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Section 8(e) Substantial Risk Notifications and FYI Submissions Received October 2010

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-1010-18119A (PDF) Confidential Confidential   Confidential Results of Chromosomal Aberration tests in Chinese Hamster Lung Cells in vitro with CBI substance.

The percentage of cells with structural aberrations in the positive control (Mitomycin C 0.05 pg/mI) was 69%. Based on these results, it was concluded, the test substance was positive in this in vitro test.
8EHQ-1010-18120A (PDF) Confidential Confidential   Syngenta crop Protection, Inc. Resutls of a 28-Day Oral (Diet) Toxicity Study in Rats with a substituted benzamide, (Sixth Submission).
8EHQ-1010-18122A (PDF) Vanadium Trioxide 1314-34-7)   Vanadium Producers & Reclaimers Association (VPRA) A preliminary results from an acute inhalation toxicity study on vanadium trioxide. No acute toxicity data have previously been publicly available for this substance at the 0.5 mg/L exposure level in mice, so these data represent new information for this substance.
8EHQ-1010-18123A (PDF) Adipic Acid 124-04-9   DuPont Haskell Global Centers Results of an acute oral toxicity in rats with adipic acid (CASRN 124-04-9).
8EHQ-1010-18124A (PDF) Dodecanedioic Acid 693-23-2   DuPont Haskell Global Centers Results of a subchronic oral toxicity study in rats (OeCD 408) with dodecanedioic acid (CASRN 693-23-2).
8EHQ-1010-18125A (PDF) Formaldehyde 50-00-0   American Chemistry Council Reporting that new information on the carcinogenicity of formaldehyde as reported in the draft manuscript, prepared by the National Cancer Institute (NCI), entitled "Mortality from Solid Tumors among Workers in Formaldehyde Industries: Update of the NCI Cohort." NCI provided the manuscript to ACC for review and conmment. NCI will publish the final manuscript in a peer-reviewed scientific journal.
8EHQ-1010-18126A (PDF) Confidential Confidential   Confidential Interim Results of an Enhanced 1 -Generation Reproduction Toxicity Screening Study in Wistar Rats with the submitted CBI substance.
8EHQ-1010-18127A (PDF) Zinc (1,2,3- Propanetriolato (2)-O1,O2) Homopolymer Stereoisomer 87189-25-1   BASF Results of a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test in Wistar rats [Crl:WI(HAN)] with Zinc (1,2,3- propanetriolato (2)-O1,O2) homopolymer stereoisomer (CASRN 87189-25-1). The substance is used as an additive (nucleating agent) in polypropylene.
8EHQ-1010-18128A (PDF) (1) 2- Pyrimidinamine, 4,6-dimethyl-N-phenyl and (2) Naphtho[2,3-b]-1,4-dithiin-2,3-dicarbonitrile, 5, 1 0-dihydro-5, 10- dioxo- 53112-28-0 & 3347-22-6   BASF Results of an Acute Toxicity Study in Water Flea (Daphnia magna) with a Mixture Containing Two Active Ingredients; (1) 2- Pyrimidinamine, 4,6- dimethyl-N-phenyl (CASRN 53112-28- 0) and (2) Naphtho[2,3-b]-1 ,4-dithiin- 2,3-dicarbonitrile, 5, 1 0-dihydro-5, 10- dioxo- (CASRN 3347-22-6)
8EHQ-1010-18129A (PDF) Bis(1 ,2,2,6,6,-pentamethyl-4piperidyl)sebacate and methyl 1,2,2,6,6, -pentamethyl-4-piperidy sebacate. 41556-26-7 & 82919-37-7   BASF Results of a Repeated Dose 28-Day Oral Toxicity Study with Bis(1 ,2,2,6,6,-pentamethyl-4piperidyl)sebacate (CASRN 41556-26-7) and methyl 1,2,2,6,6, -pentamethyl-4-piperidy sebacate (CASRN 82919-37-7)
8EHQ-1010-18130A (PDF) Halogenated Pyridine derivative Confidential   Dow chemical Company Results of a 90-day dietary study in beagle dogs with halogenated pyridine derivative.
8EHQ-1010-18131A (PDF) 3-Pentenenitrile 4635-87-4   Invista Multiple toxidity studies with 3-Pentenenitrile (CASRN 4635-87-4).
8EHQ-1010-18132A (PDF) 3-Pentenenitrile 2-methyl-3-butenenitrile (2M3BN) 16529-56-9   Invista Multiple toxidity studies with 3-Pentenenitrile 2-methyl-3-butenenitrile (2M3BN) (CASRN 16529-56-9).
8EHQ-1010-18133A (PDF) 2-Norbornene (bicyclo(2.2. 1)hept-2-ene) 498-66-8   Topas Results of a Rat Combined Repeated DoseToxicity Study on 2-Norbornene (bicyclo(2.2. 1)hept-2-ene), (CASRN 498-66-8).
8EHQ-1010-18134A (PDF) Confidential *2 Not Provided   Syngenta Report on a 28-day dietary study in mice with the CBI substance.
