The links found on this page will lead to information on the Cancer Guidelines and Supplemental Guidance (Web sites, guidance documents, EPA communications, and fact sheets) and to risk assessment resources (exposure factors and chemical-specific guidance).
You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.
EPA Cancer Guidelines
The Guidelines provide a framework to EPA scientists for assessing possible cancer risks from exposures to pollutants or other agents in the environment. They will also inform EPA decision makers and the public about these recommended procedures.
Science Policy Council Cancer Guidelines and Supplemental Guidance Implementation
Office of the Science Advisor (OSA) Cancer Guidelines and Supplemental Guidance Implementation site.
Guidelines for Carcinogen Risk Assessment (PDF) (166 pp, 468K) (EPA/630/P-03/001F, March 2005)
Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens (PDF) (126 pp, 1.78MB) (EPA/630/R-03/003F, March 2005)
EPA Communications on Implementing the Cancer Guidelines and Supplemental Guidance
Memorandum: Application of New Cancer Guidelines (PDF) (2 pp, 122K) (Memorandum from S. L. Johnson, March 2005)
Assigns the New Cancer Guidelines and Supplemental Guidance as EPA's recommended approach to EPA risk assessors preparing cancer risk assessments.
Memorandum: Science Policy Council (SPC) Cancer Guidelines Implementation Workgroup Communication I: Application of the mode of action framework in mutagenicity determinations for carcinogenicity (PDF) (8 pp, 651K) (Memorandum from W. H. Farland, October 4, 2005)
Provides summary information for applying the Cancer Guidelines' mode of action (MOA) framework in determining whether a chemical has a mutagenic mode of action.
Memorandum: Science Policy Council (SPC) Cancer Guidelines Implementation Workgroup Communication II: Performing Risk Assessments that include Carcinogens Described in the Supplemental Guidance as having a Mutagenic Mode of Action (PDF) (4 pp, 235K) (Memorandum from W. H. Farland, June 14, 2006)
Addresses how to apply the Supplemental Guidance to carcinogens that are described in the Supplemental Guidance as having a mutagenic mode of action (MOA).
Memorandum: Science Policy Council Cancer Guidelines Implementation Workgroup: Process for Internal Communication of Mutagenic Mode of Action Determinations for Carcinogens (PDF) (2 pp, 145K) (Memorandum from W. H. Farland, June 14, 2006)
Recommends a process for communication and coordination among EPA program offices and regions through the Science Policy Council steering committee.
Fact Sheet: EPA Issues Updated Cancer Guidelines and Supplemental Guidance on Risks from Early-Life Exposure (EPA/630/P-03-001F, March 29, 2005)
These revised and updated Guidelines provide a framework to EPA scientists for assessing possible cancer risks from exposures to environmental pollutants.
Fact Sheet: EPA's Guidelines for Carcinogen Risk Assessment (March 29, 2005)
Replacing the 1986 cancer risk assessment guidelines, the Guidelines for Carcinogen Risk Assessment make greater use of the increased scientific understanding of the biological mechanisms that can cause cancer, as well as improved risk assessment practices.
Fact Sheet: Implementation of the Supplemental Guidance in Cancer Risk Assessment (PDF) (5 pp, 159K) (June 2006)
This Fact Sheet was created as a tool for risk assessors and provides information that may be useful for communication with the public.
Guidance on Selecting Age Groups for Monitoring and Assessing Childhood Exposures to Environmental Contaminants (EPA/630/P-03/003F, November 2005)
This document is intended to provide guidance to EPA scientists on selecting age groups to consider when assessing childhood exposure and potential dose to environmental contaminants.
The EPA National Center for Environmental Assessment's 2008 Child-Specific Exposure Factors Handbook (EPA-600-R-06-096F, September 2008)
Provides a summary of the available and up-to-date statistical data on various factors assessing children exposures.
Estimated Per Capita Water Ingestion and Body Weight in the United States – An Update. (EPA-822-R-00-001, October 2004)
Provides current estimates of water ingestion and body weight for the population of the U.S. and selected subpopulations including pregnant women, lactating women and women of child-bearing age.
Note: See Table 5.1.A1 (Estimated Direct and Indirect Community Water Ingestion by Gender and Fine Age Categories – All Individuals) for updated water ingestion rates.
Exposure Factors Handbook (EPA/600/P-95/002F (a)-(c), August 1997)
A summary of the available statistical data on various factors used in assessing human exposure.
RAGS I Part E: Supplemental Guidance for Dermal Risk Assessment, Final (OSWER 9285.7-02EP, July 2004)
Provides a consistent methodology for assessing dermal exposures for Superfund human health risk assessments.
Note: See Exhibit C-1 for body part-specific surface area data and Exhibits C-2 and 3-3 for soil adherence factor data.
Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons (PAHs) (EPA/600/R-93/089, July 1993)
Presents some comparative risk estimates for assessment of potentially carcinogenic PAHs
Toxicological Review of Vinyl Chloride In Support of Summary Information on the Integrated Risk Information System (IRIS) (PDF) (197 pp, 4.5MB) (EPA/635R-00/004, May 2000)
Provides background and justification for the vinyl chloride hazard and dose-response assessment summaries in EPA's Integrated Risk Information Sysytem (IRIS).
Note: See Section 18.104.22.168 – Basis for Recommending Adjustment in Cancer Risk Estimates to Account for Early-Life Sensitivity.
Derivation of Vinyl Chloride Risk-Based Concentrations (RBCs) (PDF) (4 pp, 15K) (Memorandum from J. Hubbard, May 2001)
A demonstration of the assumptions behind the Region III RBCs for vinyl chloride.
National Emission Standards for Coke Oven Batteries (70 FR 19992, April 15, 2005)
Describes EPA's determination that coke oven emissions have a mutagenic mode of action for carcinogenicity.