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Section 8(e) Substantial Risk Notifications and FYI Submissions Received March 2012

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0312-18578A (PDF) N-(cyanoalkyl)-2-[(alkynyl-carbopolycyclic)substituted]alkylamide  Confidential   Confidential Results of a repeated-dose toxicity study in rats
8EHQ-0312-18579A (PDF) Macrocyclic picolinamide  Confidential   Dow Chemical Company Results of a repeated-dose toxicity study in rats
8EHQ-0312-18581A (PDF) Extracts (petroleum), light paraffinic distillate solvent  64742-05-8 Y American Petroleum Institute (API) Findings from a dermal prenatal developmental toxicity study in rats
8EHQ-0312-18582A (PDF) Distillates (petroleum), light catalytic cracked *3 64741-59-9 Y API energy Results of a Developmental Toxicity Test in Rats
8EHQ-0312-18584A (PDF) Halogenated pyridine derivative  Confidential   The Dow Chemical Company Results of a dietary developmental toxicity probe study in rabbits
8EHQ-0312-18585A (PDF) PFOA  335-67-1 N Taft Stettinius & Hollister LLP 1.) Chart summarizing publicly-available publications, reports, and other documents finding links between human exposures to PFOA and one or more adverse human health effects and 2.) C-8 Science Panel Probable Link Report: "Probable Link Evaluation of Pre
8EHQ-0312-18587A (PDF) Ethyl Acrylate (EA)  140-88-5 Y BASF Corporation Results of an Acute Inhalation Study in Rats
8EHQ-0312-18588A (PDF) 3-Hexyne-2,5-diol  3031-66-1 N BASF Corporation Results of a Skin Sensitization Study (LLNA)
8EHQ-0312-18589A (PDF) Confidential *2 Confidential   Confidential Results of a Micronucleus Screening Test in Mice
8EHQ-0312-18590A (PDF) Confidential *2 Confidential   Confidential Results of the growth of the aquatic plant (Myriophyllum aquaticum)
8EHQ-0312-18591A (PDF) Confidential *2 Confidential   Confidential Results of an Acute Toxicity Study in Daphnia magna
8EHQ-0312-18592A (PDF) Confidential *2 Confidential   Confidential Results of a Micronucleus Screening Test in Male NMRI Mice
8EHQ-0312-18593A (PDF) Confidential *2 Confidential   Confidential Results of a micronucleus screening test in male NMRI mice
8EHQ-0312-18594A (PDF) Substance C *2 Confidential   Confidential Results of an acute toxicity study in the water flea (Daphnia magna)
Substance B *2 Confidential
Substance A *2 Confidential
Substance D *2 Confidential
8EHQ-0312-18595A (PDF) Substituted tetrahydronapthalene  Confidential   Syngenta Crop Protection, LLC Histological evaluation of male rat thyroid tissue from a 28-day oral toxicity study
8EHQ-0312-18596A (PDF) Phosphonium, tributyloctyl-, chloride (1:1)  56315-19-6 N Cytec Industries Inc. Results of a daphnia 48-hour acute immobilization test
8EHQ-0312-18597A (PDF) Potassium zinc fluoride *1 13827-02-6 N Solvay Fluorides Information regarding an Ames test, micronucleus test, mouse lymphoma test, acute algal toxicity test, and a 7-day range-finding inhalation toxicity study in rats
8EHQ-0312-18598A (PDF) 4-(ethylsulfonyl)-2-nitro-benzenamine  23306-60-7 N BASF Chemical Company Results of a Repeated Dose 90-Day Oral Toxicity Study in Wistar Rats
8EHQ-0312-18602A (PDF) Isocyanates  Multiple   3M Environmental, Health and Safety Operations Notice regarding isocyanate generation from urethane-containing surface conditioning discs
8EHQ-0312-18603A (PDF) 3-(Triethoxysilyl)propanethiol  14814-09-6 N Silicones Environmental Health and Safety Council Results of an in vitro mammalian gene cell mutation assay in mouse lymphoma L5178Y cells
