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Index of Cleared Science Reviews
Index for Bifenthrin (Pc Code 128825)
January 3, 1984. Review. 2 Pages.
Allen Vaughn. Ecological Effects Branch.
Effect on pesticides on apiculture; maximizing the
effectiveness of honey bees as pollinators. 1981 Report of
Research to California Alfalfa Seed Production Research
Board.
Acc. No. 251727.
January 6, 1984. Memorandum. 30 Pages.
Robert Zendzian. Toxicology Branch.
FMC 54800 (2EC formulation) Experimental Use Permit.
Acute toxicology studies. Inert ingredient info on pages
2-3 not included. Page 19 removed, inert information.
Accession # 251726, 251725. Registration # 279-EUP-RNR.
Tox review 003585.
June 4, 1985. Memorandum. 52 Pages.
Byron Backus. Toxicology Branch.
FMC 54800 Technical. Talstar 2 EC Insecticide/Miticide.
Talstar 10 WP Insecticide/Miticide.
Manufacturing process information on pages 13, 30, 38, 43,
and 49-50 is not included.
Tox review 004501.
June 24, 1985. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
Experimental Use Permit for FMC 54800 (Biphenthrin,
Brigade, Capture) and Temporary Tolerances for Cottonseed
and Apples. Caswell #463F.
Tox review 004502.
July 11, 1985. Memorandum. 8 Pages.
Allen Vaughn. Ecological Effects Branch.
Registration Standard for Talstar - Nontarget Insect Studies
MRID VAU0TA01.
August 14, 1985. Memorandum. 4 Pages.
John Tice. Science Integration Staff.
Talstar Cover Memo: Statement of Scientific
Findings and a Discussion of Registration Potential.
September 23, 1985. Memorandum. 114 Pages.
Byron Backus. Toxicology Branch.
FMC 54800 Technical. "Three mutagenicity studies reviewed."
Pages 10-13, 22-44, 54-58, 68-72, 81-103, 111-114 removed,
registrant data. Accession 254405.
Tox review 004670.
September 24, 1985. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
FMC 54800 Technical.
Review a set of five mutagenicity studies.
Tox review 004683.
December 3, 1985. Memorandum. 15 Pages.
Byron Backus. Toxicology Branch.
FMC 54800 (Bifenthrin) Mutagenicity Studies.
Acc. 259434.
Tox review 004820.
January 30, 1986. Memorandum. 5 Pages.
Byron Backus. Toxicology Branch.
FMC 54800. Registration #279-3055, 279-3056, 279-3057.
Accession # 260700. 6(a)(2) data.
Tox review 004907.
February 5, 1986. Memorandum. 4 Pages.
Byron Backus. Toxicology Branch.
FMC 54800. 21-day dermal, rabbit; 13-week dog feeding;
rat teratology. Acc. 260178
Tox review 004921.
August 8, 1986. Memorandum. 66 Pages.
Byron Backus. Toxicology Branch.
FMC 54800 (Bifenthrin).
review of a 2-year rat chronic feeding/oncogenicity study, a
rat reproduction/2-generation study, and a mouse onco study.
Manufacturing process info pgs 16-17, 33-35, 45 not included
Tox review 005336.
August 12, 1986. Review. 2 Pages.
Michael Rexrode. Ecological Effects Branch.
Reg. No. 279-3055. Bifenthrin Technical.
Submission of Fish Life-Cycle Protocol for Review.
September 15, 1986. Memorandum. 3 Pages.
J. Garbus. Residue Chemistry Branch.
EPA Reg. No. 279-3055. Bifenthrin: Amended Registration to
Reflect Changes in Manufacturing Process and Physical State
of Technical Material. Accession No. 262950; RCB No. 1056.
October 20, 1986. Memorandum. 22 Pages.
Byron Backus. Toxicology Branch.
FMC 54800 100 g/l EC. Acute toxicology studies.
EPA Reg. No. 279-3056.
