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Chemical Safety Research

EPA's Chemical Safety research protects human health and the environment by evaluating chemicals for potential risk and providing tools and guidance for improved chemical production that supports a sustainable environment.

Hormone Disrupting Chemicals

EPA research improves the understanding of potential risks to human health and wildlife from chemicals that could disrupt the endocrine (hormone) system.

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Endocrine disruption in fish and amphibians
Pharmaceuticals products and endocrine disruption
Risk management for endocrine disrupting chemicals
Using rapid, automated technology to assess chemicals for endocrine disruption
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Toxicity Testing in the 21st Century

EPA research integrates advances in molecular biology, chemistry and computer science to more effectively and efficiently rank chemicals based on risk.

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Exposure Science in the 21st century (ExpoCast)™
Toxicity Forecaster (ToxCast)™
Toxicity Testing in the 21st century collaboration (Tox21)
The Virtual Liver Project (v-Liver)™
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EPA researchers are working to understand the potential risks to humans and the environment from exposure to nanomaterials - materials thousands of times smaller than the width of a human hair.

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Types of nanomaterials under investigation
Nanosized fuel additives
Exposure to nanomaterials
Human Health Effects
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Sustainable Solutions

EPA is researching the sustainable molecular design of less toxic ("green") chemicals.

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Green Chemistry
Design for the Environment

Chemical Exposure & Cumulative Risk

There are biological responses in humans and animals that indicate exposure to a chemical, an effect from exposure to a chemical and susceptibility to adverse effects from a chemical.

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Biological Indicators
Cumulative Risk
Perfluorinated Chemicals
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Health and Chemical Safety

EPA researchers are working to better understand the important biological processes involved with adverse outcomes and improving methods that will better assess the impacts of chemical exposure to human health.

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PCBs in Caulk Research
Population and physiological variables
Virtual Embryo
Susceptible populations

Models, Databases and Tools

Researchers provide sophisticated models, databases and tools that are widely used to manage chemical safety across the nation.

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Computational Toxicology Data Warehouse
Chemical Exposure Studies Database
Ecological Toxicity Information Database
Community-Focused Exposure Risk Screening Tool
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Grants & Funding for Chemical Safety Research

EPA provides grants and funding to the nation's leading researchers to improve the scientific basis for decisions on national environmental issues.

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Nano Centers
CompTox centers
Sustainable Molecular Design RFA
Research on biological processes relevant to adverse health effects
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