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Methyl Isobutyl Ketone (MIBK) and Methyl Ethyl Ketone (MEK) Test Results


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CAS Nos. 108-10-1 (MIBK); 78-93-3 (MEK)

ITC Designation - Fourth Report
44 FR 31866; June 1, 1979

Proposed Negotiated Testing Agreement (NTA)
47 FR 58025; December 29, 1982

Final Negotiated Testing Agreement (FAN)
48 FR 44905; September 30, 1983
Chemical Manufacturers Association (Ketones Program Panel)

Project Manager: K. McCormack, R. Troast

Section Chief: N. Merrifield

Status: Closed. All required tests have been completed. Test results have been forwarded to the Risk Assessment Division for review and disposition.

Announced Receipt of Test Data

Inhalation teratology probe study (MIBK in rats and mice) (48 FR 53159; November 25, 1983).

Subchronic inhalation toxicity study (MIBK in rats and mice) (49 FR 5187; February 10, 1984).

Inhalation teratology study (MIBK in rats and mice) and the following tests in both MEK and MIBK: Salmonella mammalian microsome mutagenicity assay (Ames test), micronucleus cytogenetic assay (mouse), DNA synthesis in rat primary hepatocytes, morphological transformation assays using BALB/3T3 mouse embryo cells, and L5178Y TK mouse lymphoma mutagenesis assays (50 FR 5421; February 6, 1985).

Results of Testing Table



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