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8(e) and FYI Submissions Received October 2008
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8EHQ# |
CHEM NAME(S) |
CAS NO.(S) |
USHV |
SUBMITTER |
DESCRIPTION |
| 8EHQ-1008-16721A (PDF) (4 pp, 169K) |
Fluorinated surfactant salt | Confidential | 3M Company | Final report of a 5-day repeated-dose oral toxicity screening study in rats. (In February of 2007, 3M notified EPA of interim study data received). | |
| 8EHQ-1008-17277A (PDF) (2 pp, 80K) |
Crude oil | Confidential | Confidential | Report of a retrospective cohort study of approximately 24,000 employees employed in production or processing for at least 6 months some time between 1946 and 2002. Mortality due to cancers and chronic illnesses (such as heart disease and respiratory disease) were assessed. | |
| 8EHQ-1008-17278A (PDF) (20 pp, 742K) |
Ethylene glycol dimethyl ether (EGDME) | 110-71-4 | Y | Clariant Corporation | Robust summary reports on a series of repeated-dose, reproductive and developmental toxicity studies in rats and rabbits. The following 5 studies were provided as attachments: |
| 1. 14 d-Inhalation toxicity study in rat (1985), Hoechst Corp., Report No. 1985.0477, GLP/OECD; reliability: 2 | |||||
| 2. 14 d-Inhalation toxicity study in rat (1986), Hoechst Corp., Report No. 1986.0002, GLP/OECD; reliability: 1 | |||||
| 3. 14 d-Inhalation toxicity study in rabbit (1986), Hoechst Corp., Report No. 1986.0426, GLP/OECD reliability: 1 | |||||
| 4. Developmental toxicity study in rabbit (1988, inhalation), Hoechst Corp., Report No. 1988.0003, GLP/OECD; reliability: 1 | |||||
| 5. Developmental toxicity study in rat (1988, inhalation), Hoechst Corp., Report No. 1988.0110, GLP/OECD; reliability: 1 | |||||
| 8EHQ-1008-17279A (PDF) (2 pp, 89K) |
2-Propenoic acid, 2-methyl, 3,3,4,4,5,5,6,6,7,7,8,8,8- tridecafluorooctyl ester | 2144-53-8 | N | DuPont Haskell Global Centers | Results of an in vivo mouse micronucleus and chromosome aberration test. |
| 8EHQ-1008-17280A (PDF) (1 pg, 60K) |
Substituted Pyrazole | Confidential | Confidential | Results of skin irritation and eye irritation tests in rabbits | |
| 8EHQ-1008-17281A (PDF) (2 pp, 84K) |
Substituted Benzyl Ether | Confidential | BASF Corporation | Results of an acute toxicity study in freshwater isopod (Asellus aquaticus). | |
| 8EHQ-1008-17282A (PDF) (2 pp, 74K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an Acute Toxicity study in Water Flea (Daphnia magna). | |
| 8EHQ-1008-17283A (PDF) (2 pp, 74K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17284A (PDF) (2 pp, 78K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17285A (PDF) (2 pp, 78K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17286A (PDF) (2 pp, 76K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17287A (PDF) (2 pp, 75K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17288A (PDF) (2 pp, 72K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17289A (PDF) (2 pp, 72K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17290A (PDF) (2 pp, 79K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17291A (PDF) (2 pp, 74K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17292A (PDF) (2 pp, 74K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water fleas (Daphnia magna) | |
| 8EHQ-1008-17293A (PDF) (2 pp, 74K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17294A (PDF) (2 pp, 75K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17295A (PDF) (2 pp, 74K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water fleas (Daphnia magna). | |
| 8EHQ-1008-17296A (PDF) (2 pp, 75K) |
Substituted Nitrogen Containing Heterocycle *2 | Confidential | BASF Corporation | Results of an acute toxicity study in water flea (Daphnia magna). | |
| 8EHQ-1008-17297A (PDF) (7 pp, 251K) |
pyrethroid compound *2 | Confidential | Confidential | Results of a two week oral toxicity study in dogs. | |
| 8EHQ-1008-17298A (PDF) (1 pg, 40K) |
Substituted Polycyclic Nitrogen Containing Heterocycle | Confidential | Confidential | Results of a Ames test in Salmonella typhimurium TA98. | |
| 8EHQ-1008-17299A (PDF) (2 pp, 116K) |
Pyrroline | Confidential | Bayer CropScience LP | Results of aa 28-day toxicity study in the rat by dietary administration. | |