8EHQ-1010-18135A (PDF) Confidential *2 Confidential   Syngenta crop Protection, Inc. Results of a 14-day dietary study in rats conducted with the chemical substance.
8EHQ-1010-18136A (PDF) Confidential Confidential   Syngenta crop Protection, Inc. Results of a 28-day dietary study in rats conducted with the chemical substance.
8EHQ-1010-18137A (PDF) Confidential Confidential   Confidential Preliminary information from a rat inhalation study conducted with multi-walled carbon nanotubes (MWCNT).
8EHQ-1010-18138A (PDF) Confidential Confidential   Confidential Results of an acute eye irritation study in Rabbits with CBI substance.
8EHQ-1010-18139A (PDF) Confidential Confidential   Keller and Heckman LLP/ Arizona Chemical Company LLC Results of a skin sensitization  study in mice with CBI test substance.
8EHQ-1010-18140A (PDF) 2-[(2-Heptadec-8-enyl)-4,5-dihydro-imidazol-1 -yl]-ethanol 95-38-5   BASF Results of a OECD 422 Combined Repeated Dose Toxicity Study with the Reproduction Developmental Toxicity Screening Test in Wistar Rats with 2-[(2-Heptadec-8-enyl)-4,5-dihydro-imidazol-1 -yl]-ethanol (CASRN95-38-5).
8EHQ-1010-18141A (PDF) Phenolic reaction product of rosin with fumarate Not Provided   Arizona Chemical Company LLC Results of a local lymph node assay with Phenolic reaction product of rosin with fumarate.
8EHQ-1010-18142A (PDF) Crude Tall oil 8002-26-4   Arizona Chemical Company Results on the acute toxicity report on fish (Danio reio) with crude tall oil (CASRN 8002-26-4)
8EHQ-1010-18143A (PDF) Tall Oil 8002-26-4   Arizona Chemical Company LLC Results of a local lymph node assay in the mouse with Tall Oil (CASRN 8002-26-4).
Confidential CBI
CBI 8002-26-4
8EHQ-1010-18144A (PDF) Gum Rosin 8050-09-7   Arizona Chemical company LLC Results of an acute toxicity test on Zebra fish (brachydanio rerio) with Rosin (CASRN 8050-09-7).
8EHQ-1010-18145A (PDF) Resin acids and Rosin acids, sodium salt 61790-51-0   Arizona Chemical Company LLC The results of an acute toxicity study with Leuciscus idus melanotus with Resin acids and Rosin acids, sodium salt (CASRN 61790-51-0).
8EHQ-1010-18146A (PDF) Fatty acids, tall-oil, esters with pentaerythritol 68188-27-2)   Arizona Chemical Company LLC The results of an acute toxicity test with Bacteria (Pseudomonas putida) with Fatty acids, tall-oil, esters with pentaerythritol (CASRN 68188-27-2).
8EHQ-1010-18147A (PDF) Rosin, fumarated, polymer with formaldehyde 68201-58-1   Arizona Chemical Company The results of a local lymph node assy in mice with rosin, fumarated, polymer with formaldehyde (CASRN 68201-58-1).
8EHQ-1010-18148A (PDF) Rosin, fumarated, polymer with glycerol and pentaerythritol 68424-99-7   Arizona Chemical Company LLC The results of a local lymph node assay in mice with Rosin, fumarated, polymer with glycerol and pentaerythritol (CASRN 68424-99-7).
8EHQ-1010-18149A (PDF) Rosin, fumarated, polymer with pentaerythritol 65997-11-7   Arizona Chemical Company LLC The results of a local lymph node assay in mice with Rosin, fumarated, polymer with pentaerythritol (CASRN 65997-11-7).
8EHQ-1010-18150A (PDF) Resin acids and Rosin acids, hydrogenated, sodium salt 68990-02-3   Arizona Chemical Company LLC The results of an acute toxicity test with Fish (Danlo rerio) with Resin acids and Rosin acids, hydrogenated, sodium salt (CASRN 68990-02-3).
8EHQ-1010-18151A (PDF) erpenes and terpenoids, turpentine-oil, aipha-pinene fraction, polymers with phenol 259094-71-8   Arizona Chemical Company LLC The results of a repeat insult patch test (sensitization study) with Terpenes and terpenoids, turpentine-oil, aipha-pinene fraction, polymers with phenol (CASRN 259094-71-8).
8EHQ-1010-18152A (PDF) Mixture (CASRNs 75-18-3, 80-56-8, 624-92-0, 127-91-3, 68956-
56-9, 74-93-1, 108-88-3)
Multiple   Arizona Chemical Company LLC The results of an acute inhalation toxicity study in rats with 75-18-3, 80-56-8, 624-92-0, 127-91-3, 68956-56-9, 74-93-1, 108-88-3).
8EHQ-1010-18153A (PDF) Formulated Adhesive 936322-31-5   Arizona Chemical Company LLC The results of a local lymph node assay in mice with formulated adhesive, containing portions of a substance (CASRN 936322-31-5).
8EHQ-1010-18154A (PDF) Rosin, fumarated 65997-04-8   Arizona Chemical Company LLC Results of an acute toxicity test on Zebra fish (Brachydanio rerio) with Rosin, fumarated (CASRN 65997-04-8).
