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Section 8(e) Substantial Risk Notifications and FYI Submissions Received June 2009

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0609-00373DB1 (PDF)
(51 pp, 3.77MB)
Perfluorooctanoic acid (PFOA) 335-67-1 N Taft Stettinius & Hollister LLP Study information on the disposition of PFOA in the pregnant and lactating mouse and her offspring, analysis of polyfluoroalkyl chemicals in the serum and milk of breastfeeding women and in utero/developmental exposure in mice.
8EHQ-0609-00373DB2 (PDF)
(2 pp, 57K)
Fluorochemicals, sulfonate- and carboxylic-based Multiple N 3M Corporation Draft biomonitoring data of residents living in the Washington County area of Minnesota.
8EHQ-0609-17537A (PDF)
(2 pp, 60K)
EXP-9078 *2 Confidential   Confidential Results of pre-screening studies in fish and honeybees.
8EHQ-0609-17538A (PDF)
(2 pp, 66K)
EXP-9095 *2 Confidential   Confidential Results of a pre-screening study in honeybees.
8EHQ-0609-17539A (PDF)
(2 pp, 59K)
EXP-8007 *2 Confidential   Confidential Results of pre-screening studies to fish and honeybees.
8EHQ-0609-17540A (PDF)
(2 pp, 69K)
Confidential Confidential   Confidential Results of an acute dermal irritation potential study in rabbits.
8EHQ-0609-17541A (PDF)
(2 pp, 81K)
Confidential Confidential   Confidential Results of an eye irritation study in rabbits.
8EHQ-0609-17542A (PDF)
(2 pp, 94K)
Benzene, 1,1'methylenebis(4-isocyanato)- *3 101-68-8 Y DuPont Haskell Global Centers for Health and Environmental Sciences Results of a pre-1977 (1966) acute inhalation toxicity study in rats.
8EHQ-0609-17543A (PDF)
(2 pp, 136K)
Benzamide, substituted Confidential   Syngenta Crop Protection, Inc. Results of a 20-day oral toxicity study in rats.
8EHQ-0609-17544A (PDF)
(112 pp, 3.35MB)
Chemical compound 1 Confidential   Confidential Unpublished study reports on acute inhalation and acute oral toxicity studies in rats (each study was conducted on 2 compounds).
Chemical compound 2 Confidential  
8EHQ-0609-17545A (PDF)
(2 pp, 103K)
Amino halogenated pyridine derivative Confidential   Dow Chemical Company Results of a 28-day dietary study in dogs.
8EHQ-0609-17546A (PDF)
(3 pp, 169K)
Dinitrile *2 Confidential   BASF Corporation Results of an acute toxicity study in Daphnia magna.
8EHQ-0609-17547A (PDF)
(2 pp, 104K)
Nitrogen containing heterocycle, substituted *2 Confidential   BASF Corporation Results of a preliminary range finding prenatal developmental toxicity study in rats.
8EHQ-0609-17548A (PDF)
(2 pp, 123K)
Benzylether *2 Confidential   BASF Corporation Results an acute eye irritation test in rabbits.
  Nitrogen containing heterocycle *2 Confidential      
8EHQ-0609-17549A (PDF)
(182 pp, 6.41MB)
Tetrakis (2,6-dimethylphenyl)m-phenylenebis phosphate Confidential   Japan Technical Information Center, Inc. Report of a reproduction/developmental oral toxicity screening test in rats.
8EHQ-0609-17550A (PDF)
(2 pp, 111K)
Triethoxysilane (TES) 998-30-1 N Momentive Performance Materials Results of an acute inhalation toxicity study in rats.
8EHQ-0609-17551A (PDF)
(1 pg, 103K)
Nitrogen containing heterocycle, substituted Confidential   Confidential Results of a pilot developmental range-finding study in rats.
8EHQ-0609-17552A (PDF)
(1 pg, 106K)
Fluorochemical Confidential   3M Company Preliminary results of an acute inhalation toxicity study in rats.
8EHQ-0609-17553A (PDF)
(2 pp, 116K)
2,2,6,6Tetramethylpiperidin (TEMP) 768-66-1 N Evonik Industries Results from an acute inhalation and acute oral toxicity study in rats.
8EHQ-0609-17554A (PDF)
(1125 pp, 36.35MB)
Pigment additive 1799u None   Lubrizol Corporation Final report of a two-generation reproduction dietary administration toxicity study in rats.
8EHQ-0609-17555A (PDF)
(2 pp, 184K)
Cyclamen Aldehyde (Benzenepropanol, .alpha-methyl-4-(1-methylethyl)-) 103-95-7 N Fragrance Materials Association of the United States Results of an oral range finding reproductive toxicity study in rats.
8EHQ-0609-17556A (PDF)
(1 pg, 90K)
Amino cyano benzaminde, substituted Confidential   Confidential Results of an eye irritation study in rabbits and an acute oral toxicity test in rats.