8EHQ-0312-18604A (PDF) Triethoxy(3-thiocyanatopropyl)silane *1 34708-08-2 N Silicones Environmental Health and Safety Council Results of an in vitro mammalian gene cell mutation in mouse lymphoma L5178Y cells and an in vitro mammalian chromosome aberration test in Chinese Hamster V79 cells
8EHQ-0312-18605A (PDF) 1-Propene, 2,3,3,3-tetrafluoro- *1 754-12-1 N DuPont Haskell Global Centers Preliminary information for an in vitro CHO/HGPRT Mutation Assay with and without metabolic activation
8EHQ-0312-18608A (PDF) Vanadium pentoxide  1314-62-1 N Vanadium Producers & Reclaimers Association (VPRA) Preliminary findings from in vitro DNA repair functional assays in mice and rat lung tissue extracts
8EHQ-0312-18609A (PDF) Copper disodium ethylenediaminetetraacetate (CuNa2-EDTA) *3 14025-15-1 N Akzo Nobel Services Inc. Interim results from an extended OECD 422 study in rats
8EHQ-0312-18612A (PDF) 4-Cyclohexane-1,2-dicarboxylic acid, ester with 2,2-dimethyl-1,3-propanediol  68071-05-6 N Momentive Speciality Chemicals Inc. Results of a Chinese hamster ovary cell in vitro chromosome aberration assay and a mammalian cell gene-mutation assay in L5178Y mouse lymphoma cells
8EHQ-0312-18616A (PDF) Hydrocarbons, C4, 1,3-butadiene-free, polymd., triisobutylene fraction, hydrogenated  93685-81-5 N Akzo Nobel Services Inc. Final results of an OECD 407 28-day oral toxicity study in rats
Bisisobutyryl peroxide  3437-84-1 N    
8EHQ-0312-18617A (PDF) Blocked polyester polyurethane, neutralized  Confidential   Confidential Results of an acute algal toxicity study
8EHQ-0312-18618A (PDF) Ethene, 1,1,2,2-tetrafluoro-, oxidized, polymd., reduced, me esters, reduced *1 88645-29-8 N Solvay Solexis, Inc. Four-week oral peroxisome proliferation study in rats
FYI-0312-01692A (PDF) PFOA  335-67-1 N Taft Stettinius & Hollister LLP 1.) Chart summarizing publicly-available publications, reports, and other documents finding links between human exposures to PFOA and one or more adverse human health effects and 2.) C-8 Science Panel Probable Link Report
FYI-0312-01693A (PDF) 2-Bromo-3,3,3-trifluoropropene  1514-82-5 N American Pacific Corporation Preliminary information for a 14-day inhalation range-finding study in rats
8EHQ-0312-17253D (PDF) Sulfone insecticide compound *2 Confidential Confidential Toxicological effects of a 28 day repeated dermal toxicity study in rats
8EHQ-0312-17279H (PDF) 2-Propenoic acid, 2-methyl-, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl ester  2144-53-8 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of a 28-day repeated-dose toxicity study in rats
8EHQ-0312-18043F (PDF) Phenyl oxadiazole compound  Confidential   Monsanto Company Results of a screening-level acute toxicity study in the zebra finch
8EHQ-0312-18505C (PDF) Piccolastic TM A5 Hydrocarbon Resin *3 9003-53-6 N Eastman Chemical Company Draft report of an oral reproduction/developmental screening study in rats
8EHQ-0312-18571B (PDF) Confidential  Confidential   Confidential Supplemental information on a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in rats
8EHQ-0312-18574B (PDF) 1,3,5-Triazine-2,4-diamine, N2, N2-dimethyl-6-(2,2,2-trifluoro-ethoxy)- *1 145963-84-4 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of an acute oral and subchronic oral studies
8EHQ-0312-18575B (PDF) 2-Pyridinesulfonamide, 3-(ethylsulfonyl)- *1 117671-01-9 N DuPont Haskell Global Centers for Health and Environmental Sciences Results of a 28-day oral toxicity study in rats


(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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