8EHQ-1010-18155A (PDF) Benzenesulfonyl isocyanate, 2-chloro- 64900-65-8   DuPont Haskell Global Centers The results of several toxicity studies with Benzenesulfonyl isocyanate, 2-chloro- (CASRN 64900-65-8).
8EHQ-1010-18156A (PDF) Isophorone 78-59-1   American Chemistry Council Report of an endocrine disruptor screening program assays on Isophorone (CASRN 78-59-1).
8EHQ-1010-18157A (PDF) Confidential Confidential   Confidential Results of a prenatal developmental toxicity screening study in Wistar Rats with (CBI substances)
8EHQ-1010-18158A (PDF) I -[(2-halo-5-heteromonocycle) alkyl]-3-(halo-carbomonocycle)-2-substituted-9-substituted-4-oxo-heterobicycle inner salt Not Provided   Confidential the results of a 14-day repeated dose toxicity study in rats with I -[(2-halo-5-heteromonocycle) alkyl]-3-(halo-carbomonocycle)-2-substituted-9-substituted-4-oxo-heterobicycle inner salt.
8EHQ-1010-18159A (PDF) Dimethyl terephthalate 120-61-6   DuPont Haskell Global Centers The results of an acute oral toxicity study in rats with dimethyl terephthalate (CASRN 120-61-6).
8EHQ-1010-18160A (PDF) 1-Dodecene 355-10-04   Shell Chemical Company Results of an acute toxicity study on rainbow trout, Daphnia magna, and green algae with 1-Dodecene, (CASRN 355-10-04).
8EHQ-1010-18161A (PDF) Calcium Hydroxide 1305-62-0   Carmeuse Lime , Inc. The results of two aquatic toxicity studies on rainbow trout and Daphnia magna with Calcium Hydroxide (CASRN 1305-62-0).
8EHQ-1010-18163A (PDF) 2-hexyl- Decanoic acid 25354-97-6   Sasol North America Inc. Results of a local lymph node assay (LLNA) and delayed dermal sensitization study in the guinea pig (Buehler test) with 2-hexyl- Decanoic acid (CASRN 25354-97-6).
8EHQ-1010-18164A (PDF) Confidential *2 Confidential   Monsanto Comapany Preliminary results have been obtained from a pilot rabbit developmental/teratology study
with (CBI substance), an experimental phenyl oxadiazole compound.
8EHQ-1010-18165A (PDF) Confidential *2 Confidential   Confidential Resutls of a four day oral toxicity study in beagles with (CBI substance),
8EHQ-1010-18166A (PDF) Confidential *2 Confidential   Confidential The results of an acute oral toxicity study in rats with (CBI substance).
Confidential Confidential  
8EHQ-1010-16436K (PDF) 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, ammonium salt  62037-80-3   DuPont Results of a 90-day early life-stage toxicity test in rainbow trout with 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, ammonium salt (CASRN 62037-80-3)
8EHQ-1010-16478P (PDF) 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, ammonium salt 62037-80-3   DuPont Results of a 90-day early life-stage toxicity test in rainbow trout with 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, ammonium salt (CASRN 62037-80-3)
8EHQ-1010-17557B (PDF) Benzenesulfonamide, 2-chloro 6961-82-6   DuPont This letter is to inform you of the results of two biodegradability tests with Benzenesulfonamide, 2-chloro (CASRN 6961-82-6).
8EHQ-1010-17557C (PDF) Benzenesulfonamide, 2-chloro 6961-82-6   DuPont This letter is to inform you of the results of two biodegradability tests with Benzenesulfonamide, 2-chloro (CASRN 6961-82-6).
8EHQ-1010-17842B (PDF) 8-halo-N- [(halo-substituted carbonmonocycle) sulfonyl] -6 substituted heterobicycle-
2- carboxamide
Not Proivde   Confidential Results of a screening developmental toxicity study in rats with -halo-N- [(halo-substituted carbonmonocycle) sulfonyl] -6 substituted heterobicycle-2- carboxamide.
8EHQ-1010-17924B (PDF) N-methylmorpholine 109-02-4   Confidential Reporting on the health effects at a commercial facility at which a two-component polyurethane system comprised in part of products supplied by the Company was installed.
8EHQ-1010-18042B (PDF) Methyl 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)aminolcarbonyl]
amino]sulfonyl]-6-(trifluoromethyl)-3-pyridinecarboxylate monosodium salt
144740-54-5   Confidential Results of a toxicity study in freshwater algae with a R&D proprietary mixture containing 50% of  Methyl 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)aminolcarbonyl]amino]sulfonyl]-6-(trifluoromethyl)-3-pyridinecarboxylate monosodium salt (CASRN 144740-54-5).
8EHQ-1010-18043C (PDF) Confidential Not Reported   Monsanto Company Summaries of the following studies; 1) a 28-day dietary study in rats; 2) a 28-day capsule study in dogs; 3) a rat teratology pilot study; and 4) a rabbit teratology pilot study.

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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