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Index of Cleared Science Reviews
Index for Metam-sodium (Pc Code 039003)
Undated. Memorandum. 20 Pages.
Dana Spitz. Environmental Fate & Ground Water Branch.
Review of Phase IV Package for Sodium and Potassium Salts of
Methyldithiocarbamate.
EFGWB No. 91-0193 - 91-0198, 91-0283.
November 24, 1967. Review. 13 Pages.
H.C. Berry. Toxicology Branch.
Chemical Name: Sodium Methyldithio carbamate
(page 2) Acute mouse oral, acute rat oral, acute
rabbit oral, subacute rabbit dermal (10 days),
acute inhalation.
February 4, 1981. Data Eval. Rec. 3 Pages.
Allen W. Vaughan. Ecological Effects Branch.
Metham (Vapam). Effect of Pesticides on Apiculture.
July 27, 1982. Memorandum. 2 Pages.
Stanley B. Gross. Toxicology Branch.
Subchronic Inhalation Testing Protocol for Vapam Using
Technical Sodium N-methyldicarbamate.
June 4, 1984. Memorandum. 6 Pages.
Deloris Graham. Fungicide-Herbicide Branch.
EPA Registration Number 1448-85. Busan 1020.
Tox Review 005279.
February 3, 1986. Memorandum. 3 Pages.
Irving Mauer. Toxicology Branch.
Metam-Sodium. Request to Specify Mutagenicity Testing
Battery.
April 30, 1986. Memorandum. 4 Pages.
Deloris Graham. Fungicide-Herbicide Branch.
EPA Registration Number 9993-2. Sanafoam Vaporooter.
Tox Review 006147.
May 27, 1986. Memorandum. 8 Pages.
Deloris Graham. Fungicide-Herbicide Branch.
EPA File Symbol 7969-AO. Metam Fluid Manufacturers
Concentrate.
Pages 7-8 removed, draft label.
Tox review 006041.
June 5, 1986. Review. 7 Pages.
Bhushan Mandava. Registration Support & Emergency Respons.
Product Chemistry Review on New Chemicals
Registration No.: 476-859
Accession No. 259624
Manufacturing process information on pages 1, 2, and 3
is not included.
September 2, 1986. Memorandum. 5 Pages.
Mary Waller. Fungicide-Herbicide Branch.
EPA Registration No. 476-859. Vapam Soil Fumigant Solution
for All Crops.
Tox review 006169.
October 27, 1986. Memorandum. 1 Page.
Robert Zendzian. Toxicology Branch.
Metam Sodium. Requirement for Acute Neurotoxicity Study
(Hen Study).
August 3, 1987. Memorandum. 8 Pages.
Mary Waller. Fungicide-Herbicide Branch.
EPA Registration Number 476-859.
Vapam Soil Fumigant Solution.
Dermal sensitization. MRID 40196601.
Tox review 006322.
January 29, 1988. Memorandum. 92 Pages.
John Chen. Toxicology Branch.
Metam-Sodium, Sodium-N-methyl-dithiocarbamate. EPA ID
No. 039003. Tox Chem No. 780.
Pages 11-16, 22-40, 46-62, 67-92 removed, registrant data.
Tox review 006570.
September 30, 1988. Memorandum. 46 Pages.
Sidney Stolzenberg. Toxicology Branch.
Metam Sodium. The biokinetics and metabolism of 14c-metam
sodium in the rat.
MRID 406410-00.
Tox review 010977.
February 7, 1989. Review. 2 Pages.
Alfred Smith. Registration Support Branch.
Product Chemistry Review on New Chemicals
EPA Registration No.: 476-859
Manufacturing process information on page 2 not included.
February 13, 1989. Memorandum. 6 Pages.
John Chen. Toxicology Branch.
Metam-Sodium ID Number 039003; Registrant's Reply to the
Previous Toxicology Branch Review Comments Concerning the
Mutagenicity Studies with Metam-Sodium.
Tox Review 007027.
March 20, 1989. Memorandum. 36 Pages.
James Akerman. Ecological Effects Branch.
Review of Comments on Waiver Request for Transban, Inc. on
a Data Call-In for the Herbicide Metam Sodium.
April 24, 1989. Memorandum. 43 Pages.
John Chen. Toxicology Branch.
Metam Sodium. Sodium-N-methyldithiocarbamate. HED Project
Nos. 9-0749 and 9-0751.
(Request toxicological data exemption...)
Manufacturing process info on pages 1, 2 is not included.
March 1, 1990. Memorandum. 12 Pages.
