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Section 8(e) Substantial Risk Notifications and FYI Submissions Received August 2010

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0810-18050A (PDF)
(154 pp, 4.99MB)
Chromium (Trivalent and Hexavalent ) 16065-83-1
18540-29-9
  US EPA Collaborative Cohort Mortality Study of four Chromate production Facilities, 1958-1998: Final Report.
8EHQ-0810-18057A (PDF) Vanadium Trioxide 1314-34-7 Y Vanadium Producers and Reclaimers Association Preliminary results from an acute inhalation study on vanadium trioxide (V203) (CASRN 1314-34-7).
8EHQ-0810-18058A (PDF) Vanadium Tetroxide 12036-73-6   Vanadium Producers and Reclaimers Association Preliminary results from an acute inhalation study on vanadium tetroxide (V204)' (CASRN 12036-73-6).
8EHQ-0810-18059A (PDF) Vanadyl Sulfate 27774-13-6   Vanadium Producers and Reclaimers Association Preliminary results from an acute inhalation study on vanadyl sulfate (VOS04) (CASRN 27774-13-6).
8EHQ-0810-18060A (PDF) ZMAT Number 4054113 Multiple Y Dow Corning the results of an acute toxicity to the Cladoceran (Daphnia magna) under static test conditions with ZMAT Number 4054113.
8EHQ-0810-18061A (PDF) Naphthenic Acid 1338-24-5 Y API Results of a reproductive toxicity findings from a range finding study on rats with naphthenic acid (CASRN 1338-24-5).
8EHQ-0810-18062A (PDF) Benzaldehyde, 2-hydroxy5-nonyl-, oxime 50849-47-3 Y Cognis Corporation Results of a local lymph node assay (LLNA) in mice with C-SAT 090069 (Benzaldehyde, 2-hydroxy-5-nonyl-, oxime CASRN 50849-47-3).
8EHQ-0810-18063A (PDF) 3-Dimethylaminopropyl oleic acid amide 109-28-4   BASF Results of OECD 421 Reproduction/ Developmental Toxicity Screening Test in Wistar rats [Crl:WI(HAN)] with 3-Dimethylaminopropyl oleic acid amide (CASRN109-28-4).
8EHQ-0810-18064A (PDF) 1-Ethyl-3-Ethylimidazolium Octanoat 1040916-85-5   BASF Results of an Acute Dermal Irritation and Corrosion Study in rabbits with 1Ethyl-3-Ethyl-imidazolium Octanoat (CASRN 1040916-85-5)
8EHQ-0810-18065A (PDF) Calcium hydrogen phosphonate (44.6%); Dithianon (17.1%) and Ametoctradin (8.5%) *2 Not Provided   BASF Results of a Local Lymph Node Assay (LLNA) with Formulation Containing Active Ingredients: Calcium hydrogen phosphonate (44.6%); Dithianon (17.1%) and Ametoctradin (8.5%).
8EHQ-0810-18066A (PDF) Aqueous Formulation Containing Active Ingredients: Dithianon (2.58.6 g/L); Pyrimethanil (257.4 g/L) *2 Not Provided   BASF Results of a Local Lymph Node Assay (LLNA) with Aqueous Formulation Containing Active Ingredients: Dithianon (2.58.6 g/L); Pyrimethanil (257.4 g/L)
8EHQ-0810-18067A (PDF) Amine 0 (1H-Imidazole-1ethanol, 2-(8heptadecenyl)-4,5-dihydro) 95-38-5   BASF Results of an Acute Toxicity Study in Water Flea with Amine 0 (CASRN 9538-5)
8EHQ-0810-18068A (PDF) Substituted Nitrogen Containing Heterocycle *2 CBI   BASF Results of a repeated-dose, range finding study in mice with substituted nitrogen containing heterocycle.
8EHQ-0810-18069A (PDF) Substituted Nitrogen Containing Heterocycle *2 Not Provided   BASF Results of a maternal toxicity study in Wistar Rats (range finding) with substituted nitrogen containing heterocycle.
8EHQ-0810-18070A (PDF) Substituted Nitrogen Containing Heterocycle *2 Not Provided   BASF Results of a repeated-dose range-finding study in Wistar Rats with substituted nitrogen containing heterocycle.
8EHQ-0810-18071A (PDF) Confidential *2 Not Provided   BASF Results of micronucleus screening tests in mice with bisphenyl derivative (substance 1, 2, 3, 4, 5, 6, 7, 8, 9)
8EHQ-0810-18072A (PDF) Quaternary Ammonium Solution plus Water-Soluble Film Forming Synthetic Polymer Dispersed by Surfactant in Aqueous Solution Not Provided   Confidential Results of an eye irritation study in rabbits with quaternary ammonium solution plus water- soluble film forming synthetic polymer dispersed by surfactant in aqueous solution.
8EHQ-0810-18073A (PDF) Substituted Isothiazolone Not Provided   Rohm and Hass Company Result of an acute toxicity study on Gobiocypris rarus with substituted isothiazolone.