Accession 260449.
Tox review 005540.
November 5, 1986. Memorandum. 4 Pages.
Byron Backus. Toxicology Branch.
FMC 54800 (Bifenthrin)
Review of a submission... on spontaneous neoplasms in
Swiss-Webster mice.
December 8, 1986. Report. 17 Pages.
FMC Toxicology Department. FMC Corporation.
Bifenthrin. Response to U.S. EPA Toxicology Branch Reviews
of Rat Chronic/Oncogenicity and Mouse Oncogenicity Studies
Conducted with Bifenthrin.
Manufacturing process information on page 7 is not included.
December 19, 1986. Review. 2 Pages.
Emil Regelman. Exposure Assessment Branch.
Reg. No. 279-3055. Brigade, Capture 2 EC, Talstar.
Protocol - Static Acculmulation in Fish.
February 20, 1987. Memorandum. 146 Pages.
Marcia Gemert. Toxicology Branch.
F petition for bifenthrin on cottonseed, meat/milk.
Pages 10-15, 20-30, 35-42, 46-54, 59-72, 78-105, 110-130
and 138-146 removed, registrant data.
Tox review 005731.
March 10, 1987. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
FMC 54800 (Bifenthrin)
Review of tumor incidence data in... mice.
March 19, 1987. Memorandum. 2 Pages.
Marcia van Gemert. Toxicology Branch.
Addition of New Impurity to Bifenthrin Technical.
Manufacturing process information on pages 1 & 3 is not
included.
April 8, 1987. Memorandum. 6 Pages.
Richard Levy, et. al. Toxicology Branch.
Bifenthrin Mouse Study - Qualitative and Quantitative Risk
Assessment of Combined Toxicity and Oncogenicity Study
in Mice. Caswell #463F.
April 16, 1987. Memorandum. 9 Pages.
Charles Frick. Tolerance Assessment Program.
Tolerance Assessment Analysis on the Chemical Bifenthrin.
(New Chemical).
April 27, 1987. Memorandum. 2 Pages.
Marcia van Gemert. Toxicology Branch.
Addition of [redacted] new impurities from a new
manufacturing process for Bifenthrin, RCB deferral.
Manufacturing process information pages 1, 2 not included.
May 28, 1987. Memorandum. 13 Pages.
Laurie Lewis. Exposure Assessment Branch.
Bifenthrin Exposure Assessment.
June 2, 1987. Memorandum. 12 Pages.
Judith Hauswirth. Toxicology Branch.
Peer Review of Bifenthrin.
June 15, 1987. Memorandum. 4 Pages.
Charles Frick. Health Effects Division.
Tolerance Assessment Analysis on the Chemical
Bifenthrin. (New Chemical). Temporary Tolerance
Proposals for Strawberries (5G3289), Pecans (6G3313)...
June 16, 1987. Memorandum. 2 Pages.
Marcia van Gemert. Toxicology Branch.
Impurities found in the new manufacturing process for
Bifenthrin.
Manufacturing process information pages 1,2 not included.
June 19, 1987. Final Report. 58 Pages.
Dynamac Corporation.
Bifenthrin.
Task 1: Review and Evaluation of Individual Studies.
Task 2: Environmental Fate Assessment
Acc. 264642.
June 23, 1987. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
Applicator Exposure Risk for Bifenthrin.
July 14, 1987. Memorandum. 1 Page.
Edwin Tinsworth. Registration Division.
Expedited Comparative Review of Ecological Effects of
Azodrin/Supracide/Capture and of Diazinon/Metasystox R/
Cygon.
July 23, 1987. Memorandum. 8 Pages.
Harry Craven. Ecological Effects Branch.
Comparative Risk Assessment on Ecological Effects of
Azodrin, Supracide, Metasystox R, Furadan 4F, Capture,
Cygon, and Diazinon to Avian Species.
September 29, 1987. Review. 2 Pages.
