confidential
Water (< 10%) 7732-18-5
Alkylated Urea Resin ( > 65%) Confidential
8EHQ-1008-17254B (PDF)
(1 pg, 34K)
Polyester Acrylate (>90%) Confidential   Confidential Response to a request by EPA for generic name/composition from the 8ehq-1008-17254 submission.
Polyol Acrylate (<10%) Confidential
8EHQ-1008-17254C (PDF)
(28 pp, 969K)
Polyester acrylate (> 90%) Confidential   Confidential Final report of a reverse mutation assay in salmonella typhimurium and escherichia coli.
Polyol acrylate (< 10%) Confidential
FYI-1008-01358 (PDF)
(10 pp, 488K)
Cesium formate

3495-36-1 N Cabot Corporation Results of a 28-day repeated-dose oral (gavage) toxicity study in rats. The following study was attached: Study Title: Twenty-eight day repeated dose oral (gavage) toxicity study in the rat; Project Number: 1004-0253; Authors: N K Dhinsa, Pwatson, P Brooks; Test Facility: Safepharm Laboratories Limited, UK.
FYI-1008-01378AX (PDF)
(31 pp, 1.02MB)
Perfluoroocatne sulfonate (PFOS) 2795-39-3 N Taft Stettinius & Hollister LLP Information regarding
1. C-8 Science Panel Status Reports (October 15, 2008); and
2. self-reported health effects among community residents exposed to perfluorooctanoate," Anderson- Mahoney, et al. 18(2) New Solutions 129-143 (2008).
Perfluorooctanoic acid
(PFOA, C8)
335-67-1 N

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit
number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial
submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report.
Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number
as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.

FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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