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OPPTS Harmonized Test Guidelines
Series 870 Health Effects Test Guidelines -- Final Guidelines
The harmonized test guidelines have been developed for use in the testing of pesticides and toxic substances, and the development of test data that must be submitted to the Agency for review under Federal regulations.
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870.1000 Acute toxicity testing--background (PDF) (9pp, 23KB)
870.1100 Acute oral toxicity (PDF) (10pp, 27KB)
870.1200 Acute dermal toxicity (PDF) (10pp, 24KB)
870.1300 Acute inhalation toxicity (PDF) (11pp, 21KB)
870.2400 Acute eye irritation (PDF) (8pp, 22KB)
870.2500 Acute dermal irritation (PDF) (8pp, 23KB)
870.2600 Skin sensitization (PDF) (9pp, 29KB)
870.3050 Repeated dose 28-day oral toxicity study in rodents (PDF) (17pp, 29KB)
870.3100 90-Day oral toxicity in rodents (PDF) (13pp, 33KB)
870.3150 90-Day oral toxicity in nonrodents (PDF) (12pp, 30KB, PDF)
870.3200 21/28-Day dermal toxicity (PDF) (15pp, 36KB)
870.3250 90-Day dermal toxicity (PDF) (14pp, 34KB)
870.3465 90-Day inhalation toxicity (PDF) (17pp, 40KB)
870.3550 Reproduction/developmental toxicity screening test (PDF) (13pp, 89KB)
870.3650 Combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (PDF) (17pp, 89KB)
870.3700 Prenatal developmental toxicity study (PDF) (11pp, 126KB)
870.3800 Reproduction and fertility effects (PDF) (14pp, 35KB)
870.4100 Chronic toxicity (PDF) (18pp, 44KB)
870.4200 Carcinogenicity (PDF) (17pp, 41KB)
870.4300 Combined chronic toxicity/carcinogenicity (PDF) (20pp, 49KB)
870.5100 Bacterial reverse mutation test (PDF) (13pp, 36KB)
870.5140 Gene mutation in Aspergillus nidulans (PDF) (7pp, 18KB)
870.5195 Mouse biochemical specific locus test (PDF) (7pp, 19KB)
870.5200 Mouse visible specific locus test (PDF) (6pp, 16KB)
870.5250 Gene mutation in Neurospora crassa (PDF) (6pp, 17KB)
870.5275 Sex-linked recessive lethal test in Drosophila melanogaster (PDF) (6pp, 16KB)
870.5300 In vitro mammalian cell gene mutation test (PDF) (14pp, 37KB)
870.5375 In vitro mammalian chromosome aberration test (PDF) (13pp, 33KB)
870.5380 Mammalian spermatogonial chromosomal aberration test (PDF) (11pp, 28KB)
870.5385 Mammalian bone marrow chromosomal aberraton test (PDF) (11pp, 28KB)
870.5395 Mammalian erythrocyte micronucleus test (PDF) (12pp, 32 KB)
870.5450 Rodent dominant lethal assay (PDF) (6pp, 16KB)
870.5460 Rodent heritable translocation assays (PDF) (7pp, 18KB)
870.5500 Bacterial DNA damage or repair tests (PDF) (7pp, 19KB)
870.5550 Unscheduled DNA synthesis in mammalian cells in culture (PDF) (7pp, 19KB)
870.5575 Mitotic gene conversion in Saccharomyces cerevisiae (PDF) (6pp, 17KB)
870.5900 In vitro sister chromatid exchange assay (PDF) (7pp, 19KB)
870.5915 In vivo sister chromatid exchange assay (PDF) (6pp, 16KB)
870.6100 Acute and 28-day delayed neurotoxicity of organophosphorus substances (PDF) (10pp, 28KB)
870.6200 Neurotoxicity screening battery (PDF) (13pp, 33KB)
870.6300 Developmental neurotoxicity study (PDF) (14pp, 36KB)
870.6500 Schedule-controlled operant behavior (PDF) (8pp, 21KB)
870.6850 Peripheral nerve function (PDF) (9pp, 23KB)
870.6855 Neurophysiology Sensory evoked potentials (PDF) (14pp, 36KB)
870.7200 Companion animal safety (PDF) (10pp, 24KB)
870.7485 Metabolism and pharmacokinetics (PDF) (14pp, 36KB)
870.7600 Dermal penetration (PDF) (14pp, 38KB)
870.7800 Immunotoxicity (PDF) (13pp, 35KB)
870.8355 Combined Chronic Toxicity/Carcinogenicity Testing of Respirable Fibrous Particles (PDF) (17pp, 183KB)
