HPV Chemical List History

Note: EPA no longer updates this information, but it may be useful as a reference or resource

October 9, 1998

The U.S. high production volume (HPV) chemicals are those which are manufactured in or imported into the United States in amounts equal to or greater than one million pounds per year. The U.S. HPV chemicals were identified through information collected under the Toxic Substances Control Act (TSCA) Inventory Update Rule (IUR). Organic chemicals that are manufactured in, or imported into, the United States in amounts equal to or exceeding 10,000 pounds per year are subject to reporting under the TSCA IUR. Reporting is required every four years.

The HPV Challenge Program Chemical List consists of all the HPV chemicals reported during the 1990 IUR reporting year. Inorganic chemicals and polymers, except in special circumstances, were not subject to the IUR reporting requirements although a number were reported in error. The HPV Challenge Program Chemical List contains about 2,800 chemicals.

The 1990 IUR list was selected as the starting point for this program. As subsequent reporting years identify additional chemicals (including inorganics, once the corresponding reporting requirements have been added under the IUR), they will be posted here for information purposes. EPA expects that, over time, the testing of new HPV chemicals will become routine, and companies may wish to test new HPV chemicals as they appear.

In keeping with that eventual goal, EPA is posting the 1994 IUR List of HPV Additions, which contains about 500 organic HPV chemicals which were newly reported as HPV in the 1994 IUR and are thus not part of the HPV Challenge Program at this time. This list is being provided particularly for use by companies who desire to propose categories of chemicals for testing and wish to include chemicals from the 1994 list in their category definitions.

Each HPV chemical list is provided in database format. The database tables contain one record per chemical. Each record contains three fields. The first field (CASNO) contains the Chemical Abstract Services registry number, which is a unique identification number assigned to a chemical. The second field (INDICATOR) is an indicator variable that, if greater than 0, signifies that the chemical falls outside the scope of the HPV Challenge Program. The possible values for the indicator and their corresponding reasons for falling outside the scope of the program are:

1 = Chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties, or

2 = Chemical is otherwise being handled under the Organisation for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Finally, the name of the chemical is found in the last field (CHEMICAL).

December 9, 1998

The scope of the HPV Challenge Program does not include testing of polymers and inorganic chemicals. These substances were excluded from the reporting requirements of the Inventory Update Rule (IUR) of 1986 unless regulated by a TSCA Section 4, 5(a)(2), 5(b)(4) or 6 rule or an order under Section 5(e) or 5(f), as stipulated under 40 CFR 710.26. To maintain consistency within the HPV Challenge Program, however, the Agency decided it would not include any polymers or inorganics in the program. Since the HPV Challenge Program Chemical List was derived from the 1990 IUR, it was expected that only a minimal number of these substances would be on the list, and that, in most cases, those inclusions would be the result of misreporting by individual companies.

In preparing the HPV Challenge Program Chemical List, the Agency reviewed the original 1990 IUR list of HPV chemicals for polymers and inorganics (misreported and appropriately reported). This review utilized a computer algorithm that, as noted by the Agency in the preamble to the 1986 IUR, would not identify all polymers and inorganic substances on the list, due to the highly complex nature of the CAS nomenclature rules and the lack of a complete molecular formula for many of the Class 2 substances on the TSCA Inventory. Because of the limitations of the screening algorithm, some polymers and inorganic chemicals did escape the automatic search and did appear on the first HPV Challenge Program Chemical List, which was published on October 9, 1998.

In response to questions regarding the polymers and inorganics that appeared on the initial HPV Challenge Program Chemical List, the Agency conducted a comprehensive manual review of the list. A similar exercise was conducted on the 1994 IUR List of HPV Additions. As a result of this effort, additional polymers and inorganic substances have been identified and removed from the scope of the HPV Challenge Program.

To avoid any potential confusion from having multiple lists of HPV Challenge Program chemicals, the Agency is not removing these chemicals from the original list, but rather is marking them with an indicator of "3" to denote that these chemicals are not included in the HPV Challenge Program. The description of this indicator reads:

3 = Chemical is not subject to the HPV Challenge Program because it is a polymer or inorganic substance.

