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Section 8(e) Substantial Risk Notifications and FYI Submissions Received January 2013

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8EHQ/FYI#
Chemical Name
CASRN
Submitter
Submission Description
8EHQ-0113-18956A (PDF) Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates 80939-62-4 BASF The results of a combined repeat dose reproduction toxicity screening test with Amines, C11-14-branched alkyl, monohexyl and dihexyl phosphates (CASRN 80939-62-4)
8EHQ-0113-18957A (PDF) Confidential Confidential Confidential The results of a combined repeat dose reproduction toxicity screening test in Wistar Rats
8EHQ-0113-18958A (PDF) Confidential *2 Confidential Confidential The results of an acute toxicity test in aquatic water plants (Lemna gibba) with an experimental pesticide
8EHQ-0113-18959A (PDF) 2,2,4-trimethylpentane-1,3,-diol Diisobutyrate (TMPDIB) and 2,2,4-trimethylpentane-1,3,-diol Monoisobutyrate (TMPMIB) 6846-50-0 and 25265-77-4 Eastman Chemical Company A metabolism/toxicokinetics study in rats with 2,2,4-trimethylpentane-1,3,-diol Diisobutyrate (TMPDIB; CASRN 6846-50-0) and 2,2,4-trimethylpentane-1,3,-diol Monoisobutyrate (TMPMIB; CASRN 25265-77-4)
8EHQ-0113-18960A (PDF) tert-butyl peroxyisobutyrate 109-13-7 AkzoNobel The results on an OECD 422 Combined Repeat Dose Toxicity with Reproduction/Developmental Toxicity Screening Test in rats with tert-butyl peroxyisobutyrate CASRN 109-13-7
8EHQ-0113-18961A (PDF) Tert-butyl peroxypivalate 927-07-1 AkzoNobel The results on an OECD 422 Combined Repeat Dose Toxicity with Reproduction/Developmental Toxicity Screening Test in rats, with tert-butyl peroxypivalate CASRN 927-07-1
8EHQ-0113-18962A (PDF) Confidential Confidential Confidential Results of a Bovine Corneal Opacity and Permeability Test (BCOP).
8EHQ-0113-18963A (PDF) Confidential *2 Confidential BASF The results of a chronic toxicity test on Collembola (Folsomia candida) with an experimental pesticide
8EHQ-0113-18964A (PDF) Confidential Confidential Confidential The results of an acute toxicity study in Chironomus (Chironomus riparius) with eight experimental pesticides
8EHQ-0113-18965A (PDF) n-dodecyl mercaptan 112-55-0 Arkema Data from a skin sensitization study using n-dodecyl mercaptan (CASRN 112-55-0).
8EHQ-0113-18966A (PDF) PFOA Not Provided Taft Stettinius & Hollister LLP Information relating to human health effects linked to exposure to perfluorooctanoate acid ("PFOA," a/k/a "C-8"):
8EHQ-0113-18967A (PDF) 2-Bromo-3,3,3-Trifluoropropene 1514-82-5 AMPAC Halotron A Reproductive Toxicity Screening Study with Trifluoropropene (CASRN 1514-82-5)
8EHQ-0113-18968A (PDF) 1H-imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-17 odd numbered, C17 -unsatd. Alkyl) derrivs. And methyl acrylate and sodium hydroxide Mixture Rhodia The results of a skin sensitization test with 1H-imidazole-1-ethanol, 4,5-dihydro-, 2-(C7-17 odd numbered, C17 -unsatd. Alkyl) derrivs. And methyl acrylate and sodium hydroxide
8EHQ-0113-18969A (PDF)  methylidynetri-p-phenylene triisocyanate 2422-91-5 Bayer Material Science The results of an acute inhalation toxicity in rats study with methylidynetri-p-phenylene triisocyanate (CASRN 2422-91-5)
8EHQ-0113-18970A (PDF) Tert-butyl peroxyisobutyrate 109-13-7 AkzoNobel The results on a range-finder for an OECD 422 combined repeat dose toxicity with reproduction/ developmental toxicity screening test, with tert-butyl peroxyisobutyrate CASRN 109-13-7.
8EHQ-0113-18971A (PDF) Tert-butyl peroxypivalate 927-07-1 AkzoNobel The results on a 14-day rangefinder for an OECD 422 Combined Repeat Dose Toxicity with reproduction/ developmental toxicity screening test, with tert-butyl peroxypivalate CASRN 927-07-1.
8EHQ-0113-18972A (PDF) Fluorocarbon Confidential Confidential The results of a cardiac sensitization study in dogs with fluorocarbon
8EHQ-0113-18973A (PDF) N-((2- Hydroxy-5-nonylphenyl) methyl)-N-methylglycine sodium salt (1:1) 56968-08-2 Dow Chemical Company The results of an in vitro micronucleus study with N-((2- Hydroxy-5-nonylphenyl) methyl)-N-methylglycine sodium salt (1:1) CASRN 56968-08-2
8EHQ-0113-18974A (PDF) 1H-lndene-1,3(2H)-dione, 2,2-dihydroxy- 485-47-2 Dow Chemical Company The results of an in vitro micronucleus study with 1H-lndene-1,3(2H)-dione, 2,2-dihydroxy- (CASRN 485-47-2)
8EHQ-0113-18976A (PDF) 2-Propanol, 1-[bis[3-(dimethylamino)propyl]amino]- 67151-63-7 Huntsman The preliminary results from a combined repeated dose toxicity study with the reproductive/ development toxicity screening testing in Rats with 2-Propanol, 1-[bis[3-(dimethylamino) propyl]amino]-(CASRN 67151-63-7)
8EHQ-0113-18977A (PDF) Confidential *2 Confidential Confidential The results of a chronic toxicity study (the non-biting midge (Chironomus riparius) with two experimental pesticides
8EHQ-0113-18978A (PDF) Confidential *2 Confidential Confidential The results of a chronic toxicity test on Collembola (Folsomia candida) conducted with an experimental pesticide
8EHQ-0113-18979A (PDF) Confidential *2 Confidential Confidential The results of an acute toxicity test (Non-GLP Indicator Test) with four substituted nitrogen containing heterocycles on aquatic water plants (Lemna gibba)
