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Section 8(e) Substantial Risk Notifications and FYI Submissions Received May 2010

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8EHQ#
CHEM NAME(S)
CAS NO.(S)
USHV
SUBMITTER
DESCRIPTION
8EHQ-0510-15945AA (PDF) 3-Bromo-l-(3-chloro-2pyridinyl)-N-[4-cyano-2methyl-6[(methylamino)carbonyl]phenyl]-1 H-pyrazole-5carboxamide Not Provided   DuPont Haskell Global Centers Results of an acute toxicity study to algae with an R&D proprietary mixture containing 3-Bromo-l-(3-chloro-2-pyridinyl)-N-[4cyano-2-methyl6[(methylamino)carbonyl]phenyl]-1 Hpyrazole-5-carboxamide
8EHQ-0510-17930A (PDF) 2-[[(4-amino-6-ethoxyI,3,5-triazin-2yl)aminocarbonyl]aminosul fonyl]-, methyl ester Not Provided   Dupont Results of an aquatic plant study with Benzoic acid, 2-[[(4-amino-6-ethoxyI,3,5-triazin-2yl)aminocarbonyl]aminosulfonyl]-, methyl ester
8EHQ-0510-17932A (PDF) Substituted Tetrahydronapthalene Confidential   Syngenta Crop Protection, Inc. Acute Inhalation Study in the Rat with [ CBI chemical], a substituted tetrahydronapthalene,.
8EHQ-0510-17933A (PDF) Confidential Confidential   Syngenta Crop Protection, Inc. Results of a 14-day preliminary dietary toxicity study in mice with [CBI chemical ], a Substituted Benzamide, First Submission.
8EHQ-0510-17934A (PDF) 1-[2(carboxymethoxy)ethyl]-1(carboxymethyl)-4,5dihydro-2-norcoco alkyl, hydroxides, sodium salts 68650-39-5   Rhodia Evaluation of the ability of alkylamidoamine glycinate (1-[2(carboxymethoxy)ethyl]-1(carboxymethyl)-4,5-dihydro-2norcoco alkyl, hydroxides, sodium salts CASRN 68650-39-5) Majority in C12 & 14 (Amphoacetate) to induce chromosome aberrations in cultured peripheral human lymphocytes.
8EHQ-0510-17935A (PDF) Substituted Nitrogen Containing Heterocycle Confidential   BASF Results of a repeated dose range finding study in Wistar Rats [Crl:WI(HAN)] with Substituted Nitrogen Containing Heterocycle The test substance is an experimental pesticide.
8EHQ-0510-17936A (PDF) Confidential Confidential   W.R. Grace & Co. Letter stating that the chemical submitted is confidential
8EHQ-0510-17937A (PDF) 1-[2(carboxymethoxy)ethyl]-1(carboxymethyl)-4,5dihydro-2-norcoco alkyl, hydroxides, sodium salts 68650-39-5   Environ UK Ltd Evaluation of the ability of alkylamidoamine glycinate (1-[2(carboxymethoxy)ethyl]-1(carboxymethyl)-4,5-dihydro-2norcoco alkyl, hydroxides, sodium salts CASRN 68650-39-5) Majority in C12 & 14 (Amphoacetate) to Induce chromosome aberrations in cultured peripheral human lymphocytes.
8EHQ-0510-17938A (PDF) 2-Amino-6-chloro-4methyl-11H-pyrido[2,1b]quinazolin-11-one Not Provided   Dupont Results of an Ames mutagenicity study with 2-Amino-6-chloro-4-methyl-11Hpyrido[2,1-b]quinazolin-11-one.
8EHQ-0510-17939A (PDF) Substituted Nitrogen Containing Heterocycle Confidential   Confidential Results of an acute fish toxicity study with substituted nitrogen containing heterocycle compound.
8EHQ-0510-17940A (PDF) 1,5-Naphthylene Diisocyanate Not Provided   Bayer Material Science Results of V79/HPRT - Test in vitro for the detectionof induced forward mutations. With 1,5-naphthylene diisocyanate
8EHQ-0510-17941A (PDF) Titanium Dioxide and Titanium Tetrachloride 13463-67-7 and 7550-450   Dupont Preliminary results from an epidemiology study titled "Occupational Exposure�and Mortality Among Workers at Three Titanium Dioxide Plants
8EHQ-0510-17942A (PDF) Vanadium Tetroxide 12036-73-6   Vanadium Producers & Reclaimers Association Preliminary results from an acute inhalation study on vanadium tetroxide (V204).
8EHQ-0510-17943A (PDF) Vanadyl Sulfate 27774-13-6   Vanadium Producers & Reclaimers Association Preliminary results from an acute inhalation study on vanadyl sulfate (VOS04)(CASRN 27774-13-6).
