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Section 8(e) Substantial Risk Notifications and FYI Submissions Received February 2010

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0210-17818A (PDF) Ethane, 1,1-difluoro-*3 75-37-6 Y DuPont Haskell Gobal Centers Results of a modeled 96-hour EC50 in green algae
8EHQ-0210-17819A (PDF) Trifluoroacetic acid 76-05-1 Y DuPont Haskell Gobal Centers Results of two 72-hour static toxicity tests in green algae
8EHQ-0210-17820A (PDF) Nitrogen containing heterocycle, substituted Not Provided   Confidential Results of a 24-hour static toxicity test in fish
8EHQ-0210-17821A (PDF) Cyclohexane, 1,4bis[(ethenyloxy)methyl] (1,4cyclohexandimethanoldivin ylether *1 17351-75-6 N BASF Corporation Results of a reproduction/developmental toxicity screening test in rats
8EHQ-0210-17822A (PDF) Tetrahydronaphthalene, substituted Not Provided   Syngenta Crop Protection, Inc. Information from a local lymph node assay in CBA C/a mice.
8EHQ-0210-17823A (PDF) 1,2-bis(triethoxysilyl)ethane *1 16068-37-4 N Dow Corning Corporation Information from an acute oral toxicity study in rats
8EHQ-0210-17826A (PDF) Aromatic epoxide Not Provided   Dow Chemical Company Results of a local lymph node assay in CBA/Ca mice
8EHQ-0210-17827A (PDF) Halogenated pyridine derivative Not Provided   Dow Chemical Company Results of a non-GLP probe reproduction study in bobwhite quail
8EHQ-0210-17829A (PDF) Nitrogen containing heterocycle, substituted *2 Not Provided   BASF Corporation Results of an acute toxicity study in the water flea (Daphnia magna) (Non-GLP indicator study)
8EHQ-0210-17830A (PDF) Alkylnitrile, substituted *2 Not Provided   BASF Corporation Results of a repeated-dose oral range finding study in rats
8EHQ-0210-17831A (PDF) Nitrogen containing heterocycle, substituted *2 Not Provided   BASF Corporation Results of an acute toxicity study in the water flea (Daphnia magna) (Non-GLP indicator study)
8EHQ-0210-17832A (PDF) Heterocyclic compound, experimental insecticide *2 Not Provided   Confidential Results of an acute oral toxicity study in rats
8EHQ-0210-17833A (PDF) Mixtures extracted from an R&D material (Samples A - J) Not Provided   Confidential Results of three bacterial reverse mutation tests (Ames tests)
8EHQ-0210-17834A (PDF) Octylmethylcyclotetrasiloxa ne (D4) *3 556-67-2 Y Dow Corning Corporation Information from a monitoring program currently in progress on cyclic volatile methylsiloxanes (cVMS) including 5 final reports from studies that have been completed, and information from 3 studies currently in progress.
Dodecamethylcyclohexasilo xane (D6) 540-97-6 Y
Decamethylcyclopentasilox ane (D5) *3 541-02-6 Y
8EHQ-0210-17835A (PDF) Sodium sulfonate surfactant *1 Not Provided   Confidential Results of a study on acute toxicity with the Rainbow Trout (Oncorhynchus mykiss)
8EHQ-0210-17836A (PDF) n-Propyl isocyanate Not Provided   Confidential Results of an acute inhalation toxicity study in the rat
8EHQ-0210-17837A (PDF) bis-(2-hydroxyethyl) coco alkyl amine 61791-31-9 Y Akzo Nobel Surface Chemistry LLC Preliminary results of an OECD 422 oral (gavage) reproduction/developmental toxicity screening test in the rat
8EHQ-0210-17838A (PDF) OS28527AB 91745-46-9 N Lubrizol Corporation Draft report of a repeateddose/reproduction/ developmental study (OECD 421) in rats
8EHQ-0210-17839A (PDF) Halogenated pyridine derivative Not Provided   Dow Chemical Company Results of a 90-day repeated-dose toxicity study in rats
8EHQ-0210-17840A (PDF) Halogenated pyridine derivative Not Provided   Dow Chemical Company Results of a 28-day dietary toxicity study in rats
8EHQ-0210-17841A (PDF) Nitrogen containing heterocycle, substituted Not Provided   Confidential Results of a 24-hour acute toxicity test in fish and daphnia.
