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EPA at Society of Toxicology Annual Meeting

EPA Research Posters Featured at 2014 Society of Toxicology

Monday – March 24

Functional Assays and Alternative Species: Using Larval Zebrafish in Developmental Neurotoxicity Screening (PDF) (1 pp, 530 K, About PDF)
Stephanie Padilla; Megan Culbreth; Robert C. MacPhail; Deborah L. Hunter; Kimberly Jarema; Karl Jensen; Jeanene Olin; and Alan Tennant
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Integrated analysis of Mechanistic Considerations Informative to Cancer Mode of Action in the Upper Respiratory Tract Following Formaldehyde inhalation (PDF) (1 pp, 870 K, About PDF)
Jason M. Fritz, Lynn S. Adams, Andrew D. Kraft, Barbara S. Glenn, Danielle DeVoney, Suryanarayana V. Vulimiri, and Ravi P. Subramaniam
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Sensitivity Analysis of Internal Dose-Metrics for Hexavalent Chromium Toxicity Using Physiologically-Based pharmacokinetic Modeling (PDF) (1 pp, 378 K, About PDF)
Alan F. Sasso; Paul. Schlosser
Time: 9:30am-12:30pm
Location: CC Exhibit Hall

Quantitative Model of Systemic Toxicity Using ToxCast and ToxRefDB (PDF) (1 pp, 1.3 MB, About PDF)
Lisa Truong; Gladys Oeudraogo; Sophie Loisel-Joubert; Matt Martin
Time: 9:30am-12:30pm
Location: CC Exhibit Hall

Toxicity Screening of the ToxCast Phase II Chemical Library Using Zebrafish Developmental Assay (PDF) (1 pp, 701 K, About PDF)
Mosher S.; Houck K.; Frady S.; Judson R.; Wambaugh J.; Reif D.; and Padilla S.
Time: 9:30am-12:30pm
Location: CC Exhibit Hall

Effects of ToxCast Phase I Chemicals on Steroidgenesis in H295R Human Adrenocortical Carcinoma Cells (PDF) (1 pp, 303 K, About PDF)
MT Martin; AL Forgacs; DL Filer; KC Lewis; CM Toole
Time: 9:30am-12:30pm
Location: CC Exhibit Hall

Computational Embryology and Predictive Toxicology of Hypospadias (PDF) (1 pp, 1.1 MB, About PDF)
M.C.K. Leung; N.C. Baker; B.K. Ahir; C.J. Wolf; A.W. Seifert; M.S. Hutson; S.D. Perreault; R.M. Spencer; and T.B. Knudsen
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

Deriving Points of Departure and Performance Baselines for Predictive Modeling of Systemic Toxicity using ToxRefDB (PDF) (1 pp, 757 K, About PDF)
Keith McLaurin; Lisa Truong; Gladys Ouedraogo; Sophie Loisel-Joubert; Matthew Martin
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

Toluene PBPK Models to Extrapolate Neurological Effects between Rats and Humans, Across Acute Durations and Severity Categories (PDF) (2 pp, 743 K, About PDF)
George M. Woodall, PhD; Elaina M. Kenyon, PhD DABT; Vernon Benignus; Christopher Eklund; Philip J. Bushnell, PhD; and William K. Boyes, PhD
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

Utilization of Gene Expression Marker Data to Computationally Generate Nested Networks Underlying Embryonic Stem Cell Differentiation (PDF) (1 pp, 893 K, About PDF)
William LeFew; James Crooks; Mitch Rosen; Kelly Chandler; Sid Hunter
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

In Vitro Lung Model Considerations: Extent of Bronchial Epithelial Cell Differentiation Confounds Assessment of Pro-Inflammatory Response (PDF) (1 pp, 875 K, About PDF)
Emma. C. Bowers; Shaun D. McCullough; Juliette J. Kahle; Lisa. A. Dailey; David Diaz-Sanchez
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

Using High-Content Screening Data from ToxCast to Analyze Cell State Trajectories (PDF) (1 pp, 1.4 MB, About PDF)
Imran Shah; Woodrow Setzer; John Jack; Keith Houck; Thomas Knudsen; Matt Martin; David Reif; Ann M. Richard; David J. Dix; and Robert J. Kavlock
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

