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Index of Cleared Science Reviews for 1-Bromo-3-chloro-5,5-dimethylhydantoin (Pc Code 006315)
September 26, 1980. DER. 35 Pages.
James Felkel. Ecological Effects Branch.
Aquatic invertebrate 48-hour LC50.
Test Species: Daphnia magna.
Acc. 243015.
Attachment(s) following:
September 4, 1980. DER.
James Felkel. Ecological Effects Branch.
Fish acute 96-hour LC50.
Test Species: Rainbow trout, Fathead minnows.
Acc. 243015.
October 21, 1980. DER.
James Felkel. Ecological Effects Branch.
Acute toxicity to estuarine and marine organisms.
Test Species: Juvenile sheepshead minnow, Grass shrimp,
American oyster.
Acc. 243015.
October 23, 1980. DER.
James Felkel. Ecological Effects Branch.
96-hour fish and 48-hour aquatic invertebrate LC50.
Test Species: Rainbow trout, Fathead minnows, Daphnia magna.
Acc. 243015.
October 16, 1980. DER.
James Felkel. Ecological Effects Branch.
Acute toxicity (96-hour) to estuarine and marine organisms.
Test Species: Juvenile sheepshead minnow, Grass shrimp,
American oyster.
Acc. 243015.
*End of attachments*
October 24, 1980. Review. 40 Pages.
James Felkel. Ecological Effects Branch.
File Nos. 1729-REE, -REG. Spa Brom Mini-Pak; Spa Brom
Feeder Sticks. Incremental Risk Assessment for Proposed
Conditional Registration of Uses in Spas and Hot Tubs.
Manufacturing process info. and product ingredient source
info. on pp. 1-2, 6, 11-13, 16-17, and 23-27 not included.
July 28, 1981. Review. 3 Pages.
Willa Garner. Environmental Fate Branch.
Reg./File No. 1729-REE, 1729-REG.
Use in spas - incremental exposure.
May 9, 1983. Review. 3 Pages.
James Wilson. Disinfectants Branch.
Technical Support Section Toxicology Review I - New
Application.
October 21, 1983. Memorandum. 23 Pages.
None. Toxicology Branch.
Spa-Brom; Review of Toxicity Studies on Dimethylhydantoin.
April 13, 1984. Review. 6 Pages.
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 38906-RE.
Proposed registration of various cooling tower uses
including lagoons.
April 13, 1984. Review. 10 Pages.
Samuel Creeger. Exposure Assessment Branch.
Reg./File No. 38906-RE.
Registration of new chemical for use
in recirculating cooling towers.
Hydrolysis, photolysis, biodegradability.
Acc. 252642.
April 18, 1984. Review. 23 Pages.
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 38906-T.
Submission of data to support registration. Acc. 252094.
1/13/84 Avian acute oral LD50; page 8. 1/13/84 Eight-day
dietary LC50; page 11. 1/16/84 Eight-day dietary LC50;
page 13. 96-hour LC50; page 15. 96-hour LC50; page 18.
April 26, 1984. Review. 1 Page.
Anna Skapars. Disinfectants Branch.
Dantobrom RW.
April 26, 1984. Review. 3 Pages.
James Wilson. Disinfectants Branch.
New Application (Dantobrom RW).
Pending registration information on page 3 is not included.
July 16, 1984. Efficacy Review. 1 Page.
None. Disinfectants Branch.
Dantobrom P.
July 18, 1984. Review. 9 Pages.
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 38906-RU.
Proposed registration of uses in spas,
swimming pools, recirculating water systems,
pulp & paper mfg, and in oil recovery systems.
Acc. 252719.
July 26, 1984. Review. 14 Pages.
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 38906-RE, 38906-RG, 38906-RU.
Submission of Data to Support Proposed
Registrations of Microbicide Uses.
96-hour LC50 (Bluegill, page 6) (Trout, page 9).
48-hour LC50 Daphnia magna, page 12. Acc. 252074, 252072.
August 13, 1984. Review. 3 Pages.
Samuel Creeger. Exposure Assessment Branch.
Reg./File No. 8959-UN.
registration in spas and hot tubs.
EAB has not received any environmental fate data for review
in this submission.
August 17, 1984. Review. 1 Page.
Anna Skapars. Disinfectants Branch.
Dantobrom S.
September 5, 1984. Review. 1 Page.
Anna Skapars. Disinfectants Branch.
Dantobrom P.
Commercial/financial information is not included.
September 12, 1984. Efficacy Review. 3 Pages.
William Campbell. Disinfectants Branch.
New Product Registration.
