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September 16 - 19, 2008: The Agency's Evaluation of the Toxicity Profile of Chlorpyrifos

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Federal Register Notice

Federal Register Notice extending this meeting by one-half day.

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Directions and Other Logistics Information

General directions and other logistical information is available.

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Agenda

Agenda (PDF) (5 pp, 24K)

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Panel Members

Panel Members

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Meeting Materials

Charge to the Panel (PDF) (12 pp, 71K)

Chlorpyrifos Hazard Dose and Response Characterization (Issue Paper) (PDF) (81 pp, 400K)

Revised Table 2 in Section 2.4 of Issue Paper (PDF) (2 pp, 32K)

DDEF Calculations (Excel Spreadsheet)

Appendix A - Metabolism (PDF) (82 pp, 1.5M)

Appendix B - Mode of Action: Inhibition of Acetylcholinesterase (AChE) (PDF) (60 pp, 283K)

Appendix C - Effects on the Developing Brain (PDF) (35 pp, 429K)

Appendix D - Human Epidemiology: Effects in Children (PDF) (97 pp, 590K)

Appendix E - Data Derived Extrapolation Factor Analysis (PDF) (41 pp, 450K)

Appendix F

Appendix G

Supplemental Documents

NOTE: All documents for this meeting (including additional background documents and public comments) will be available in the OPP Regulatory Public Docket (Docket # EPA-HQ-OPP-2008-0274). Some of these documents may be available online in the FDMS Docket System located at http://www.regulations.gov. Copyright protected material and material otherwise subject to protection is not placed on the Internet and will be publicly available only at the OPP Regulatory Public Docket in Rm. S-4400, One Potomac Yard (South Bldg), 2777 S. Crystal Dr., Arlington, VA. The hours of operation of this Docket Facility are from 8:30 a.m. to 4:00 p.m., Monday through Friday, excluding legal holidays. The Docket Facility telephone number is (703) 305-5805.

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Meeting Minutes

Meeting Minutes PDF (80 pp, 5 MB)

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