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Section 8(e) Substantial Risk Notifications and FYI Submissions Received March 2009

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0309-17401A (PDF)
(1pg, 70K)
Tertiary butyl hydroperoxide (TBHP) 75-91-2 Y Lyondell Chemical Company Supplemental information regarding a 5 day sub acute rat inhalation toxicity study.
8EHQ-0309-17422A (PDF)
(41 pp, 1.21MB)
Confidential Confidential   Center for Regulatory Services, Inc. Report of a bacterial reverse mutation assay.
8EHQ-0309-17423A (PDF)
(2 pp, 71K)
Confidential Confidential   Confidential Results of an acute inhalation toxicity study in rats.
8EHQ-0309-17424A (PDF)
(2 pp, 72K)
Confidential Confidential   Confidential Findings from an acute inhalation toxicity study in rats.
8EHQ-0309-17425A (PDF)
(2 pp, 73K)
Confidential Confidential   Bayer Results of an acute inhalation toxicity study in rats.
8EHQ-0309-17426A (PDF)
(2 pp, 79K)
Nitrogen containing heterocycle, substituted *2 Confidential   BASF Corporation Interim results of a preliminary range finding prenatal developmental toxicity study in rats.
8EHQ-0309-17427A (PDF)
(2 pp, 60K)
Isothiazol derivative (Substance A) Confidential   BASF Corporation Results of an in vivo mouse micronucleus screening test.
Isothiazol derivative (Substance B) Confidential   BASF Corporation  Results of an in vivo mouse micronucleus screening test.
8EHQ-0309-17429A (PDF)
(2 pp, 75K)
Nitrogen containing heterocycle *2 Confidential   BASF Corporation Results of a combined oral (dietary) chronic toxicity/carcinogenicity study in Wistar rats.
8EHQ-0309-17430A (PDF)
(3 pp, 105K)
Nitrogen containing heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study with Fathead Minnow (Pimephales promelas).
8EHQ-0309-17431A (PDF)
(2 pp, 78K)
Nitrogen containing heterocycle, substituted *2 Confidential   BASF Corporation Results of a toxicity test on Green Alga (Pseudokirchneriella subcapitata).
8EHQ-0309-17432A (PDF)
(2 pp, 79K)
Nitrogen containing heterocycle, substituted *2 Confidential   BASF Corporation Results of a toxicity test on Green Alga (Pseudokirchneriella subcapitata).
8EHQ-0309-17433A (PDF)
(2 pp, 78K)
Nitrogen containing heterocycle, substituted *2 Confidential   BASF Corporation Results of a screening test on acute toxicity in Daphnia (Daphnia magna).
8EHQ-0309-17434A (PDF)
(2 pp, 85K)
Pyrazole, substituted Confidential   Syngenta Crop Protection, Inc. Results from a rabbit enucleated eye test.
8EHQ-0309-17435A (PDF)
(2 pp, 78K)
Confidential Confidential   Confidential Results of an acute inhalation toxicity study in rats.
8EHQ-0309-17436A (PDF)
(8 pp, 288K)
2,2'-ethylidenebis(4,6-di-tert-butylphenyl)fluorophosphite 118337-09-0 N Eastman Chemical Company Information regarding exposure symptoms experienced by two employees and which symptoms are alleged to be associated with manufacturing operations involving the production of the sponsored chemical.
8EHQ-0309-17437A (PDF)
(1 pg, 67K)
Adhesive Confidential   Confidential Results of a dermal sensitization study (Murine Local Lymph Node Assay) in female CBAlJHsd mice.
8EHQ-0309-17438A (PDF)
(7 pp, 307K)
Mediator-Laccase Blend None   Danisco US Inc. Information from biodegradation and ecotoxicity studies on both the single substance and on the substance as part of the mixture notified to EPA in the NOC (see "other information" below).