8EHQ-0810-18074A (PDF) Vanadium Pentoxide 1314-62-1 Y Vanadiium producers And Reclaimers Association Results of acute inhalation studies on rats with vanadium pentoxide (CARSN 1314-62-1).
8EHQ-0810-18075A (PDF) Resin acids and Rosin acids, Fumarated, Esters with Pentaerythritol 94581-15-4 or 65997-11-7   Arizona Chemical Results of a local lymph node assay (LLNA) on mice with resin acids and rosin acids, fumarated, esters with pentaerythritol (CASRN 94581-15-4).
8EHQ-0810-18076A (PDF) Confidential CBI   Confidential Report on the findings from an OECD 440 uterotrophic assay in rodents which was conducted with confidential test materials
8EHQ-0810-18077A (PDF) Multi-walled Carbon nanotube Substance Not Provided   Ropes and Gray Notification that Ropes and Gray is removing the CBI status of a submission by Showa Denko Carbon, Inc. submitted on July 15, 2010 on a toxicity test conducted in hamsters exposed to a multi-walled carbon nanotube substance.
8EHQ-0810-18078A (PDF) Benzene, 1,4-diisocyanato 104-49-4   DuPont Results of an acute toxicity study in fathead minnows with benzene, 1,4diisocyanato (CASRN 104-49-4).
8EHQ-0810-18079A (PDF) Fluorinated Acrylic Copolymer in an Organic Solvent CBI   Confidential Results of a skin sensitization study and an acute oral toxicity study with fluorinated acrylic copolymer in an organic solvent.
8EHQ-0810-18080A (PDF) 3-Amino-2-Substituted Thiophene CBI   Confidential Results of several studies, that we recently became aware of, with 3amino-2-substituted thiophene.
8EHQ-0810-18081A (PDF) Mixture of Hexamethylene Diisocyanate/isophorone Diisocyanate in Xylol and Ethyl Glycol Acetate Not   Provided Bayer Material Science LLC The results of an acute inhalation toxicity study in rats with a mixture of hexamethylene diisocyanate/isophorone diisocyanate in xylol and ethyl glycol acetate.
8EHQ-0810-18082A (PDF) Toluene Diisocyanate 26471-62-5   Bayer Material Science LLC The results of an acute inhalation toxicity study in rats with Toluene Diisocyanate (CASRN 26471-62-5).
8EHQ-0810-18083A (PDF) Dow Corning® APZ-5 125441-85-2 and 2530-838   Dow Corning Results of a genetic Evaluaton of Dow Corning® APZ-5 In bacterial reverse mutation assays.
8EHQ-0810-18084A (PDF) Single Super Phosphate and Triple Super Phosphate 8011-76-5 & 65996-95-4 Y Koch Fertilizer LLC Results of an acute eye irritation/corrosion study with single super phosphate (SSP) and triple super phosphate (TSP) (CASRNs 8011-76-5 and 65996-95-4.
8EHQ-0810-18085A (PDF) Confidential CBI   Confidential Results of a 28-day repeat dose oral gavage toxicity study in rats with a chemical substance described as "Polyolefin modified with ethylenically unsaturated nitrogen compound, complex
8EHQ-0810-18086A (PDF) Confidential *2 CBI   BASF Results of a Toxicity Study on the Growth of the Aquatic Plant Lemna gibba with a Formualtion Containing Two Active Ingredients; (1) Chlorcyanbenzole and (2) Substituted Epoxide, conducted by BASF SE, l.udwiqshafen, Germany. The test substance is an experimental pesticide.
8EHQ-0810-18087A (PDF) Confidential *2 CBI   BASF Results of an acute toxicity screening test in Daphnia (Daphnia magna) with nitrogen containing heterocycle substituted,
8EHQ-0810-18088A (PDF) Confidential *2 CBI   BASF Results of a maternal toxicity study in Wistar Rats with substituted nitrogen containing heterocycle.
8EHQ-0810-18089A (PDF) 2,2',2 "-Nitriloethanol (Triethanolamin) *2,*3 102-71-6   BASF Results of a reproduction/developmental toxicity screening test in Wistar Rats [Crl:WI(HAN) Charles River, Sulzfeld, Germany], administration via gavage, according to GECD Guideline 421, with 2,2',2 "-Nitriloethanol (Triethanolamin) (CASRN 102-71-6)
8EHQ-0810-18090A (PDF) 3,7, 11-trimethyldodeca1,6,10-trien-3-ol 7212-44-4 Y BASF Results of a combined repeated dose toxicity study/reproduction/developmental toxicity screening test in Wistar Rats with 3,7, 11-trimethyldodeca-1,6,10trien-3-ol (CASRN. 7212-44-4).
