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Section 8(e) Substantial Risk Notifications and FYI Submissions Received June 2010

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0610-17962A (PDF) Alkyl Aminoalcohol Not Provided   Dow Chemical Company Reporting on the corrosive ability of alkyl amino alcohol to skin.
8EHQ-0610-17963A (PDF) Alkyl Aminoalcohol Not Provided   Dow Chemical Company Reporting on the corrosive ability of alkyl amino alcohol to skin.
8EHQ-0610-17964A (PDF) 4-(Tertburoxycarbonyloxy) Styrene 87188-51-0   Dupont Results of an acute oral toxicity study in rats with 4-(tert-buroxycarbonyloxy) styrene (CASRN 87188-51-0).
8EHQ-0610-17965A (PDF) 4-Hydroxyacetophenone ethoxylate-propoxylate 50684-36-1   Dupont Results of an acute oral toxicity study in rats with 4-Hydroxyacetophenone ethoxylate-propoxylate(CASRN 5068436-1).
8EHQ-0610-17966A (PDF) 1,1,1-tris(phydroxyphenyl) ethane 27955-94-8   Dupont Results of two mouse micronucleus assays with 1,1,1-tris(phydroxyphenyl) ethane (CASRN 27955-94-8).
8EHQ-0610-17967A (PDF) Dimethyl 2Methylglutarate 14035-94-0   Rhodia Results of a 13-Week inhalation toxicity study in the Wistar Rat with Dimethyl 2-Methylglutarate (CASRN 14035-94-0).
8EHQ-0610-17968A (PDF) Oleyl tartrimide No Yet Assigned   Harlan Developmental toxicity study in the Himalayan Rabbit usiing Oleyl tartrimide.
8EHQ-0610-17969A (PDF) Mixture containing hydroxylamine, monoethanolamine, glycolic acid, and water 7803-49-8:
141-43-5:
7914-1:
773218-5
  Confidential Results of an acute oral toxicity study in rats with a mixture containing hydroxylamine (CASRN 7803-49-8), monoethanolamine (CASRN 141-435), glycolic acid ( CASRN 79-14-1, and water (CASRN 7732-18-5).
8EHQ-0610-17970A (PDF) Mixture containing hydroxylamine, diglycolamine, monoethanolamine, propyleneglycol, catecholl, and water 929-06-6:
141-43-5:
57-55-6:
20-80-9:
7732-18-5
  Confidential Results of an dermal toxicity study in rats with a mixture containing hydroxylamine (CASRN 7803-49-8), diglycolamine (CASRN 929-06-6), monoethanolamine (CASRN 141-435), propyleneglycol (CASRN 57-55-6, catecholl (CASRN 20-80-9, and water (CASRN 7732-18-5).
8EHQ-0610-17971A (PDF) Mixture Containing
Hydroxylamine 50%;
Diglycolamine; Catechol;
Water; Diethylene glycol
7803-49-8:
929-06-6;
120-80-9;
732-18-5:
111-46-6
  Confidential Results of an acute dermal and acute oral toxicity studies in New Zealand White rabbits with a mixture containing hydroxylamine 50% (CASRN 7803-49-8); Diglycolamine (CASRN 929-06-6); Catechol (CASRN 120-80-9); Water (7 CASRN 732-18-5); Diethylene glycol (CASRN 111-46-6).
8EHQ-0610-17972A (PDF) Bisphenyl derivative Confidential   BASF Results of an In vivo mouse micronucleus screening test with bisphenyl derivative
8EHQ-0610-17973A (PDF) Substituted Nitrogen Containing Heterocycle Compound *2 Confidential   BASF Results of a pernatal developmental toxicity study in New Zealand White Rabbits with substituted nitrogen containing hererocycle compound.
8EHQ-0610-17974A (PDF) Substituted Nitrogen Containing Heterocycle and Substituted Epoxide Confidential   BASF Results of a toxicity study on the growth of the green alga (Pseudokirchneriella subcapitata) with formulattion containing tow active ingredients: (1) Substituted Nitrogen Containing Heterocycle and (2) Substutied Epoxide.
8EHQ-0610-17975A (PDF) Substituted Cyclohexenone Confidential   BASF Results of long term effects of substitted cyclohexenone on the parthenogenetic reporduction rate of the waterflea Daphnia magna Straus.
8EHQ-0610-17976A (PDF) Substituted Phenylether Confidential   BASF Results of a prenatal toxicity screening study in Wistar Rats [Crl:WI(HAN)] with substituted phenylether.