Les Touart. Ecological Effects Branch.
Re. No. 279-3055. Bifenthrin.
Registrant Request for Confirmation of Discussion on
Proposed Protocol Changes for Aquatic Field Study.
October 6, 1987. Review. 2 Pages.
Les Touart. Ecological Effects Branch.
Reg. No. 279-3055. Bifenthrin.
Submission of Daphnia Magna Life Cycle Study with Raw Data.
Acc. 265012.
October 15, 1987. Review. 4 Pages.
Les Touart. Ecological Effects Branch.
Reg. No. 279-3055. Bifenthrin
Submission of Oyster Shell Deposition Study.
MRID 402665-01.
November 4, 1987. DER. 4 Pages.
Allen Vaughn. Ecological Effects Branch.
Effect on pesticides on apiculture; maximizing the
effectiveness of honey bees as pollinators. (Report of 1986
FMC 54800 field tests on honey bees). Project No. 1499.
Submitted by FMC Corp., Philadelphia, PA.
Acc. No. 264649.
December 14, 1987. Memorandum. 4 Pages.
Margaret Jones. Toxicology Branch.
Bifenthrin Pesticide Petition 7F3453 for a permanent
tolerance for residues of (2-methyl [1,1-biphenyl]-3-yl
methyl-3-(2-chloro-3,3,3-trifluoro-1-propenyl) -2,2-
dimethyl cyclopropanecarboxylate in or on cottonseed/milk,
meat ...; response to company letter and to RCB deferral.
February 10, 1988. Review. 39 Pages.
Emil Regelman. Exposure Assessment Branch.
6F3453. Bifenthrin.
Review registrant's response to EAB's review dated
August 7, 1987.
MRID 404140-01.
March 2, 1988. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
Subject: TS Impurity.
Reg. No. 279-3055.
Review 4 mutagenicity studies (Ames assay, CHO/HGPRT assay,
CHO chromosomal aberration, and UDS assay... rat oral LD50.
Manufacturing process info on page 1 not included.
March 28, 1988. Review. 3 Pages.
Les Touart. Ecological Effects Branch.
File Number 279-3055. Biphenthrin.
Registrant Response to Previous EEB Review.
April 20, 1988. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
Bifenthrin G Petition Extension - Walnuts [5G3238].
April 20, 1988. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
Bifenthrin G Petition Extension - Corn [5G3235].
April 29, 1988. Memorandum. 15 Pages.
Byron Backus. Toxicology Branch.
Bifenthrin Metabolism Studies [rat].
Page 15 removed, registrant data.
Accession 404151.
Tox review 006697.
May 9, 1988. Memorandum. 1 Page.
Byron Backus. Toxicology Branch.
Additional Information on TS Impurity CHO/HGPRT Assay.
[clarification... by the registrant... regarding
the solubility and osmolality limit of FMC 102032].
June 28, 1988. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
FMC Response to EPA Review of 52 Week Chronic Oral Toxicity
Study in Dogs.
Tox review 006888.
July 8, 1988. Memorandum. 1 Page.
Michael Firestone. Exposure Assessment Branch.
Use Information for Bifenthrin.
July 15, 1988. Memorandum. 9 Pages.
Yuen-Shaung Ng. Science Support Branch.
Transmittal of Exposure Parameters for Bifenthrin
in Cotton.
July 19, 1988. Memorandum. 10 Pages.
Michael Firestone. Exposure Assessment Branch.
Conduct exposure assessment for ornamental,
non-food, greenhouse use.
Pages 6-8 removed, draft label.
July 20, 1988. Summary. 4 Pages.
Rick Whiting. Health Effects Division.
Biphenthrin
Reference Dose for Chronic Oral Exposure (RfD)
Acc. 264637.
July 20, 1988. Memorandum. 3 Pages.
Robert Zendzian. Toxicology Branch.
Bifenthrin, Protocol for Dermal Absorption.
