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Section 8(e) Substantial Risk Notifications and FYI Submissions Received January 2010

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0110-17792A (PDF) Preparation based on calcium salts Not Provided   BASF Corporation Results of a 5-day inhalation toxicity study in rats
8EHQ-0110-17793A (PDF) Acetaldehyde (AA) 75-07-0 Y Vinyl Acetate Council (VAC) Preliminary results of two micronucleus assays in TK6 cells
Vinyl acetate (VA) 108-05-4 Y
8EHQ-0110-17794A (PDF) Dilauroyl peroxide 105-74-8   Akzo Nobel Services Inc. Un-audited draft results of a 7-day oral (gavage) range-finding study
8EHQ-0110-17795A (PDF) Nitrogen containing heterocycle, substituted Not Provided   Confidential Results of an in vivo micronucleus test in rats
8EHQ-0110-17796A (PDF) Nitrogen containing heterocycle, substituted Not Provided   Confidential Results of an in vivo micronucleus test in rats
8EHQ-0110-17797A (PDF) Sample A Not Provided   Confidential Results of five bacterial reverse mutation tests (Ames test)
Sample D Not Provided  
Sample B Not Provided  
Sample C Not Provided  
8EHQ-0110-17798A (PDF) Perfluorooxyalkanoic acid salt Not Provided   Confidential Results from an in vitro mammalian chromosome aberration test in CHO cells
8EHQ-0110-17800A (PDF) Mixture extracted from a R&D material (Sample A) Not Provided   Confidential Results of three bacterial reverse mutation tests (Ames test)
Mixture extracted from a R&D material (Sample B) Not Provided  
Mixture extracted from a R&D material (Sample C) Not Provided  
8EHQ-0110-17801A (PDF) Poly[oxy(methyl-1,2ethanediyl)],.alpha.-butyl-.omega.-hydroxy- *3 9003-13-8 N Dow Chemical Company Information from a combined repeated-dose toxicity study in rats with a reproduction/developmental toxicity screening test
8EHQ-0110-17802A (PDF) EDTA-MnNa2 *3 15375-84-5 N Akzo Nobel Services, Inc. Interim results of a combined repeated-dose study in rats with a reproductive/developmental toxicity screening test (OECD 422)
8EHQ-0110-17803A (PDF) 1,1,2,3,3-Pentamethyl-6,7dihydro-4(5H)-indanone 33704-61-9 N International Flavors & Fragrances Inc. (IFF) Results from an oral (gavage) repeat dose 90-day study in rats
8EHQ-0110-17804A (PDF) Pyridine, substituted Not Provided   Syngenta Crop Protection, Inc. Information from a screening acute oral toxicity study in the rat
8EHQ-0110-17805A (PDF) Pyridine, substituted Not Provided   Syngenta Crop Protection, Inc. Information from an in vivo micronucleus assay in the mouse
8EHQ-0110-17806A (PDF) Pyridine, substituted Not Provided   Syngenta Crop Protection, Inc. Information from an oral (gavage) combined preliminary non-pregnant and pre-natal developmental toxicity dose range finding study in the rat.
8EHQ-0110-17807A (PDF) Heptafluoro-1-butanol 375-01-9 N 3M Company Final report of a 5-day inhalation toxicity study in rats
8EHQ-0110-17808A (PDF) 6,6'-((3,3',5,5'-Tetrakis(1,1dimethylethyl)(1,1'-biphenyl)-2,2'diyI) bis(oxy)) bisdibenzo (d,f)(1,3,2)dioxaph osphepin 138776-88-2 N Dow Chemical Company Information from a 28-day dietary study in rats
8EHQ-0110-17809A (PDF) Nitrogen containing heterocycle, substituted Not Provided   Confidential Results of a developmental toxicity study in rats
8EHQ-0110-17810A (PDF) Hydratropic aldehyde 93-53-8 N Fragrance Materials Association (FMA) of the United States Results from an oral (gavage) repeated dose 14-day toxicity study in rats, including an evaluation of the reproductive organs.
8EHQ-0110-17811A (PDF) 3-(p-Isopropyl phenyl) propionaldehyde *1 7775-00-0
7775-00-0
N Fragance Materials Association (FMA) of the United States Results from a 14-day oral (gavage) repeated-dose toxicity study in rats, including an evaluation of the reproductive organs
8EHQ-0110-17812A (PDF) p-tert-Butyldihydrocinnamaldehy de 18127-01-0 N Fragrance Materials Association (FMA) of the United States Results from an oral (gavage) repeated dose 14-day toxicity study in rats, including an evaluation of the reproductive organs.
8EHQ-0110-17813A (PDF) Disodium dihydrogen ethylenediaminetetraacetate *3 139-33-3 Y Confidential Results of a subacute 5-day inhalation study in rats
8EHQ-0110-17814A (PDF) Cyanamide, N[methyloxido[1-[6(trifluoromethyl)-3pyridinyl]ethyl]-.lamda.4sulfanylidene] 946578-00-3 N Dow Chemical Company Results of a 90-day repeated-dose dietary toxicity study in mice
8EHQ-0110-17817A (PDF) Perfluorooctanoic acid 335-67-1 N Taft Stettinius & Hollister LLP Information on the association between (PFOA) PFOA and thyroid disease: Melzer, D., et al., "Association Between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the NHANES Study," Environ. Health Persp. (online doi: 10.1289/ehp.0901584) (Jan. 20, 2010)."
8EHQ-0110-17824A (PDF) 2,3,4,7,8- pentachlorodibenzofuran (PeCDF) 57117-31-4 N Dow ChemicalCompany Information from three new pending scientific manuscripts:

