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VCCEP Status

Trichloroethylene (CAS No. 79-01-6)


Stage of VCCEP Process

 Completion Date
 (links to data/document)
Date of Commitment for Tier 1 and some Tier 2 and Tier 3 studies*

June 21, 2001 (PDF) (1 pp., 52)
Expected Tier 1 Start Date

Will be specified within 6 months in testing agreement with ATSDR.
Expected Submission Date of Initial Peer Consultation Document**

Dependent on completion of testing agreement with ATSDR, expected in 2007.
Actual Submission Date of Initial Peer Consultation Document**

 
Date of Peer Consultation Meeting

 
Date of TERA's Report on Initial Peer Consultation**

 
Date of EPA's Decision on Tier 2/3 Data Needs

 
Date of EPA's Final Decision on Tier 2/3 Data Needs

 


* The commitment for Tier 2 studies includes oral immunotoxicity, physiologically-based pharmacokinetic (PB-PK) modeling, on-going one-species inhalation prenatal developmental toxicity, and existing inhalation subchronic toxicity. The commitment for Tier 3 includes an oral developmental neurotoxicity study in rats and an existing battery of inhalation neurotoxicity tests. The PB-PK modeling will bridge between the existing inhalation studies and the oral route.

** Will include Tier 1 information, some Tier 2 and Tier 3 studies, exposure assessment, risk assessment, and data needs assessment.

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