William Woodrow. Registration Support Branch.
EPA Reg. No./File Symbol 37507-L
Transbas, Inc. submitted acute oral, dermal, inhalation,
primary eye, skin irritation, dermal sensitization studies.
MRID 412770-02 thru 07.
Tox review 009101.
July 30, 1990. Memorandum. 4 Pages.
Sheila moats. Registration Support Branch.
EPA Reg. No./File Symbol 7969-69
BASF Corporation submitted an acute inhalation study...
MRID 414861-01
Tox review 009021.
December 12, 1990. Memorandum. 6 Pages.
John Chen. Toxicology Branch.
Metam Sodium. HED Project No. 0-0499
Review of the position document submitted for the proposed
toxicology testing program.
April 29, 1991. Memorandum. 9 Pages.
Mary Waller. Registration Support Branch.
EPA Reg. No./File Symbol 34704-647
acute oral, acute dermal, acute inhalation...
MRID 417240-01 thru -06.
Tox review 009151.
May 31, 1991. Memorandum. 3 Pages.
Mark Perry. Registration Support Branch.
EPA File Symbol/EPA Reg. No: [10182-229] VAPAM Soil Fumigant
ICI Americas has submitted revised labeling for review...
Upon further review, the unacceptable dermal sensitization
study [MRID# 401966-01] has been found acceptable...
Tox review 008939.
June 18, 1991. Data Eval. Rec. 9 Pages.
Henry Craven. Ecological Effects Branch.
Freshwater Fish Static Acute Toxicity Test.
Bluegill Sunfish.
MRID 411062-01.
June 18, 1991. Data Eval. Rec. 11 Pages.
Henry Craven. Ecological Effects Branch.
Freshwater Fish Static Acute Toxicity Test.
Rainbow Trout.
MRID 411062-02.
June 18, 1991. Data Eval. Rec. 8 Pages.
Henry Craven. Ecological Effects Branch.
Freshwater Invertebrate Static Acute Toxicity Test.
Daphnia magna.
MRID 411062-03.
June 18, 1991. Data Eval. Rec. 10 Pages.
Henry Craven. Ecological Effects Branch.
Avian Dietary LC50 Test. Bobwhite quail.
MRID 414764-01.
June 18, 1991. Data Eval. Rec. 16 Pages.
Henry Craven. Ecological Effects Branch.
Avian Single Dose Oral LD50 Test. Bobwhite quail.
MRID 414764-02.
June 18, 1991. Data Eval. Rec. 12 Pages.
Henry Craven. Ecological Effects Branch.
Avian Dietary LC50 Test. Mallard.
MRID 414764-03.
August 16, 1991. Memorandum. 93 Pages.
Yiannakis Ioannou. Toxicology Branch.
Metam-Sodium - Review of Two Developmental Toxicity Studies
in Rats and Rabbits Submitted by the Registrant.
Pages 41-52, 55-93 removed, registrant data.
MRID 415771-01, 403309-01
Tox Review No. 008520.
August 28, 1991. Memorandum. 5 Pages.
Ameesha Mehta. Occupational & Residential Exposure Br.
Expedited Review of Inhalation Worker Exposure Protocol from
the Metam-Sodium Task Force (HED Project # 1-2018).
October 22, 1991. Memorandum. 1 Page.
Yiannakis Ioannou. Toxicology Branch.
Metam Sodium - Report of Adverse Effects
Under Section 6 (a)(2) of FIFRA.
November 5, 1991. Review. 122 Pages.
Emil Regelman. Environmental Fate & Groundwater Branch.
Metam-Sodium Task Force
Review studies submitted in support of registration.
Hydrolysis, photodegradation in water, on soil, dissipation.
MRID 41631101, 41517701, 41097004, 41514401, -02, 41798601.
Pages 25-38, 43-50, 55-68, 74-91, 97-122 removed, reg. data.
November 12, 1991. Memorandum. 2 Pages.
Yiannakis Ioannou. Toxicology Branch.
Metam Sodium - Notification of Adverse Effects
Under FIFRA Section 6 (a)(2).
Tox review 008805.
December 24, 1991. Memorandum. 11 Pages.
Gary Burin. Science Analysis & Coordination Branch.
Developmental and Reproductive Toxicity Peer Review
of Metam-Sodium.
January 14, 1992. Memorandum. 20 Pages.
Yiannakis Ioannou. Toxicology Branch.
Metam Sodium - Review of Additional Data Submitted by the
Registrant in Support of the Developmental Toxicity Studies
in Rats and Rabbits with Metam Sodium.