Herve et al., submitted for publication in Toxicological Sciences: Cytochrome P4501A induction by 2,3,7,8tetrachlorodibenzo-p-dioxin and two chlorinated dibenzofurans in primary hepatocytes cultures of three avian species.

Herve et al., submitted for publication in Toxicology in Vitro: Ethoxyresorufin-O-deethylase induction by TCDD, PeCDF and TCDF in ring-necked pheasant and Japanese quail hepatocytes: time-dependent effects on concentration-response curves.

Herve et al., submitted for publication in Environmental Science & Technology: Relative potencies of dioxin-like chemicals in primary cultures of herring gull hepatocytes: 2,3,4,7,8-PeCDF is more potent CYP1A inducer than 2,3,7,8-TCDD.
2,3,7,8-tetrachlorodibenzofuran (TCDF) 51207-31-9 N
2,3,7,8-tetrachlorodibenzop-dioxin (TCDD) 1746-01-6 N
8EHQ-0110-17825A (PDF) 9-Octadecenoic acid (9Z)-, methyl ester *3 112-62-9 Y Dow Chemical Company Results of Local Lymph Node Assay in mice
8EHQ-0110-17828A (PDF) SP-7607 *2 Not Provided   Confidential Results of an in vivo micronucleus test in rats
8EHQ-0110-17552D (PDF) 2,2,3-trifluoro-3(trifluoromethoxy)-1propanol (MTDID 18255) Not Provided   3M Company Final report of an acute inhalation toxicity study in rats.
8EHQ-0110-17692B (PDF) Acetylated lecithin 91053-50-8 N DuPont Haskell Global Centers Results of an octanol water partition coefficient assay
8EHQ-0110-17730B (PDF) Acetylated lecithin 91053-50-8 N DuPont Haskell Global Centers Results of an octanol/water partition coeficient assay
FYI-0110-01621A (PDF) Perfluorooctanoic acid (PFOA) 335-67-1 N Taft Stettinius & Hollister LLP Information on the association between PFOA and thyroid disease: Melzer, D., et al., "Association Between Serum Perfluorooctanoic Acid (PFOA) and Thyroid Disease in the NHANES Study," Environ. Health Persp. (online doi: 10.1289/ehp.0901584) (Jan. 20, 2010)."

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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