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Index of Cleared Science Reviews
Index for Linuron (Pc Code 035506)
April 29, 1963. Memorandum. 11 Pages.
Dr. M.L. Quaife. Division of Pharmacology.
Evaluation of pharmacological data, submitted in petition to
establish residue tolerance on corn, fodder or forage
(including field corn, sweet corn, and popcorn); soybeans
(dry and succulent forms); and meat fat, meat, and meat...
Tox review 000681.
December 12, 1968. Review. 14 Pages.
L.B. Dale. Toxicology Branch.
Acute Oral Toxicity (Rat)....
Tox Review 000680.
May 8, 1973. Memorandum. 3 Pages.
Robert Schmidt. Toxicology Branch.
Linuron - The petitioner is proposing the establishment of
a tolerance of 0.25 ppm for residues of the herbicide
linuron in or on asparagus.
November 14, 1977. Review. 8 Pages.
Larry Turner. Efficacy & Ecological Effects Branch.
Prowl, EPA Reg. No. 241-243. Amendment (Tank Mix or
Sequential Application with Lorox or Amiben).
March 15, 1978. Review. 2 Pages.
William Dykstra. Toxicology Branch.
352-EUP-96. DuPont LOROX DF Weed Killer for use on soybeans
and potatoes.
Inert ingredient information on page 2 not included.
July 31, 1979. Review. 9 Pages.
B.T. Backus. Insecticide Rodenticide Branch.
EPA File Symbol: 1812-EUL Griffin Linuron 4L Flowable
Weed Killer. (Acute oral LD50, Acute dermal LD50...)
Acc. 237806.
September 4, 1979. Review. 9 Pages.
Byron Backus. Insecticide Rodenticide Branch.
EPA File Symbol: 352-GOU LOROX DF
Oral LD50 (rats); Skin Absorption LD50 (rabbits); Eye
Irritation (Rabbits); Skin Irritation (rabbits).
October 5, 1979. Memorandum. 1 Page.
Charles Frick. Toxicology Branch.
Registration #352-270 - 32-Week Mouse Feeding Study with
Linuron.
October 30, 1979. Review. 4 Pages.
Sherell Sterling. Fungicide Herbicide Branch.
EPA File Symbol 352-GOR
Lorox 4L, Caswell #528
DuPont has submitted Acute Oral, Acute Dermal, Eye and Skin
Irritation studies...
December 10, 1979. Review. 3 Pages.
Charles Frick. Toxicology Branch.
Review of Linuron Rat Teratology Study Re: Lorox Weed Killer
EPA Reg.#252-270.
February 11, 1980. Memorandum. 2 Pages.
Charles Frick. Toxicology Branch.
Reg. #352-270 Preliminary report on chronic rat feeding
study with the compound Linuron. 6(a)(2) data. Acc #241635.
March 19, 1980. Review. 6 Pages.
Deloris Graham. Fungicide Herbicide Branch.
EPA Registration Number: 33660-11
Linuron Technical: Caswell # 528
Acute oral, acute dermal, acute inhalation...
Acc. No 232505. MRID 18178, 18179, 18180, 18181, 27625.
Page 6 removed, draft labeling.
May 16, 1980. Memorandum. 6 Pages.
William Dykstra. Toxicology Branch.
EPA Reg. #352-270; Lorox; Long-term Feeding Study in Rats
with... (Lorox, Linuron, INZ-326) Acc #241897 and 241898.
October 8, 1980. Review. 7 Pages.
Deloris Graham. Fungicide Herbicide Branch.
EPA File Symbol 2749-UIO
Aceto linuron Technical Herbicide
Submitted Acute Oral... Pages 6-7 removed, registrant data.
MRID 18178, 18179, 18180, 18181, 27625.
Tox review 000482.
May 26, 1981. Review. 7 Pages.
M. Nelson. Residue Chemistry Branch.
PP#1E2486. Linuron in or on lettuce. Evaluation of
anlytical methodology and residue data.
Formulation information on page 2 is not included.
August 12, 1981. Memorandum. 4 Pages.
Amal Mahfouz. Toxicology Branch.