Tox review 009030.
Attachment(s) following:
January 14, 1992. Memorandum.
K.E. Whitby. Toxicology Branch.
Addendum to MRID No. 41577101: Report on the Study of the
Prenatal Toxicity of Metam Sodium in Rats After Oral
Administration (Gavage).
*End of attachments*
March 18, 1992. Memorandum. 1 Page.
K. E. Whitby. Toxicology Branch.
Review of Supplemental Information on Historical Control
Skeletal Variations in the Metam Sodium Rat Teratology
Study Addendum to MRID 41577101.
April 2, 1992. Memorandum. 35 Pages.
Timothy McMahon. Toxicology Branch.
Sodium N-methyldithiocarbamate: Review of Toxicology Data
Submitted by the Registrant (UCB Chemicals, acute studies)
MRID Nos: 419861-01 through 419861-05; 421877-01.
Pages 18-22, 26, 30, 34 removed, registrant data.
Tox review 009416.
May 14, 1992. Memorandum. 23 Pages.
Yiannakis Ioannou. Toxicology Branch.
Metam Sodium - Review of a 90-Day Study in Mice
MRID No. 421173-01
from Tox review 009501.
June 1, 1992. Memorandum. 7 Pages.
K. Dockter. Chemistry Branch II.
Reregistration of Sodium methyldithiocarbamate. ICI
Americas Product Chemistry Considerations. Rereg.
case# 2390; Chemical# 39003. MRID#s 422771-01 & 02...
Guidelines 61-2, 62-1, 62-3.
June 23, 1992. Memorandum. 3 Pages.
Yiannakis Ioannou. Toxicology Branch.
Metam Sodium - Selection of Dose Levels for the
Chronic Toxicity Study in Dogs.
September 23, 1992. Memorandum. 2 Pages.
Timothy McMahon. Toxicology Branch.
Sodium N-methyldithiocarbamate: Review of Toxicology data
Submitted by the Registrant
MRID 424260-01. (Data submitted in support of acute tox
studies, MRIDs 419861-01 thru 05 and 421877-01)
Tox review 009737.
October 6, 1992. Memorandum. 3 Pages.
Mark Perry. Registration Support Branch.
EPA File Symbol/EPA Reg. No. : 5481-350 Metam-Sodium.
Amvac Chemical submitted a dermal irritation study...
MRID 422831-01
Tox review 009914.
November 6, 1992. Memorandum. 2 Pages.
Douglas Urban. Ecological Effects Branch.
Data Review for PNMDC
Please Note- The bean sheet accompanying the [bluegill
sunfish and rainbow trout acute toxicity] studies also
questioned if the studies could be used to support
the reregistration of... metam sodium.
November 24, 1992. Memorandum. 31 Pages.
Linnea Hansen. Toxicology Branch.
Section 18: 93DA0001 - 15. Quarantine Exemption
Renewal Request by APHIS for the Use of Various
Pesticides on Multiple Nonfood/Nonfeed Commodities.
December 23, 1992. Memorandum. 2 Pages.
William Sette. Science Analysis Branch.
Metam Sodium: ICI Proposal for route, dose levels, and
special measures for 90 day Neurotoxicity Study.
December 30, 1992. Memorandum. 2 Pages.
K. Dockter. Chemistry Branch II.
Reregistration of Metam-sodium. UCB Chemicals Corp.
Product Chemistry Considerations. Rereg. case# 2390;
Chemical# 39003. MRID# 424989-01...
Guideline 61-1.
January 5, 1993. Memorandum. 3 Pages.
Freshteh Toghrol. Chemistry Branch II.
Metam Sodium (Sodium Methyldithiocarbamate)
Reregistration (Case No. 2390, Chemical No. 039003):
The Metam Sodium Task Force (10/6/92) Response
to the Phase 4 DCI Concerning "Test Substance" for
Product Chemistry 61, 62, and 63 Series. No MRID.
January 29, 1993. Memorandum. 7 Pages.
William Woodrow. Registration Support Branch.
EPA Reg. No./File Symbol 10182-150
Vapam Soil Fumigant For All Crops.
The Stauffer Chemical Company submitted a new
primary dermal irritation study. MRID 425214-01
Tox review 010218.
February 12, 1993. Memorandum. 25 Pages.
Timothy McMahon. Toxicology Branch.
Sodium N-methyldithiocarbamate (Metam Sodium): Review of a
Study Submitted by the Registrant under Section 6a2 of FIFRA
Pages 24-25 removed, registrant data.
Tox review 010028.