4-hydroxy- 3,5 dimethoxy benzonitrile (syringonitrile) 72684-95-8  
8EHQ-0309-17439A (PDF)
(2 pp, 87K)
Fluoroallcyl alcohol Confidential   Confidential Results of an acute oral toxicity study in rats and mice.
8EHQ-0309-17440A (PDF)
(1 pg, 54K)
Fluoroalkyl phosphoric acid salt, aqueous solution Confidential   Confidential Results of an acute oral toxicity study in mice.
8EHQ-0309-17441A (PDF)
(1 pg, 63K)
2,4,4-Trimethyl Pentene (TMP) 25167-70-8 Y Lyondell Chemical Company Preliminary results of a 21-day Daphnia magna reproduction test.
8EHQ-0309-17442A (PDF)
(2 pp, 91K)
2,3-Pyridine Dicarboxylic Acid (PDC) 89-00-9 N BASF Corporation Results of an oral repeated-dose toxicity study in male and pregnant female Wistar rats.
8EHQ-0309-17443A (PDF)
(2 pp, 91K)
1,6-Hexamethylene Diacrylate (HDDA) 13048-33-4 Y American Chemistry Council Results of a combined oral repeated-dose/reproductive/developmental toxicity study in rats.
8EHQ-0309-17444A (PDF)
(2 pp, 91K)
N-Acetyl-L-Aspartate 997-55-7 Y DuPont Haskell Global Centers for Health and Environmental Sciences Results of an oral toxicity study in rats.
8EHQ-0309-17445A (PDF)
(1 pg, 60K)
Halogenated alkene Confidential   Arkema Inc. Information from animal inhalation studies.
8EHQ-0309-17446A (PDF)
(1 pg, 50K)
Halogenated pyridine derivative Confidential   Dow Chemical Company Information regarding the half-life determinations in laboratory aerobic and anaerobic sediment/water systems.
8EHQ-0309-17447A (PDF)
(1 pg, 69K)
Alkyl sulfonyl fluoride Confidential   3M Company Results of an acute oral toxicity study in Sprague-Dawley rats
8EHQ-0309-17448A (PDF)
(2 pp, 112K)
Poly [oxy [trifluoro (trifluoromethy1)-1,2-ethanediyl]], a-(1-carboxy-1,2,2,2-tetrafluoroethy1)-w-[tetrafluoro (trifluoromethyl) ethoxyl- 51798-33-5 N Confidential Results of a 28-day oral toxicity study in rats
8EHQ-0309-17449A (PDF)
(1 pg, 76K)
Carboxylic acid Confidential   Confidential Results of an acute toxicity study in algae and daphnia.
8EHQ-0309-17450A (PDF)
(3 pp, 173K)
Dimethyoxydimethylsilane 1112-39-6 N Silicones Environmental Health and Safety Council (SEHSC) Results of an ongoing combined repeated-dose toxicity study with reproductive/developmental toxicity screening test in Sprague-Dawley rats via oral gavage.
8EHQ-0309-17451A (PDF)
(1 pg, 69K)
Imidazole, substituted Confidential   Syngenta Crop Protection, Inc. Results of a screening acute oral toxicity study in rats.
8EHQ-0309-17452A (PDF)
(40 pp, 1.01MB)
Bicyclo[2.2.1]hept-2-ene,5-(2-phenylethyl)- *1 717099-35-9 N Promerus Results of an acute toxicity study in daphnia
8EHQ-0309-17453A (PDF)
(2 pp, 99K)
Carboxylic acid Confidential   Confidential Results of three acute aquatic toxicity studies: algae, invertebrates, fish
8EHQ-0309-17454A (PDF)
(2 pp, 93K)
Carboxylic acid Confidential   Confidential Results of acute toxicity studies in green algae and daphnia magna
8EHQ-0309-17455A (PDF)
(2 pp, 74K)
Nitrogen containing heterocycle *2 Confidential   BASF Corporation Results of an acute toxicity study in carp.
