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Chlorinated Paraffins Test Results


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CAS Nos. Chlorinated paraffins are defined as a series of mixtures of chlorination products of paraffin oils or waxes, with a chlorine content of 35 to 70% by weight, excluding similar products with a different manner of production. Four representative compounds with different chain lengths and degrees of chlorination were selected for the voluntary testing program. These compounds were: Chlorowax 500C® (58% chlorination, short chain length), Electrofine S70® (70% chlorination, long chain length), Cereclor S52® (52% chlorination, intermediate chain length), and Chlorowax 40® (43% chlorination, long chain length).

ITC Designation - First Report
42 FR 55026; October 12, 1977

Negotiated Testing Agreement (NTA)
47 FR 1017; January 8, 1982
Consortium of Chlorinated Paraffin Manufacturers

Project Manager: P. Wirdzek, C. Glasgow, R. Troast

Section Chief: N. Merrifield

Status: Closed. All required tests have been completed. Test results have been forwarded to the Risk Assessment Division for review and disposition.

Announced Receipt of Test Data

Unless otherwise noted, results were submitted by the Consortium of Chlorinated Paraffin Manufacturers. Testing was performed on the following representative compounds: Chlorowax 500C® (58% chlorination, short chain length), Electrofine S70® (70% chlorination, long chain length), Cereclor S52® (52% chlorination, intermediate chain length), and Chlorowax 40® (43% chlorination, long chain length).

Cell transformation studies of a modified Styles type (Chlorowax 500, Electrofine S70®) (47 FR 54160; December 1, 1982).

Teratology studies (Chlorowax 500C® in rats, Chlorowax 40® in rabbits) (48 FR 12124; March 23, 1983).

Teratology study (Cereclor S52® in rabbits) (48 FR 20132; May 4, 1983).

Teratology study (Chlorowax 500C® in rabbits) (48 FR 34119; July 27, 1983).

Teratology (Electrofine S70® in rabbits), water solubility and 60-day toxicity studies (rainbow trout and mussels) of the four representative compounds, 14-day bioassay (Chlorowax 500C® in freshwater and marine alga, aerobic, and anaerobic biodegradation/ inhibition (Chlorowax 500C®), chronic toxicity (Chlorowax 500C® in midges), and life-cycle (to Chlorowax 500C® in Daphnia) (48 FR 53159; November 25, 1983).

Embryo-juvenile (Chlorowax 500C® in sheepshead minnow), growth (Chlorowax 500C® in mussel, bioconcentration (Chlorowax 500C® in rainbow trout andmussels), life-cycle (Chlorowax 500C® in Mysid shrimp Daphnia magna), growth (Chlorowax 500C® in rainbow trout), anaerobic biodegradability (Chlorowax 500C®), mutagenicity and teratogenicity (Chlorowax 500C® in rats), in vivo cytogenetic study (Electrofine S70® in rats) (49 FR 5187; February 10, 1984).

13-Week dietary toxicity (Chlorowax 500C® in rats), teratology (Cerechlor S52® and Electrofine S70® in rats) (49 FR 30114; July 26, 1984).

13-Week dietary toxicity (Cereclor S52® and Chlorowax 500C® in rats), reproductive study (Chlorowax 500C® in mallard duck), subchronic toxicity (Chlorowax 500C® and Chlorowax 40® in rats and mice) (submitted by NTP) (49 FR 44142 November 2, 1984).

Results of range-finding studies were also announced (47 FR 36958; August 24, 1982, 48 FR 12124; March 23, 1983, 48 FR 20132; May 4, 1983, 48 FR 53159; November 25, 1983, 49 FR 5187; February 10, 1984, 50 FR 1892; May 3, 1985).

Results of Testing Table



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