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Section 8(e) Substantial Risk Notifications and FYI Submissions Received April 2010

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0410-17883A (PDF) Perfluorooctanoic acid (PFOA) Not provided   3M Environmental, Health, and Safety Operations Resullts of a PFOA study
8EHQ-0410-17884A (PDF) Vanadium Pentoxide 1314-62-1 N Vanadium Producers and Reclaimers Association Results of an acute inhalation studies in rats
Vanadium Trioxide 1314-34-7 N
8EHQ-0410-17885A (PDF) Quaternary ammonium compounds, C20-22-alkyltrimethyl, chlorides 68607-24-9 N Clariant Corporation Results of a 28-day rat oral gavage study, and oral gavage and feeding dose range-finding studies for a combined repeated dose toxicity with reproductiveldevelopmental screening test in rats
8EHQ-0410-17886A (PDF) Halogenated Pyridine derivative Not provided   Dow Chemical Company Results of a 90 day dietary study
8EHQ-0410-17887A (PDF) Ethane, 1,1,2,2-tetrafluoro1-methoxy- 425-88-7 N 3M Center Results of an acute inhalatioin study in rats
8EHQ-0410-17888A (PDF) MTDID 18132 Not provided   3M Center Results of an acute inhalation toxicity study in rats
8EHQ-0410-17889A (PDF) Substituted Benzamide Not provided   Syngenta Crop Protection, Inc Results of a repeated-dose toxicity study in mice
8EHQ-0410-17890A (PDF) Confidential Not provided   Confidential Preliminary results of a second 28-day inhalation study in rats
8EHQ-0410-17891A (PDF) Substituted Alkylnitrile Not provided   BASF Chemical Company Results of a Repeated Dose Range Finding Study in Wistar Rats
8EHQ-0410-17892A (PDF) Chlorcyanbenzole Not provided   BASF Chemical Company Results of an Acute Toxicity Study in Water Flea (Daphnia magna)
Substituted Epoxide Not provided  
8EHQ-0410-17893A (PDF) Not provided Not provided   Rhodia Inc. Results of an eye irritation study in rabbits
8EHQ-0410-17894A (PDF) Not provided Not provided   Rhodia Results of an eye irritation study in rabbits
8EHQ-0410-17895A (PDF) Not provided Not provided   Rhodia Inc. Results of an acute oral toxicity study in rats
8EHQ-0410-17896A (PDF) Not provided Not provided   Rhodia Results of an eye irritatioin study in rabbits
8EHQ-0410-17897A (PDF) Mackamide PK Lot tAQ-18 Not Provided   Rhodia Health and Safety Environment Results of an eye and skin irritation study in rabbits and an acute oral toxicity study using Mackamide PK Lot tAQ-18.

A submission to pursue an audit agreement with EPA Headquarters which was entered into pursuant to the "Interim Approach to Applying the Audit Policy to New Owners," 73 Fed. Reg. 44991 (Aug. I, 2008) ("New Owner Audit Agreement"). Rhodia received EPA's approved undated New Owner Audit Agreement on January 7,2010.
8EHQ-0410-17898A (PDF) MACXANATE LO-SPECIAL Lot #10168 Not Provided   Rhodia, Inc Results of a primary skin irritation study using macxanate Lo-Special Lot #10168.
8EHQ-0410-17899A (PDF) STEARALKONIUM CHLORIDE AT 4.0% ACTIVES Not Provided   Rhodia, Inc Results of an eye irration study in rabbits using stearalkonium chloride at 4.0% actives.
8EHQ-0410-17901A (PDF) Decyl Polygjlcoside Not Provided   Rhodia, Inc. An Eye Irritation Study Using Decyl Polygjlcoside Using Chick Embryos using decyl polygjlcoside.
8EHQ-0410-17902A (PDF) DMDM Hydanton Lot 6018 Not Provided   Rhodia, Inc. Results of eye irritation,skin irritation and acute oral toxicity studies using DMDM Hydanton Lot 6018.
8EHQ-0410-17903A (PDF) Mackam J(F) (5%) Not Provided   Rhodia, Inc. Results of a Hen's Egg Test Utilizing the Chorioallantoic membrane (HET-CAM) using Mackam J(F) (5%).
