Waste and Cleanup Risk Assessment
Risk Assessment Guidance for Superfund (RAGS), Volume I: Human Health Evaluation Manual (Part F, Supplemental Guidance for Inhalation Risk Assessment)
Risk Assessment Guidance for Superfund
Background |
Development and Availability | Implementation
and Use of the Guidance
Future Developments | Additional
Information
Background
The U.S. Environmental Protection Agency (EPA) developed Risk Assessment Guidance for Superfund: Volume I Human Health Evaluation Manual (Part F, Supplemental Guidance for Inhalation Risk Assessment) ("Part F") to address human health risk related to inhalation exposures. Parts A, B, C, D and E of RAGS address other aspects of a human health risk assessment on a Superfund site. RAGS Part F provides a methodology to use the type of human health toxicity values which are currently derived by the EPA Integrated Risk Information System (IRIS) as concentrations (Reference Concentrations for non-cancer effects and Inhalation Unit Risk values for cancer endpoints) rather than the earlier and now superseded intake-based approach used by the inhalation component of RAGS Part A. It should be noted that other inhalation toxicity values derived by other parties can also be used with RAGS Part F (provided that the toxicity values are presented as concentrations in air).
Development and Availability
- EPA held a workshop in 2003 addressing inhalation risk assessment in the EPA Superfund Program. That workshop formed the general consensus and the workgroup which developed RAGS Part F.
- In 2007, internal EPA comments on RAGS Part F were received and addressed by the RAGS Part F workgroup.
- In the Spring of 2008, an external peer review of RAGS Part F was conducted. Concurrent with that review, State risk assessors and some other non-EPA risk assessors also reviewed and commented on RAGS F. Both sets of those comments were reviewed by the RAGS Part F workgroup, and certain changes were made to RAGS Part F in consideration of those comments.
- Early in 2009, after a draft of RAGS Part F had been distributed to EPA Regional Offices, RAGS Part F and an Implementation Memorandum were posted on the EPA Offie of Solid Waste and Emergency Response risk assessment website.
RAGS Part F Guidance Documents
You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.
The link above is a large pdf for the entire guidance document.
The below links are for viewing/downloading one section at a time.
Sections
- Title page and Preface (PDF) (1 pg, 75K)
- Table of Contents (PDF) (4 pp, 170K)
- Acknowledgements (PDF) (1 pg, 78K)
- Acronyms / Abbreviations (PDF) (2 pp, 81K)
- Chapter 1: Introduction (PDF) (3 pp, 101K)
- Chapter 2: Background on Derivation of Inhalation Toxicity Values (PDF) (9 pp, 216K)
- Chapter 3: Characterizing Exposure (PDF) (7 pp, 146K)
- Chapter 4: Selecting Appropriate Toxicity Values (PDF) (3 pp, 107K)
- Chapter 5: Estimating Risk (PDF) (3 pp, 107K)
- Chapter 6: Example Exposure Scenarios (PDF) (3 pp, 105K)
- Chapter 7: Target Concentrations for Screening Analysis of Inhalation Pathways (PDF) (3 pp, 110K)
- Chapter 8: Developing Aggregate and Cumulative Risk Estimates (PDF) (3 pp, 100K)
- Chapter 9: Risk Characterization (PDF) (4 pp, 107K)
- References (PDF) (3 pp, 93K)
- Appendices Table of Contents (PDF) (3 pp, 37K)
- Appendix A: Analysis of Default Approach for HEC Derivation as Compared to Population and Lifestage-Specific Calculations (PDF) (15 pp, 296K)
- Appendix B: Chemicals on IRIS with Extrapolated Inhalation Unit Risks (PDF) (3 pp, 99K)
- Appendix C: The Superfund Health Risk Technical Support Center's Process for Deriving Alternative Inhalation Toxicity Values (PDF) (3 pp, 83K)
Disclaimer: These electronic files contain the text of a policy issued by the U.S. Environmental Protection Agency (EPA). These files have been reformatted to make them available to you in electronic form. Formatting (margins, page numbering, etc.) may be different than the original hard copy to make the document more easily readable on your computer screen. These electronic files are a courtesy copy of the official policy. If any discrepancies are found, the file copy (hard copy original) which resides at the U.S. EPA provides the official policy.
Implementation and Use of the Guidance
In the development of RAGS Part F, the workgroup also developed and released this implementation memorandum which provides additional information about the intended use of this guidance on Superfund sites.
"Supplemental Guidance for Inhalation Risk Assessment," Part F of Volume I of Risk Assessment Guidance for Superfund, Human Health Evaluation Manual (Volume I) (PDF#2) (3 pp, 487K, About PDF)
Questions regarding the use or application of RAGS Part F can be directed to EPA toxicologists or risk assessors in EPA's Regional Offices, or to the below members of the workgroup that developed this guidance. Users of the RAGS Part F guidance from outside of EPA are asked to coordinate the use of Part F on Superfund sites with the EPA Regional Office in which that site is located.
| Name and Location | Telephone Number | Email Address |
|---|---|---|
| Chau Vu (Region 1) | 617-918-1446 | Vu.Chau@epa.gov |
| Michael Sivak (Region 2, workgroup leader) | 212-637-4310 | Sivak.Michael@epa.gov |
| Jennifer Hubbard (Region 3) | 214-814-3328 | Hubbard.Jennifer@epa.gov |
| Ofia Hodoh and Kevin Koporec (Region 4) |
404-562-0176 and 404-562-8644 |
Hodah.Ofia@epa.govand Koporec.Kevin@epa.gov |
| no current contact (Region 5) | ||
| no current contact (Region 6) | ||
| Jeremy Johnson (Region 7) | 913-551-7510 | Johnson.Jeremy@epa.gov |
| Bob Benson and Susan Griffin (Region 8) |
303-312-7070 and 303-312-6651 |
Benson.Bob@epa.gov and Griffin.Susan@epa.gov |
| Dan Stralka (Region 9) | 415-972-3048 | Stralka.Daniel@epa.gov |
| Marcia Bailey (Region 10) | 206-553-0684 | Bailey.Marcia@epa.gov |
| Michele Burgess, OSWER/OSRTI | (202) 564-8006 | Burgess.Michele@epa.gov |
Future Developments
This website will be used to provide guidance on implementation issues associated with inhalation risk and the use of RAGS Part F guidance. Thus, users of the RAGS Part F guidance should recognize that some of the values presented in the original version of RAGS Part F may be superseded by or replaced with newer values on this website.
Other EPA progams and other agencies and departments may also have developed information relevant to inhalation risk. Periodically, additional links to such information may be provided on this webpage.
Additional Information
Users of RAGS Part F may find additional information relevant to inhalation risk on the following EPA Office of Air Quality Planning and Standards (OAQPS) Air Toxics and Modeling webpage, including the Air Toxics Risk Assessment Reference Library link.