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Organophosphate Pesticides: Preliminary OP Cumulative Risk Assessment

Information provided for informational purposes only

Note: This information is provided for reference purposes only. Although the information provided here was accurate and current when first created, it is now outdated.

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December 3, 2001: EPA released today its preliminary assessment of the cumulative risks of organophosphorus pesticides. EPA considers the results to be preliminary and is seeking both scientific peer review and widespread public comment on its analysis and the many new scientific techniques used to develop the risk assessment. EPA will soon open a comment period in which the public and all interested parties are invited to submit comments on the preliminary assessments. Comments should directly relate to the issues and information in the assessment.

The Agency is examining the results of these analyses. Therefore, it is too soon to draw firm conclusions about risks or consider risk management possibilities. The Agency cautions against premature conclusions based on this preliminary assessment, and against any use of information contained in these documents out of their full context. The risk mitigation measures that have already been taken on individual members of this group of pesticides have led to significant reduction in potential risk. The Agency is reviewing the results of the assessment to determine if any issues may need to be addressed related to food commodities, drinking water and residential uses. However, EPA has confidence in the overall safety of our food supply and emphasized the importance of eating a varied diet rich in fruits and vegetables.

These files are in Portable Document Format (PDF) and require the Acrobat Reader. The PDF documents may not be fully accessible using assistive technology. For this type of accessibility problem, please contact either Bill Wooge (wooge.william@epa.gov) at (703) 308-8794 or Kathleen Martin (martin.kathleen@epa.gov) at (703) 308-2857. For other issues concerning the PDF files, please contact OPP's Web support staff.

Due to some difficulties with the software used to generate these electronic files, the page numbering in individual sections may not exactly match the table of contents. The content of the document is accurate. For additional information on the Preliminary Organophosphate Risk Assessment, please call (703) 308-8000 .

Relative Potency Factors (4/17/2002)

Health Effects Input files

Zip file of this page and documents (77 MB) - compressed archive. May be expanded with Winzip Exit EPA disclaimer.

Table of Contents (536 KB)

Glossary / Acronyms (119 KB)

Technical Executive Summary (98 KB)

I. Preliminary OP Cumulative Risk Assessment

A. Introduction (64 KB)

B. Hazard / Relative Potency Factor (RPF) (1,000 KB)

C. Food (147 KB)

D. Residential (99 KB)

E. Water (4,240 KB)

F. Cumulative Assessment (776 KB)

G. Risk Characterization (166 KB)

H. Future Work (60 KB)

I. References (107 KB)

II. Regional Assessments

A. Region1 -- Heartland (5.79 MB)

B. Region 2-- Northern Crescent (2.44 MB)

C. Region 3 -- Northern Great Plains (4.45 MB)

D. Region 4 -- Prairie Gateway (5.42 MB)

E. Region 5 -- Eastern Uplands (3.75 MB)

F. Region 6 -- Southern Seaboard (3.67 MB)

G. Region 7a -- North Fruitful Rim, California (2.21 MB)

H. Region 7b -- South Fruitful Rim, California (2.02 MB)

I. Region 8 -- Basin and Range (2.79 MB)

J. Region 9 -- Mississippi portal (3.04 MB)

K. Region 10 -- North West Fruitful Rim (2.09 MB)

L. Region 11 -- Texas Fruitful Rim (1.68 MB)

M. Region 12 -- Florida Fruitful Rim (923 KB)

III. Appendices

A. Introduction (10 KB)

B. Hazard / Relative Potency Factor (RPF)

1. Technical Aspects of Dose-Response Analysis (2,100 KB)

2. Dose-Response Curves (4,660 KB)

3. Response to SAP Comments from September 2001 Report (79 KB)

4. R Programs for the Revised Analysis (105 KB)

C. Food

1. The Sources of Residue Inputs for the Assessment of the Cumulative Dietary Exposure to Organophosphorus Pesticides on Foods (65 KB)

2. Summary of PDP Residue Analyses of Organophosphorus Pesticides on Foods (277 KB)

3. A Summary of FDA Total Diet Study Analyses for Organophosphorus Pesticides on Meats (44 KB)

4. Permissible Crop Translations for Pesticide Monitoring Data (12 KB)

5. Processing Factors Used in Estimating Residues of OP Pesticides in Food Commodities (592 KB)

6. Translation of PDP Foods to Food Forms in DEEM7 and DEEM-FCID (139 KB)

7. DEEM-FCID Inputs for Cumulative OP Exposure Assessment (84 KB)

8. Summary of Cumulative Residue Distributions Estimated by RPF Method (110 KB)

9. Cross-walk Table for Comparison of DEEM 7 (RS7) Foods to DEEM-FCID (R98) Foods (251 KB)

10. Co-occurrence of Organophosphorus Pesticides on PDP Samples, 1994-1999 (19 KB)

D. Residential (9 KB)

E. Water

1. Water Exposure Assessment: Summary of Organophosphorous (OP) Occurrence in Ambient Waters from the USGS NAWQA Program (202 KB)

2. Summary of State Monitoring Programs (59 KB)

3. Water Exposure Assessment: Preliminary Analysis of the USGS-EPA Pilot Reservoir Monitoring Program (196 KB)

4. Water Exposure Assessment: Effects of Drinking Water Treatment on Organophosphate Pesticides (37 KB)

5. Chemical-Specific Inputs Used in the Drinking Water Exposure Assessment (90 KB)

6.Water Exposure Assessment: Application-Specific Input Parameters for PRZM/EXAMS by Region (80 KB)

7.Water Exposure Assessment: Standard Procedure for Quality Assurance / Control in Developing and Documenting Pesticide Root Zone Model (PRZM) (686 KB)

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