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Tuesday – March 25

Assessment of In Vivo Toxicological Interactions from Criteria Air Pollutant Mixtures (PDF) (1 pp, 1.3 MB, About PDF)
Laura Datko-Williams; Brianna Young; Adrien Wilkie; Meagan Madden; Jean-Jacques Dubois; Lindsay Wichers Stanek; Doug Johns; Beth Oesterling Owens
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Scoping the Need for PBPK Modeling of Child-Adult Metabolism Differences: Case Studies Applying and Enzyme Ontogeny Database (PDF) (1 pp, 102 K, About PDF)
Suryanarayana V. Vulimiri; Yu-Seng Lin; Jayaram Kancherla; Gary Ginsberg; Brenda Foos; and Bob Sonawane
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Evaluation of Environmental Chemicals Computationally Predicted to Disrupt Angiogenesis (PDF) (1 pp, 732 K, About PDF)
Tuula Heinonen; Tarja Toimela; Thomas B. Knudsen; Nicole C. Kleinstreuer; and Jertta-Riina Sarkanen
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Adaptation of T47D-Kbluc and MDA-kb2 to Screening and Comparison to Other Receptor Platforms (PDF) (1 pp, 468 K, About PDF)
Katie B. Paul; Dayne L. Filer; Richard S. Judson; Vicki S. Wilson; Kevin M. Crofton; Steven O. Simmons; Matthew T. Martin
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Identifying Developmental Vascular Disruption Compounds Using a Predictive Signature and Alternative Toxicity Models (PDF) (1 pp, 1.1 MB, About PDF)
Tamara Tal; Nicole Kleinstreuer; Peggy Harris; Jeanene Olin; Alisha Palekar; Tarja Toimela; Riina Sarkanen; Tuula Heinonen; Charles Wood; Michael Hemmer; Thomas Knudsen; and Stephanie Padilla
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Computational Modeling of Limb Development using ToxCastTM High-Throughput Screening Data for Predictive Toxicology (PDF) (1 pp, 1.1 MB, About PDF)
Ahir BK; Sipes NS; Spencer RM; Baker NC; Leung MCK; DeWoskin RS; Judson RS; Martin MT; and Knudsen TB
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Prenatal Inhalation Exposure to Evaporative Condensates of Gasoline with 15% Ethanol and Evaluation of Sensory Function in Adult Rat Offspring (PDF) (1 pp, 369 K, About PDF)
Boyes, William K.; Degn, Lyke; Beasley, Tracey E.; Evansky, Paul; Martin, Sheppard; Ortenzio, Jayna N.; Pantlin, Lara N.; Bushnell, Philip; and Herr, David W.
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

Developmental Thyroid Hormone (TH) Disruption: Sensitive Bioindicators of Altered TH-Dependent Signaling in Brain (PDF) (1 pp, 455 K, About PDF)
Carmen Wood; Andrew Johnstone; Mary Gilbert
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

Brain Malformation Following Maternal Hypothyroxinemia: Structural and Functional Characteristics (PDF) (1 pp, 2.2 MB, About PDF)
M.E. Gilbert; R.L. Ramos; D.P. McCloskey; J.H. Goodman; A. Johnstone
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

Biological and Behavioral Modifiers of Urinary Arsenic Metabolic Profiles in a U.S. Population (PDF) (1 pp, 941 K, About PDF)
David J. Thomas; Edward E. Hudgens; John Rodgers
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

Gestational Exposure to Inhaled Vapors of Ethanol and Gasoline-Ethanol Blends in Rats (PDF) (1 pp, 325 K, About PDF)
P.J. Bushnell; T.E. Beasley; P.A. Evansky; S.A. Martin; V.C. Moser; K.L. McDaniel; J. Norwood; C. Grace; C. Gordon; R.W. Luebke; C. Copeland; J.M. Rogers
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

Effects of Ethanol-Gasoline Blended Fuels on Learning and Memory (PDF) (1 pp, 292 K, About PDF)
TE Beasley; WM Oshiro; VC Moser; ME Gilbert; KL McDaniel; PA Evansky, and PJ Bushnell
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

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Wednesday – March 26

RNA-Seq Analysis of the Functional Link between Vascular Disruption and Adverse Developmental Consequences (PDF) (1 pp, 1.4 MB, About PDF)
Franzosa JA; Settivari RS; Ellis-Hutchiings RG; Kleinstreuer NC; Houck KA; Carney EW; Knudsen TB
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Ozone Induces Lung Epithelial Cell Inflammation Through MAP Kinase Activation Without NF-κB Activation (PDF) (1 pp, 1.3 MB, About PDF)
Shaun D. McCullough; Kelly E. Duncan; Samantha M. Swanton; Lisa Dailey; David Diaz-Sanchez; and Robert B. Devlin
Time: 9:00am-12:30pm
Location: CC Exhibit Hall

Comparing Bioactivity Profiles of Diverse Nanomaterials Based on High-throughput Screening (HTS) in ToxCast (PDF) (1 pp, 1.5 MB, About PDF)
A. Wang; J. Franzosa; I. Shah; D. Filer; N. Kleinsteuer; E. Berg; S. Marinakos; A. El-Badawy; K. Houck
Time: 1:00pm-4:30pm
Location: CC Exhibit Hall

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Thursday – March 27

Inferring Population Exposure from Biomonitoring Data on Urine Concentrations (PDF) (1 pp, 675 K, About PDF)
R. Woodrow Setzar; James R. Rabinowitz; John Wambaugh
Time: 8:30am-12:00pm
Location: CC Hall 1

High Throughput Exposure Estimation Using NHANES Data (PDF) (1 pp, 840 K, About PDF)
Cory Strope; Barbara Wetmore; Robert Pearce; Woodrow Setzar; James Rabinowitz; Kathie Dionisio; John Wambaugh
Time: 8:30am-12:00pm
Location: CC Hall 1

