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Section 8(e) Substantial Risk Notifications and FYI Submissions Received December 2009

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-1209-17712A (PDF) Not provided Not provided   3M Drug Delivery Systems Results on a lung tissue assay in rats
8EHQ-1209-17754A (PDF) Tetrahydronapthalene, substituted Not provided   Syngenta Crop Protection, Inc. Results of a repeated dose dietary study in mice
8EHQ-1209-17755A (PDF) Potassium cyanide 151-50-8 N DuPont Haskell Laboratory Results of a 13-week drinking water study in rats
8EHQ-1209-17756A (PDF) Octylmethylcyclotetrasiloxane (D4) 556-67-2 Y Dow Corning Corporation An inter-laboratory comparison of processing and analytical procedures for analysis of cyclic volatile methylsiloxane (cVMS) materials in fish liver obtained from Atlantic cod collected from the inner Oslofjord.
Decamethylcyclopentasiloxan (D5) 541-02-6 N
Dodecamethylcyclohexasiloxane (D6) 540-97-6 Y
Hexamethylcyclotrisiloxane (D3) 541-05-9 Y
8EHQ-1209-17757A (PDF) Mixture of Substituted Nitrogen-Containing Heterocyclic Compounds Not provided   Confidential Results of an Ames test conducted in Salmonella typhimurium tester strain TA98 in the presence of S9 (Aroclorinduced rat liver S9) metabolic activation
8EHQ-1209-17758A (PDF) p-Phenylenediamine 106-50-3 Y DuPont Haskell Laboratory Results of several published and unpublished studies from the "European Commission, Scientific Committee on Consumer Products (SCCP), Opinion on p-Phenylenediamine, COLIPA # A7, SCCP/0989/06", October 10, 2006
8EHQ-1209-17759A (PDF) Decamethylcyclopentasiloxane 541-02-6 Y Dow Corning Results on Cyclic volatile methylsilaxane materials in Atlantic cod (Gadus morhua)
Dodecamethylcyclohexasiloxane 540-97-6 Y
Hexamethylcyclotrisiloxane 541-05-9 Y
Octylmethylcyclotetrasiloxane 556-67-2 Y
8EHQ-1209-17760A (PDF) Substituted Pyridine Confidential   Syngenta Crop Protection, Inc. Results of a Prenatal Developmental Toxicity Study in rabbits
8EHQ-1209-17761A (PDF) Substituted Pyridine Not provided   Syngenta Crop Protection, Inc. Results of a Prenatal Developmental Toxicity study in rabbits
8EHQ-1209-17762A (PDF) Substituted Pyridine Not provided   Syngenta Crop Protection, Inc. Results of 104-week rat dietary carcinogenicity study with combined 52-week toxicity study
8EHQ-1209-17763A (PDF) Methyl 2-[[[[[4-ethoxy-6(methylamino)-1,3,5triazin-2yl]amino]carbonyl]amino]s ulfonyl]benzoate 97780-06-8 N DuPont Haskell Global Centers Results of two, acute algae studies, a chronic toxicity study for Daphnia magna, and an early-life-stage for toxicity test for Rainbow Trout
8EHQ-1209-17764A (PDF) Spunbond Nonwoven Made from Polyolefin with Flame Retardant Coating of Ammonium Sulfamate 7773-06-0 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of a human patch test for skin irritation study
Cocoalkyltrimethylammonium Methyl Sulfate 68002-60-8 N
8EHQ-1209-17765A (PDF) Methacrylonitrile 126-98-7 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of a dermal toxicity study in rabbits
8EHQ-1209-17766A (PDF) Acrylonitrile 107-13-1 Y DuPont Haskell Global Centers for Health and Environmental Sciences Results of an acute dermal toxicity study in rabbits
8EHQ-1209-17767A (PDF) Exfoliated Graphite Not provided   BASF Corporation Results of a Subacute 5-day inhalation study in Wistar rats
8EHQ-1209-17768A (PDF) Mixture Containing Substituted Epoxide, Benzylether and Nitrogen Containing Heterocycle *2 Not provided   BASF Corporation Results of an Acute Toxicity Study in Bluegill Sunfish
8EHQ-1209-17769A (PDF) Mixture Containing Benzylether and Nitrogen Containing Heterocycle *2 Not provided   BASF Corporation Results of an Acute Toxicity Study in Rainbow Trout (Oncohynchus mykiss)
8EHQ-1209-17770A (PDF) Substituted Nitrogen Containing Heterocycle *2 Not provided   BASF Corporation Results of a Toxicity Study on the Growth of the Aquatic Plant Lemna gibba
8EHQ-1209-17771A (PDF) Confidential Not provided   BASF Corporation Results of a skin sensitizing study using the Local Lymph Node Assay (LLNA) with CBA/J mice
8EHQ-1209-17772A (PDF) Bicyclo 2.2.1 hept-2-ene, 5(2-phenylethy1)-, *1 717099-35-9 N Promerus LLC Results of a Skin Sensitization study in Local Lymph Node Assay in the Mouse
8EHQ-1209-17773A (PDF) Aluminum hydroxide oxide 13 18-23-6 N DuPont Haskell Laboratory Results of a subchronic dermal toxicity study in rabbits
8EHQ-1209-17774A (PDF) 3-Pyridinecarboxylic acid, 2-(aminosulfony1)-6(trifluoromethy1)-, methyl 144740-59-0 N DuPont Haskell Laboratory Results of a biodegradation test, green algae and acute daphnia studies, a skin sensitization test in guinea pigs and a 4week oral subchronic test in rats
8EHQ-1209-17775A (PDF) Benzoic acid, 2(chlorosulfonyl)-3-methyl, methyl ester 126535-26-0 N DuPont Haskell Laboratory Results of 2 algal studies, a daphnid and fish study, eye irritation and skin sensitization studies, an in vitro Ames assay in Salmonella and a chromosomal aberration assay in human peripheral blood lymphocytes
8EHQ-1209-17776A (PDF) Phosphorous acid, tris(methylphenyl) ester 25586-42-9 Y Invista Results of a local lymph node assay
8EHQ-1209-17777A (PDF) Aluminum hydroxide oxide 1318-23-6 N DuPont Haskell Laboratory Results of an acute inhalation toxicity study in rats
8EHQ-1209-17778A (PDF) Pyrazole, substituted Not Provided   Syngenta Crop Protection, Inc. Results of a 14-day preliminary dietary toxicity study in mice
8EHQ-1209-17779A (PDF) Benzamide, substituted Not Provided   Syngenta Crop Protection, Inc. Results of a 14-day dietarytoxicity study and toxicokinetic study in rats
8EHQ-1209-17781A (PDF) 1,6bis(trimethoxysilyl)hexane 87135-01-1 N Dow Corning Preliminary information from an ongoing combined repeated dose toxicity study with a reproductive/developmental toxicity screening test in rats and a final report of a 28-day repeated-dose study in rats
8EHQ-1209-17782A (PDF) Methyltrimethoxysilane 1185-55-3 Y Dow Corning Preliminary information from a contact hypersensitivity (skin sensitization) study in guinea pigs.