| 8EHQ-1008-17300A (PDF) (2 pp, 120K) |
Pyrroline | Confidential | Bayer CropScience LP | Results of a range-finding study with fetal evaluation for developmental toxicity in the rat by gavage. | |
| 8EHQ-1008-17301A (PDF) (1 pg, 49K) |
Substituted Isoxazole | Confidential | Syngenta Crop Protection, Inc. | Results of a rat local lymph node assay. | |
| 8EHQ-1008-17302A (PDF) (2 pp, 55K) |
Substituted Isoxazole | Confidential | Syngenta Crop Protection, Inc. | Results of a rat local lymph node assay. | |
| 8EHQ-1008-17303A (PDF) (2 pp, 72K) |
Substituted Nitrogen Containing Heterocycle | Confidential | BASF Corporation | Results of an acute toxicity test in fathead minnow (Pimephales promelas). | |
| 8EHQ-1008-17304A (PDF) (3 pp, 118K) |
Substituted Nitrogen Containing Heterocycle | Confidential | BASF Corporation | Results of a developmental toxicity screening study in rats. | |
| 8EHQ-1008-17305A (PDF) (2 pp, 68K) |
2,3,7,8 tetrachlorodibenzofuran
(TCDF) |
51207-31-9
|
N
|
Dow Chemical Company | Results of a reproduction/ developmental toxicity study with mink. |
| 2,3,4,7,8 Pentachlorodibenzofuran (4-PeCDF) | 57117-31-4 | N | |||
| 2,3,7,8 Tetrachlorodibenzo-pdioxin (TCDD) | 1746-01-6 | N | |||
| 8EHQ-1008-17306A (PDF) (9 pp, 465K) |
Cesium Formate | 3495-36-1 | N | Cabot Corporation | Results of a 28-day repeated dose oral gavage toxicity study in rats. |
| 8EHQ-1008-17307A (PDF) (1 pg, 51K) |
Substituted Nitrogen Containing Heterocycle | Confidential | Confidential | Results of an in vivo mouse micronucleus assay. | |
| 8EHQ-1008-17308A (PDF) (1 pg, 70K) |
Substituted Nitrogen Containing Heterocycle | Confidential | Confidential | Results of an in vivo mouse micronucleus assay. | |
| 8EHQ-1008-17309A (PDF) (1 pg, 70K) |
Substituted Nitrogen Containing Heterocycle | Confidential | Confidential | Results of an in vivo mouse micronucleus assay. | |
| 8EHQ-1008-17310A (PDF) (2 pp, 83K) |
N-(3-aminopropyl)-Ndodecylpropane-1,3diamine | 2372-82-9 | Akzo Nobel | Results of a one year dietary feeding study in rats. | |
| 8EHQ-1008-17311A (PDF) (2 pp, 99K) |
Aminoethylethanolamine (AEEA) *3 | 111-41-1 | Y | Ethyleneamines Product Stewardship Discussion Group (EPSDG) Aminoethylethanol amine (AEEA) Testing Consortium | Interim results of a preliminary developmental toxicity study to explore the intraperitoneal route of administration of AEEA to rats. |
| 8EHQ-1008-17312A (PDF) (130 pp, 2.80MB) |
Acryloylisocyanate (AOI) | Confidential | ENVIRON International Corporation | Three study reports titled Acryloylisocyanate (AOI) were provided with the following stubtitles: 1. acute toxicity study in fish 2. acute toxicity study in Daphnia magna 3. algal growth inhibition assay. |
|
| 8EHQ-1008-17313A (PDF) (1 pg, 53K) |
Methyl (E)- a(methoxymethylene)-2-[[[6(trifluoromethyl)-2pyridinyl]oxy]methyl] benzeneacetate | 117428-22-5 | DuPont Haskell Global Centers | Results of an eye irritation test in rabbits. | |
| 8EHQ-1008-00373CR (PDF) (30 pp, 1.15MB) |
Perfluorooctanoic acid (PFOA, C8) |
335-67-1 |
N | Taft Stettinius and Hollister LLP | Information regarding 1. C-8 Science Panel Status Reports (October 15, 2008); and 2. "Self-reported health effects among community residents exposed to Perfluorooctanoate," Anderson-Mahoney, et al. 18(2) New Solutions 129-143 (2008). |
| Perfluorooctane sulfonate (PFOS) | 2795-39-3 | N | |||
| 8EHQ-1008-16819E (PDF) (2 pp, 80K) |
Halogenated pyridine derivative | Confidential | Dow Chemical Company | Results of an acute neurotoxicity study in rats. | |
| 8EHQ-1008-17079C (PDF) (3 pp, 152K) |
Hydrated magnesium silicate |
63800-37-30 |
N | Confidential | Request by EPA for a copy of the complete report: pulmonary bioassay screening study in rats for Sepiolite (hydrated magnesium silicate) and Sepiolite Nanoclay (organically modified hydrated magnesium silicate). This submission references 8ehq_0208_17079A and 8ehq_0408_17079B. This first pages of these submissons are included as attachments. |
| Hydrated magnesium silicate, organically modified | Confidential | ||||
| 8EHQ-1008-17146B (PDF) (322 pp, 9.02MB) |
tert-butyl acetate | 540-88-5 | N | Lyondell Chemical company | Final report of a oral developmental toxicity study in rats. |
