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Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC)

April 18 - 20, 2006 Meeting

Agenda

PDF File [4 pp., 210KB, About PDF] HTML File [19KB]

Federal Register Notices Announcing Meeting | Copy for Public Comment

Endocrine Disruptor Methods Validation Advisory Committee (EDMVAC); Notice of Public Meeting [PDF file, 3 pp., 94KB, About PDF]

Background Documents and Corresponding Presentation(s)

EDMVAC Workplan

Male and Female Pubertal Assay Interlaboratory Study

Individual Laboratory Summary Reports

Interlaboratory Validation of the Pubertal Male Assay - Charles River/Argus Male [PDF file, 48 pp., 311KB, About PDF]

Interlaboratory Validation of the Pubertal Female Assay - Charles River/Argus Female [PDF file, 38 pp., 311KB, About PDF]

Interlaboratory Validation of the Pubertal Male Assay - WIL Male [PDF file, 59 pp., 651KB, About PDF]

Interlaboratory Validation of the Pubertal Female Assay - WIL Female [PDF file, 53 pp., 850KB, About PDF]

Interlaboratory Validation of the Pubertal Male Assay - Huntingdon Male [PDF file, 49 pp., 1.9MB, About PDF]

Interlaboratory Validation of the Pubertal Female Assay - Huntingdon Female [PDF file, 51 pp., 1.9MB, About PDF]

Interlaboratory Statistical Comparisons

Interlaboratory Validation of the Pubertal Male Assay - Battelle Male [PDF file, 127 pp., 13.5MB, About PDF]

Interlaboratory Validation of the Pubertal Female Assay - Battelle Female [PDF file, 105 pp., 2.1MB, About PDF]

Summary of the Pubertal Male And Female Interlaboratory Validation Studies by Chemical - Summary of Results [PDF file, 14 pp., 119KB, About PDF]

Graphs Showing Organ Weights and Hormones (but not Histopathology) of Treated Groups as Percent of Controls, by Chemical, then by Lab (First Graphs) or by Dose Level (Last Graphs)

Male [PDF file, 8 pp., 654KB, About PDF]

Female [PDF file, 6 pp., 457KB, About PDF]

Questions for the EDMVAC on the Pubertal Interlaboratory Validation Study [PDF file, 1 pp., 9KB, About PDF]

EDSP's Applied Approach to Validation

Validation of Screening and Testing Assays Proposed for the EDSP [PDF file, 20 pp., 105KB, About PDF]

Appendix A - Statistical Power [PDF file, 2 pp., 111KB, About PDF]

Appendix B - Sensitivity of Cooper Statistics to the Number and Choice of Chemicals Used in Validation Study [PDF file, 42 pp., 6.3MB, About PDF]

Aromatase Assay Update

Materials will be posted as they become available.

Steroidogenesis Cell Based H295R Assay

Materials will be posted as they become available.

Fish Screen Assay Validation Status

Fish Screening Assay Discussion Paper [PDF file, 121 pp., 1.6MB, About PDF]

Questions for the EDMVAC on the Fish Screening Assay Discussion Paper [PDF file, 1 pp., 8KB, About PDF]

Public Comments

EDMVAC Recommendations

Meeting Summary


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