Cresols Test Results

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CAS Nos. Cresols are members of a chemical category consisting of three isomers: ortho-, meta-, and para-cresol. The CAS registry numbers of the three isomers and the unspecified mixture of isomers are:

o-Cresol 95-48-7
m-Cresol 108-39-4
p-Cresol 106-44-5
Cresols (mixed isomers) 1319-77-3

Cresols are used as individual isomers or as mixtures thereof.

ITC Designation - First Report
42 FR 55026; October 12, 1977

Proposed Test Rule/Phase I (PRM)
48 FR 31812; July 11, 1983

Final Test Rule/Phase I (FRM)
51 FR 15771; April 28, 1986
CMA Cresols Program Panel

Proposed Test Rule/Phase II Test Standards (PRMT)
51 FR 15803; April 28, 1986

Final Test Rule/Phase II Test Standards (FRMT)
52 FR 19082; May 20, 1987

Modifications
54 FR 27352; June 29, 1989/Technical amendment

Project Manager: L. Tuxen; K. Cronin

Section Chief: R. Troast

Status: Closed. All required tests have been completed. Test results have been forwarded to the Risk Assessment Division for review and disposition.

Announced Receipt of Test Data

The Cresol Program Panel of the Chemical Manufacturers Association submitted the following tests for o-, m-, and p-cresol: in vitro cytogenetic assay on o-, m-, and p-cresol measuring chromosomal aberration frequencies with CHO cells; unscheduled DNA syntheses in rat primary hepatocytes on m-cresol; mouse lymphoma mutation assay on m- and p-cresol; in vitro transformation of BALB/C-3T3 cells on m- and p-cresol; developmental toxicity evaluation of o, m-, or p-cresol (rabbit, rat); an analytical chemistry report in support of in vitro genetic toxicity assessment of o-, m-, and p-cresol (53 FR 27564; July 21, 1988).

In vitro transformation of BALB/C-3T3 cells in the presence of a rat liver activation system with o-cresol (53 FR 37643; September 27, 1988).

In vitro transformation of BALB/C-3T3 cells in the presence of a rat liver activation system with m-cresol (53 FR 51134; December 20, 1988).

In vivo mouse bone marrow cytogenetic test on m-cresol (54 FR 7093; February 16, 1989).

Drosophila Melanogaster sex-linked recessive lethal test on p- and o-cresol (54 FR 14861; April 13, 1989).

In vitro transformation of BALB/C-3T3 cells in the presence of a rat liver activation system with o-cresol; dominant lethal assay in mouse on o- and p-cresol (54 FR 30460; July 20, 1989).

2-Generation reproduction study (rat) on o-, m-, and p-cresol (54 FR 52449; December 21, 1989).

Results of Testing Table

Cresols Test Results

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