September 12, 1984. Review. 3 Pages.
Samuel Creeger. Exposure Assessment Branch.
Use in Swimming Pools.
September 12, 1984. Review. 10 Pages.
Samuel Creeger. Exposure Assessment Branch.
Reg./File No. 38906-RL
use in swimming pools.
Discussion of Data. The three active ingredients
in the product were... previously reviewed (13 April 1984).
Page 6 removed, confidential statement of formula.
September 27, 1984. Review. 4 Pages.
Samuel Creeger. Exposure Asssessment Branch.
Response to Data Requirements.
November 6, 1984. Review. 24 Pages.
Curtis Laird. Ecological Effects Branch.
File No. 8959-UU. Brominating Compounds. Proposed
Registration of Uses in Spas and Hot Tubs.
November 13, 1984. Review. 3 Pages.
Samuel Creeger. Exposure Assessment Branch.
Reg./File No. 8959-UN.
Request for waiver from the aqueous photolysis study.
February 26, 1985. Review. 3 Pages.
Samuel Creeger. Exposure Assessment Branch.
Review Protocols (Hydrolysis Study).
March 12, 1985. Memorandum. 2 Pages.
Robert Zendzian. Toxicology Branch.
Dantobrom, Dantobrom S, & Dantobrom P Data Requirements for
Use in Spas and Swimming Pools - Glycol.
July 11, 1985. Review. 2 Pages.
Les Touart. Ecological Effects Branch.
8622-EL
Submission of data to support proposed
microbicide uses
Acc. 258164.
July 15, 1985. Review. 3 Pages.
James Wilson. Disinfectants Branch.
8622-EL
New Application
Acute Oral, Acute Dermal, Skin Irritation, Eye Irritation
Acc. 258165.
October 31, 1985. Memorandum. 4 Pages.
Joycelyn Stewart. Toxicology Branch.
Dantobrom, EPA Registration No. 38906-14.
Dantobrom P, EPA File Symbol 38906-RL.
Data Requirements for Use in Spas and Swimming Pools.
Manufacturing process information on page 2 is not included.
November 26, 1986. Review. 3 Pages.
James Wilson. Disinfectants Branch.
Resubmission - Tox Data.
January 12, 1987. Memorandum. 10 Pages.
Joycelyn Stewart. Toxicology Branch.
Bromochloro-5,5,dimethylhydantoin; 1-bromo-
3-chloro-5,5-dimethylhydantoin
EPA ID# 8622-EL
Mutagenicity. Acc. 264468.
Tox review 005654.
February 17, 1987. Review. 4 Pages.
James Adams. Exposure Assessment Branch.
8622-EL
Registration for use in indoor and outdoor swimming pools
and spas
Hydrolysis and Photodegradation in Water. Acc. 264468.
May 1, 1987. Review. 8 Pages.
Akiva Abramovitch. Exposure Assessment Branch.
Reg./File No. 3377-EG, 3377-EE, 3377-EU.
Registration for use in swimming pools.
May 12, 1987. Review. 4 Pages.
Akiva Abramovitch. Exposure Assessment Branch.
Registration for Use in Indoor and Outdoor Swimming
Pools and Spas.
May 13, 1987. Review. 4 Pages.
Akiva Abramovitch. Exposure Assessment Branch.
Reg./File No. 8959-44.
Registration for use in indoor and outdoor swimming pools.
Both the hydrolysis and the aqueous photodegradation
studies should be repeated with a purified material...
Acc. # 265455 and 265456.
May 14, 1987. Memorandum. 17 Pages.
Joycelyn Stewart. Toxicology Branch.
Dantobrom S, EPA ID No. 38906-13 and Dantobrom P,
EPA ID No. 38906-15.
Commercial/financial information on page 1 is not included
Tox review 005876.
June 30, 1987. Memorandum. 19 Pages.
Joycelyn Stewart. Toxicology Branch.
Dantobrom S, EPA ID No. 38906-13 and Dantobrom P,
EPA ID No. 38906-15.
July 7, 1987. Review. 4 Pages.
James Wilson. Disinfectants Branch.
Resubmission (Skin Irritation and Eye Irritation Data).
July 17, 1987. Review. 24 Pages.
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 3377-EG, 3377-EE, 3377-EU.
Data Review for Technical.
Avian acute oral LD50, Bobwhite quail, page 5. Eight-day
dietary LC50, Bobwhite, p.9; Mallard, p.12. 96-hour LC50,
Bluegill, Fathead, p.15; Trout, p.18. 48-hour LC50 p.22.
March 3, 1988. Memorandum. 3 Pages.