PP#1E2486. Linuron in Lettuce, (Lorox 50 WP). EPA Reg.
#352-270; Minor Use Tolerance of 0.25 ppm. Caswell #528
Accession #099948.
June 21, 1982. Review. 1 Page.
James Holder. Toxicology Branch.
Registration Number 82-MA-03
Section 18 request by the State of Mass to apply Lorox 50WP
on dry bulb onions.
July 19, 1982. Review. 4 Pages.
James Holder. Toxicology Branch.
Pesticide Petition No(s): 2E2705 and 2H5354
Incremental Risk Analysis, i.e. the increase in TMRC.
November 8, 1982. Memorandum. 9 Pages.
Jesse Mayes. Residue Chemistry Branch.
PP#2E2706/2H5354. Linuron in or on Sugar Beets: Evaluation
of Residue data and Analytical Methodology
Formulation information on page 4 not included.
January 7, 1983. Memorandum. 4 Pages.
Orville Paynter. Toxicology Branch.
Linuron Risk Assessment, Statistical Aspects of.
MRID 00029680.
June 27, 1983. Review. 2 Pages.
Joseph Reinert. Exposure Assessment Branch.
Reg. No. 352-326
protocol - applicator exposure.
July 21, 1983. Memorandum. 5 Pages.
Bernard Haberman. Carcinogen Assessment Group/Toxicology.
Review of Data for the Carcinogenicity of Linuron.
October 31, 1983. Memorandum. 9 Pages.
Frank Boyd. Residue Chemistry Branch.
PP #3E2920. Linuron in or on Taro, Dasheen and
Ginger: Evaluation of Residue Data and Analytical
Methodology. Formulation information on page 4 not included.
April 25, 1984. Review. 5 Pages.
Joseph Reinert. Exposure Assessment Branch.
Reg. No. 352-326
Human Exposure.
May 25, 1984. Memorandum. 15 Pages.
Robert McGaughy. Carcinogen Assessment Group/Toxicology.
Review of Rat and Mouse data from the Dupont Chemical Co.
for the Carcinogenicity of Linuron.
August 16, 1984. Memorandum. 2 Pages.
Charles Aldous. Toxicology Branch.
Return of Linuron "Bean Sheet" on Linuron Chronic
Mouse Study.
Acc. No. 249255 and 249256.
September 5, 1984. Memorandum. 1 Page.
Robert Zendzian. Toxicology Branch.
Registration #352-326
Linuron, Review of Protocol for Dermal Absorption.
October 25, 1984. Memorandum. 19 Pages.
Charles Aldous. Toxicology Branch.
Completion of General Linuron Mutagenicity Testing
Requirements. Reg. #352-326
MRID 131738, 137152, 137153, 132583.
November 1, 1984. Review. 7 Pages.
Joseph Reinert. Exposure Assessment Branch.
Reg. No. 352-326
Review exposure data (mixer/loader and applicator).
November 9, 1984. Review. 3 Pages.
Carolyn Offutt. Exposure Assessment Branch.
Reg. No. 352-326
Registrant's request for a waiver from a
Registration Standard data requirement.
November 9, 1984. Memorandum. 12 Pages.
Robert Zendzian. Toxicology Branch.
Linuron, Calculation of Mixer/Loader and Applicator
Body Dose from Dermal Exposure and Dermal Absorption.
March 7, 1985. Memorandum. 2 Pages.
Robert Zendzian. Toxicology Branch.
Linuron, Revision of Calculation of Applicator
Body Dose from Dermal Exposure and Dermal Absorption.
March 8, 1985. Memorandum. 6 Pages.
Robert Zendzian. Toxicology Branch.
Linuron on Carrots, Calculation of Mixer/Loader
and Pilot Systemic Dose from Dermal Exposure and
Dermal Absorption and Calculation of Oncogenic
Risk Assessment.
March 14, 1985. Review. 6 Pages.
Joseph Reinert. Exposure Assessment Branch.
Aerial Applicator Exposure Assessment.
March 21, 1985. Review. 2 Pages.
Lionel Richardson. Exposure Assessment Branch.