8EHQ-0309-17456A (PDF)
(2 pp, 79K)
Nitrogen containing heterocycle, substituted (Substance A) *2 Confidential   BASF Corporation Results of acute oral toxicity studies in rats.
Nitrogen containing heterocycle, substituted (Substance B) *2 Confidential   BASF Corporation Results of acute oral toxicity studies in rats.
Nitrogen containing heterocycle, substituted (Substance C) *2 Confidential   BASF Corporation Results of acute oral toxicity studies in rats.
8EHQ-0309-17457A (PDF)
(18 pp, 570K)
Tetramethylammonium chloride 75-57-0 Y Sachem Results of an acute dermal toxicity study in rabbits
8EHQ-0309-17458A (PDF)
(3 pp, 157K)
3-Sulphonylisocyanato-2-thiophene carboxylate 79277-18-2 N DuPont Haskell Global Centers for Health and Enviornmental Sciences Results of 4 mutagenicity studies (Ames assay, in vitro chromosomal aberration study, in vivo rat bone marrow micronucleus test and an unschedule DNA synthesis assay) as well as a 28-day oral toxicity study in rats.
8EHQ-0309-17459A (PDF)
(1 pg, 63K)
Hydroxy-chloro-cyclopropyl-heteromonocycliccarboxylic acid Confidential   Confidential Results of a ready biodegradability assay and an acute algae assay
8EHQ-0309-17460A (PDF)
(2 pp, 76K)
anhydrous ammonia 7664-41-7 Y MillerCoors LLC Written report for the non-reportable anhydrous ammonia release at Millers-Coors LLC - Fort Worth, Texas brewery.
8EHQ-0309-17461A (PDF)
(3 pp, 132K)
Dow Corning 949 Cationic Emulsion None   Dow Corning Results of an acute toxicity to daphnia study
8EHQ-0309-17462A (PDF)
(2 pp, 79K)
Nitrogen containing heterocycle, substituted *2 Confidential   BASF Corporation Results of a screening test on acute toxicity in daphnia
8EHQ-0309-17463A (PDF)
(2 pp, 81K)
Nitrogen containing heterocycle, substituted *2 Confidential   BASF Corporation Results of a toxicity study in green algae
8EHQ-0309-17464A (PDF)
(2 pp, 94K)
Copolymer containing acrylates and acrylamide Confidential   BASF Corporation Results of a 90-day sub chronic inhalation study in Wistar rats.
8EHQ-0309-17465A (PDF)
(2 pp, 199K)
Carboxamide Confidential   Bayer CropScience LP Results of a chronic toxicity and carcinogenicity study in the male Wistar rat by dietary administration
8EHQ-0309-00373CU (PDF)
(37 pp, 1.49MB)
Perfluorooctane sulfonate (PFOS) *1 2795-39-3 N Taft Stettinius & Hollister LLP Information regarding PFOA/PFOS worker exposure.
Perfluoroocatnoic acid (PFOA) *1 335-67-1 N
8EHQ-0309-00373CV (PDF)
(5 pp, 155K)
Perfluorooctanoic acid (PFOA) *1 335-67-1 N Taft Stettinius & Hollister LLP A status report summarizing the relationship between C8 and several markers of immune status and inflammation in the mid Ohio population exposed to PFOA and studied by the C8 Science Panel as part of its court appointed role.
8EHQ-0309-00373CW (PDF)
(85 pp, 4.98MB)
Perfluorooctane sulfonate (PFOS) *1 2795-39-3 N Taft Stettinius & Hollister LLP Epidemiological studies and correspondence related to PFOA/PFOS exposure in humans.
Perfluorooctanoic acid (PFOA, C8) *1 335-67-1 N Taft Stettinius & Hollister LLP Epidemiological studies and correspondence related to PFOA/PFOS exposure in humans.