8EHQ-0510-17944A (PDF) 1,3,5-triazin-2-amine, 4methoxy-6-methyl 1668-54-8   Dupont Results ofa non-DuPont acute inhalation toxicity test in rats with 1,3,5-triazin-2-amine, 4-methoxy-6methyl (CASRN 1668-54-8).
8EHQ-0510-17945A (PDF) Diphenylcresylphosphate 26444-49-5   Bayer Material Science Results of an acute and repeated dose studies to evaluate the neurotoxicity potential of Diphenylcresylphophate (CASRN 26444-49-5) in chickens.
8EHQ-0510-17946A (PDF) Multiple Chemicals Not Provided   Confidential The results of an acute inhalation toxicity study in rats with a mixture containiing aromatic 200 fluid, catechol, alkylbenzenesulfonic acid, ethyleneglycol-phenethylether, shellsol A 150, diethyleneglycolphenethylether, alkylbenzene, sulfuric acid, and sulfur dioxide.
8EHQ-0510-17947A (PDF) Alkenyl Succinic Anhydride 68784-12-3   BASF Results of a skin sensitization study (Maximization Test in Guinea Pigs) with Alkenyl Succinic Anhydride (CASRN 68784-12-3).
8EHQ-0510-17948A (PDF) Alkenyl Succinic Anhydride 68784-12-3   BASF Preliminary results of a combined repeated-dose toxicity Study with the reproduction developmental toxicity screening test in Wistar Rats with Alkenyl Succinic Anhydride (CASRN 68784-12-3).
8EHQ-0510-17949A (PDF) 5-chloro-2-(2,4-dichlorophenoxy)-aniline 56966-52-0   BASF Results of a screening test on acute toxicity in Algae (Desmodesmus subspicatus) with 5-chloro-2-(2,4dichloro-phenoxy)-aniline (CASRN 56966-52-0).
8EHQ-0510-17950A (PDF) Benzoic acid, 2[(isocyanato)sulfonyl]methyl ester 74222-95-0   Dupont Results of a dermal irritation study in rabbits with Benzoic acid, 2[(isocyanato)sulfonyl]-methyl ester (CASRN 74222-95-0).
8EHQ-0510-17951A (PDF) ZMAT number 4054114 Not Provided   Dow Corning Acute toxicity to the cladoceran (Daphnia magna) under static test conditions using ZMAT number 4054114.
8EHQ-0510-17952A (PDF) Octamethyltrisiloxane 107-51-7   Silicones Environmental Health and safety Council (SEHSC) 28-Day oral (Gavage) toxicity study in the Sprague-Dawley Rat with Octamethyltrisiloxane (CASRN 107-51-7).
8EHQ-0510-17953A (PDF) Melamincyanurat 37640-57-6   BASF Results of a 7 Day feeding study in Wistar Rats [Crl:WI(HAN)] with Melamincyanurat (CASRN 37640-57-6).
8EHQ-0510-17954A (PDF) Mixture of Chlorcyanbenzole and triazole Not Provided   BASF Results of an acute toxicity study in rainbow trout (Oncorhynchus mykiss) with a Mixture Containing Two Active Ingredients: (1) Chlorcyanbenzole and (2) triazole.
8EHQ-0510-17955A (PDF) Confidential Not Provided   BASF Results of acute toxicity screening tests in fathead minnow (Pimephales promelas) with Substituted Nitrogen Containing Heterocycle (SUBSTANCE A), (SUBSTANCE B) and (SUBSTANCE C).
8EHQ-0510-17956A (PDF) Substituted Nitrogen Containing Heterocycle and�Substituted Thiophene Not Provided   BASF Results of acute toxicity screening tests in Daphnia (Daphnia magna) with Substituted Nitrogen Containing Heterocycle (Substance 1) and Substituted Thiophene (Substance 2).
8EHQ-0510-17957A (PDF) Confidential Confidential   Confidential Results of two acute oral toxicity studies with rats; a preliminary developmental toxicity study with rats; a micronucleus study with rats; an acute inhalation study with rats; a micronucleus study in rats; a 2-week oral toxicity study inrats; and an unscheduled DNA Synthesis (UDS) study in rats.
8EHQ-0510-17958A (PDF) Confidential Confidential   Confidential Results of two acute oral toxicity studies with rats; a preliminary developmental toxicity study with rats; a micronucleus study with rats; an acute inhalation study with rats; a micronucleus study in rats; a 2-week oral toxicity study inrats; and an unscheduled DNA Synthesis (UDS) study in rats.
