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Tributyl Phosphate (TBP) Test Results


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CAS No. 126-73-8

ITC Recommendation/Designation - 18th and 19th Reports
51 FR 18368; May 19, 1986/Recommended
51 FR 41417; November 14, 1986/Designated

Proposed Test Rule (PRM)
52 FR 43346; November 12, 1987

Final Test Rule (FRM)
54 FR 33400; August 14, 1989
Tributyl phosphate Task Force (TBFTF) of the Synthetic Organic Chemical Manufacturers Association (SOCMA)

Modifications/Notices
51 FR 24222; July 2, 1986/Solicitation for Consent Agreement
54 FR 49844; December 1, 1989/Correction
56 FR 23228; May 21, 1991/Technical Amendment
57 FR 24958; June 12, 1992/Technical Amendment

Project Manager: Ray Locke, R. Northrop

Section Chief: Ralph Northrop

Status: Closed. All required tests have been completed. Test results have been forwarded to the Risk Assessment Division for review and disposition.

Announced Receipt of Test Data

Skin sensitization study (guinea pigs) (55 FR 13956; April 13, 1990).

The TBP Task Force submitted the following environmental effects tests: acute toxicity to Selanastrum capricornutum, Daphnia magna, Gammarid [Hyalella azteca], and rainbow trout [Oncorhynshys mykiss] (55 FR 29411; July 19, 1990).

SOCMA submitted sediment/soil adsorption isotherms, a hydrolysis rate test, and vapor pressure determinations (55 FR 50055; December 4, 1990).

SOCMA submitted an acute study of the potential neurotoxic effects of TBP and a 3-month study of the potential effects of orally administered TBP on behavior and neuromorphology (56 FR 16333; April 22, 1991).

The TBP Task Force submitted an early-life stage toxicity study in rainbow trout (57 FR 3203; January 28, 1992).

Test data on TBP were submitted by SOCMA’s TBP Task Force pursuant to a test rule and received by EPA on December 29, 1992 (58 FR 7784; February 9, 1993). The submissions describe a pharmacokinetic study in rats. Section 1 contains the distribution, metabolism, and excretion of 14C-TBP following I.V., oral and dermal administration; section II contains the blood levels following I.V., oral and dermal administration. Another study contains the adsorption, distribution and excretion of 14C-TBP in Yucatan® minipigs.

Test data concerning an oncogenicity study of TBP in the rat and in the mouse via dietary administration were submitted by SOCMA pursuant to a test rule and received by EPA on February 25, 1994 (59 FR 17101; April 11, 1994 ).

Results of Testing Table



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