8EHQ-0410-17904A (PDF) Paragon Lot 11653 Not Provided   Rhodia, Inc. Results of an Eye Irritation, Primary Skin Irritattion, and an Acute Oral Toxicity Studies Using Paragon, lot #11653
8EHQ-0410-17905A (PDF) Mackine 301 Not Provided   Rhodia, Inc. Resutls of an Eye Irritation Study using Mackine 301.
8EHQ-0410-17906A (PDF) Organosulfide-Confidental Confidential   Rohm and Hass chemicals LLC (RH LLC) Results of a 28 day dietary study in rats.
8EHQ-0410-17907A (PDF) Confidential *2 Confidental   Confidential Results of two acute oral toxicity studies and a prelimianry developmental study with rats.
8EHQ-0410-17908A (PDF) Confidential Confidential   Rohm and Haas Chemicals LLC (RH
LLC)
Results of a 90 day dietary study in Rats.
8EHQ-0410-17909A (PDF) Confidential Confidential   Syngenta Results of  an Assay for Clastogenic Activity in Mouse Micronucleus Assay (MMNA) in Male Mice.
8EHQ-0410-17910A (PDF) BLJ 1435, KNH 1414, and EIF 3768 13680-3 5-8   Bayer Material Science LLC A preliminary comparative carcinogenicity studies with subcutaneous injection BLJ 1435, KNH 1414, and EIF 3768 into rats.
BLJ 1435, KNH 1414, and EIF 3768 Multiple CASRN  
8EHQ-0410-17911A (PDF) Multiple Chemicals Multiple   Dupont Results of an acute inhalation toxicity study in rats with a proprietary mixture containing Urea, NY-(3,4-dichloropheny1)-N,N-dimethyl(CASRN 330-54- 1) [6 1%] 1,3,5-Triazine-2,4(1 H,3H)-dione, 3-cyclohexyl-6-(dimethylamino)- 1 -methyl- (CASRN 5123 5-04-2)
8EHQ-0410-17912A (PDF) Multiple Chemicals Multiple   Dupont Results of an acute oral toxicity study in rats with a proprietary mixture containing Urea, NY-(3,4-dichloropheny1)-N,N-dimethyl(CASRN 330-54- 1) [6 1%] 1,3,5-Triazine-2,4(1 H,3H)-dione, 3-cyclohexyl-6-(dimethylamino)- 1 -methyl- (CASRN 5123 5-04-2) [17%]
8EHQ-0410-17913A (PDF) Urea, N'-(3,4-dichloropheny1)- N,N-dimethyl 330-54- 1   Dupont Results of an acute inhalation toxicity study in rats with a proprietary mixture containing Urea, N'-(3,4-dichloropheny1)-N,N-dimethyl (CASRN 330-54- 1) [80 %].
8EHQ-0410-17914A (PDF) Multiple Multiple   Dupont Results of an acute oral toxicity study in rats with a proprietary mixture containing Urea, N'-(3,4-dichloropheny1)-N,N-dimethyl(CASRN 330-54- 1) [6 1%] 1,3,5-Triazine-2,4(1 H,3H)-dione, 3-cyclohexyl-6-(dimethylamino)- 1 -methyl- (CASRN 5123 5-04-2) [17%]
8EHQ-0410-17915A (PDF) Terephthalic Acid 100-2 1-0   Dupont Results of a 1975 acute oral toxicity study in rats, which we recently became aware of through REACH SIEF activity, with Terephthalic Acid CASRN 100-2 1-0.
8EHQ-0410-17916A (PDF) N,N-Dimethylacetamide 127-19-5   Dupont Report summarizing unpublished studies and personal communications on N,N-Dimethylacetamide.
8EHQ-0410-17917A (PDF) Urea, N'-(3,4-dichlorophenyl)- N,N-dimethyl- and
1,3,5-Triazine-2,4(lH,3H)-dione, 3-cyclohexyl-6-(dimethylamino)-l-methyl-
Multiple   Dupont Results ofa skin sensitization study with a proprietary mixture containing Urea, N'-(3,4-dichlorophenyl)-N,N-dimethyl-  and 1,3,5-Triazine-2,4(lH,3H)-dione, 3-cyclohexyl-6-(dimethylamino)-l-methyl-.