April 21, 1993. Memorandum. 18 Pages.
Timothy McMahon. Toxicology Branch.
Sodium N-methydithiocarbamate (Metam Sodium): Review of
Toxicology Data Submitted by the Registrant.
MRID 421173-02
Tox review 010180.
July 27, 1993. Memorandum. 7 Pages.
Timothy McMahon. Toxicology Branch.
Sodium N-methyldithiocarbamate (Metam Sodium)
Action Requested: Provide current information and status
of the Toxicology database for Metam Sodium.
October 1, 1993. Review. 8 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Submission of additional information supporting
why potassium methyldithiocarbamate aquatic studies can be
used to support SNMDC.
December 8, 1993. Memorandum. 47 Pages.
Timothy McMahon. Toxicology Branch.
Metam Sodium: Review of a Rat Developmental Toxicity
Study Submitted by the Registrant under FIFRA Section 6(a)2.
Review of a Rabbit Developmental Toxicity Study.....
MRID 429837-01, 429632-01. Pages 38-47 removed, reg. data.
Tox review 010693.
January 12, 1994. Review. 23 Pages.
Anthony Maciorowski. Ecological Effects Branch.
Submission of avian dietary studies in
support of reregistration of List B, Case No. 2390
Pages 10-11, 17 removed, registrant data.
MRID 429140-01, 02.
March 11, 1994. Memorandum. 26 Pages.
Timothy McMahon. Toxicology Branch.
Metam Sodium: Review of an Acute Neurotoxicity Study
Submitted by the Registrant
MRID 429778-01, 02. Pages 21 & 24 removed, registrant data.
Registrant data on page 22 is not included.
from Tox review 010828.
April 21, 1994. Memorandum. 34 Pages.
Timothy McMahon. Toxicology Branch.
Metam Sodium: Review of a 2-Generation Reproduction Study
in Rats Submitted by the Registrant.
Pages 3-7 removed, registration data.
MRID 431361-01
Tox review 010928.
May 5, 1994. Memorandum. 15 Pages.
Ameesha Mehta. Occupational and Residential Exposure Br.
Worker and Residential Exposure Assessment of Metam-Sodium
MRID 42968402, 42440501, 42968401, 42791701, 42659901.
June 17, 1994. Memorandum. 2 Pages.
Timothy McMahon. Toxicology Branch.
Metam Sodium: Review of an Acute Neurotoxicity Study in Rats
MRID 429778-01
from Tox review 011050.
June 22, 1994. Memorandum. 23 Pages.
Ameesha Mehta. Occupational and Residential Exposure Br.
Worker and Residential/Bystander Risk Assessment
of Metam Sodium During Soil Applications.
July 29, 1994. Memorandum. 34 Pages.
Timothy McMahon. Toxicology Branch.
Metam Sodium: Review of a Mouse Carcinogenicity Study
Submitted Under FIFRA Section 6(a)(2) by the Registrant
Page 34 removed, registrant data.
MRID 432335-01.
from Tox review 011139.
August 30, 1994. Memorandum. 52 Pages.
Timothy McMahon. Toxicology Branch.
Metam Sodium: Review of a Chronic Toxicity/ Carcinogenicity
Study in Rats and Chronic Toxicity Study in Dogs Submitted
by the Registrant.
MRID 432758-01, 432758-02
Tox review 11192.
September 7, 1994. Memorandum. 3 Pages.
Timothy McMahon. Toxicology Branch.
Methyl isothiocyanate (MITC): Review of Interim Risk
Assessment for MITC by the Department of Pesticide
Regulation, State of California.
September 7, 1994. Memorandum. 15 Pages.
Timothy McMahon. Toxicology Branch.
Metam Sodium: Review of a Subchronic Neurotoxicity Study
in Rats. MRID 432488-01
Registrant data on pages 11, 12, 13 not included.
Page 15 removed, registrant data.
from Tox review 011202.
December 1, 1994. DER. 4 Pages.
Susan Makris. Toxicology Branch.
Chemical: Metam Sodium
From: Developmental/Reproduction RfD Subcommittee
The HED Developmental and Reproductive Toxicity Peer Review
Committee met on October 15 and December 12, 1991
to evaluate the data package for metam sodium.
January 18, 1995. Memorandum. 9 Pages.
George Ghali. Health Effects Division.
RfD/Peer Review Report of Metam Sodium [Sodium N-
methyldithiocarbamate].
Tox review 011421.
February 1, 1995. Memorandum. 24 Pages.
Timothy McMahon. Toxicolgy Branch.