8EHQ-0609-17557A (PDF)
(1 pg, 97K)
2-Chlorobenzenesulfonamide 6961-82-6 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of an acute oral toxicity study in rats.
8EHQ-0609-17558A (PDF)
(2 pp, 95K)
Perfluorohexanoate anion 307-24-4 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of serum sampling for PFHxA from the chambers works facility, Deepwater, New Jersey DuPont site for 2009.
8EHQ-0609-17559A (PDF)
(2 pp, 144K)
Benzoic acid, 2-[(aminosulfonyl)methyl]-, methyl ester 112941-26-1   DuPont Haskell Global Centers for Health and Environmental Sciences Results of a biodegradation study, an acute oral toxicity study in rats, and a sub-chronic oral toxicity study in rats.
8EHQ-0609-17560A (PDF)
(2 pp, 176K)
1H-Pyrazole-5-sulfonamide, 1-methyl-4-(2-methyl-2H-tetrazol-5-yl)- 139481-22-4   DuPont Haskell Global Centers Results of a biodegradation study, an acute daphnia toxicity study, an acute oral toxicity study in rats, and a sub-chronic oral toxicity study in rats.
8EHQ-0609-17561A (PDF)
(1 pg, 112K)
Heptafluorobutanol Confidential   3M Company Preliminary data in an inhalation toxicity study with Sprague-Dawley rats
8EHQ-0609-17562A (PDF)
(1 pg, 139K)
1-Octanesulfonic acid, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluoro- in 27619-97-2   DuPont Haskell Global Centers Results of an acute oral toxicity study in rats.
  Methanol *3 67-56-1 Y    
8EHQ-0609-17563A (PDF)
(2 pp, 94K)
pyrimidine derivative *2 Confidential   BASF Corporation Results of an in vivo mouse micronucleus screening test.
8EHQ-0609-17564A (PDF)
(2 pp, 115K)
Carbamate, substituted *2 Confidential   BASF Corporation Results of a screening test on acute toxicity in Daphnia.
8EHQ-0609-17565A (PDF)
(2 pp, 120K)
carbamate, substituted *2 Confidential   BASF Corporation Results of a screening test on acute toxicity in fathead minnow
8EHQ-0609-17569A (PDF)
(1 pg, 62K)
Octafluorocyclobutane None   DuPont Haskell Global Centers for Health and Environmental Sciences Results of an acute inhalation toxicity study in rats.
8EHQ-0609-17570A (PDF)
(2 pp, 120K)
Oil Residues (Uncharacterized) from Octafluorocyclobutane Process None   DuPont Haskell Global Centers for Health and Environmental Sciences Results of an acute skin absorption study in rabbits.
8EHQ-0609-17572A (PDF)
(2 pp, 128K)
Octafluorocyclobutane 115-25-3   DuPont Haskell Global Centers for Health and Environmental Sciences Results of an inhalation cardiac sensitization study in dogs.
8EHQ-0609-17573A (PDF)
(2 pp, 146K)
Octafluorocyclobutane None   DuPont Haskell Global Centers for Health and Environmental Sciences Results of an acute inhalation study in rats.
8EHQ-0609-17582A (PDF)
(2 pp, 123K)
Aziridine Confidential   Confidential Results of an in vivo micronucleus test in male mice.
8EHQ-0609-00373DC (PDF)
(9 pp, 1.10MB)
Pefluorooctanoic acid (PFOA) 335-67-1 N Taft Stettinius & Hollister LLP Information on the occurrence and potential significant of PFOA detected in New Jersey public drinking water systems.
8EHQ-0609-16105Q (PDF)
(2 pp, 114K)
N-[2-(1,3-dimethylbutyl)-3-thienyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazole None   DuPont Haskell Results of a developmental neurotoxicity study in rats.
8EHQ-0609-16446L (PDF)
(7 pp, 469K)
Pefluorooctanoic anion (PFOA) 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Occupational PFOA serum sampling results for workers at the Fayetteville Works facility in Fayetteville, NC.
8EHQ-0609-16446M (PDF)
(2 pp, 90K)
Perfluorooctanoic anion (PFOA) 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Occupational PFOA serum sampling results for workers at the Experimental Station facility in Wilmington, DE.
8EHQ-0609-16446N (PDF)
(14 pp, 618K)
Perfluorooctanoic anion (PFOA) 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Occupational PFOA serum sampling results for workers at the Chambers Works facility in Deepwater, NJ.
8EHQ-0609-16446O (PDF)
(6 pp, 275K)
Perfluorooctanoic anion (PFOA) 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Occupational PFOA serum sampling results for workers at the DuPont Performance Elastomers Chambers Works facility in Deepwater, NJ.
8EHQ-0609-16598C (PDF)
(7 pp, 430K)
Perfluorooctanoic anion (PFOA) 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Occupational PFOA serum sampling results for workers at the First Chemical facility in Pascagoula, MS.
8EHQ-0609-16663D (PDF)
(15 pp, 806K)
Perfluorooctanoic anion (PFOA) 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Occupational PFOA serum sampling results for workers at the Chambers Works Facility in Deepwater New Jersey.