A few Class 2 substances and pigments, which may be polymers or inorganics, may remain on the HPV Challenge Program Chemical List because the name and/or definition provided by the original submitter to the TSCA Inventory lacked conclusive information on which to determine whether the chemical was a polymer or inorganic substance. In the absence of additional definitive information, those substances were left on the HPV Challenge Program Chemical List.

Although the HPV Challenge Program Chemical List was developed using Inventory Update Rule submissions, the removal of chemicals from the scope of the HPV Challenge Program does not necessarily mean that they are excluded from current or future IUR reporting. All questions concerning whether a chemical is subject to IUR reporting should be submitted to the Agency as described in the IUR Instruction Manual (http://www.epa.gov/opptintr/iur98).

May 20, 1999

The Agency has updated the HPV Challenge Program Chemical List to add an indicator of "2" to sixteen additional chemicals, as these chemicals are otherwise being handled under the OECD HPV SIDS Program. Fourteen of these chemicals were selected in the latest phase of the OECD SIDS chemical selection process (Phase 7), completed in February, 1999. The remaining two chemicals were already in the SIDS Program but had not been identified on the previous HPV Challenge Program Chemical List. The sixteen additional chemicals, listed by CAS number, are:

85416	88448	88608	89725
91769	93685	98920	99047
101837	118796	119471	126330
141979	611198	16219753	34590948

July 27, 1999

The HPV Challenge Program Chemical List and 1994 List of HPV Additions have been updated to add a column entitled Sponsorship Status. This indicator identifies the 1990 and 1994 HPV chemicals which have been sponsored under the HPV Challenge Program as of July 19, 1999. Sponsored chemicals are identified by an "F" for fully sponsored, a "P" for provisionally sponsored, or an "N" for Not Sponsored under the HPV Challenge Program.

Please note that sponsorship status has been indicated only for those chemicals appearing on the HPV Challenge Program Chemical List or on the 1994 List of HPV Additions. A complete list of sponsored chemicals, including those chemicals which are not on either of the above-mentioned lists, can be found on our Sponsored Chemicals page.

The key is as follows:

Indicator Values

0 = Chemical is a candidate for sponsorship under the HPV Challenge Program

1 = Chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties

2 = Chemical is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program

3 = Chemical is not subject to the HPV Challenge Program because it is a polymer or inorganic substance.

Sponsorship Status Values

F = Fully Sponsored

P = Provisionally Sponsored

N = Not Sponsored

The Sponsorship Status Column will be periodically updated as commitments are received by the Agency. In addition, a link to the actual letters received by sponsor will be added at a later date.

Changes made on October 27, 1999:

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to add a new column identifying the companies or consortia that have submitted full or provisional commitments to EPA to sponsor chemicals under the HPV Challenge Program. The lists reflect responses received through the close of business on October 15, 1999. The Agency has also updated the lists to reflect changes to chemical sponsorship under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

If you have any questions concerning this list, please submit them using the comment button located at the bottom of this page.

Sponsor Commitment Status Column

Companies or consortia that have submitted full or provisional commitments to EPA to sponsor chemicals under the HPV Challenge Program are identified in a new column entitled Sponsor Commitment Status. In addition to the company or consortium name, an "F" or "P" is shown in brackets, indicting whether the commitment is full or provisional. Consortia member companies are not listed. Please consult the HPV Challenge Summary Report to learn which companies or organizations are members of a particular consortium (www.epa.gov/chemrtk/sumresp.htm). The start year for the chemical is also included in this column.

In this column, "F" and "P" refer specifically to the commitment of a company or consortium to sponsor a particular chemical. The "F" or "P" shows whether the company or consortium has provided all or only part of the required elements for a commitment to the Program. This differs from the "F" and "P" found in the Chemical Sponsorship Status column.