8EHQ-0510-17959A (PDF) Hexamethylcyclotrisiloxane and Hexamethyldisiloxane 541-05-9 and 107-46-0   Dow Corning A 28-Day sub-chronic oral gavage feasibility study of various low molecular weight silicone oligomers in Rats.
8EHQ-0510-17960A (PDF) PFOA/PFOS Not Provided   Taft Stettinius & Hollister LLP Report on emerging contaminants of PFOA/PFOS in Cape cod drinking water.
8EHQ-0510-17961A (PDF) Chloromethyl bis (4fluorophenyl) methylsilane 85491-26-5   Dupont Results ofa biodegradation study, an acute algal study and a chronic Daphnia magna study with Chloromethyl bis (4-fluorophenyl) methylsilane (CASRN 85491-26-5).
FYI-0510-01627A (PDF) PFOA/PFOS Not Provided   Taft Stettinius &Hollister LLP Report on emerging contaminants in Cape cod drinking water.
8EHQ-0510-00373DM (PDF) PFOA Not Provided   3M Environmental Health Safety Operations 2009 Annual report on method development for PFOA generation testing.
8EHQ-0510-12263C (PDF) Pentane, 1,1,1,2,2,3,4,5,5,5decafluoro 138495-42-8   Dupont Results of two aquatic toxicity studies with the test substance Pentane, 1,1,1,2,2,3,4,5,5,5-decafluoro (CASRN 138495-42-8).
8EHQ-0510-15580C (PDF) 2-Amino-2-methyl-1propanol hydrochloride 3207-12-3   Dow Chemical Company Follow-up on a reproductive developmental study in rats using 2-Amino-2-methyl-1-propanol hydrochloride; CASRN 3207-12-3.
8EHQ-0510-15945AB (PDF) 3-Bromo-l-(3-chloro-2pyridinyl)-N-[4-cyano-2methyl-6[(methylamino)carbonyl ]phenyl]-IH-pyrazole- 5carboxamide 736994-63-1   Dupont Final results of a one-year dog study with 3-Bromo-l-(3-chloro-2-pyridinyl)N-[4-cyano-2-methyl-6[(methylamino)carbonyl]phenyl]-IHpyrazole- 5-carboxamide (CASRN 736994-63-1).
8EHQ-0510-16985E (PDF) 4-Pyrimidinecarboxylic acid, 6-amino-5-chloro-2cyclopropyl 858956-08-8   Dupont Results of an acute toxicity study in rats and mice with 4Pyrimidinecarboxylic acid, 6-amino-5chloro-2-cyclopropyl (CASRN 858956-08-8)
8EHQ-0510-17258B (PDF) Fluorocarbon Not Provided   Confidential Results of an acute inhalation study in rats with Fluorocarbon.
8EHQ-0510-17326B (PDF) Anionic Surfactant Not Provided   Confidential Results of an inherent biodegradation test with Anionic Surfactant.
8EHQ-0510-17356B (PDF) Dimethylsilanediol 1066-42-8   Dow Corning An acute oral gavage study in mice to determine the Maximum Tolerated Dose and Systemic Availability using Dimethylsilanediol (CASRN 1066-42-8).
8EHQ-0510-17466B (PDF) BURA, Asphalt,oxidized 64742-93-4   Asphalt Institute Summary reporting supplemental information on findings from a mouse skin carcinogenicity evaluation using (BURA) (CASRN: 64742-93-4) fume condensate sample (referred to as "TRA").
8EHQ-0510-17763F (PDF) Methyl 2-[[[[[4-ethoxy-6(methylamino)-1,3,5triazin2yl]amino]carbonyl]amino ]sulfonyl]benzoate 97780-06-8   Dupont Results of an aquatic toxicity study with an R&D proprietary mixture containing Methyl 2-[[[[[4-ethoxy-6(methylamino)-1,3,5-triazin2yl]amino]carbonyl]amino ]sulfonyl]benzoate (CASRN 97780-06-8).
8EHQ-0510-17781B (PDF) 1,6bis(trimethoxysilyl)hexane 87135-01-1   Dow Corning Results of a combined repeated dose toxicity study and a reproductive developmental toxicity Screening Test using 1,6-bis(trimethoxysilyl)hexane (CASRN 87135-01-1) in Sprague-Dawley Rats Via Oral Gavage.
8EHQ-0510-17782B (PDF) Methyltrimethoxysilane 1185-55-3   Dow Corning Results of a contact hypersensitivity study in Albino guinea Pigs, Buehler Test using methyltrimethoxysilane (CASRN 1185-55-3).
8EHQ-0510-17848B (PDF) Fluorocarbon Not Provided   Confidential Results of an acute inhalation study in rats with fluorocarbon.
8EHQ-0510-17848C (PDF) Methyl 2-[[[[[4-ethoxy-6(methylamino)-1,3,5triazin2yl]amino]carbonyl]amino ]sulfonyl]benzoate 97780-06-8   Dupont Results of two aquatic toxicity studies with Methyl 2-[[[[[4-ethoxy-6(methylamino)-1,3,5-triazin2yl]amino]carbonyl]amino ]sulfonyl]benzoate (CASRN 97780-06-8).

