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Section 8(e) Substantial Risk Notifications and FYI Submissions Received July 2010

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0710-18019A (PDF) Chlor-Amid D-3 Bleach 10049-04-4   Dupont Results of several pre-1977 (1955) toxicity studies, that Dupont recently became aware of with Chlor-Amid D-3 Bleach containing ~12% sodium chlorite King Heavy Duty Dry Bleach containing Chlor-Amid D-3, a Detergent and a Solid Acid Chlorine Dioxide (CASRN 10049-04-4).
8EHQ-0710-18020A (PDF) Dodecene, hydroformylation products 68526-91-0   BASF Results of a Skin Sensitization Study (LLNA) with Dodecene, hydroformylation products, high-boiling (CASRN 68526-91-0)
8EHQ-0710-18021A (PDF) Basazol Violet 60 L Not Provided   BASF Results of two studies with Basazol Violet 60 L; (1) Acute Lethal Toxicity in Daphnia magna; and (2) Acute Lethal Toxicity in Rainbow Trout.
8EHQ-0710-18022A (PDF) Substituted Nitrogen Containing Heterocycle Confidential   BASF Results of a Repeated-Dose RangeFinding Study in Wistar Rats with Substituted Nitrogen Containing Heterocycle
8EHQ-0710-18023A (PDF) Substituted Nitrogen Containing Heterocycle Confidential   BASF Results of a Repeated-Dose RangeFinding Study in Mice with Substituted Nitrogen Containing Heterocycle
8EHQ-0710-18024A (PDF) Substituted Phenylether Confidential   BASF Results of a Prenatal Developmental Toxicity Screening Study in Wistar Rats with Substituted Phenylether (Substance A, B, C, D, E)
8EHQ-0710-18026A (PDF) Halogenated Pyridine derivative Confidential   Dow Results of a 90 day dietary study, in Rats with Halogenated Pyridine derivative.
8EHQ-0710-18027A (PDF) Propane, 1,1,1,2,3,3,3heptafluoro 431-89-0   Dupont Results of a biodegradation test with Propane, 1,1,1,2,3,3,3-heptafluoro (CASRN 431-89-0).
8EHQ-0710-18028A (PDF) Multiple toxicity studies using 1,3,3,4,4,5,5 Heptafluorocyclopentene 1892-03-1   Zeon Chemicals L.P. Multiple toxicity studies using 1,3,3,4,4,5,5-Heptafluorocyclopentene (CASRN 1892-03-1).
8EHQ-0710-18029A (PDF) Aryl thiophosphate 597-82-0   BASF Results of a Combined Repeated Dose and Reproduction Screening Study in Rats with Aryl thiophosphate CASRN 597-82-0
8EHQ-0710-18030A (PDF) PFOA/PFOS Not Provided   Taft Stettinius & Hollister LLP Information concerning PFOA/PFOS.
8EHQ-0710-18031A (PDF) Halogenated pyridine derivative (CBI) CBI   Dow Results of an acute toxicity study on Rats using Halogenated pyridine derivative.
8EHQ-0710-18032A (PDF) Confidential Confidential   Shin-Etsu Silicones of America, Inc. Results of a 28-Day Repeated dose Oral Toxicity Study in Rats using a CBI Chemical
8EHQ-0710-18033A (PDF) 4,7,10, 15-Tetraoxa-14-silaecos-19-yn-18-ol,14,14-dibutyl-1,1,1,2,2,3,3,5,6,6,8- undecafluoro18- methyl-5,8bis (trifluoromethyl)- 717825-76-8   Shin-Etsu Silicones of America, Inc. Results of a 28-Day Repeated dose Oral Toxicity Study in Rats using a 4,7,10, 15-Tetraoxa-14-silaecos-19-yn18- ol,14,14-dibutyl-1,1,1,2,2,3,3,5,6,6,8-undecafluoro18-methyl-5,8-bis(trifluoromethyl)( CASRN 717825-76-8)
8EHQ-0710-18034A (PDF) 4,7,10,15-Tetraoxa-14silaecos-19-yn-18-ol,14,14dibutyl 1,1,1,2,2,3,3,5,6,6,8- undecafluoro18-methyl-5,8bis(trifluoromethyl) 717825-76-8   Shin-Etsu Silicones of America, Inc. Results of an acute inhalation toxicity study in rats using 4,7,10,15-Tetraoxa14-silaecos-19-yn-18-ol,14,14-dibutyl1,1,1,2,2,3,3,5,6,6,8-undecafluoro18methyl-5,8-bis(trifluoromethyl)(CASRN 717825-76-8).