Chemical Sponsorship Status Column

The "F" and "P" found in the Chemical Sponsorship column refer to the status of a chemical in the HPV Challenge Program. A chemical is fully sponsored if the Agency has received at least one full commitment from a company or consortium. A chemical is provisionally sponsored if the Agency has received at least one provisional commitment, but no full commitments, from a company or consortium.

A description of what constitutes full and provisional commitments and fully and provisionally sponsored chemicals can be found in the section on "How to Use the Lists."

Both the Chemical Sponsorship Status and the Sponsor Commitment Status columns will be updated weekly as commitments are received by the Agency. In addition, a link to the actual letters submitted or received by sponsors will be added at a later date. The Sponsor Commitment Status column is not yet searchable, and data from that column will not appear in searches performed using the other indicators available on the list. The Agency is currently modifying the search function to allow searches using data in this column, and when that search capability becomes available, the Agency will provide notification on the "What's New" page.

The Agency recognizes that some chemicals are sponsored by more than one company or consortium. In these cases, the Agency suggests that the companies or consortia coordinate sponsorship of the particular chemical to avoid duplication of effort and ensure costs are minimized. When multiple companies or consortia submit commitments covering the same chemical, the Agency contacts all of the sponsors to alert them to the duplication and to encourage coordination of effort.

SIDS Chemicals

The Agency has updated the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to add an indicator of "2" to thirteen chemicals. The "2" indicator denotes chemicals that are otherwise being handled under the OECD HPV SIDS Program. Eight of these 13 chemicals were selected in the latest phase of the OECD HPV SIDS chemical selection process. The chemicals were nominated by sponsor countries at the SIDS Initial Assessment Meeting held in Paris, France June 29-30, July 1, 1999. The remaining five chemicals (74-87-3, 111-41-1, 135-19-3, 4461-52-3, and 20324-32-7) are also in the SIDS Program and were nominated at other times. Twelve of the 13 chemicals are on the HPV Challenge Program Chemical List. The remaining chemical is on the 1994 List of HPV Additions. The thirteen chemicals, listed by CAS number, are:

74-87-3	111-41-1	839-90-7	25321-09-9
80-09-1	123-11-5	1330-20-7
94-36-0	135-19-3	4461-52-3
98-51-1 (1994 list)	793-24-8	20324-32-7

Additionally, the indicator "2" was removed from two chemicals (25640-78-2 and 26896-20-8), as these chemicals are no longer included in the OECD HPV SIDS program, and thus can be sponsored in the HPV Challenge Program.

The HPV Challenge Program Chemical List and the 1994 List of HPV Additions are provided below for downloading in two forms, DBF and Portable Data Format (PDF). While the content of the lists in DBF and PDF format are the same, the DBF versions include more records than the PDF versions. With the PDF versions, the CAS number is listed only once for all companies and consortia that are sponsoring that chemical. With the DBF versions, the CAS number is repeated for each sponsor. Repeating the information allows users to sort the file by something other than CAS number. A key to the various values used in the lists can be found on the "How to Use the Lists" page.

November 5, 1999

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on October 29, 1999.

November 10, 1999

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on November 5, 1999. Additionally, an indicator of "2" was added to CAS No. 77-92-9 indicating that this chemical is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program. An indicator of "3" was added to CAS No. 11097-59-9 indicating that this chemical is not subject to the HPV Challenge Program because it is a polymer or inorganic substance.

November 17, 1999

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on November 12, 1999.

November 30, 1999

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on November 26, 1999. If you have any questions concerning these lists, please submit them using the comment button located at the bottom of this page.

March 7, 2000

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on March 3, 2000. This update captures all commitments received by the close of the voluntary sign-up period on December 1, 1999.

An indicator of "2" was added to CAS Nos. 95-50-1, 106-42-3, 624-41-9, and 25376-45-8, indicating that these chemicals are otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Three new codes were added to the list during this update, two numerical ones in the "Indicator" column and one letter code in both the "Chemical Sponsorship Status" and the "Sponsor Commitment Status" columns. These new codes are:

Indicator Column Values:

4 = A company or consortium has clearly indicated to and has had confirmed by ICCA their sponsorship of this chemical in the Global HPV Initiative of the International Council of Chemical Associations, and all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) has been provided to the Agency.