8EHQ-0610-17977A (PDF) Tinuvin 292 41556-26-7 and 8291937-7   BASF Results of an acute toxicity study in Zebra Fish (Danio rerio) with Tinuvin 292 (CASRN 41556-26-7 and 82919-37-7)
8EHQ-0610-17978A (PDF) N-Chloroethyl, N-Ethyl-4Aminobenzaldehyde 7/4/2643   BASF Results of two studies with Nchloroethyl, N-ethyl-4aminobenzaldehyde: 1) An In vitro gene mutation study in chinese hamster CHO cells and 2) An In vitro cytogenetic study in chinese hamster V79 cells.
8EHQ-0610-17979A (PDF) Mixture containing C10C16 Alkylbenzenesulfonic acid; Phenol ; Shellsol A150; 1,2,4trichlorobenzene Naphthalene; 1,2,3trichlorobenzene ; CI0CI6 Alkylbenzene; Sulfuric acid; Sulfur dioxide Multiple   Dupont Results of an acute inhalation and acute oral toxicity study in rats with a mixture containing C10-C16 Alkylbenzenesulfonic acid (CASRN 68584-22-5) 15.9-17.5% ; Phenol (CASRN 108-95-2) 17.6-19.4%; Shellsol A150 (CASRN 4742-94-5) 1820%; 1,2,4-trichlorobenzene (CASRN 120-82-l) 34.4-38%; Naphthalene (CASRN 91-20-3) 0.8-1.7%; 1,2,3-trichlorobenzene (CASRN 87-61-6) 6.1%; CI0-CI6 Alkylbenzene (CASRN 68648-87-3) 0.16-0.18%; Sulfuric acid (CASRN 7664-93-9) 0.16-0.18%; Sulfur dioxide (CASRN 7446-09-5) 0.016-0.018%
8EHQ-0610-17980A (PDF) Mixture containing hydroxylamine; diglycolamine ; catechol; water ; diethylene glycol 7803-49-8,
929-06-6,
120-80-9,
7732-18-5,
11-46-6
  Confidential Results of an acute dermal and oral toxicity studies in Rats with a mixture containing hydroxylamine 50% (CASRN 7803-49-8; diglycolamine (CASRN 929-06-6); catechol (120-80-9); water (CASRN 7732-18-5); diethylene glycol (CASRN 11-46-6).
8EHQ-0610-17981A (PDF) Mixture containing Hydroxylamine -50% , Monoethanolamine, Catechol, and Water 7803-49-8,
78-96-6,
141-43-5,
120-80-9,
7732-18-5
  Confidential Results of an acute inhalation toxicity study in rats and a Corrositex assay with mixture containing Hydroxylamine -50% (CASRN 780349-8), 1-Amino-propan-z-ol (CASRN 78-96-6), Monoethanolamine (CASRN 141-43-5), Catechol (CASRN 120-80-9), and Water (CASRN 7732-18-5).
8EHQ-0610-17982A (PDF) Mixture containing Hydroxylamine 50%, Gallic acid, Water, Diglycolamine, and Pyrogallol 7803-49-8,
49-91-7,
7732-18-5,
929-06-6,
87-66-1
  Confidential Results of an acute dermal toxicity in New Zealand White Rabbits and acute oral toxicity in rats studies with a mixture containing Hydroxylamine 50% (CASRN 7803-49-8), Gallic acid (CASRN 149-91-7), Water (CAS#7732-18-5); Diglycolamine (CASRN 929-06-6), and Pyrogallol (CASRN 87-66-1)
8EHQ-0610-17983A (PDF) Mixture containing Diglycolamine, Hydroxylamine 50%, Gallic acid, Water ,1Aminopropan-z-ol, Monoethanolamine, Catechol, Diethylene glycol, Diethanolamine. Multiple   Confidential Results of an acute oral and acute dermal toxicity studies with a mixture containing Diglycolamine (CASRN 929-06-6), Hydroxylamine 50% (CASRN 7803-49-8), Gallic acid (CASRN 149-91-7), Water (CASRN 7732-18-5), l-Aminopropan-z-ol (CASRN 78-96-6), Monoethanolamine (CASRN 141-43-5), Catechol (CASRN 120-80-9), Diethylene glycol (CASRN 111-46-6), Diethanolamine (CASRN 111-42-2).