(A) PMN; (B) Pesticide; (C) Pesticide Inert

DEFINITION OF TERMS

8EHQ# - This is the EPA submission number that includes a 4-digit month and year followed by a 5-digit number assigned sequentially from the year 1977, followed by a sequence letter ( “A” for the initial submission and “B”, “C”, “D”, etc. for supplemental submissions) (8EHQ-MMYY-XXXXX A).
Supplemental means that it is a follow-up to an earlier submitted report. Supplemental submissions reflect the month and year logged in but retain the same 5-digit sequential number as a link to the initial submission. 8EHQ number is a useful reference to request a copy of a submission.FYI (For Your Information) submissions are the voluntary adjuncts of 8(e)s. The FYI# is similar to that for 8(e) described above (FYI-MMYY-XXXXX A). The submitter either judges that the information is not reportable under TSCA 8(e) reporting requirements or is not subject to TSCA 8(e) reporting but wants to share the information with EPA (and the public) on a voluntary basis.

NOTE that OPPT routinely sends follow-up requests to 8(e) submitters. Other EPA programs and other federal agencies can ask OPPT to request follow-up information as well.

CHEM Name - This is the name used by the submitter.

CAS No. - The Chemical Abstracts Service Number. Use of the term "CBI" indicates that the submitter is claiming the identity of the chemical to be confidential business information. This claim can be challenged in some cases, and users should notify EPA if they wish to pursue the chemical identity.

USHV - High production volume chemical in the U.S., including domestic manufacture and importation. EPA defines high production volume as annual production one million pounds or more pounds.

Description - A general description of the type of study or information submitted, but not study results. A PDF electronic copy of the submission is attached.


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