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EPA Records Schedule 468
Status: Final, 10/31/2009
Title: Integrated Risk Information System (IRIS)
Program: Research and Development
Applicability: Agency-wide
Function: 316-258-03 - Human Health Research
NARA Disposal Authority:
This schedule authorizes the disposition of the record copy in any media (media neutral), excluding any records already in electronic form. Records designated for permanent retention must be transferred to the National Archives in accordance with NARA standards at the time of transfer.
- N1-412-01-1/2
Description:
The Integrated Risk Information System (IRIS) database contains summary toxicity information for use in human health risk assessment. IRIS is the Agency's primary vehicle for communication of chronic health hazard information representing EPA consensus positions following comprehensive review by Agency scientists. It is a useful information resource tool that points the user to the underlying human and/or animal data used to support the Agency's opinion. The system contains hazard identification and dose-response risk information for more than 500 chemicals.
IRIS is comprised of three major sections: non-cancer health effects resulting from oral exposure, non-cancer health effects resulting from inhalation exposure, and carcinogenic assessment for both oral and inhalation exposure. It contains full bibliographic citations for each substance file, directing the user to the primary cited studies and pertinent scientific literature. IRIS is accessible to the public as well as EPA staff.
Disposition Instructions:
Item a: Electronic software program
This item is to be used only by the Office of Research and Development, National Center for Environmental Assessment at Headquarters.
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Disposable
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Destroy when no longer needed to ensure access to, and use of, the electronic records throughout the authorized retention period.
Item b: Input
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Varies
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See EPA 460 - IRIS Documentation Files
Item c: Electronic data
This item is to be used only by the Office of Research and Development, National Center for Environmental Assessment at Headquarters.
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Permanent
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Transfer data annually to the National Archives, as specified in 36 CFR 1235.44-1235.50 or standards applicable at the time.
Item d: Output and reports
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Varies
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File with related records and follow instructions for the related records.
Item e: System documentation
This item is to be used only by the Office of Research and Development, National Center for Environmental Assessment at Headquarters.
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Permanent
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Transfer those records necessary to document how the system captures, manipulates, and outputs data to the National Archives, as specified in 36 CFR 1235.44-1235.50 or standards applicable at the time. Documentation is transferred with the electronic data (item c).
Guidance:
IRIS documentation files are scheduled as EPA 460.
Reasons for Disposition:
The following change was made in the 06/30/2008 version:
- Updated contact information.
The following changes were made in the 04/30/2008 version:
- Revised the disposition instructions for item a.
- Added applicability to disposition items a, c and e.
- Revised title of disposition item e.
IRIS was developed in response to a growing demand for consistent chemical substance risk information, representing EPA consensus opinions, for use in decision making and regulatory activities. It is intended to serve as a pointer system to more detailed data contained in supporting scientific studies. IRIS is available electronically on EPA's Web server, and updated as needed.
Custodians:
Office of Research and Development, National Center for Environmental Assessment
- Contact: Brenda E. Washington
- Telephone: 703-347-8581
Related Schedules:
EPA 460
Previous NARA Disposal Authority:
Entry: 03/01/1993
EPA Approval: 10/25/2000
NARA Approval: 10/20/2001