8EHQ-0610-17984A (PDF) 4-Amino-6-(methylamino)- 1,3, 5-triazin-2(1H)-one 850879-26-4   Dupont Results of an aquatic toxicity study on Lemna gibba G3 with 4-Amino-6- (methylamino)-1,3,5-triazin-2(1H)-one CASRN 850879-26-4
8EHQ-0610-17985A (PDF) Mixture containing Hydroxylamine -50% , Monoethanolamine, Diglycolamine, Gallic acid, and Water 7803-49-8,
141-43-5,
929-06-6,
149-91-7,
7732-18-5
  Dupont Results of an acute dermal and an acute oral toxicity study with Mixture containing Hydroxylamine -50% (CASRN 7803-49-8) , Monoethanolamine (CASRN 141-43- 5) ,Diglycolamine (CASRN 929-06-6), Gallic acid (CASRN 149-91-7) and Water (CASRN 7732-18-5)
8EHQ-0610-17986A (PDF) Mixture containing Citric acid monohydrate, Hydroxylamine 50% , and Water. 5949-29-1,
7803-49-8 and 7732-18- 5
  Confidential Results of an acute oral toxicity study in rats with mixture containing Citric acid monohydrate (CASRN 5949-29- 1), Hydroxylamine 50% (CASRN 7803-49-8) and Water (CASRN 7732- 18-5.
8EHQ-0610-17987A (PDF) Substituted Nitrogen Containing Heterocycle – Sample and B Confidential   Confidential An incident report recently received regarding an R&D proprietary mixture containing one of the two Substituted Nitrogen Containing Heterocycle – Sample and B.
8EHQ-0610-17988A (PDF) Mixture containing 2-(2- Amino-ethoxy) ethanol, 1- Methyl-2-Pyrrolidone, Diethylene glycol, and Water 929-06-6,
872-50-4,
111-46-6,
7732-18-5
  Confidential Results of several studies with Mixture containing 2-(2-Amino-ethoxy) ethanol (CASRN 929-06-6), 1-Methyl-2- Pyrrolidone (CASRN 872-50-4), Diethylene glycol (CASRN 111-46-6), and Water (CASRN 7732-18-5)
8EHQ-0610-17989A (PDF) Mixture containing o- Dichlorobenzene (28.69%), Phenol (14.45%), Dodecylbenzenesulfonic acid, branched (22.35%), Perchloroethylene (33.82%), Tetrapropylenebenzene (0.23%), Sulfuric acid (0.23%), and Sulfur dioxide (0.02%) Multiple   Dupont Results of an acute oral and an acute inhalation study with a mixture containing o-Dichlorobenzene (CASRN 95-50-1) 28.69%; Phenol (CASRN 108-95-2) 14.45%; Dodecylbenzenesulfonic acid, branched (CASRN 68411-32-5) 22.35%; Perchloroethylene (CAS#127- 18-4) 33.82%; Tetrapropylenebenzene (CASRN 25265-78-5) 0.23%; Sulfuric acid (CASRN 7664-93-9) 0.23%; and Sulfur dioxide (CASRN 7446-09-5) 0.02%.
8EHQ-0610-17990A (PDF) Mixture containing o-Dichlorobenzene (25.73%), Phenol (12.86%), Dodecylbenzenesulfonic acid, branched (20.41%), Perchloroethylene (30.79%), triethanolamine (3.61%), Richonate-YLA (3.19%), triton QS-30 (3.40%) Multiple   Dupont Results of a dermal irritation study with a mixture containing o-Dichlorobenzene (CASRN 95-50-1) 25.73%; Phenol (CASRN 108-95-2) 12.86%; Dodecylbenzenesulfonic acid, branched (CASRN 68411-32-5) 20.41%; Perchloroethylene (CASRN127-18-4) 30.79%; triethanolamine (CASRN102-71-6) 3.61%; Richonate-YLA (CASRN#77030-90-1) 3.19%; triton QS-30 (CASRN 59817-77-5) 3.40%
8EHQ-0610-17992A (PDF) 4-Amino-6-(methylamino)1,3,5-triazin-2( 1H)-one 850879-26-4   Dupont Results of an aquatic plant toxicity study with 4-Amino-6-(methylamino)1,3,5-triazin-2( 1H)-one CASRN 850879-26-4.
8EHQ-0610-17993A (PDF) Substituted Nitrogen Containing Heterocycle Not Provided   Confidential Results of a 28-day repeated dose toxicity study in rats with substituted nitrogen containing heterocycle.