8EHQ-0810-18091A (PDF) Resin Acids and Rosin Acids, Fumarated, Esters with Pentaerythritol 94581-15-4   Arizona Chemical Company Results on an acute toxicity test to Daphnia magna with resin acids and rosin acids, fumarated, esters with pentaerythritol (CASRN 94581-15-4) (known as CASRN 65997-11-7 in the US)
8EHQ-0810-18092A (PDF) Tetrafluoroethylene and Ammonium Perfluorooctanoate 116-14-3 and 3825-26-1   DuPont results from several analyses that indicate statistical associations with mortality from liver cancer and kidney and other urinary organ cancers and occupational TFE exposure with tetrafluoroethylene (CASRN 116-14-3) and ammonium perfluorooctanoate (CASRN 3825-26-1)
8EHQ-0810-18095A (PDF) N- (2-aminoethyl)-N'- {2- (2-aminoethyl)amino} ethyl} -1,2-ethanediamine; tetraethylenepentamine (TEPA) 112-57-2 Y 3M Results of an acute systemic injection test on tetraethylenepentamine (TEPA) that did not meet the requirements of the IS)-10993-11 guidelines for the Systemic Injection Test.
8EHQ-0810-18097A (PDF) 3-(1,1-dimethylethyl).beta.-[3-(1,1dimethylethyl)4hydroxyphenyl]4-hydroxy-.beta.-methyl-, 1,l'-(1,2-ethanediyl) ester 32509-66-3   INVISTA Results from an inhalation study in rats with Benzenepropanoic acid, 3(1,1-dimethylethyl). Beta.-[3-(1,1dimethylethyl)-4-hydroxyphenyl]-4hydroxy-.beta.-methyl-, 1,l'-(1,2ethanediyl) ester (CASRN 32509-66-3).
8EHQ-0810-18098A (PDF) 2-methyll, 5pentanemethylenediamine (MPMD) 15520-10-2 Y INVISTA Results from a study of the growth inhibition on Pseudomonas putida by 2methyll, 5-pentanemethylenediamine (MPMD) (CASRN 15520-10-2).
8EHQ-0810-18099A (PDF) N-(6aminohexyl)-1,6Hexanediamine1 43-23-7 Y INVISTA Results from a study of the growth inhibition on Pseudomonas putida by N-(6aminohexyl)1,6-Hexanediamine (CASRN 143-237).
FYI-0810-01671A (PDF) Tricyclodecanedimethanol 26160-83-8 and 2689648-0 Y OXEA Results of a combined 28-day repeated dose toxicity study with the reproduction/developmental toxicity screening test of Tricyclodecanedimethanol (TCD Alcohol OM ;CASRN 26160-838/26896-48-0) in rats by oral gavage.
8EHQ-0810-16446Z (PDF) PFOA Not Provided Y DuPont Results reported for samples of PFOA collected in March 2010 at the dordrecht Works, Dordrecht, Netherlands.
8EHQ-0810-17531B (PDF) Pentanoic acid, Nonafluoro 2706-90-3 Y Dupont Results of an in vitro skin corrosion assay (Corrositex) with Pentanoic acid, nonafluoro (CASRN 2706-90-3)
8EHQ-0810-17699B (PDF) Caprolactam (2H-Azepin2-one, hexahydro-) 105-60-2 Y DuPont Results of an acute oral LD50 study in rats, with Caprolactam (2H-Azepin-2one, hexahydro- CASRN 105-60-2)
8EHQ-0810-17740C (PDF) Methyl 2-(((((4-ethoxy-6(methylamino)-1,3,5triazin-2yl)amino)carbonyl)amino)s ulfonyl)benzoate *2297780-06-8 Y DuPont Results of a toxicity study in Lemna gibba G3 with a R&D proprietary mixture containing 75.8 % of Methyl 2-[[[[[4-ethoxy-6(methylamino)-1,3,5-triazin-2yl]amino]carbonyl] amino] sulfonyl]benzoate
8EHQ-0810-17815B (PDF) 1,4-Butanediol 110-63-4 Y Dupont Results of multiple toxicity studies with 1,4-butanediol (CASRN 110-634).
8EHQ-0810-17816B (PDF) Tetrahydrofuran 109-99-9 Y DuPont Results of multiple toxicity studies with tetrahydrofuran (CASRN 109-999).
8EHQ-0810-17843B (PDF) Trisubstituted phenyl)(disubstituted phenyl)alkyl- substituted heteromonocycle Confidential   Confidentrial The results ofa micronucleus test in rats with Trisubstituted phenyl)(disubstituted phenyl)- alkyl-substituted heteromonocycle.
8EHQ-0810-17849B (PDF) Chloroform 67-66-3   DuPont The results of three aquatic fish bioassay with chloroform (CASRN 6766-3).
8EHQ-0810-17850B (PDF) Hydrogen Fluoride 7664-39-3   DuPont Results of multiple toxicity studies with hydrogen fluoride (CASRN 766439-3).
8EHQ-0810-17920B (PDF) O-Phenylenediamine 95-54-5 Y DuPont Results of multiple toxicity studies with O-Phenylenediamine (CASRN 9554-5
8EHQ-0810-17991B (PDF) 1,1,1,2-Tetrafluoroethane 811-97-2 Y DuPont Results of multiple toxicity studies with 1,1,1,2-Tetrafluoroethane (CASRN 811-97-2)
8EHQ-0810-18043B (PDF) Confidential *2 CBI   Monsanto Company Preliminary results on 28-day and a 90day, and a tolerability studies in mice on the confidential chemical.

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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