Joycelyn Stewart. Toxicology Branch.
5,5-Dimethylhydantoin and 5-ethyl, 5-methylhydantoin.
EPA ID # 38906-3, -4, -7, -9, -12, -13, -14, -15.
Tox Chem Nos. 366D, 568E, 309C.
Product formulation information on page 1 is not included.
May 4, 1988. Memorandum. 8 Pages.
Joycelyn Stewart. Toxicology Branch.
Dantobrom S and Dantobrom P. EPA ID Nos. 6836-116;
6836-118. Acc. Nos. 403313-01 and 403313-07
Tox review 006687.
June 2, 1988. Memorandum. 14 Pages.
Joycelyn Stewart. Toxicology Branch.
Dantobrom S and Dantobrom P. EPA ID #s 6836-116 and
6836-118. Acc. Nos. 403313-01 and 403313-07.
April 5, 1989. Review. 10 Pages.
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 5785-IU.
Proposed registration of uses in brewery
pasteurizers and recirculating cooling water systems.
Attachment(s) following:
May 13, 1988. Memorandum.
Curtis Laird. Ecological Effects Branch.
Data Requirement for Dantobrom BTB.
May 4, 1988. Memorandum.
Emil Regelman. Exposure Assessment Branch.
Data Requirements for Dantobrom BTB.
May 4, 1988. Review.
Curtis Laird. Ecological Effects Branch.
File or Reg. No. 6336-RGL.
New chemical screen for three hydantoin
compounds proposed for use in recirculating
cooling water systems and airwashers.
*End of attachments*
August 23, 1989. Memorandum. 3 Pages.
Joycelyn Stewart. Toxicology Branch.
Dantobrom S; EPA ID # 6836-116; Record No. 245107.
MRID #s 410889-01, -02
Tox review 007447.
January 16, 1990. Review. 6 Pages.
Paul Mastradone. Environmental Fate & Ground Water Branch.
Reg. Nos. 5785-65 and 5785-63. BromoCide Tablets,
BromoCide Granules. Review Amendment Request for Additional
Use Pattern and Additional Brand Name (BromoCide Tablets
and Granules).
Attachment(s) following:
February 10, 1989. Review. 17 Pages.
Dynamac Corporation.
Dimethylhydantoin - Task 1: Review and Evaluation of
Task 1: Review and Evaluation of Individual Studies
Task 2: Environmental Fate Assessment
Initial Draft Report
MRIDs 408046-01 thru -07, 406852-01.
*End of attachments*
May 21, 1990. Review. 14 Pages.
Curtis Laird. Ecological Effects Branch.
Submission of estuarine data to support
proposed label amendment for once-through
use in industrial cooling water systems.
Pages 13-14 removed, registrant data.
MRID 409931-01, -02, -03.
May 21, 1990. Review. 14 Pages.
Curtis Laird. Ecological Effects Branch.
Submission of estuarine data to support
proposed label amendment for once-through
use in industrial cooling water systems.
Pages 7-8 removed, registrant data.
MRID 409931-01, -02, -03.
January 7, 1992. Memorandum. 9 Pages.
Melba Morrow. Toxicology Branch.
ID No.: 006836-00115, 90 Day Subchronic Oral Study in
Rats with Dimethylhydantoin.
MRID 42009201.
Tox review 008972.
March 30, 1992. Memorandum. 22 Pages.
Melba Morrow. Toxicology Branch.
ID No.: 006836-00115, Metabolism Studies with
Dimethylhydantoin in Rats.
MRID 42173901.
Tox review 009394.
August 27, 1992. Review. 48 Pages.
Douglas Urban. Ecological Effects Branch.
Lonza Inc.; List C Phase IV.
MRID 930760-02, -03, 04, 05, 20, 06, 27,
07, 22, 08, 09, 10.
March 20, 1993. Review. 1 Page.
Bernice Slutsky. Environmental Fate and Effects Division.
EFED's comments on dihalodialkylhydantoins DCI (Case 3055).
September 27, 1993. Review. 55 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Review of data for hydantoin submitted by Lonza Inc.
Flow-through life-cycle toxicity. Daphnia magna.
Early life-stage toxicity. Fathead minnow.
Pages 15-22, 37-40 removed, registrant data.
MRID 42721701, 42721702.
May 13, 1994. Memorandum. 2 Pages.
Paul Chin. Toxicology Branch.
EPA ID # 006836: Registrant's Response to Agency Review
of MEH (5-methyl-5-ethylhydantoin) General Metabolism
Study. MRID 430204-02.
Tox review 010966.