Metam Sodium Qualitative Risk Assessment Based On
Hsd/Ola: Wistar Tox Rat and C57BL/10JfCD-1/Alpk Mouse
Drinking Studies.
Tox review 012763.
February 8, 1995. Memorandum. 127 Pages.
Esther Rinde. Health Effects Division.
Carcinogenicity Peer Review Meeting on METAM SODIUM.
March 10, 1995. Memorandum. 2 Pages.
Bernice Fisher. Science Analysis Branch.
Metam Sodium-Quantitative Risk, Q1*, Two-Year Drinking
Water Study in C57BL/10JfCD-1/Alpk Mice.
April 26, 1995. Memorandum. 9 Pages.
Deborah McCall. Risk Characterization & Analysis Branch.
REVISED Margins of Exposure for Worker and
Residential/Bystanders During Applications of Metam
Sodium.
May 1, 1995. Memorandum. 25 Pages.
Timothy McMahon. Toxicology Branch II.
Carcinogenicity Peer Review of Metam Sodium
Tox review 0011541.
May 1, 1996. Memorandum. 2 Pages.
Timothy McMahon. Toxicology Branch.
Review of Additional Data Submitted for a Subchronic
Neurotoxicity Study with Metam Sodium.
MRID 43875201 and 43875202 End of May 1999.
June 18, 1996. Memorandum. 3 Pages.
Jim Carleton. Occupational and Residential Exposure Br.
Review of proposal to shorten reentry interval for Metam 376
(Metam Sodium) from 48 hours to 8 hours
MRID No 439343-01.
June 26, 1996. Memorandum. 11 Pages.
Stephanie H. Willett. Chemistry Branch I.
Metam-Sodium. Registrant Response to Residue Chemistry
Reregistration Data Deficiencies. Reregistration Case No.
2390. Chemical I.D. No.039003. D215298. MRID Nos. 43632600,
43632601, 43632602. CB No. 15996.
April 20, 1998. Memorandum. 24 Pages.
Dana Spatz. Environmental Risk Branch.
Metam Sodium - Request for a waiver of the Spray Drift Data
Requirements (201-1 and 202-1). Letter from Carl F. Watson
(Buckman Laboratories) dated February 19, 1998 and revised
labels [Busan 1236 (EPA Reg. No. 1448-361) and Busan 1020
(EPA Reg. No. 1448-85) which delete Sprinkler Irrigation use.
March 21, 2000. Memorandum. 23 Pages.
P.V. Shah. Registration Action Branch.
Metam Sodium - Report of the Hazard Identification
Assessment Review Committee.
August 7, 2002. Memorandum. 23 Pages.
Steven Weiss. Reregistration Branch 3 HED.
Study Review of Field Volatility of Metam-Sodium During
and After Applications (MRID 42659901).
January 10, 2003. DER. 12 Pages.
Judy Facey. Reregistration Branch 2.
Subchronic toxicity - dog (capsule); OPPTS 870.4100b;
OECD 452. Tox Review No. 0051394. Registration Data info
removed from pages 5-12.
MRID No. 42600001.
May 13, 2004. Memorandum. 7 Pages.
Anna Lowit. Reregistration Branch 2 HED.
Quantification of carcinogenic potential for MITC with
metam sodium cancer slope factor.
Tox review 0052547.
* See MITC file for copy.
August 19, 2004. DER. 4 Pages.
Judy Facey. Reregistration Branch 2.
Subchronic toxicity - dog (capsule); OPPTS 870.4100b;
OECD 452. Tox Review No. 0051475.
MRID No. 42600001.
Attachment(s) following:
August 19, 2004. DER. 2 Pages.
Judy Facey. Reregistration Branch 2.
DER for Metam sodium (039003) & Methyl isothiocynate (MITC,
PC Code 008103). Tox Review No. 0051475.
MRID No. 42600001.
*End of attachments*
August 19, 2004. Memorandum. 9 Pages.
Anna Lowit. Reregistration Branch 2 HED.
Addendum to Memo from May 13, 2004 (TXR No. 0052547):
Quantification of carcinogenic potential for MITC
with metam sodium cancer slope factor and cancer
classification of metam sodium. * See MITC file for copy.
Tox review 0052776.
September 30, 2004. Memorandum. 64 Pages.
Sherrie Kinard. Reregistration Branch 2 HED.
Metam sodium: HED Human Health Risk Assessment For Phase 1:
DP Barcode308417, Metam Sodium PC Code: 039003, MITC PC
Code: 068103. * See MITC file for copy.