8EHQ-0309-10734B (PDF)
(2 pp, 89K)
1H, 3H-Benzol[1,2-c:4,5-c']difuran-1,3,5,7-tetrone (Pyromellitic dianhydride; PMDA) 89-32-7 Y DuPont Haskell Global Centers for Health and Environmental Sciences Results of pre-1977 (1962) acute and repeated expsoure inhalation toxicity studies in rats.
8EHQ-0309-11239B (PDF)
(2 pp, 95K)
Decanoic acid, nonadecafluoro- 335-76-2 N DuPont Haskell Global Centers for Healtha nd Environmental Sciences Results of an acute algae and an acute rainbow trout toxicity study.
8EHQ-0309-12943B (PDF)
(1 pg, 72K)
Ethanesulfonyl fluoride, 2-[1-[difluoro[(trifluoroethenyl)oxy] methyl]-1,2,2,2-tetrafluoroethoxy]-1,1,2,2-tetrafluoro- 16090-14-5 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of a pre-1977 (1 974) acute inhalation toxicity study in rats.
8EHQ-0309-14727B (PDF)
(2 pp, 153K)
Chemical None   DuPont Haskell Global Centers for Health and Environmental Sciences Results of a pre-1977 (1974) acute inhalation toxicity study in rats.
8EHQ-0309-16105O (PDF)
(1 pg, 63K)
Thiophene derivative, substituted Confidential   DuPont Haskell Global Centers for Health and Environmental Sciences Results of an acute inhalation toxicity study in rats.
8EHQ-0309-16721K (PDF)
(3 pp, 140K)
Fluorinated surfactant salt Confidential   3M Company Results of a 90-day study and toxicokinetic evaluation in rats to supplement a 28-day study in rats submitted to EPA in May of 2007.
8EHQ-0309-16911B (PDF)
(1 pg, 81K)
Lactose with zinc oxide nanoparticles surfacetreated with trimethylhexanoate and hydrophobic zinc oxide nanoparticles consisting of a zinc oxide core surface-modified with hexanoic acid, 3,5,5-trimethyl-, zinc salt none   3M Company Preliminary data from a two-week inhalation study in rats
8EHQ-0309-16983B (PDF)
(1 pg, 73K)
Difluoro (fluorosulfonyl) acetyl fluoride 677-67-8 N DuPont Haskell Global Centers for  Health and Environmental Sciences Results of a pre-1977 (1974) acute inhalation toxicity study in rats.
8EHQ-0309-17368B (PDF)
(2 pp, 109K)
Carboxylic acid Confidential   Confidential Results of acute toxicity studies in algae, the water flea, and rainbow trout.
8EHQ-0309-17369B (PDF)
(1 pg, 71K)
Carboxylic acid Confidential   Confidential Results of a recently conducted acute toxicity study in green algae.
8EHQ-0309-17441B (PDF)
(42 pp, 5.89MB)
2,4,4-Trimethyl Pentene (TMP) 25167-70-8 Y Lyondell Chemical Company Final report of 21-day Daphnia magna reproduction study
FYI-0309-01378BA (PDF)
(6 pp, 168K)
Perfluorooctanoic acid (PFOA) *1 335-67-1 N Taft Stettinius & Hollister LLP Results of an epidemiological study in humans.
FYI-0309-01378AZ (PDF)
(38 pp, 1.51MB)
Perfluorooctanoic acid (PFOA) *1 335-67-1 N Taft Stettinius & Hollister LLP Results of an occupational monitoring and an epidemiological study in humans
Perfluorooctane sulfonate (PFOS) *1 2795-39-3 N
FYI-0309-01378BB (PDF)
(86 pp, 4.91MB)
Perfluorooctane sulfonate (PFOS) *1 2795-39-3 N Taft Stettinius & Hollister LLP Epidemiological studies and correspondence related to PFOA/PFOS exposure in humans.
Perfluorooctanoic acid (PFOA, C8) *1 335-67-1 N

 

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit
number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial
submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report.
Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number
as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.

FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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