July 28, 1988. Memorandum. 3 Pages.
Yuen-Shaung Ng. Science Support Branch.
Transmittal of Exposure Parameters for Bifenthrin
in Greenhouses.
July 28, 1988. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
FMC Response to EPA Review of a CHO/HGPRT Mutation Assay.
August 4, 1988. Review. 2 Pages.
Les Touart. Ecological Effects Branch.
File Number 279-3055. Bifenthrin.
Registrant Response Concerning Gizzard Shad Mortalities.
August 10, 1988. Memorandum. 2 Pages.
James Akerman. Ecological Effects Branch.
Gizzard Shad Mortalities in Bifenthrin Pond Study.
September 29, 1988. Review. 8 Pages.
Les Touart. Ecological Effects Branch.
File Number 279-3055. Bifenthrin.
Supplementary study addressing effects on oyster
embryo-larvae.
MRID 403835-01.
September 29, 1988. Review. 2 Pages.
James Akerman. Ecological Effects Branch.
Reg. No. 279-3055. Bifenthrin.
Submission of Preliminary Results [via 6(a)(2)] from
Pond Study.
January 25, 1989. Review. 54 Pages.
James Akerman. Ecological Effects Branch.
File Number 279-3055, 279-3069.
Submission of raw data for fathead minnow life-cycle study.
Pages 8-54 removed, registrant data.
MRID407913-01.
March 15, 1989. Memorandum. 3 Pages.
John Doherty. Toxicology Branch.
EPA Reg. No.: 279-3057. Bifenthrin: Contamination
of the product TALSTAR 10 WP with cypermethrin.
Registrants request to market TALSTAR 10 WP
containing approximately 1000 ppm (0.1%)
cypermethrin. Commercial/financial info pgs 1,2 not included.
May 4, 1989. Review. 3 Pages.
James Akerman. Ecological Effects Branch.
File Number 279-3069. Capture 2EC (Bifenthrin).
Registrant Response to Previous EEB Review of Fish Full
Life-Cycle Study.
June 28, 1989. Review. 4 Pages.
James Akerman. Ecological Effects Branch.
Reg. No. 279-3069. Capture 2EC. Registrant Response
Concerning Agency's Review of Fish Life-Cycle Study.
August 3, 1989. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch.
TFP Acid Impurity in Bifenthrin.
August 14, 1989. Memorandum. 9 Pages.
Steven Knott. Non-Dietary Exposure Branch.
Non-Dietary Exposure Assessment for the Application
of Capture 2 EC (Bifenthrin) to Seed Corn and PoP Corn
(HED Project # 9-1859 and 9-1524).
October 5, 1989. Review. 3 Pages.
Emil Regelman. Environmental Fate & Groundwater Branch.
Reg. Nos. 279-3055, 279-3069. Capture 2 EC.
Review of an 08/10/89 Letter from FMC Corporation to OPP
Requesting an Extension of 12 Months for Submitting the
Terrestrial Field Dissipation Report.
November 9, 1989. Memorandum. 6 Pages.
James Akerman. Ecological Effects Branch.
EEB Reconsideration of FMC Fathead Minnow Life-Cycle Study
Conducted with Capture 2EC.
January 8, 1990. Memorandum. 8 Pages.
Curt Lunchick. Non-Dietary Exposure Branch.
Reevaluation of Closed System Label Resriction
for Capture 2EC (Bifenthrin)
(HED Project #0-0201).
February 6, 1990. Memorandum. 4 Pages.
Curt Lunchick. Non-Dietary Exposure Branch.
Mixer/Loader and Applicator Exposure Assessment
for Section 18 Use of Bifenthrin on Hops in
Washington (HED Project #0-0726B).
July 30, 1990. Memorandum. 10 Pages.
Anne Lindsay. Registration Division.
Section 18 - Reinstatement of Kansas' and Nebraska's Crisis
Authority for Use of Bifenthrin (Capture) to Control Various
Mites on Field Corn - Action Memorandum.
