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Triethylene Glycol Ethers Test Results


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CAS No.   This PRM applies to three chemicals; triethylene glycol monomethyl ether (TGME) (CAS No.112-35-6), triethylene glycol monoethyl ether (TGEE) (CAS No.112-50-5), and triethylene glycol monobutyl ether (TGBE) (CAS No. 143-22-6). In this summary, these three chemicals are referred to collectively as the "triethylene glycol ethers."

ITC Recommendation/Designation - 16th Report
50 FR 20930; May 21, 1985

Proposed Test Rule (PRM)
51 FR 17883; May 15, 1986

Consent Agreement/Triethylene Glycol Monomethyl Ether (CO)
54 FR 13470; April 3, 1989
CMA Glycol Ethers Panel

Final Test Rule/Triethylene Glycol Monomethyl Ether (FRM)
54 FR 13472; April 3, 1989

Modifications
55 FR 12639; April 5, 1990/Technical Amendment
52 FR 18738; May 19, 1987/Notice - Proposed Consent Agreement
56 FR 23228; May 21, 1991/Technical Amendment
57 FR 24958; June 12, 1992/Correction

Project Manager: Carol Glasgow

Section Chief: Ralph Northrop

Status: Closed. All required tests for the FRM and CO (required only for the monomethyl ether) have been completed. Test results have been forwarded to the Risk Assessment Division for review and disposition.

Announced Receipt of Test Data

Ames assay; CHO/HGPRT forward mutation assay; mouse bone marrow micronucleus test (55 FR 13956; April 13, 1990) and oral developmental toxicity studies in rabbits and pregnant rats (55 FR 17670; April 26, 1990). These studies were submitted pursuant to a consent order.

CMA submitted a 13-week dermal toxicity test in rats and a 90-day subchronic drinking water including a neurotoxicity study in rats required by the CO (55 FR 50055; December 4, 1990).

CMA submitted a developmental neurotoxicity evaluation of TGME pursuant to a test rule. The TGME was administered by gavage to time-mated CD rats on gestational day 6 through postnatal day 21 (57 FR 11614; April 6, 1992).

Results of Testing Table

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