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Waste and Cleanup Risk Assessment

2008 Notice of Public Meeting

Science Advisory Board Meeting to Review the Proposed Approach for Estimation of Bin-Specific Cancer Potency Factors for Inhalation Exposure to Asbestos

AGENCY: Environmental Protection Agency (EPA).

ACTION: Notice of Public Meeting

SUMMARY: This notice announces a public meeting of the EPA Science Advisory Board (SAB) Asbestos Committee to provide consultative advice for the Office of Solid Waste and Emergency Response (OSWER) on A Proposed Approach for Estimation of Bin-Specific Cancer Potency Factors for Inhalation Exposure to Asbestos. The purpose of the meeting is to obtain consultative advice on the proposed approach during the model development phase of this project. The proposed approach for selecting and parameterizing a multi-bin model will provide an incremental improvement to the current method that EPA employs for estimating cancer risk from inhalation exposure to asbestos at Superfund sites. This effort is intended to serve as an intermediate step in a larger Agency-wide review and update of its asbestos risk assessment. OSWER has requested that the SAB provide consultative advice on its proposed approach for the estimation of bin-specific cancer potency factors for inhalation exposure to asbestos. After seeking advice from EPA’s Science Advisory Board (SAB) on the proposed approach, OSWER is planning to use their input to finalize an approach and then ask SAB to review the revised approach.

At present, EPA uses an approach developed in 1986 for quantifying cancer risk from asbestos exposure based on phase contrast microscopy as the measure of asbestos exposure. The 1986 method used existing epidemiological data from cohorts of workers exposed to asbestos in a variety of mining and manufacturing settings to select quantitative risk models and estimate potency factors for lung cancer and mesothelioma. OSWER is proposing an interim approach to account for the potential differences of cancer potency between different mineral types and particle size distributions at different human exposure conditions. The document submitted to the SAB describes a "multi-bin" mathematical approach to estimate cancer risk according to mineral groups (amphibole or chrysotile) and particle size (length and width) based on transmission electron microscopy.

DATES: The meeting dates are Monday, July 21, 2008 from 9:00 a.m. to 5:30 p.m. through Tuesday, July 22, 2008 from 8:30 a.m. to 5:00 p.m. (Eastern Time).

ADDRESS: The meeting will be held in the Embassy Suites Hotel, located at: 1259 22nd Street, Washington, DC.

FOR FURTHER INFORMATION CONTACT:

The agenda and related materials for the upcoming meeting will be posted on the SAB web site.

Members of the public who wish to obtain further information about this meeting can contact Ms. Vivian Turner, Designated Federal Officer (DFO). Ms. Turner may be contacted at the EPA Science Advisory Board (1400F), U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue, N.W., Washington, D.C. 20460; or via telephone/voice mail; (202) 343-9697; fax (202) 233-0643; or e-mail at: turner.vivian@epa.gov.

The EPA technical contact for this proposed approach is Mr. Stiven Foster, of EPA’s Office of Solid Waste and Emergency Response. Mr. Foster may be contacted by telephone at: (202) 566-1911 or via e-mail at: foster.stiven@epa.gov.

SUPPLEMENTARY INFORMATION: Interested members of the public may submit relevant written or oral information for the SAB Committee to consider on the topics under review, usually 30 days in advance of the meeting. Contact Ms. Turner, DFO, in writing, preferably via e-mail, for the deadlines for this meeting. Oral Statements: In general, individuals or groups requesting an oral presentation at a public meeting will be limited to five minutes per speaker, with no more than a total of one hour for all speakers. Interested parties should contact Ms. Turner, DFO, in writing, preferably via e-mail, at the contact information noted above, to be placed on a list of public speakers for the meeting. Written Statements: Written statements should be received in the SAB Staff Office so that the information may be made available to the SAB Panel members for their consideration. Written statements should be supplied to the DFO in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file formats: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format).

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