5 = Chemical meets the criteria for being "No Longer HPV" and is thus no longer subject to the HPV Challenge Program. This chemical may be sponsored.

June 16, 2000

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect responses received through the close of business on May 26, 2000. This update captures all commitments received by the close of the voluntary sign-up period on December 1, 1999. Letters received since December 1, 1999 reflect clarifications to previously submitted commitments. As of today, no new commitments have been received.

An indicator of "2" was added to CAS Number 8007189 indicating that this chemical is otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Ind = 2
8007189

An indicator of "5" was added to the CAS Numbers below indicating that these chemicals meet the criteria for being "No Longer HPV" and are no longer subject to the HPV Challenge Program. These chemicals may be sponsored
Ind = 5
101633	534156	619669	824782	1300738	2738069
13188608	13360639	21729986	35884663	68308678

December 15, 2000

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect letters received through the close of business on December 1, 2000. This update captures all commitments received by close of the voluntary sign-up period on December 1, 1999. Letters received since December 1, 1999 generally reflect clarifications to previously submitted commitments.

The International Council of Chemical Associations (ICCA) HPV commitments have also been updated at this time

Indicator Column Values:

0 = Chemical is a candidate for sponsorship under the HPV Challenge Program

1 = Chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties

2 = Chemical is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program

3 = Chemical is not subject to the HPV Challenge Program because it is a polymer or inorganic substance.

4 = A company or consortium has had confirmed by the International Council of Chemical Associations (ICCA) their sponsorship of this chemical in the HPV Initiative of ICCA, and all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone) has been provided to the Agency.

5 = Chemical meets the criteria for being "No Longer HPV" and is thus no longer subject to the HPV Challenge Program. This chemical may be sponsored, however.

An indicator of "1" was added to the CAS Numbers below indicating that these chemicals are not considered candidates for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties. These chemicals may be sponsored, however.

Ind = 1

142472 65996636 65996647

An indicator of "2" was added to the CAS Numbers below indicating that these chemicals are otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Ind = 2

78795	95498	96311	96333	97632	97869
99990	100549	103764	106638	106887	106989
107153	108316	108996	109068	110861	110985
111900	112072	112152	112254	112572	122521
122996	123546	124174	140318	140885	141106
141322	143226	301100	513359	556821	584849
616386	683181	753731	770354	818086	993168
1461229	1461252	1559348	3290924	3590849	5102830
5131668	5567157	6358856	6881943	13048334	15625895
20324338	23783428	25498491	26471625	29911282	42978665
57583343	57583354	63449398	68515935	68784269	68815678
68855458	68909182	72275866	73758620

An indicator of "5" was added to the CAS Numbers below indicating that these chemicals meet the criteria for being "No Longer HPV" and are no longer subject to the HPV Challenge Program. These chemicals may be sponsored, however.

Ind = 5

54217	85698	89087	94746	132274	139026
554121	616217	13927770	28984896	68476482	68477225
68609643

Chemical Sponsorship Status Column Values:

I = ICCA Confirmed Commitment

Company or consortium has clearly indicated to and has had confirmed by ICCA their sponsorship of a chemical(s) in the HPV Initiative of the International Council of Chemical Associations.

All confirmed Company and Consortium ICCA commitments are identified in a letter to EPA's Administrator from ICCA dated August 4, 2000. This letter supercedes the earlier ICCA letter dated February 25, 2000.

Companies can meet the requirements of the HPV Challenge Program either directly through the Challenge Program or indirectly through the OECD HPV SIDS Program and/or the ICCA HPV Initiative. U.S. companies deciding to sponsor chemicals under the HPV Challenge Program can also identify those chemicals as U.S. contributions to the OECD HPV SIDS Program and/or the ICCA HPV Initiative. Such chemicals may have both an "I" (confirmed ICCA sponsorship) and an "F" (Full sponsorship or fully sponsored HPV Challenge Program Commitment) in the Sponsor Commitment Status field.