Determine potential for ground water
contamination.
March 28, 1985. Memorandum. 3 Pages.
Charles Aldous. Toxicology Branch.
Review of research progress report of studies entitled
"Linuron - Related Interstitial Cell Adenomas"
Tox review 004364.
April 23, 1985. Memorandum. 16 Pages.
Charles aldous. Toxicology Branch.
Review of Linuron Reproduction Study.
Identifying Number 352-326 and Action Code 800.
Accession No. 255829.
Tox review 004405.
June 5, 1985. Memorandum. 9 Pages.
Robert Zendzian. Toxicology Branch.
Linuron, Calculation of Risk Assessment for use on
Crops.
June 13, 1985. Memorandum. 10 Pages.
Charles Aldous. Toxicology Branch.
Toxicological assessment of alternatives to linuron by
crop.
June 25, 1985. Memorandum. 15 Pages.
James Rowe. Toxicology Branch.
Expedited Review of Linuron Rat Metabolism Study
Accession # 257451; Caswell # 528
Tox review 004506.
July 9, 1985. Review. 3 Pages.
Carolynn Offutt. Exposure Assessment Branch.
Comment on need for reentry data for Linuron
used on asparagus.
July 17, 1985. Memorandum. 4 Pages.
James Rowe. Toxicology Branch.
Dermal sensitization test for linuron in guinea pigs;
Identifying No. 353-326; Accession No. 257620
Tox review 004563.
July 19, 1985. Review. 8 Pages.
Bonnie Hileman. Ecological Effects Branch.
Submission of 48-Hour Daphnia Study to support
reregistration of linuron
Acc. No. 258300.
August 28, 1985. Review. 3 Pages.
Emil Regelman. Exposure Assessment Branch.
Data Review: Bioconcentration in Bluegill
Accession No. 258300.
September 24, 1985. Memorandum. 3 Pages.
James Rowe. Toxicology Branch.
Review of Data Call In Notice for Linuron, Draft of 9/5/85.
October 8, 1985. Review. 9 Pages.
Emil Regelman. Exposure Assessment Branch.
Review of 'cold' field dissipation data
for comparison with C14 field studies.
Attachment(s) following:
October 2, 1985. Final Report.
Dynamac. Dynamac/Exposure Assessment Branch.
Task 1: Review and Evaluation of Individual Studies.
*End of attachments*
October 16, 1985. Review. 3 Pages.
Emil Regelman. Exposure Assessment Branch.
Waiver Request: Long Term Field Dissipation.
November 19, 1985. Memorandum. 8 Pages.
James Rowe. Toxicology Branch.
Review of Linuron sulf- and methemglobin study performed
in the rat. Haskell Laboratory Report No. 521-85, MR No.
7606-001 September 4, 1985: Caswe;;#528
Accession No. 259185.
Tox review 004775.
November 25, 1985. Data Eval. Rec. 4 Pages.
Elizabeth Zucker. Ecological Effects Branch.
Acute Toxicity Study on a Warmwater Fish Species
Species Tested: Bluegill sunfish
Acc. No. 259206.
November 25, 1985. Data Eval. Rec. 4 Pages.
Elizabeth Zucker. Ecological Effects Branch.
Acute Toxicity Study on a Coldwater Fish Species
Species Tested: Rainbow trout
Acc. No. 259206.
November 25, 1985. Data Eval. Rec. 7 Pages.
Elizabeth Zucker. Ecological Effects Branch.
Avian Acute Oral Toxicity Study on an Upland Game Species
Species Tested: Bobwhite quail
Acc. No. 259296.
November 25, 1985. Review. 3 Pages.
Elizabeth Zucker. Ecological Effects Branch.
Reg. No. 352-326
Submission of data in response to registration
standard
EEB Evaluation of Avian Acute Oral Tox Data; Acc. 259296.
November 25, 1985. Review. 3 Pages.
Elizabeth Zucker. Ecological Effects Branch.
Reg. No. 352-326
Submission of data in response to registration
standard
EEB Evaluation of Fish Acute Toxicity Data, Acc. No. 259206.
November 29, 1985. Memorandum. 7 Pages.