August 31, 1990. Review. 92 Pages.
James Akerman. Ecological Effects Branch.
Submission of Pond Study Results to Support Conditional
Registration of Cotton Use.
Pages 12-13, 19-22, 45-59, and 70-92 are not included -
registrant data.
September 18, 1990. Memorandum. 3 Pages.
Stephanie Irene. Registration Division.
Section 18 - Reinstatement of Kansas' and Nebraska's Crisis
Authority for Use of Bifenthrin (Capture) to Control Various
Mites on Field Corn - Action Memorandum.
September 27, 1990. Memorandum. 2 Pages.
Curt Lunchick. Non-Dietary Exposure Branch.
Applicator and Occupant Exposure to Bifenthrin
during Experimental Use as a Termiticide (HED
Intra #0049).
October 2, 1990. Memorandum. 9 Pages.
Anne Lindsay. Registration Division.
Section 18 - Specific Exemption for Use of Bifenthrin
(Capture) to Control Various Mites on Seed Corn in Texas -
Action Memorandum.
April 10, 1991. Memorandum. 41 Pages.
James Akerman. Ecological Effects Branch.
Amended Data Evaluation Record for the Bifenthrin Pond Study
Conducted by FMC Corp.
MRID 409818-01.
July 15, 1991. Memorandum. 7 Pages.
David Jaquith. Occupational and Residential Exposure Br.
Review of Bifenthrin EUP for Termiticide Use
(HED Projects 1-0321, 1-0774, 1-1057).
July 30, 1991. Notes. 13 Pages.
anonymous. Occupational and residential Exposure Br.
Bifenthrin
Use: on nursery stock (balled) & sod
for quarentine from infected areas...
Commercial/financial information on page 9 not included.
November 5, 1991. Memorandum. 94 Pages.
Byron Backus. Toxicology Branch 2.
Toxicology Data on Two Bifenthrin Technical Impurities (FMC
78161 & FMC 78162). Manufacturing Process info removed from
pages 4, 7 & 53; Registration Data removed from pages 14-20,
26-30, 37-50, 57-63, 69-74 & 81-94.
December 12, 1991. Memorandum. 17 Pages.
Alfred Smith. Registration Support Branch.
Product Chemistry Review of Bifenthrin Technical
Insecticide/Miticide (EPA Reg. No. 279-3055).
Manufacturing Process Info removed from pages 5-17.
January 3, 1992. Memorandum. 49 Pages.
Esther Rinde. Health Effects Division.
Carcinogenicity Peer Review Meeting on Bifenthrin 3rd.
Pages 13-25 are not included - registrant data.
January 29, 1992. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch 2.
Addendum to Mouse Oncogenicity Study on Bifenthrin.
April 29, 1992. Memorandum. 13 Pages.
Byron Backus & Esther Rinde. Science Analysis and Coordination Branch.
Third Carcinogenicity Peer Review of Bifenthrin.
July 6, 1992. Memorandum. 2 Pages.
Byron Backus. Toxicology Branch 2.
Histopathogical Reevaluation of Microscope Slides From the
Biphenthrin Mouse Carcinogenicity Study.
August 3, 1992. Memorandum. 5 Pages.
Bruce Kitchens. Occupational and Residential Exposure Br.
Review FMC Request for Removal of the Closed System
Mixing/Loading Label Requirement for Five Bifenthrin
Formulations and Dislodgeable Residue on Cotton Leaves
for Capture 2.0 EC Insecticide/Miticide.
August 13, 1992. Memorandum. 3 Pages.
Byron Backus. Toxicology Branch.
Toxicology Comments on Worker Exposure Study to Support
Application for Registration of Biflex Termiticide.
Tox review 009672.
March 25, 1993. Memorandum. 11 Pages.
Bruce Kitchens. Occupational and residential Exposure Br.
Review Dislodgeable Foliar Residue data for the Use of
Bifenthrin on Cotton.