It is noted that a chemical with confirmed sponsorship under the ICCA HPV Initiative may not be listed with a "4" in the indicator column. All data elements necessary for Full Commitment status under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) must also be provided to the Agency in order for the chemical to be designated as an ICCA sponsored chemical under the HPV Challenge Program (and thus receive a "4" in the indicator column.

October 12, 2001

The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect letters received through the close of business on July 13, 2001. This update generally reflects clarifications or changes to previously submitted commitments.

These updated lists also reflect changes to the following Indicator Column Values:

Indicator = 1

50000	105602	124403	7659861	64742489
56815	105646	128370	8032324	64742490
58082	106310	134203	8052413	64742810
65850	107415	137326	13674878	64742821
68111	107926	139333	13952846	64742887
68122	107960	139899	15708415	64742898
71410	108112	140012	16111629	64742945
74895	108189	142825	16470249	64742956
75014	108214	142847	16485475	64771728
75047	108394	142905	18328900	66455172
75310	108678	287923	18719034	67762258
75387	108918	528449	20824560	67762270
75503	109524	532321	21265509	67762305
75649	109604	538932	22473785	67762418
75683	109739	540841	25103097	67859512
77474	109831	544763	25155253	68333802
78637	109897	552307	25264931	68390567
78784	110054	582252	25339564	68410968
78922	110190	598561	25377837	68410979
78966	110543	614459	25550145	68476506
79094	110623	629505	25584832	68477316
79312	110918	629629	26523784	68516187
79345	111273	629732	26748414	68527059
79947	111659	629969	27215958	68551166
80159	111842	661198	29964849	68551177
80433	111864	818611	30618849	68551199
88733	111875	822060	32360057	68551202
88744	111922	927071	36653824	68603156
90722	112301	1222055	38051104	68603178
95658	112403	1321944	45294186	68911615
96059	112425	1338234	61788452	70024929
96184	112709	1704627	61788463	70693060
97723	112721	1761713	63393828	70955112
97858	112889	2050922	64741635	75782864
98942	112903	2495274	64741657	75782875
100378	116530	2549533	64741737	90622461
100516	121448	2935902	64741840	93924073
102067	121915	3006824	64741851	129813678
102829	123057	3033623	64741919
103093	123626	5332730	64742069
104756	123966	5421465	64742467
105599	124301	7534943	64742478

1994 List of HPV Additions:

58559	107835	1939362	3425614	19910657
107711	1717006	2495252	6140745	25378227

Additionally, the indicator "2" was removed from the following chemical, as this chemical is no longer included in the OECD HPV SIDS program, and thus can be sponsored in the HPV Challenge Program:

4461523

Indicator = 4

No new Indicator "4"s have been added to the list. All confirmed Company and Consortium International Council of Chemical Associations (ICCA) commitments are identified in a letter to EPA's Administrator from ICCA dated August 4, 2000. This letter supercedes the earlier ICCA letter dated February 25, 2000.

Indicator = 5

62544	107562	118296	141526	141980	693210
1497683	2738069	4356609	6423434	13393936	13889924
17564646	18169578	25037450	32131172	36876138	39464705
52836314	55701058	61790350	68308678	68443856	73467773

The following Values were added to the Sponsor Commitment Status Column:

V = Viable Commitment. Same as Full Commitment but the commitment to sponsor the particular chemical was received after the December 26, 2000 proposed test rule was published (65 FR 81658). In addition to meeting the standard requirements of the HPV Challenge Program, sponsors must also provide full copies of studies for viable chemicals.

Q = Provisional Viable Commitment. Same as Provisional Commitment (all the required commitment information was not provided.) but the commitment to sponsor a particular chemical was received after the December 26, 2000 proposed test rule was published (65 FR 81658). Provisional viable commitments will be upgraded to Viable status (see above) upon receipt and processing of required commitment information.

