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This online handbook contains information and resources for use in applying EPA's Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens (Supplemental Guidance) to cancer risk assessments at waste and cleanup sites.

This handbook does not establish any new practices or policies, but rather provides examples and other tools to assist risk assessors.  Although the Handbook is designed to assist risk assessors and other environmental professionals, interested citizens and risk managers may also use it to understand how the Supplemental Guidance may affect cancer risk calculations and resulting cleanup levels at a site.

The 2005 Guidelines for Carcinogen Risk Assessment (Cancer Guidelines) and the Supplemental Guidance are the results of an EPA-wide effort to update key scientific risk assessment methodologies.  For more information on these documents, visit EPA's Cancer Guidelines and Supplemental Guidance Web sites.  The Science Policy Council (SPC) Cancer Guidelines Implementation Workgroup has provided information to facilitate the development of new carcinogenicity risk assessments and to promote consistency with EPA policy, guidance, and guidelines.  For more information on the SPC Workgroup and their guidance for implementing the Cancer Guidelines, visit the SPC’s Cancer Guidelines and Supplemental Guidance Implementation Web site.

Browse the links below for more specific information on applying the Supplemental Guidance to cancer risk assessments:

Basic Information – Overview of the Cancer Guidelines and Supplemental Guidance for the general public and risk assessors. Cancer Risk Calculations – Description of how to quantify cancer risks for chemicals that operate with a mutagenic MOA for carcinogenesis and example risk calculations.
Frequent Questions and EPA Response Documents – Answers to some of the frequently asked questions on the Supplemental Guidance and the Cancer Guidelines. Preliminary Remediation Goals (PRGs) – Description of how to derive PRGs for chemicals that operate with a mutagenic MOA for carcinogenesis and example PRG calculations.
Chemical-Specific Information – Summary of chemicals determined to operate with a mutagenic mode of action (MOA) for carcinogenesis and the recommended potency adjustment factors. Risk Assessment Guidance for Superfund, Part D (RAGS D) – Example of how cancer risks for chemicals that operate with a mutagenic MOA for carcinogenesis could be summarized in standardized RAGS D table format.
Exposure Assessment – Summary of exposure parameter values for use in calculating cancer risks and Preliminary Remediation Goals (PRGs). Resources – Links to relevant guidance documents, EPA communications, and risk assessment references.

Waste and Cleanup Risk Assessment | Superfund Risk Assessment | Superfund Human Health: Toxicity | Risk Assessment Topics

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