8EHQ-0210-17842A (PDF) Nitrogen containing heterocycle, substituted Not Provided   Confidential Results of a 14-day oral toxicity study in rats
8EHQ-0210-17843A (PDF) Nitrogen containing heterocycle, substituted Not Provided   Confidential Results of a 48-hour acute toxicity test in daphnia
8EHQ-0210-17844A (PDF) Nitrogen containing heterocycle, substituted Not Provided   Confidential Results of an acute aquatic toxicity test in fish and daphnia
8EHQ-0210-17845A (PDF) Ethyltriacetoxysilane (Dow Coming@ Q3-7056) 17689-77-9 Y Dow Corning Corporation Final report of an acute oral toxicity study in rats
8EHQ-0210-17846A (PDF) Ethanol, 2-butoxy-, 1,1,1"phosphate (Amgard TBEP) *3 78-51-3 Y Rhodia Inc. Final report of a local lymph node assay in mice
8EHQ-0210-17847A (PDF) 2,4,6-Triaryl 1,3,5-triazine alkyl ether Not Provided   Confidential Results of a skin sensitization study in guinea pigs
8EHQ-0210-00373DG (PDF) Carboxylic- and sulfonate-based fluorochemicals Multiple N 3M Company A second 3M report entitled "3M Environmental Laboratory Report No. E09-0372, Fluorochemical Analysis of Fish Fillet Homogenates Collected fiom the Mississippi River by the Minnesota Pollution Control Agency May 2009 - Phase 2: Perfluorocarboxylic Acids (C4-C 12), Perfluorobutane sulfonate (PFBS), Perfluorohexane sulfonate (PFHS) and Perfluorooctanesulfonamide (FOSA).
8EHQ-0210-00373DH (PDF) Perfluorobutanesulfonate; PFBS 375-73-5 N 3M Company Final report entitled "Mechanism of the effect of different PFAS's (PFBS vs PFHS vs PFOS) on lipid and lipoprotein metabolism in APOE*3Leiden/ huCETP transgenic mice".
Perfluorohexanesulfonate; PFHS *1 355-46-4 N
Perfluorooctanesulfonate; PFOS *1 1763-23-1 N
8EHQ-0210-00373DI (PDF) Sulfonate-based and carboxylic-based fluorochemicals Multiple N 3M Environmental, Health, and Safety Operations Annual report on the evaluation of any thermal generation of PFOA from PTFE
8EHQ-0210-16436K (PDF) Perfluorinated aliphatic carboxylic acid, ammonium salt *1 Not Provided   DuPont Haskell Global Centers Preliminary results of a developmental toxicity study in rats
8EHQ-0210-16478K (PDF) Perfluorinated aliphatic carboxylic acid, ammonium salt *1 Not Provided   DuPont Haskell Global Centers Preliminary results results of a developmental toxicity study in rats
8EHQ-0210-17104D (PDF) Fluorinated hyrdocarbon Not Provided   Confidential Results of an inhalation developmental toxicity study in rats
8EHQ-0210-17279G (PDF) 2-Propenoic acid, 2-methyl, 3,3,4,4,5,5,6,6,7,7,8,8,8tridecafluorooctyl ester 2144-53-8 N DuPont Haskell Global Centers Results of an octanol/water partition coefficient assay.
8EHQ-0210-17313I (PDF) Methyl (E)-a(methoxymethylene)-2-[[[6(trifluoromethyl)-2pyridinyl]oxy]methyl]benzeneacetate *2 117428-22-5 N DuPont Haskell Global Centers Results of a 7-day acute toxicity study in duckweed and a 28-day chronic toxicity study in mysid shrimp.
8EHQ-0210-17450C (PDF) Dimethyldimethoxysilane 1112-39-6 N Silicones Environmental Health and Safety Council (SEHSC) Final study report of a combined repeated-dose oral toxicity study with a reproductive/ developmental toxicity screening test in rats
8EHQ-0210-17726B (PDF) Nitrogen containing heterocycle, substituted Not Provided   Confidential Results of a dermal sensitization study in mice (Murine Local Lymph Node Assay)
8EHQ-0210-17763B (PDF) Methyl 2-[[[[[4-ethoxy-6(methylamino)-1,3,5triazin-2yl]amino]carbonyl]amino]s ulfonyl]benzoate 97780-06-8 N DuPont Haskell Global Centers Results of a 10-day aquatic toxicity study in the macrophyte, M. spicatum
FYI-0210-01622A (PDF) Lactose blended with hydrophilic zinc oxide nanoparticles Not Provided   3M Company Draft data from a 2-week inhalation study in rats.

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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