V = Viable-Sponsored Chemical. The Agency has received at least one viable commitment from a company or consortium to sponsor the particular chemical.

Q = Provisional Viable-Sponsored Chemical. Company/Consortia has provided most, but not all, of the Viable Commitment information. The Agency has received at least one provisional viable commitment, but not viable commitments, from a company or consortium to sponsor the particular chemical.

A = Test Rule Chemical. Chemicals listed in the proposed "Testing of Certain High Production Volume Chemicals; Data Collection and Development on High Production Volume (HPV) Chemicals" rule (65 FR 81658). These chemicals may be sponsored prior to publishing a final rule. Note that sponsorship after the December 26, 2000 date (a viable commitment) requires that, in addition to meeting the standard requirements of the HPV Challenge Program, sponsors also provide full copies of studies.

C = Voluntary Children's Chemical Evaluation Program Chemical. Chemicals listed in the Voluntary Children's Chemical Evaluation Program notice (64 FR 81699). These chemicals may be sponsored. Note that sponsorship after the December 26, 2000 date (a viable commitment) requires that, in addition to meeting the standard requirements of the HPV Challenge Program, sponsors also provide full copies of studies.

March 13, 2002

In some cases, companies or consortia have sponsored chemicals that are not on either the HPV Challenge Program Chemical List or the 1994 List of HPV Additions. A list of these chemicals, called "Additional Chemicals Sponsored Under the HPV Challenge Program" is being added with this update. The Agency has updated both the HPV Challenge Program Chemical List and the 1994 List of HPV Additions to reflect letters received through the close of business on January 18, 2002. This update generally reflects clarifications or changes to previously submitted commitments.

These updated lists also reflect changes to the following Indicator Column Values:

Indicator = 1

No new indicators of "1" were added to the list. A "1" indicates that the chemical is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties. A chemical with an indicator of "1" may be sponsored, however.

Indicator = 2

CAS Number	CAS Number	CAS Number	CAS Number	CAS Number
75763	75945	78104	80104	98135
107186	107460	108463	108985	115219
124709	131179	527071	540976	541026
541059	675627	872504	919302	919313
999973	1066359	1067534	1185553	1310583
1310732	1313139	1322981	1760243	2487903
2530838	2530872	2550063	4253343	4518983
7351613	7447407	7647010	7778543	7782505
10025782	10026047	10043524	11099062	12125029
13528886	17689779	22984549	27636755	85117506

Additionally, the indicator "2" was removed from the following chemical2, as these chemicals are no longer included in the OECD HPV SIDS program, and thus can be sponsored in the HPV Challenge Program:

95658 20324327

Indicator = 4

Based on the January 31, 2002 letter from ICCA, new Indicator "4"s have been added to the list. All confirmed Company and Consortium International Council of Chemical Associations (ICCA) commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000 and January 31, 2002. These letters supercede the earlier ICCA letter dated February 25, 2000.

Indicator = 5

No new indicator "5"s were added to the lists. A "5" indicates that the chemical meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program. A chemical with an indicator of "5" may be sponsored, however.

May 22, 2002

The Agency has updated the HPV Challenge Program Chemical List, the 1994 List of HPV Additions and the Additional Chemicals Sponsored under the HPV Challenge Program to reflect letters received through the close of business on March, 15, 2002. This update generally reflects clarifications or changes to previously submitted commitments.

August 8, 2002

The Agency has updated the HPV Challenge Program Chemical List, the 1994 List of HPV Additions and the Additional Chemicals Sponsored under the HPV Challenge Program to reflect letters received through the close of business on July 12, 2002. This update generally reflects clarifications or changes to previously submitted commitments.

These updated lists also reflect changes to the following Indicator Column Values:

Indicator = 1

No new incator "2" were added to the list. A "2" indicates that these chemicals are otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program.

Indicator = 4

No new indicator "4" was added to the list. All confirmed International Council of Chemical Associations (ICCA) commitments are identified in documents to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002 and April 12, 2002. These letters supercede the earlier ICCA letter dated February 25, 2000.