James Rowe. Toxicology Branch.
Review of linuron reproductive study addendum: cross-mating
study in rats; report no. 413-85; August 8, 1985;
Accession # 259393
Tox review 004819.
February 12, 1986. Review. 6 Pages.
Carolynn Offutt. Exposure Assessment Branch.
For the Linuron data Call-In, SRB
asked EAB to review its position which initially was to
require ground and surface water monitoring.
February 19, 1986. Reference Doses. 3 Pages.
Health Effects Division.
Reference Doses (RfDs) for Oral Exposure
Carcinogenicity: Preliminary Classification as Category C
(limited evidence) oncogen (CAG).
April 14, 1986. Review. 4 Pages.
Joseph Reinert. Exposure Assessment Branch.
Label Amendment.
April 22, 1986. Review. 17 Pages.
Emil Regelman. Exposure Assessment Branch.
Response to Agency review of environmental fate data.
Acc. No. 255830.
Manufacturing information on page 8 is not included.
April 23, 1986. Memorandum. 2 Pages.
James Rowe. Toxicology Branch.
Guidance regarding the dose levels to be used for the
chronic studies being required in the linuron DCI: I.D.
035506; Record number 169837.
MRID 00029680.
August 11, 1986. Memorandum. 8 Pages.
James Rowe. Toxicology Branch.
Review of Linuron erythrocyte precursor study performed
in the rat. Haskell Laboratory Report No. 760-85,
December 6, 1985;
Acc. # 26053.
Tox review 005338.
September 29, 1986. Review. 3 Pages.
Carolynn Offutt. Exposure Assessment Branch.
Letter from registrant changing position on
submission of reentry data for Linuron use on asparagus.
September 29, 1986. Memorandum. 3 Pages.
Bertram Litt. Toxicology Branch.
Linuron - Evaluation of Rabbit Teratology Study
Tox review 005609.
November 13, 1986. Memorandum. 2 Pages.
James Rowe. Toxicology Branch.
Review of linuron "medical records" from Dupont production
area in LaPorte plant... Based on reported cases of
chloracne and methemoglobinemia...
November 21, 1986. Memorandum. 2 Pages.
James Rowe. Toxicology Branch.
Proposed one-year dog feeding study with linuron...
December 5, 1986. Memorandum. 12 Pages.
James Rowe. Toxicology Branch.
Review of linuron rabbit developmental toxicity study;
Acc. # 260064; Caswell 528; EPA ID 035506; Project 891
Tox review 005609.
December 12, 1986. Memorandum. 2 Pages.
James Rowe. Toxicology Branch.
Proposed two-year rat feeding study with linuron.
December 12, 1986. Memorandum. 3 Pages.
James Rowe. Toxicology Branch.
Linuron rebuttal comments for reproduction study;
Caswell 528; EPA ID # 035506; Project 7-0130; Record
No. 183739.
Tox review 005626.
December 31, 1986. Memorandum. 3 Pages.
Bertram Litt. Toxicology Branch.
Linuron Special review Comments of Risk Assessment.
January 12, 1987. Memorandum. 5 Pages.
James Rowe. Toxicology Branch.
Dupont rebuttal comments on PD-1, linuron dietary and
exposure risk assessment...
January 16, 1987. Memorandum. 2 Pages.
James Rowe. Toxicology Branch.
Linuron Data Call-In, Chronic Rat Protocol and Reanalysis
of Hemotological data from Rat Chronic Study; Caswell 528;
EPA ID # 035506; Project 2270; Record No. 180331.
January 16, 1987. Memorandum. 4 Pages.
James Rowe. Toxicology Branch.
Linuron Data Call-In, reanalysis of Hematological Data
from Rat Chronic Study; Caswell 528; EPA ID 035506;
Project 7-0133; Record No. 183736.
Tox review 005670.
January 27, 1987. Memorandum. 8 Pages.
James Rowe. Toxicology Branch.
Linuron Data Call-In, Effect of linuron fed to aged male
rats; Caswell 528; EPA ID # 035506; Project 7-0132; Record
No. 183741
Tox review 005687.