8EHQ-0410-17918A (PDF) Hydrofluorocarbon Fluid Confidential   Confidential Results of a developmental toxicity study in rats and acute inhalation toxicity study in rats with hydrofluorocarbond fluid
8EHQ-0410-17919A (PDF) Para-Phenylenediamine 106-50-3   DuPont Results of several aquatic toxicity studies Para-Phenylenediamine (CASRN 106-50-3)
8EHQ-0410-17920A (PDF) Orthro-Phenylenediamine 95-54-5   DuPont Results of an Ames assay with Orthro-Phenylenediamine (CASRN 95-54-5). Also, the submission contains a mucous membrane compatibility sensitization study on o-phenylenediamine.
8EHQ-0410-17921A (PDF) Ethylthioethanol 110-77-0   Chevron Phillips Bovine Corneal Opacity and Permeability Assay (BCOP) with Ethylthioethanol (CASRN 110-77-0)
8EHQ-0410-17922A (PDF) Confidential Confidential   Confidential Results regarding a skin sensitization study in mice.
8EHQ-0410-17923A (PDF) Confidential Confidential   Confidential An OECD 440 uterotrophic assay in rodents.
8EHQ-0410-17924A (PDF) N-methylmorpholine and bis(2dimethylaminoethyl) ether 109-02-4 and 3033-62-3   Confidential Summary of health effects alleged by property occupants following potential inhalation exposure to tertiary amine catalysts. These catalysts,  are  N-methylmorpholine (CASRN 109-02-4) and bis(2dimethylaminoethyl) ether (CASRN 3033-62-3).
8EHQ-0410-17925A (PDF) Octamethylcyclotetrasiloxane (D4)
Decamethylcyclopentasiloxane (D5)
Dodecamethylcyclohexasiloxane (D6)
Octamethyltrisiloxane (L3)
556-67-2,
541-02-6,
540-97-6,
107-51-7
  Dow An on going program of sediment studies with cyclic and linear methylsiloxanes.
8EHQ-0410-17926A (PDF) tert-Butylperoxy 3,5,5 trimethylhexanoate 13122-18-4
  United Initiators,
Inc.
A 28 day toxicity study (OECD 407) with tert-Butylperoxy 3,5,5 trimethylhexanoate (CASRN 13122-18-4).
8EHQ-0410-17927A (PDF)
tert-Butylperoxy-2-ethylhexanoate 3006-82-4   United Initiators,
Inc.
Draft results for an in vitro mammalian cell gene mutation test (HPRT Assay, OECD 476) with tert-butylperoxy-2-ethylhexanoate (CASRN 3006-82-4).
8EHQ-0410-17928A (PDF) Amides, tall-oil fatty, N-[3-(dimethylamino)propyl] 68650-79-3   Bayer Material Science LLC Summaries of the laboratory studies on partition coefficient, adsorption coefficient, and biodegradation of amides, tall-oil fatty, N-[3-(dimethylamino)propyl] (CASRN 68650-79-3).
8EHQ-0410-17929A (PDF) alkyl dimethyl benzyl ammonium chloride *2 68391-01-5   3M Environmental TSCA 8(e) substantial risk notice on alkyl dimethyl benzyl ammonium chloride (CASRN 68391-01-5) which occurred on March 21, 2010.
8EHQ-0410-17931A (PDF) Mixture of Dipropylene glycol dimethyl ether 111109-77-4   Rohm and Haas Electronic materials, LLC Results of a skin sensitization study using a Mixture of Dipropylene glycol dimethyl ether (CASRN 111109-77-4) and a CBI Chemical.
FYI-0410-01626A (PDF) cyclohexyl mercaptan 1569-69-3   Chevron Phillips Results of a Local Lymph Node Assay in the Mouse using cyclohexyl mercaptan (CASRN 1569-69-3).
8EHQ-0410-17763E (PDF) Methyl 2-[[[[[4-ethoxy-6- (methylamino)-1,3,5-triazin-2-yl]amino]carbonyl]amino] sulfonyl]benzoate 97780-06-8   Dupont Results of an aquatic toxicity study with Methyl 2-[[[[[4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl]amino]carbonyl] amino]sulfonyl]benzoate (CASRN 97780-06-8).
8EHQ-0410-17847B (PDF) dipropylene glycol dimethyl ether and 2,4,6-triaryl 1,3,5-triazine alkyl ether 111109-77-4   Rohm and Haas Results of a skin sensitization study on a dipropylene glycol dimethyl ether (CASRN 111109-77-4) and 2,4,6-triaryl 1,3,5-triazine alkyl ether.

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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