8EHQ-0610-17994A (PDF) N-(6-Chloro-4-methyl-11oxo-11H-pyrido[2,1b]quinazolin-2yl)formamide Not Provided   Dupont Results of an Ames mutagenicity study with N-(6-Chloro-4-methyl-11-oxo11H-pyrido[2,1-b]quinazolin-2yl)formamide.
8EHQ-0610-17995A (PDF) N-[2-[3-Bromo-1-(3chloro-2-pyridinyl)-1Hpyrazol-5-yl]-3,4-dihydro3,8-dimethyl-4-oxo-6quinazolinyl]formamide Not Provided   Dupont Results of an Ames mutagenicity study with N-[2-[3-Bromo-1-(3-chloro-2pyridinyl)-1H-pyrazol-5-yl]-3,4dihydro-3,8-dimethyl-4-oxo-6quinazolinyl]formamide.
8EHQ-0610-17996A (PDF) Acetic acid, mercapto-, 1, 2-ethanediyl ester 123-81-9   Dupont Results of an acute oral toxicity study in rats with Acetic acid, mercapto-, 1, 2-ethanediyl ester CASRN 123-81-9
8EHQ-0610-17997A (PDF) Tert-butyl Peroxybenzoate 614-45-9   AkzoNobel Polymer Chemicals LLC Interim study results of an OECD 429 Skin Sensitization: Local Lymph Node Assay on tert-butyl peroxybenzoate (CASRN 614-45-9)
8EHQ-0610-17998A (PDF) Cyclamen Aldehyde 103-95-7   Fragrance Materials Association of the United States (FMA) Results from a oral (gavage) one-generation reproduction study of cyclamen aldehyde (CASRN 103-95-7) in rats, with an evaluation through sexual maturation in the F1generation.
8EHQ-0610-17999A (PDF) 2-[(2-Heptadec-8-enyl)-4,5-dihydroimidazol-1-yl]ethanol 95-38-5   BASF Results of an Acute Toxicity Study in Unicellular Algae (Desmodesmus subspicatus CHODAT) with 2-[(2- Heptadec-8-enyl)-4,5-dihydroimidazol- 1-yl]-ethanol (CASRN 95-38-5).
8EHQ-0610-18000A (PDF) TDA-vicinals (ortho- TDA);[50% of 4-methyl-ophenylendiamine, toluol- 2,3-diamine (45%),4- methyl-mphenylendiamrne( 1%). 496-72-0,
2687-25-4,
95-80-7
  BASF Results of a Reproduction/Developmental Toxicity Screening Test in Wistar Rats with TDA-vicinals (ortho-TDA);[50% of 4- methyl-o-phenylendiamine (CASRN 496-72-0), 45% of toluol-2,3-diamine (CAS No. 2687-25-4),1% of 4-methylm- phenylendiamrne (CASRN 95-80-7).
8EHQ-0610-18001A (PDF) Tris[4- (diethylamino)phenyl] methylium acetate 63157-72-2   BASF Results of an Acute.Toxicity Study in Water Flea Daphnia magna STRAUS with Tris[4-(diethylamino)phenyl] methylium acetate (CASRN 63157-72- 2)
8EHQ-0610-18002A (PDF) Tris[4- (diethylamino)phenyl] methylium acetate 63157-72-2   BASF Results of an Acute Toxicity Study in Desmodesmus subspicatus CHODAT with Tris[4-(diethylamino)phenyl] methylium acetate (CASRN 63157-72- 2)
8EHQ-0610-18003A (PDF) Dihydromyrcenol 18479-58-8   Lyondell Chemical Company Results of two Acute Aquatic Toxicity Studies with Dihydromyrcenol (CASRN 18479-58-8)
8EHQ-0610-18004A (PDF) Oligomeric MDA 25214-70-4   BASF Results of an Acute Toxicity Screening Test in Daphnia (Daphnia magna) with Formaldehyde, Oligomeric Reaction Products with Aniline (Oligomeric MDA), (CASRN 25214-70-4).
8EHQ-0610-18005A (PDF) 1-Propene, hydroformylation products 68551-11-1   BASF Results of a repeated dose 28-day oral toxicity study in Wistar Rats with 1- Propene, hydroformylation products, high-boiling (CASRN 68551-11-1).
8EHQ-0610-18006A (PDF) Isobutyl Methacrylate 97-86-9   Keller and Hecman LLP Results of a mouse lymphoma and
chromosomal aberration test using the
test substanceisobutyl methacrylate
(IBMA) (CASRN 97-86-9).