MRID 419175-04, 419175-05.
Pages 9-11 removed, registrant data.
November 1, 1993. Memorandum. 14 Pages.
David Jaquith. Occupational and Residential Exposure Br.
Review of Study Monitoring Exposure to Mixer/Helpers
and Applicators to Bifenthrin Insecticide Used as a
Post Construction Termiticide.
June 30, 1994. Memorandum. 6 Pages.
Bruce Kitchens. Occupational and Residential Exposure Br.
Evaluation of Foliar Dislodgeable Residue Study on
Chrysanthemums and Roses with Talstar WSB
Insecticde/Miticide (a.i. bifenthrin)
MRID 421422-00, 421422-01.
March 18, 1997. Memorandum. 6 Pages.
Mark Perry. Registration Support Branch RD.
Primary Dermal Irritation 6(a) (2) Data Review for EPA
Reg No. 279-3160, DP Barcode D234285.
FMC Corporation.
MRID 43758405, 44226201.
November 14, 1997. Memorandum. 170 Pages.
P. Hurley et al. RAB2/HED.
Risk Assessment for Extension of Tolerances for Synthetic
Pyrethroids.
Attachment(s) following:
October 18, 1997. Memorandum.
Jess Rowland. Science Analysis Branch, HED.
Synthetic Pyrethroids - Report of the Hazard Identification
Assessment Review Committee (Attachment 1, page 3).
November 12, 1997. Memorandum.
Karl Baetcke.
Clarefication of Data Requirements for Pyrethroids and
Documentation of Decision Logic Applied to Determination
of Appropriate Uncertainty Factors for Infants and Children.
(Attachment 1, Appendix A, page 17).
September 12, 1997. Note.
David Brassard. Biological Analysis Branch, BEAD.
Review of Pyrethroid Working Group Percent Crop Treated
Estimates (Attachment 3, page 29).
October 8, 1997. Note.
David Brassard. Biological Analysis Branch, BEAD.
Review of Pyrethroid Working Group Percent Crop Treated
Estimates (page 35).
Undated. Memorandum.
Robert Matzner. Environmental Fate and Effects Division.
Preliminary Estimates of Synthetic Pyrethroid Drinking Water
Concentrations (Attachment 4, page 38).
Undated. .
Non-Dietary Exposure and Risk Assessments for the Synthetic
Pyrethroids (Attachment 5, page 41).
Undated. .
Bifenthrin. Toxicology and Residue Chemistry Details
(Attachment 6).
Undated. .
Cyfluthrin. Toxicology and Residue Chemistry Details
(Attachment 7, page 106).
Undated. .
Cyhalothrin. Toxicology and Residue Chemistry Details
(Attachment 8, page 128).
July 28, 1997. Review.
Jess Rowland. HED.
Toxicology Endpoint Selection Document; lambda-Cyhalothrin.
Undated. .
Cypermethrin. Toxicology and Residue Chemistry Details
(Attachment 9, page 151).
*End of attachments*
November 14, 1997. Memorandum. 13 Pages.
Jess Rowland. Science Analysis Branch.
SYNTHETIC PYRETHROIDS - REVISED Report of the Hazard
Identification Assessment Review Committee.
June 11, 1999. Memorandum. 30 Pages.
Yan Donovan. Registration Action Branch.
PP#6F04629, PP#6E04760, PP#8E05009, PP8E04993, PP#8E5064,
PP#8F5014, PP#9E5069, PP#9E5084. FQPA Human Health Risk
Assessment for Bifenthrin - Proposal for Tolerance of
Residues in/on Globe Artichoke, Cucubits, Eggplalnts, Legume
Vegetalbes, Peas & Beans, Sweet Corn, Head & Stem Brassica.
Attachment(s) following:
June 11, 1999. Memorandum.
Yan Donovan. Registration Action Branch.
Vegetables, and Canola.
*End of attachments*