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N-Methylpyrrolidone (NMP) Test Results


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CAS No. 872-50-4

Notice of Proposed Rulemaking (NPRM)
55 FR 11398; March 28, 1990

Consent Order (CO)
58 FR 61814; November 23, 1993
Arco Chemical Company, BASF Corporation, and International Specialty Products Company

Modifications/Notices
56 FR 32292; July 15, 1991/Correction
58 FR 16669; March 30, 1993

Project Manager: Robert Jones

Branch Chief: Frank Kover

Status:  Closed. All required tests have been completed. Test results have been forwarded to the Risk Assessment Division for review and disposition. 

Announced Receipt of Test Data

Test data were submitted by the NMP Producers Group on behalf of the test sponsors pursuant to a testing consent order and received by EPA on May 24, 1994. The submissions describe the subchronic oral toxicity 28-day feeding study in rats and repeated-dose toxicity study in B6C3F1 mice: administration in the diet for 4 weeks (range finding study) with NMP (59 FR33291; June 28, 1994).

Test data were submitted by the NMP Producers Group pursuant to a testing consent order and received by EPA on November 22, 1995. The submissions includes 3 final reports entitled “N-Methylpyrrolidone - Subchronic oral toxicity study in B6C3F1 mice, administration in the diet for 3 months”, Subchronic oral toxicity: 90-day feeding and neurotoxicity study in rats with N-Methylpyrrolidone (NMP)” and “Oral, dermal, and inhalation pharmacokinetics and disposition of [2-14C]NMP in the rat” (61 FR 3403; January 31, 1996).

Results of Testing Table



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