8EHQ-0710-18035A (PDF) Cyclotetraslloxane, 2,4,6,8-tetramethyl-2-[3[2,3,3,3- tetrafluoro-2[1,1,2,3,3,3,-hexafluoro2(heptafluoropropoxy) prop oxy] propoxyJpropyl] 56819-73-5   Shin-Etsu Silicones of America, Inc. Results of a 28-Day Repeated Dose Oral Toxicity Study in Rat using Cyclotetraslloxane, 2,4,6,8-tetramethyl2-[3-[2,3,3,3-tetrafluoro-2-[1,1,2,3,3,3,hexafluoro2(heptafluoropropoxy)propoxy] propoxyJpropyl] (CASRN 756819-73-5).
8EHQ-0710-18036A (PDF) Cyclotetrasiloxane, 2,4,6,8tetramethyl-2-[3-[2,3,3,3tetrafluoro-2-[1, 1,2,3,3,3hexafluoro2 (heptafluoropropoxy) prop oxy]propyl]-,Si-[3-(2oriranylmethoxy)propyl] derives 1005771-59-4   Shin-Etsu Silicones of America, Inc. Results of a 28-Day Repeated Dose Oral Toxicity Study in Rat using Cyclotetrasiloxane, 2,4,6,8-tetramethyl2-[3-[2,3,3,3-tetrafluoro-2-[1, 1,2,3,3,3hexafluoro2(heptafluoropropoxy) propoxy]propyl],Si-[3-(2-oriranylmethoxy)propyl] derives (CASRN 1005771-59-4)
8EHQ-0710-18037A (PDF) Hydroquinone Diglycidyl Ether (HQDGE) 2425-01-6   Keller and Heckman LLP Results of a mouse lymphoma forward mutation screen using the test substance hydroquinone diglycidyl ether (HQDGE) (CASRN 2425-01-6).
8EHQ-0710-18041A (PDF) Halogenated Pyridine Derivative CBI   Dow The results of a two year dietary study in rats with halogenated pyridine derivative.
8EHQ-0710-18042A (PDF) Methyl 2-[[[[(4,6dimethoxy-2pirimidinyl)amino]carbonyl ]-amino] sulfonyl]-6(trifluoromethyl)-3pyridinecarboxylate sodium salt 144740-54-5   Dupont Results of a toxicity study to Lemna gibba (duckweed) with Methyl 2[[[[(4,6-dimethoxy-2pirimidinyl)amino]carbonyl]-amino] sulfonyl]-6-(trifluoromethyl)-3pyridinecarboxylate sodium salt (CASRN 144740-54-5).
8EHQ-0710-18043A (PDF) phenyl oxadiazole compound CBI   Monsanto Company Results of a 28-day range-finding study in mice with and experimental phenyl oxadiazole compound.