January 27, 1987. Memorandum. 12 Pages.
James Rowe. Toxicology Branch.
Special Review Submission on Hormonal Effects of Linuron;
Caswell 528; EPA ID 035506; Project 7-0134; Record No 183738
Tox review 005688.
February 3, 1987. Memorandum. 6 Pages.
James Rowe. Toxicology Branch.
Registrant's rebuttal comments on Linuron met- and
sulfhemoglobin study in the rat; Caswell 528; EPA ID 035506;
Project 7-0129; Original Accession # 259185; HLR 521-85.
Tox review 005708.
April 22, 1987. Review. 5 Pages.
Ester Rinde. Toxicology Branch.
Abbreviated Peer Review of Linuron
(re: oncogenic potential).
April 27, 1987. Memorandum. 6 Pages.
Deloris Graham. Fungicide-Herbicide Branch.
EPA File Symbol 10182-RRO. Prelude Herbicide
Tox review 006189.
May 20, 1987. Note to Files. 1 Page.
Mark Boodee. Special Review Branch.
Note to the Files
Meeting with du Pont
... study entitled "Supplement to: Linuron Residue Study -
Volumes I and II".
May 21, 1987. Memorandum. 6 Pages.
Bernice Fisher. Toxicology Branch.
Linuron Rat Study - Evaluation of
Hematological Measure - HB (g %)
Tox review 005926.
June 2, 1987. Memorandum. 26 Pages.
James Holder. Carcinogen Assessment Group/Toxicology.
Re-evaluation of the Carcinogenicity of Linuron Based on
Additional Rat Tumor and Testicular Hormone Data Submitted
by the Haskell Laboratory of Dupont.
June 4, 1987. Memorandum. 9 Pages.
James Rowe. Toxicology Branch.
Linuron Data Call-In, Statistical Reanalysis of
Hematological Data from Rat Chronic Study; Caswell 528;
EPA I.D.# 035506; Project 7-0509; Record No. 192059
Tox review 005926.
November 27, 1987. Memorandum. 8 Pages.
James Rowe. Toxicology Branch.
Dermal sensitization test for linuron in guinea pigs;
EPA ID No. 352-326; Accession No. 401876-01; Caswell
No. 528; Project no. 7-1082
Pages 6-8 removed, registrant data.
Tox review 006477.
April 20, 1988. Memorandum. 4 Pages.
Mary Waller. Fungicide-Herbicide Branch.
EPA Registration Number 10182-119. Prelude Herbicide.
July 27, 1988. Review. 4 Pages.
Emil Regelman. Exposure Assessment Branch.
Reg./File #: 223601
Review of registrant responses to DERs
MRIDs 40615301, 40635501, 40103601.
June 29, 1989. Memorandum. 13 Pages.
Sidney Stolzenberg. Health Effects Division.
Linuron One-Year Dog Study Call-In Data
MRID 409526-01
Tox review 007284.
March 20, 1990. Memorandum. 14 Pages.
Elizabeth Doyle. Health Effects Division.
Linuron Generic Reregistration - One-Year Dog Study
MRID 409526-01.
September 27, 1990. Memorandum. 20 Pages.
Elizabeth Doyle. Toxicology Branch.
Linuron - Evaluation of a Two-Generation Reproduction
Study Provided as 6(a)(2) Data
MRID 414634-01
Tox review 008113.
August 28, 1991. Memorandum. 10 Pages.
Susan Makris. Toxicology Branch.
Linuron - Supplemental histopathology data to evaluate eye
lesions observed in multigeneration reproduction study No.
HLR 20-90 (MR project no. 8511-001)
MRID 414634-01, 418647-01
Tox review 008533.
September 16, 1991. Memorandum. 36 Pages.
Susan Makris. Toxicology Branch.
Linuron - Investigation of a mechanism for Leydig cell
tumorigenesis by Linuron in rats. MRID No. 41630101.
Pages 23-36 removed, registration data.
Tox review 008612.
July 2, 1992. Letter. 14 Pages.
Susan Makris. Toxicology Branch.