8EHQ-0610-18007A (PDF) Hydroquinone Diglycidyl Ether 2425-01-6   Keller and Hecman LLP Results of an "Ames" test using the test substance hydroquinone diglycidyl ether(HQDGE) (CASRN 2425-01-6).
8EHQ-0610-18012A (PDF) Vinylidene Fluoride 75-38-7   Dupont Results of a non-DuPont Ames mutagenicity assay, which we recently became aware of through REACH SIEF activity with vinylidene fluoride CASRN 75-38-7
8EHQ-0610-18013A (PDF) Hexamethylene Diisocyanate (HDI) trimer MEKO Blocked 85940-94-9   American Chemistry Council Information Acquired During Study with Hexamethylene Diisocyanate (HDI) trimer MEKO Blocked (CAS No. 85940-94-9)
8EHQ-0610-18014A (PDF) Substituted Epoxide and Substituted Nitrogen Containing�Heterocycle Confidential   BASF Results of an Acute Eye Irritation Test in Rabbits with a Formulation Containing Two Active Ingredients; (1) Substituted Epoxide and (2) Substituted Nitrogen Containing Heterocycle
8EHQ-0610-18015A (PDF) Confidential Confidential   Confidential A preliminary findings from an OECD 440 uterotrophic assay in rodents which was conducted with the confidential test material.
8EHQ-0610-18016A (PDF) Confidential Confidential   Confidential Results of a one week oral toxicity study in rats with the confidential submitted substance.
8EHQ-0610-18017A (PDF) Diaryl-p-phenylene diamines 68953-84-4   The Goodyear Tire & Rubber Company Results of a 21-day daphnia reproduction study conducted with Diaryl-p-phenylene diamines (CASRN 68953-84-4).
8EHQ-0610-18018A (PDF) 1-0ctanamine, N,N-Dimethyl-, N-Oxide Not Provided   Rhodia Results of a 28-day repeated dose oral (gavage) toxicity study in the Rat using 1-octanamine, N,N-dimethyl-, N-oxide.
8EHQ-0610-18025A (PDF) Confidential Confidential   Syngenta Crop Protection, Inc. Information from a ten-day tolerability study in nonpregnant New Zealand white rabbits and a dose range-finding prenatal developmental toxicity study in New Zealand white rabbits conducted with the confidential chemical substance.
8EHQ-0610-16446U (PDF) PFOA/PFOS Not Provided   Dupont The occupational PFOA serum sampling results for workers at the above referenced DuPont site for samples collected in March-April 2010.
8EHQ-0610-16446V (PDF) PFOA/PFOS Not Provided   Dupont The occupational PFOA serum sampling results for workers at the above referenced DuPont site for samples collected in March-April 2010.
8EHQ-0610-17008B (PDF) Acrylamide Not Provided   BASF Results of possible neurlogical and male reproductive effects of acrylamide in workers.
8EHQ-0610-17367C (PDF) PFOA/PFOS Not Provided   Dupont The occupational PFOA serum sampling results for workers at the above referenced DuPont site for samples collected in March-April 2010.
8EHQ-0610-17726C (PDF) Substituted Nitrogen Containing Heterocycle Confidential   Confidential Results of a one-generation reproduction study with substituted nitrogen containing heterocycle compound.
8EHQ-0610-17726D (PDF) Substituted Nitrogen Containing Heterocycle Confidential   Confidential Results of a 28-day repeated dose toxicity study in dogs with substituted nitrogen containing heterocycle.
8EHQ-0610-17779B (PDF) Substituted Benzamide Confidential   Syngenta Crop Protection, Inc. Results of a 14-Day Oral (Diet) Dose Range Finding Toxicity Study and Toxicokinetic Study in Rats with A Substituted Benzamide,Third Submission, (Supplemental to 8EHQ-09-17779).
8EHQ-0610-17889B (PDF) Substituted Benzamide Confidential   Syngenta Crop Protection, Inc. Results of a 14-Day Preliminary Dietary Toxicity Study in Mice with a Substituted Benzamide, fourth submission, (Supplemental to 8EHQ10-17889).
8EHQ-0610-17938B (PDF) 2-Amino-6-chloro-4methyl-11 H-pyrido[2,1b]quinazolin-11-one Not Provided   Dupont Results of an Ames mutagenicity study with 2-Amino-6-chloro-4-methyl-11 Hpyrido[2,1-b]quinazolin-11-one

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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