September 15, 1994. Review. 3 Pages.
Alfred Smith. Registration Support Branch.
Product Chemistry Review of Halobrom (RR Case#3055, Phase 4)
Page 3 removed, quality control procedures.
January 12, 1995. Letter. 2 Pages.
Mark Wilhite. Accelerated Reregistration Branch.
Review of product chemistry and toxicology studies for the
chemical 1-Bromo-3-chloro-5, 5-dimethyllhydantoin.
February 15, 1995. Memorandum. 4 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Review of three acute estuarine toxicity tests for
Halobrom (DP Barcode D171469).
MRID 420761-02, -01, -03.
May 12, 1995. Memorandum. 14 Pages.
Paul Chin. Toxicology Branch.
EPA ID # 006315: 5,5-Dimethylhydantoin (DMH)-
Review of 90-Day Subchronic Dermal Toxicity
Study in Rats (MRID No. 431739-01).
Tox review 011544.
May 12, 1995. Memorandum. 16 Pages.
Raymond Locke. Toxicology Branch.
5,5-Dimethylhydantoin. Review of Toxicology Data.
MRID 43553101. Chronic (One-Year) Toxicity (Dog).
Tox review 011546.
May 19, 1995. Memorandum. 33 Pages.
Paul Chin. Toxicology Branch.
EPA ID # 006315: 5,5-Dimethylhydantoin (DMH) -
-Review of Carcinogenicity Study in Mice and
Chronic Toxicity/Caarcinogenicity Study in
Rats (MRID No. 433977-01 and -02).
Tox review 011556.
July 9, 1996. Memorandum. 26 Pages.
Raymond Locke. Toxicology Branch.
BCDMH. Review of Toxicology Data.
Multigeneration Reproduction - Rat (83-4).
MRID 43290601.
Tox review 011975.
July 24, 1996. Memorandum. 12 Pages.
Raymond Locke. Toxicology Branch.
1-Bromo-3-chloro-5,5-dimethylhydantoin: Review of
Toxicology Data. Subchronic oral toxicity (feeding) - Dog;
Range-finding study for chronic toxicity - Dog.
MRID 43553101.
Tox review 011997.
October 23, 1996. Letter. 16 Pages.
Kathleen Depukat. Accelerated Reregistration Branch SRRD.
Review od Chronic (One-Year) Feeding Study in the Dog
Supporting the Reregistration of 1-bromo-3-chloro-5,5-
dimethylhydantoin, Case # 3055, AI 006315.
Attachment(s) following:
September 20, 1996. Memorandum.
Raymond Locke. Toxicology Branch.
1-Bromo-3-chloro-5,5-dimethylhydantoin. Review of
Toxicology Data. Chronic (One-Year) Toxicity (Dog).
MRID 43813301.
Tox review 012060.
*End of attachments*
January 29, 1997. Memorandum. 3 Pages.
Raymond Locke. Toxicology Branch.
1-Bromo-3-chloro-5,5-dimethylhydantoin (BCDMH).
Addenda to Data Evaluation Records (DERs).
[Addenda to Doc. No. 011997 and 011546.]
MRID 44111900, 44111901, 44111902.
Tox review 012153.
January 29, 1997. Memorandum. 15 Pages.
Raymond Locke. Toxicology Branch.
1-Bromo-3-chloro-5,5-dimethylhydantoin: Review of
toxicology data. 18-month oncogenicity study in mice, 83-2b.
MRID 44063901.
Tox review 012154.
July 10, 1997. Memorandum. 34 Pages.
Raymond Locke. Toxicology Branch.
BCDMH. Review of Toxicology Data.
Combined chronic/oncogenicity feeding - Rat. (83-5)
MRID 44095901.
July 14, 1999. Memorandum. 3 Pages.
Bruce Mann. Efficacy and Science Support Branch AD.
Efficacy Review and Label Review for "Dantabrom TBS-5B",
for "Dantabrom TBS-4A", and for "Dantabrom TBS-5A"
EPA Reg. No(s) 6836-ETU, 6836-ETE and 6836-ETG.
MRID 44801904 & -05. [in-tank sanitizing data].
August 14, 2000. Memorandum. 18 Pages.
Timothy McMahon. Risk Assessment & Science Support Branch.
5,5-Dimethylhydantoin - Report of the Hazard Identification
Assessment Review Committee.
Tox review 014292.
August 28, 2000. Memorandum. 18 Pages.
Timothy McMahon. Risk Assessment & Science Support Branch.
5,5-Dimethylhydantoin - Revised Report of the Hazard
Identification Assessment Review Committee.
Tox review 014298.