Linuron- Developmental Toxicity in the Rat (Guideline 83-30)
Pages 12-14 removed, registration data
MRID 00018167
Tox Review 009561.
August 21, 1992. Memorandum. 7 Pages.
George Ghali. Health Effects Division.
Rfd/Peer Review Report of Linuron.
January 14, 1994. Memorandum. 16 Pages.
Susan Makris. Toxicology Branch.
Toxicology Review for the Reregistration Eligibility
Document on linuron.
May 4, 1994. Memorandum. 32 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Linuron RED: (1) EEB's chapter for Linuron (2) Data
Requirement Table.
MRID 00150170, 00034769, 42541801 & 02, 40445501, 40354201
00018165, 00018198, 42061804, 00142932, 00018199, 42153401,
42061801 - 03, 00018842 & 42086801.
May 16, 1994. Memorandum. 34 Pages.
William Effland. Environmental Fate & Groundwater Branch.
Linuraon RED Candidate - EFGWB Science Chapter.
July 14, 1994. Memorandum. 16 Pages.
James Kariya. Science Analysis Branch.
Linuron: Dietary Exposure Analysis in Support of the
Reregistration Eligibilty Decision.
Product impurity information on page 1 not included.
August 4, 1994. Memorandum. 12 Pages.
Jeff Evans. Occupational & Residential Exposure Br.
OCCUPATIONAL AND RESIDENTIAL EXPOSURE ASSESSMENT AND
RECOMMENDATIONS FOR THE REREGISTRATION ELIGIBILITY
DOCUMENT FOR LINURON.
MRID 254943, 403418-01.
August 19, 1994. Memorandum. 28 Pages.
Betsy Grim. Environmental Fate & Effects Branch.
Transmittal of EFED List A Summary Report for Linuron.
Chemical # 035506. Case No. 0047.
MRID 40916201, 40103601, 40171711, 41625401, 40142501,
00148443, 41734201 & 41734202.
Acc. No. 255830, 258300.
August 19, 1994. Memorandum. 17 Pages.
Betsy Grim. Environmental Fate and Effects Division.
EFED Recommendations and Mitigation Measures for Linuron.
Case No. 0047.
August 19, 1994. Memorandum. 47 Pages.
John Redden. Health Effects Division.
The HED Chapter of the Reregistration Eligibility
Decision Document (RED) for Linuron.
Impurity information on pages 45 not included.
Product source information on pages 6,7, 43, 45 & 46
not included.
September 22, 1994. Memorandum. 57 Pages.
Karen Jones. SRRD.
CBRS Reregistration Eligibility Document for Linuron -
Product Chemistry Section (dated February 15, 1994).
Product source info on pages 1, 7, 8, 10 is not included.
Attachment(s) following:
February 15, 1994. Memorandum.
Dennis Mc Neilly. Chemistry Branch.
Linuron Reregistration Eligibility Document (RED).
December 9, 1993. Report.
Anonymous. Chemistry Branch.
Task 2A: Reregistration Eligibility Document:
Product Chemistry Considerations.
*End of attachments*
September 23, 1994. Memorandum. 43 Pages.
David Miller. Chemistry Branch.
Linuron. Addendum to RED. Storage Stability Study (fresh
and cooked carrots and fresh and cooked asparagus)
DP Barcode: D206666; CBRS No. 14229 case No. 0047
MRID 432883-01, 02.
December 8, 1994. Memorandum. 15 Pages.
David Miller. Chemistry Branch.
Linuron. Product Chemistry Review for Agan Chemical
Manufacturers, Ltd. Linuron Technical.
Product source information on pages 1, 3, 4, 6, 8, 15
not included.
MRID 429273-01 thru 429273-03, 429593-01.
February 21, 1995. Memorandum. 19 Pages.
Susan Hummel. Chemistry Branch.
Linuron. 035506 Addendum to RED Residue Chemistry Chapter.
January 28, 1998. Memorandum. 12 Pages.
Marianne Lewis. Product Reregistration Branch.
EPA Reg. No. 51026-78/Linuron 4L Weed Killer; DP Barcode:
D241573; Case No. 119401. MRID Nos. 155906 thru 155911.