8EHQ-0710-18044A (PDF) 5,6-Dihydro-5-apo-beta-6-carotinon 3604-90-8   BASF Results of a Skin Sensitization Study (LLNA) with 5,6-Dihydro-5-apo-beta6-carotinon (CASRN 3604-90-8)
8EHQ-0710-18045A (PDF) 2,2,6,6-tetramethyl-4- piperidinamine 152261-33-1   BASF Results of a Skin Sensitization Study (LLNA) in Mice with Alkenes, C20-24 .alpha.-, polymers with maleic anhydride, reaction products with 2,2,6,6-tetramethyl-4-piperidinamine (CASRN 152261-33-1)
8EHQ-0710-18046A (PDF) Acetic acid, oxo-, sodium salt, reaction products with ethylene-diamine and phenol, iron sodium salts 84539-55-9   BASF Results of a Skin Sensitization Study (LLNA) with Acetic acid, oxo-, sodium salt, reaction products with ethylenediamine and phenol, iron sodium salts (CASRN 84539-55-9)
8EHQ-0710-18047A (PDF) Alkylnitrile *2 CBI   BASF Results of an Acute Oral Screening Study with Substituted Alkylnitrile in Wistar Rats
8EHQ-0710-18048A (PDF) Substituted Nitrogen Containing Heterocycle *2 CBI   BASF Results of a Prenatal Developmental Toxicity Screening Study in Wistar Rats with Substituted Nitrogen Containing Heterocycle (Substance A, B, C, D, E)
8EHQ-0710-18049A (PDF) Bisphenyl Derivative *2 CBI   BASF Results of In vivo Mouse Micronucleus Screening Tests with Bisphenyl Derivative (Substance A, B, C, D, E)
8EHQ-0710-18051A (PDF) Confidential Confidential   Confidential Results of a screen study on acute/chronic toxicity with the Cladoceran (Ceriodaphnia dubia) and fish (Pimephales promelas) on an internal olefin sulfonate surfactant (PMN# P-09448).
8EHQ-0710-18052A (PDF) Ethoxylated, Propoxylated 78330-23-1   Stephan Company Results of a screen study on acute/chronic toxicity with the Cladoceran (Ceriodaphnia dubia) and fish (Pimephales promelas) on an internal olefin sulfonate surfactant (PMN# P-09448).
8EHQ-0710-18054A (PDF) 1-Dodecanethiol 112-55-0 Chevron Phillips Chemical Company LP Results of an acute dermal irritation study in rabbits with 1-dodecanethiol (CASRN 112-55-0
8EHQ-0710-18055A (PDF) l-(Halosubstituted heteromonocycle-methyl)3-(halosubstituted carbomonocycle)2substituted-4-substitutedheterobicycle CBI Confidential The results of a developmental toxicity screening study in rats with l(Halosubstituted heteromonocyclemethyl)-3-(halosubstituted carbomonocycle)2- substituted-4substituted-heterobicycle.
8EHQ-0710-18056A (PDF) Glycidoxypropyl trimethoxysilane 2530-83-8 Dow Corning Genetic Evaluaton ofDow Corning® APZ-3 In Bacterial Reverse Mutation Assays (Report number: 1987-10005-1631) with Glycidoxypropyl trimethoxysilane CASRN 2530-83-8.
FYI-0710-01628A (PDF) PFOA/PFOS Not Provided   Taft Stettinius & Hollister LLP Information concerning PFOA/PFOS.
8EHQ-0710-00373DN (PDF) Sulfonate-based and Carboxylic-based Fluorochemicals Not Provided   3M Supplement update to the results of sulfonate-based and carboxylic-based fluorochemicals to mink (Mustela vison).
8EHQ-0710-15211I (PDF) Phenol, (tetrapropenyl) derivatives 74499-35-7 Y Confidential Report findings from an OEDC 440 uterotrophic assay in rodents which was conducted with test material Phenol, (tetrapropenyl) derivatives; CASRN 74499-35-7.
8EHQ-0710-16436O (PDF) perfluorinated aliphatic carboxylic acid, ammonium salt Not Provided   Dupont Results of a developmental toxicity study in rats with perfluorinated aliphatic carboxylic acid, ammonium salt in rats. This test substance is subject to a Consent Order, PMN P-08509.
