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VCCEP Status

Tetrachloroethylene (CAS No. 127-18-4)


Stage of VCCEP Process

 Completion Date
 (links to data/document)
Date of Commitment for Tier 1 and some Tier 2 and Tier 3 studies *

June 22, 2001 (PDF) (9 pp., 211K)
Expected Tier 1 Start Date

Will be specified within 6 months in testing agreement with ATSDR.
Expected Submission Date of Initial Peer Consultation Document **

Dependent on completion of testing agreement with ATSDR, expected 2007.
Actual Submission Date of Initial Peer Consultation Document**

 
Date of Peer Consultation Meeting

 
Date of TERA's Report on Initial Peer Consultation **

 
Date of EPA's Decision on Tier 2/3 Data Needs

 
Date of EPA's Final Decision on Tier 2/3 Data Needs

 


* The commitment for Tier 2 studies includes oral immunotoxicity, inhalation prenatal developmental toxicity in rats, physiologically-based pharmacokinetic (PB-PK) modeling, existing subchronic toxicity, and existing inhalation multigeneration reproductive toxicity in rats. The commitment for Tier 3 includes an oral developmental neurotoxicity study in rats and existing inhalation neurotoxicity studies in rats. The PB-PK modeling will bridge between the existing inhalation studies and the oral route.

** Will include Tier 1 information; some Tier 2 and Tier 3 studies, exposure assessment, risk assessment, and data needs assessment.

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