8EHQ-0113-18980A (PDF) Confidential *2 Confidential Confidential The results of a chronic toxicity study (NON-GLP Indicator Study) on non-biting midge (Chironomus riparius) with an experimental pesticide
8EHQ-0113-18981A (PDF) Confidential *2 Confidential Confidential The results of a 90-day study in beagle dogs with a developmental pesticide
8EHQ-0113-18982A (PDF) Confidential *1 Confidential Confidential The results of a chronic toxicity study (the non-biting midge (Chironomus ripanius) with an experimental pesticide
8EHQ-0113-18983A (PDF) 2-(2Hbenzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol 25973-55-1 BASF The results of a BCF study with 2-(2Hbenzotriazol-2-yl)-4,6-bis(1,1-dimethylpropyl)phenol (CASRN 25973-55-1)
8EHQ-0113-18984A (PDF) Confidential *2 Confidential Confidential The results of acute toxicity test on the growth of the aquatic water plant (Lemna gibba) with an herbicidal formulation containing a mixture of two nitrogen-containing substituted heterocycle
FYI-0113-01700A (PDF) PFOA Not Provided Taft Stettinius & Hollister LLP Information relating to human health effects linked to exposure to perfluorooctanoate acid ("PFOA," a/k/a "C-8"):
FYI-0113-01701A (PDF) N-(3-aminopropyl)diethanolamine (APDEA) 4985-85-7 Confidential The Results of the Acute and Reproductive Toxicity on Daphnia with N-(3-aminopropyl) diethanolamine (APDEA); CASRN 4985-85-7
FYI-0113-01702A (PDF) Perfluoroalkyl substances Not Provided Taft Stettinius & Hollister LLP An Article on The “Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood”.
FYI-0213-01704A (PDF) Hexamethyldisilazane 999-97-3 Shin-Etsu MicroSi, Inc. The final report on an acute dermal toxicity study of HMDS in NZW rabbits after exposure to Hexamethyldisilazane (CASRN 999-97-3)
8EHQ-0113-0898B (PDF) 1,3-bis (4-aminophenoxy) benzene 2479-46-1 DuPont Haskell Global Centers for Health and Environmental Sciences The preliminary results on survival from an ongoing oncogenicity study in mice with 1,3-bis (4-aminophenoxy)benzene CASRN 2479-46-1
8EHQ-0113-13896B (PDF) Trifluoromethane 75-46-7 DuPont Haskell Global Centers for Health and Environmental Sciences The results of a micronucleus assay with Trifluoromethane (CASRN 75-46-7
8EHQ-0113-16436P (PDF) 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, ammonium salt *1 62037-80-3 DuPont Haskell Global Centers The preliminary results of a 2 year rat oral gavage study with 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, ammonium salt CASRN 62037-80-3
8EHQ-0113-16478Q (PDF) 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, ammonium salt *1 62037-80-3 DuPont Haskell Global Centers The preliminary results of a 2 year rat oral gavage study with 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, ammonium salt CASRN 62037-80-3
8EHQ-0113-18264B (PDF) Phosphoric acid, mixed esters with polyethylene glycol and *1 85342-62-7 DuPont Haskell Global Centers for Health and Environmental Sciences Results of an acute inhalation study with Phosphoric acid, mixed esters with polyethylene glycol and
3,3,4,4,5,5,6,6, 7,7,8,8,8-tridecafluoro-l-octanol, ammonium salts (CASRN 85342-62-7 from PMN Report) Consent Order, PMN P-09-0294
8EHQ-0113-18717B (PDF) Nitrogen Containing Heterocycle Confidential Confidential The results of the repeat dose toxicity study with Substituted Nitrogen Containing Heterocycle
8EHQ-0113-18832C (PDF) Phosphonium, tributyltetradecyl-, chloride 81741-28-8 Cytec The final report entitled "Acute Inhalation Toxicity Study in Rats" after exposure to Phosphonium,
tributyltetradecyl-, chloride, (CASRN 81741-28-8)
8EHQ-0113-18878B (PDF) A mixture of cesium sulfate, potassium pyrosulfate, diatomaceous earth, vanadium pentoxide, amorphous silica, sulfur trioxide, absorbed Multiple Confidential The results of a local lymph node assay (LLNA) with a mixture of cesium sulfate (CASRN 10294-54-9),potassium pyrosulfate (CASRN 7790-62-7), diatomaceous earth, natural (CASRN 61790-53-2), vanadium pentoxide (CAS 1314-62-1), Amorphous silica (CASRN 763 1-8
8EHQ-0113-18975A (PDF) aromatic diamine reaction product with alkyl phenol and alkyl aldehyde (Generic Name) *1 Confidential Dow Chemical Company The results of a 28-day repeated dose study, with DuCrI Fisher 344 rats after exposure to aromatic diamine reaction product with alkyl phenol and alkyl aldehyde

*1 =  PMN;  *2  =  Pesticide;  * 3 = Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A). Supplemental means that it is a follow-up to an earlier submitted report.
Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission.  8EHQ number is a useful reference to request a copy of a submission.
FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s.  The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A).  The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.
 
NOTE that OPPT routinely sends follow-up requests to 8(e) submitters.  Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number.  Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information.  This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

Description - A general description of the type of study or information submitted, but not study results.  A PDF electronic copy of the submission is attached.


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