8EHQ-0710-16446W (PDF) Perfluorooctanoate Anion (PFOA) Not Provided   Dupont Results for occupational serum sampling for workers at DuPont chemicals & Fluoro Products located at Fayetteville Works, Fayetteville, North Carolina site. Samples were collected in March 2010 for Perfluorooctanoate Anion (PFOA).
8EHQ-0710-16446X (PDF) Perfluorooctanoate Anion (PFOA) Not Provided   Dupont Results for occupational serum sampling for workers at DuPont chemicals & Fluoro Products located at Washington Works, Parkersburg, West Virginia site. Samples were collected in March 2010 for Perfluorooctanoate Anion (PFOA).
8EHQ-0710-16446Y (PDF) Perfluorooctanoate Anion (PFOA) Not Provided   Dupont Results for occupational serum sampling for workers at DuPont chemicals & Fluoro Products located at Chambers Works Facility, Deepwater, New Jersey site. Samples were collected in March 2010 for Perfluorooctanoate Anion (PFOA).
8EHQ-0710-16478O (PDF) perfluorinated aliphatic carboxylic acid, ammonium salt. CBI Information   DuPont Supplement to the February 5, 2010 summarizing the final results of a developmental toxicity study in rats with perfluorinated aliphatic carboxylic acid, ammonium salt.
8EHQ-0710-16663H (PDF) Perfluorooctanoate Anion (PFOA) Not Provided   Dupont Results for occupational serum sampling for workers at DuPont chemicals & Fluoro Products located at Chambers Works Facility, Deepwater, New Jersey site. Samples were collected in March - April 2010 for Perfluorooctanoate Anion (PFOA).
8EHQ-0710-17015B (PDF) mixture containing partially fluorinated condensation polymer, formulation ingredient and wate CBI   Confidential The results of an acute inhalation toxicity study with a mixture containing partially fluorinated condensation polymer, formulation ingredient and water in rats. This test mixture contains a substance that is subject to a Consent Order, PMN P-070087.
8EHQ-0710-17104E (PDF) Cis-1,1,1,4,4,4hexafluorobutene 692-49-9   Dupont Results of a subchronic inhalation study in rats with Cis-1,1,1,4,4,4hexafluorobutene (CASRN 692-49-9).
8EHQ-0710-17347C (PDF) Perfluorooctanoate Anion (PFOA) Not Provided   Dupont Results for occupational serum sampling for workers at DuPont chemicals & Fluoro Products located at CShimizu Facility, Japan site. Samples were collected in March 2010 for Perfluorooctanoate Anion (PFOA).
8EHQ-0710-17740B (PDF) Methyl 2-[[[[[4-ethoxy-6(methylamino)- 1,3,5triazin-2yl]amino]carbonyl]amino] sulfonyl]benzoate a Not Provided   Dupont This letter is to inform you of the results of a toxicity study in Lemna gibba G3 with Methyl 2-[[[[[4-ethoxy6-(methylamino)-1,3,5-triazin-2yl]amino]carbonyl]amino] sulfonyl]benzoate a R&D proprietary mixture containing 75.8 % of the above referenced substance.
8EHQ-0710-17906B (PDF) 5,10-Dioxa-3, 12-dithiatetradecanedioic acid, 4,11-dimethyl-, 1,14-bis(2ethylhexyl) ester 926010-02-8   Rohm and Haas Results of a 28 day dietary study in Sprague Dawley Rats with 5,10-Dioxa3, 12-dithiatetradecanedioic acid, 4,11-dimethyl-, 1,14-bis(2-ethylhexyl) ester (CASRN 926010-02-8)
8EHQ-0710-17908B (PDF) Results of a 90 day dietary study in Sprague Dawley Rats with 5,10-Dioxa3, 12-dithiatetradecanedioic acid, 4,11-dimethyl-, 1,14-bis(2-ethylhexyl) ester (CASRN 926010-02-8)

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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