8EHQ-0609-16663G (PDF)
(7 pp, 433K)
Perfluorooctanoic anion (PFOA) 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Occupational PFOA serum sampling results for workers at the DuPont Performance Elastomers Chambers Works facility in Deepwater, NJ.
8EHQ-0609-16721L (PDF)
(313 pp, 9.87MB)
Fluorinated surfactant salt (MTDID 6675) Confidential   3M Corporation Final reports for a 90-day oral toxicity study and a toxicokinetic evaluation in rats.
8EHQ-0609-16911C (PDF)
(174 pp, 8.59MB)
lactose with zinc oxide nanoparticles surface-treated with trimethylhexanoate None   3M Corporation Final report of a two-week inhalation toxicity study of MTDID 11009 in CD rats.
8EHQ-0609-16913F (PDF)
(1 pg, 132K)
Fluorinated Aliphatic Alcohol Confidential   Confidential Results of an acute inhalation study in rats.
8EHQ-0609-17229D (PDF)
(7 pp, 394K)
Perfluorooctanoate Anion (PFOA) 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of an occupational PFOA serum sampling study for workers at the DuPont site in Changshu Works, Changshu, China.
8EHQ-0609-17313B (PDF)
(3 pp, 110K)
Methyl (E)-alpha-(methoxymethylene)-2-[[[6-(trifluoromethyl)-2-pyridinyl]oxy]methyl]-benzeneacetate 117428-22-5 N DuPont Haskell Global Centers Preliminary results of an acute neurotoxicity test in rats.
8EHQ-0609-17334B (PDF)
(3 pp, 187K)
3-Amino-4-octanol 1001354-72-8   Dow Chemical Company Results of a 90-day repeated dose toxicity study in rats.  This document also contains a response to results obtained during an oral reproduction/developmental study in rats in 8EHQ-08-17334.
8EHQ-0609-17365D (PDF)
(2 pp, 136K)
Chemical None   Dupont Haskell Global Centers for Health and Environmental Sciences Results of an acute oral toxicity study in rats.
8EHQ-0609-17367B (PDF)
(2 pp, 96K)
Perfluorooctanoate anion 335-67-1 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of occupational PFOA serum sampling monitoring in workers at the Tralee Park, Newark, Delaware DuPont site for 2009.
8EHQ-0609-17418B (PDF)
(3 pp, 203K)
Methylaminoethanol 109-83-1 Y American Chemistry Council Results of an oral combined repeated-dose toxicity with reproductive/developmental toxicity in rats.
8EHQ-0609-17498B (PDF)
(2 pp, 88K)
Phenyl isothiocyanate (PITC)/n-Heptane None   Life Technologies Revised non-confidential 8(e) submission letter regarding an adverse health allegation.

 

On April 28, 2009 Life Technologies submitted an adverse health allegation (8EHQ-09-17498A) and claimed the following information to be confidential information: The identity of the person making the report and the composition of the product.  The sponsor has reconsidered their stance and decided to waive confidentiality on the product composition only.  However, they still wish to protect the privacy of the employee of the customer in France making the allegation. Accordingly, please see a revised, non-confidential 8(e) submission letter which has removed the name of the individual. The revised letter is intended to replace both the public and confidential 8(e) letters originally submitted on April 28, 2009.
8EHQ-0609-17552B (PDF)
(1 pg, 45K)
Fluorochemical Confidential   3M Company The submission letter states that the CBI Substantiation Questionnaire corresponding to the initial submission (8EHQ-0609-17552A) is enclosed.  However, no enclosures were provided.
FYI-0609-01615A (PDF)
(1 pg, 111K)
Chlorodifluoromethane (R-22) None   Honeywell Report of an incident involving an over exposure to the test substance.
FYI-0609-01616A (PDF)
(30 pp, 1.10MB)
multi-walled carbon nanotubes None   Arkema Inc. An enclosed research paper on the carcinogenic response to multi-walled carbon nanotubes on a 2-year bioassay in the peritoneal cavity of the rat.
FYI-0609-01378BC (PDF)
(52 pp, 4.39MB)
Perfluoroonanoic acid (PFNA) 375-95-1 N Taft Stettinius & Hollister LLP Results of three studies with fluorochemicals: 1. Analysis of PFOA in Dosed CD-1 Mice Part 2: Disposition of PFOA in Tissues and Fluids From Pregnant and Lactating Mice and Their Pups; 2. Polyfluoroalkyl Chemicals in the Serum and Milk of Breastfeeding Wo
  Perfluorooctanoic acid (PFOA) 335-67-1 N    
  perfluorohexane sulfonic acid (PFHxS) 355-46-4 N    
  Perfluoroocatne sulfonic acid (PFOS) 1763-23-1 N    
FYI-0609-01378BD (PDF)
(9 pp, 1.08MB)
Perfluorooctanoic Acid (PFOA) 335-67-1 N Taft Stettinius & Hollister LLP Results of analysis of PFOA in drinking water

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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