| 8EHQ-1008-17177B (PDF) (944 pp, 21.02MB) |
allyl alcohol *3 | 107-18-6 | Lyondell Chemical Company | Final report of an acute inhalation toxiciy study in rats. | |
| 8EHQ-1008-17197E (PDF) (2 pp, 60K) |
Isoxazole, substituted | Confidential | Syngenta Crop Protection Inc. | Results of two local lymph node assays in the mouse. | |
| 8EHQ-1008-17224E (PDF) (1 pg, 47K) |
Imidazole, substituted | Confidential | Syngenta Crop Protection, Inc. | Results of a single oral dose acute toxicity study in rats. | |
| 8EHQ-1008-17225E (PDF) (2 pp, 60K) |
Pyrazole, substituted | Confidential | Syngenta Crop Protection | Results of an oral feed two year study in rats. | |
| 8EHQ-1008-17227E (PDF) (1 pg, 47K) |
Imidazole, substituted | Confidential | Syngenta Crop Protection | Results of a rat single oral dose acute toxicity study. | |
| 8EHQ-1008-17241C (PDF) (1 pg, 35K) |
Ethanol (< 10%) | 64-17-5 | Confidential | Response to a request by EPA for the generic name/composition for the 8ehq-1008-17241 submission. | |
| Proprietary Solvent ( < 15%) | Confidential | ||||
| Water (< 10%) | 7732-18-5 | ||||
| Alkylated Urea Resin ( > 65%) | Confidential | ||||
| 8EHQ-1008-17254B (PDF) (1 pg, 34K) |
Polyester Acrylate (>90%) | Confidential | Confidential | Response to a request by EPA for generic name/composition from the 8ehq-1008-17254 submission. | |
| Polyol Acrylate (<10%) | Confidential | ||||
| 8EHQ-1008-17254C (PDF) (28 pp, 969K) |
Polyester acrylate (> 90%) | Confidential | Confidential | Final report of a reverse mutation assay in salmonella typhimurium and escherichia coli. | |
| Polyol acrylate (< 10%) | Confidential | ||||
| FYI-1008-01358 (PDF) (10 pp, 488K) |
Cesium formate |
3495-36-1 | N | Cabot Corporation | Results of a 28-day repeated-dose oral (gavage) toxicity study in rats. The following study was attached: Study Title: Twenty-eight day repeated dose oral (gavage) toxicity study in the rat; Project Number: 1004-0253; Authors: N K Dhinsa, Pwatson, P Brooks; Test Facility: Safepharm Laboratories Limited, UK. |
| FYI-1008-01378AX (PDF) (31 pp, 1.02MB) |
Perfluoroocatne sulfonate (PFOS) | 2795-39-3 | N | Taft Stettinius & Hollister LLP | Information regarding 1. C-8 Science Panel Status Reports (October 15, 2008); and 2. self-reported health effects among community residents exposed to perfluorooctanoate," Anderson- Mahoney, et al. 18(2) New Solutions 129-143 (2008). |
| Perfluorooctanoic acid (PFOA, C8) |
335-67-1 | N |
(A) PMN; (B) Pesticide; (C) Pesticide Inert
DEFINITION OF TERMS
8EHQ# - This is the EPA submission number that includes a 4-digit month and
year followed by a 5-digit
number assigned sequentially from the year 1977, followed by a sequence letter
( “A” for the initial
submission and “B”, “C”, “D”, etc. for
supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report.
Supplemental submissions reflect the month and year logged in but retain the
same 5-digit sequential number
as a link to the initial submission. 8EHQ number is a useful reference to
request a copy of a submission.
FYI (For Your
Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is
similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter
either judges that the information is not reportable under TSCA 8(e) reporting
requirements or is not subject to TSCA 8(e) reporting but wants to share the
information with EPA (and the public) on a voluntary basis.
NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other
EPA programs and other federal agencies can ask OPPT to request follow-up
information as well.
CHEM Name - This is the name used by the submitter.
CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI"
indicates that the submitter is claiming the identity of the chemical to be
confidential business information. This claim can be challenged in some cases,
and users should notify EPA if they wish to pursue the chemical identity.
USHV - High production volume chemical in the U.S., including domestic manufacture
and importation. EPA defines high production volume as annual production one
million pounds or more pounds.
Description - A general description of the type of study or information submitted,
but not study results. A PDF electronic copy of the submission is attached.