Indicator = 2,4

An Indicator "2,4" was added to the CAS numbers below. A "2" indicates that these chemicals are otherwise being handled under the Organizational for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program and a indicator "4" indicates that these chemicals are confirmed International Council of Chemical Associations (ICCA) commitments identified in documents to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002 and April 12, 2002. These letters supercede the earlier ICCA letter dated February 25, 2000.

Chemicals receiving new Ind=2, 4 flags

75127	3323533
78591	4454051
87569	6104309
100005	288324
106445	1312761
115071	1490046
115866	6834920
120809	7775146
603350	7791255
947046	10213793
1319773	13517243
1328536	85422920
2855132	86089170

Indicator = 5

November 21, 2002

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemicals are otherwise being handled under the OCED SIDS program.

60242	67481	67561	75978	77587
78046	89781	97905	100709	108894
109091	109160	110894	111488	112276
112594	112607	144558	496720	497198
870086	994058	1118463	2235430	2687254
2809214	3091256	4792158	5995426	8013078
8016113	10126688	13547701	15356602	15827608
20592852	22042962	22591215	26864379	26998970
27193868	29329713	42272708	55680030	61789013
67845947	67845958	67953768	68186903	68391117
68609927	74499357	88917220	98246878	122384854
122384876	201687572

An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS Program.

75070 75150 75218 110270 72275866

December 18, 2002

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

110305

210555945

An indicator of "2" was removed from the following chemical as it is no longer included in the OECD SIDS Program.

27193868

March 6, 2003

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

64186	74931	75081	75661	79210
79221	79389	95476	106423	106752
107039	107313	108236	108383	109795
111886	112550	141537	142961	280579
501531	541413	544172	760678	1344009
2837890	3268493	3282302	4300974	5188078
6422862	24468131	25103586	25360105	40292828
68153300	68953582

An indicator of "2" was removed from the following chemical as it is no longer included in the OECD SIDS Program.

1319773

June 4, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

64-17-5

78-87-5

825-90-1	1572-52-7
61791-47-7	27288-44-4

September 3, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

31570-04-4

75-00-3

October 14, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

95-55-6	99-54-7	107-86-8	110-93-0	120-92-3
298-12-4	1300-72-7	3648-20-2	7727-21-1	7727-54-0
7775-27-1	10035-10-6	12068-03-0	26401-86-5	26401-97-8
26447-10-9	28348-53-0	32073-22-6	37475-88-0	68515-43-5
68515-47-9	69669-44-9	85507-79-5	90194-45-9	127184-52-5

Search the HPV Challenge Program Chemical List

Please note that dashes have been added to all CAS Numbers on this website. This change ensures that all CAS Numbers conform to standard CAS format. Dashes must now be included when searching for a CAS Number.

January 22, 2003

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added to the list.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

78-95-5	79-77-6	80-54-6	85-44-9	98-07-7
101-54-2	106-43-4	106-49-0	107-25-5	109-53-5
109-92-2	111-36-4	119-64-2	124-04-9	139-96-8
764-41-0	868-85-9	1309-37-1	1317-61-9	1653-19-6
2235-54-3	4098-71-9	5124-30-1	5324-84-5	7719-12-2
7757-82-6	7783-20-2	9084-06-4	10025-87-3	11071-47-9
12070-12-1	16090-02-1	24549-06-2	25321-14-6	25339-17-7
27458-94-2	36290-04-7	51000-52-3	68081-96-9	68081-98-1
68153-01-5	68439-57-6	68585-47-7	70942-01-7	91078-68-1
93924-63-1	117875-77-1

An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

109-86-4

527-07-1

4300-97-4

Indicator = 3 (Polymer or Inorganic)

A chemical that is not subject to the HPV Challenge Program because it is a polymer or inorganic substance has been assigned an indicator of "3." This chemical may be sponsored, however.

No new indicators of "3" were added to the list.