Protein-fragment Complementation Assays Detect and Describe Nuclear Receptor Activity across the ToxCast Chemical Library (PDF) (1 pp, 750 K, About PDF)
Dayne L. Filer; Richard Judson; Daniel Rotroff; David Reif; Ann M. Richard; Keith Houck; Matthew T. Martin
Time: 8:30am-12:00pm
Location: CC Hall 1

In-Silico Structure Activity Relationship Study of Toxicity Endpoints by QSAR Modeling (PDF) (1 pp, 1.3 MB, About PDF)
Kamel Mansouri; Nisha Sipes; and Richard Judson
Time: 8:30am-12:00pm
Location: CC Hall 1

Web Application Supporting Chemical Safety Decisions (PDF) (1 pp, 1.4 MB, About PDF)
Sean Watford; Jeff Edwards; Richard Judson; Monica Linnenbrink; Jayaram Kancherla; Matthew Martin
Time: 8:30am-12:00pm
Location: CC Hall 1

High Throughput Modeling of Indoor Exposures to Chemicals (PDF) (1 pp, 762 K, About PDF)
Chantel Nicolas; Rocky Goldsmith; Bhavesh K. Ahir; Thomas B. Knudsen; James Rabinowitz; R. Woodrow Setzer; Kamel Mansouri; and John Wambaugh
Time: 8:30am-12:00pm
Location: CC Hall 1

Estimation of Octanol/Warter Parition Coefficient and Aqueous Solubility of Environmental Chemicals Using Molecular Fingerprints and Machine Learning Methods (PDF) (1 pp, 475 K, About PDF)
Qingda Zang; Kamel Mansouri; Richard S. Judson
Time: 8:30am-12:00pm
Location: CC Hall 1

High Throughput Pharmacokinetics for Environmental Chemicals (PDF) (1 pp, 392 K, About PDF)
John Wambaugh; Cory Strope; Chantel Nicolas; Robert Pearce; Richard Judson; Rocky Goldsmith; Hisham El-Masri; Barbara Wetmore; James Sluka; Alex Tropsha; Sieto Bosgra; Imran Shah; Russell Thomas; and R. Woodrow Setzer
Time: 8:30am-12:00pm
Location: CC Hall 1

ToxCast Assay Annotation: an Application of BioAssay Ontology to Produce and Assay Metadata Reference (PDF) (1 pp, 873 K, About PDF)
Phuong, Jimmy; Houck, Keith A.; Truong, Lisa; Sipes, Nisha; Judson, Richard; Martin, Matthew
Time: 8:30am-12:00pm
Location: CC Hall 1

Integrating Biological and Chemical Data for Hepatotoxicity Prediction (PDF) (1 pp, 611 K, About PDF)
Jie Liu; Richard Judson; Matthew T. Martin; Huixiao Hong; and Imran Shah
Time: 8:30am-12:00pm
Location: CC Hall 1

ToxCast Workflow: High-Throughput Screening Assay Data Processing, Analysis and Management (PDF) (1 pp, 127 K, About PDF)
PG Kothiya; DL Filer; DM Reif; RS Judson; AM Richard; MT Martin
Time: 8:30am-12:00pm
Location: CC Hall 1

In Vitro Screening of 1877 Industrial and Consumer Chemicals, Pesticides, and Pharmaceuticals in up to 782 Assays; ToxCast Phase I and II (PDF) (1 pp, 424 K, About PDF)
R Judson; K Houck; M Martin; A Richard; T Knudsen; N Sipes; I Shah; S Little; J Wambaugh; W Setzer; J Franzosa; P Kothiya; J Phuong; K McLaurin; D Filer; MCK Leung; C Strope; L Truong; R Thomas; D Smith; D Reif; D Rotroff; N Kleinstreuer; M Xia; R Huang
Time: 8:30am-12:00pm
Location: CC Hall 1

Predicting Toxic and Therapeutic Mechanisms of the ToxCast Chemical Library by Phenotypic Screening (PDF) (1 pp, 1.1 MB, About PDF)
Houck K.; Kleinstreuer N.; Yang J.; Berg E.; Knudsen T.; Richard A.; Martin M.; Reif D.; Judson R.; Polokoff M.
Time: 8:30am-12:00pm
Location: CC Hall 1

Exploring Exposure Pathways with Chemical/Product Categorical (CPCat) Data (PDF) (1 pp, 164 K, About PDF)
KL Dionisio; A Frame; M-R Goldsmith; JF Wambaugh; A Liddell; T Cathey; D Smith; J Vail; RS Judson
Time: 8:30am-12:00pm
Location: CC Hall 1

Constructing a Cleft Palate Adverse Outcome Pathway through HTS Data and Literature Mining Integration (PDF) (1 pp, 500 K, About PDF)
Nancy C. Baker; Nisha S. Sipes; M. Shane Hutson; Thomas B. Knudsen
Time: 8:30am-12:00pm
Location: CC Hall 1

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