8EHQ-1209-17783A (PDF) Trimethoxyphenylsilane Not Provided   SEHSC Pathology reports/tables, historical control data (Appendix VII) and functional observational battery methods (Appendix VIII) from a report of a reproductive oral (gavage) toxicity study in rats.
8EHQ-1209-17784A (PDF) Fluorochemicals Multiple   3M Company A letter to EPA documenting 3M's understanding of what types of environmental monitoring data need to be submitted to the TSCA Section 8(e) docket due to "the increased amount of environmental monitoring for fluorochemicals (FCs) being conducted under a variety of programs".
8EHQ-1209-17785A (PDF) Methacrylic copolymer Not Provided   Confidential Results of a local lymph node assay in mice
8EHQ-1209-17791A (PDF) Cyclohexyldiamino ethylesters Not Provided   Confidential Results from a 21-day reproduction test in Daphnia magna.
8EHQ-1209-17799A (PDF) Busperse 293 Not Provided   Buckman Laboratories International, Inc. Incident report/adverse effects incident information from alleged exposure to a product distributed by Buckman Laboratories.
8EHQ-1209-17866A (PDF) Confidential Not provided   Confidential Results of an acute oral toxicity study in rats
8EHQ-1209-15945Y (PDF) Anthranilamide, substituted Not provided   DuPont Haskell Global Centers for Health and Environmental Sciences Results of a skin sensitization study in guinea pigs
8EHQ-1209-16436J (PDF) Perfluorinated aliphatic carboxylic acid, ammonium salt *1 Not Provided   DuPont Haskell Laboratory Results of a 90-day oral toxicity study in mice
8EHQ-1209-16446P (PDF) Perfluorooctanoic acid (PFOA) 335-67-1 N Dupont Haskell Laboratory Results of an Occupational Serum Sampling study for Fayetteville Works, Fayetteville, North Carolina
8EHQ-1209-16446Q (PDF) Perfluorooctanoate Anion (PFOA) 335-67-1   DuPont Haskell Laboratory for Health and Environmental Sciences Results of a Perfluorooctanoate Anion (PFOA) Occupational Serum Sampling Dordrecht Works, Dordrecht, Netherlands
8EHQ-1209-16446R (PDF) Perflurooctanoic anion (PFOA) 335-67-1   DuPont Haskell Laboratory Results of an Occupational Serum Sampling Washington Works, Parkersburg, West Virginia
8EHQ-1209-16446S (PDF) Perfluorooctanoic anion (PFOA) 335-67-1   DuPont Haskell Laboratory Results of an Occupational Serum Sampling DuPont Performance Elastomers Chambers Works Facility, Deepwater, New Jersey
8EHQ-1209-16478J (PDF) Perfluorinated aliphatic carboxylic acid, ammonium salt Not Provided   DuPont Haskell Laboratory Results of a 90-day oral toxicity study in mice
8EHQ-1209-16663F (PDF) Perfluorooctanoite anion (PFOA) 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Occupational Serum sampling results for DuPont Performance Elastomers Chambers Works Facility, Deepwater, New Jersey
8EHQ-1209-17313H (PDF) Methyl (E)-a(methoxymethylene)-2-[[[6(trifluoromethyl)-2pyridinyl]oxy]methyl]benzeneacetate 117428-22-5 N DuPont Haskell Laboratory Pathology results from an acute oral neurotoxicity test in rats
8EHQ-1209-17574B (PDF) Amino Bromo Benzamide, Substituted Not provided   Confidential Results of acute algae toxicity assay Pseudokirchneriella subcapitata
8EHQ-1209-17600C (PDF) Substituted Acetophenone Not provided   Confidential Results of an in vitro skin and an in vitro eye irritation study
FYI-1209-01618A (PDF) 2,4-MDI
5873-54-1   Bayer MaterialScience Results of Air Monitoring Studies in Residential Buildings during SPF Application
4,4'-Methylene diphenyl diisocyanate (MDI) 101-68-8  
pMDI 9016-87-9  
1,1,1,3,3-pentafluoropropane 460-73-1  
aliphatic amine catalysts undetermined Confidential  
FYI-1209-01619A (PDF) SUBSTANZ MT Not Provided   ESPE Dental AG Report of a contact hypersensitivity study in guinea pigs (maximization test)

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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