Indicator = 4 (ICCA)

Chemicals sponsored under the International Council of Chemical Associations (ICCA) HPV Initiative, confirmed by ICCA and having all information essentially equivalent to a Full Commitment under the HPV Challenge Program (i.e., chemical name, CAS number, start year for each chemical, technical contact person and telephone number) provided to the Agency have been assigned an indicator of "4."

Based on the October 7, 2003 letter from ICCA, new indicators of "4" have been added to the list. Also based on this letter, indicators of "4" have been removed from some chemicals. All confirmed company and consortia ICCA commitments are identified in letters to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, and October 7, 2003.

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

No new indicators of "5" were added. March 12, 2004

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

One new indicators of "1" was added to the list:

1152-61-0

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

56-23-5	71-55-6	75-09-2	75-18-3	75-35-4
90-80-2	91-64-5	95-53-4	110-16-7	299-27-4
299-28-5	526-95-4	527-07-1

An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

May 28, 2004

In order to standardize the chemical names of the HPV Challenge Program chemical lists, with this update, EPA is changing the chemical names to reflect the Chemical Abstracts (CA) 9th Collective Index (9CI) names. Ninth Collective Index names are those used for the TSCA Inventory. Changes have been made to the following lists only: the HPV Challenge Program Chemical List, the 1994 List of HPV Additions, the Additional Chemicals Sponsored Under the HPV Challenge Program, and the Sponsored Chemicals List. Please note that chemical name changes are not highlighted on these lists. Chemical names on the HPV Challenge Summary Report have not been changed. Additional changes to chemical names will occur with future website updates as the Agency continues to review and modify its lists to reflect the appropriate chemical names.

Indicator = 1 (Not Considered a Candidate for Testing)

A chemical that is not considered a candidate for testing under the HPV Challenge Program, based on preliminary EPA review indicating that testing using the SIDS base set would not further our understanding of the chemical's properties has been assigned an indicator of "1." This chemical may be sponsored, however.

No new indicators of "1" were added.

Indicator = 2 (SIDS)

A chemical that is otherwise being handled under the Organization for Economic Co-operation and Development (OECD) HPV Screening Information Data Set (SIDS) Program has been assigned an indicator of "2." This chemical may be sponsored, however.

An indicator of "2" was added to the CAS numbers below indicating that these chemical are otherwise being handled under the OCED SIDS program.

128-44-9

137-26-8

7414-83-7

An indicator of "2" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

78-51-3	80-56-8	354-33-6	372-09-8	1333-86-4
8002-26-4	8006-64-2	8016-81-7	8050-09-7	8050-15-5
8050-26-8	8050-31-5	8052-10-6	9005-90-7	61790-12-3
61790-51-0	64365-17-9	65996-96-5	65997-03-7	65997-04-8
65997-06-0	65997-13-9	68201-59-2	68938-00-1	68955-98-6

An indicator of "4" was removed from the following chemicals as they are no longer included in the OECD SIDS program.

90-72-2	119-61-9	301-02-0	630-08-0	3048-65-5
16883-83-3	32210-23-4	34690-00-1	38051-10-4

Indicator = 5 (No Longer HPV)

A chemical that meets the criteria for being "No Longer HPV" and is no longer subject to the HPV Challenge Program has been assigned an indicator of "5." This chemical may be sponsored, however.

Two new indicators of "5" were added.

6842-15-5

27157-94-4

Indicator = 2, 4 (SIDS/ICCA)

An Indicator "2,4" was added to the CAS number below. A "2" indicates that this chermical is otherwise being handled under the Organization for Economic Cooperation and Development (OECD) HPV Screening Information Data Set (SIDS) Program and an indicator "4' indicates that this chemical is a confirmed International Council of Chemical Associations (ICCA) commitment identified in documents to EPA's Administrator from ICCA dated August 4, 2000, January 31, 2002, April 12, 2002, August 26, 2002, March 28, 2003, July 14, 2003, October 7, 2003 and May 17, 2004.

One Chemical received a new Ind=2,4 flag; 5995-42-6

HPV Chemical List History

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