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Endocrine Disruptor Methods Validation Subcommittee (EDMVS)

Ninth Plenary Meeting - December 10-12, 2003

Agenda

PDF File [3pp., 139KB, About PDF] HTML File [16KB]

Federal Register Notices Announcing Meeting | Copy for Public Comment

Endocrine Disruptor Methods Validation Subcommittee (EDMVS) under the National Advisory Council for Environmental Policy and Technology (NACEPT); Notice of Public Meeting [PDF file, 3pp., 50KB, About PDF]

Background Documents and Corresponding Presentation(s)

Pubertal Assays

Assessment of Pubertal Development and Thyroid Function in Juvenile Male CD (Sprague-Dawley) Rats After Exposure to Selected Chemicals Administered by Gavage on Postnatal Days 23 to 52/53 [PDF file, 68pp., 263KB, About PDF]

Assessment of Pubertal Development and Thyroid Function in Juvenile Female CD (Sprague-Dawley) Rats After Exposure to Selected Chemicals Administered by Gavage on Postnatal Days 22 to 42/43 [PDF file, 56pp., 303KB, About PDF]

Pubertal Toxicity Study of Vinclozolin, Flutamide and Phenobarbital in Male Sprague Dawley Rats and Methoxychlor, Ethinyl Estradiol and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage [PDF file, 69pp., 370KB, About PDF]

Presentation: Pubertal Male and Female Rat Assay by Dr.Earl Gray [PDF file, 109pp., 2MB, About PDF]

Presentation: Male and Female Puberal Protocols: Identifying Environmental Compounds that alter the Thyroid Axis by Dr. T. Stoker [PPT file, 39pp., 1.6MB, About PDF]

Questions on Pubertal Assay for the EDMVS [PPT file, 22pp., 120KB, About PDF]

Aromatase Assay

Human Placental and Recombinant Data:

Aromatase Optimization Supplementary Studies - Experiment #1 [PDF file, 29pp., 237KB, About PDF]

Estrogen Production in Human Placental Assay Results [PDF file, 28pp., 218KB, About PDF]

Figure 9 - Graphic Representation of Control Means and Standard Deviations [PDF file, 4pp., 1.2MB, About PDF]

Figure 10 - Placental Aromatase Response Curves [PDF file, 5pp., 1.5MB, About PDF]

Figure 11- Recombinant Aromatase Assay Response Curves [PDF file, 5pp., 1.5MB, About PDF]

Presentation: In Vitro Aromatase Assay: Prevalidation Studies by Dr. Susan Laws [PPT file, 25pp., 419KB, About PDF]

Presentation: Questions on Aromatase Assay for EDMVS [PPT file, 10pp., 80KB, About PDF]

Adult Intact Male Assay

Presentation: The Intact Male Assay as an Alternative Tier I Screening Assay for Detecting Endocrine-Active Compounds by Dr. John O'Connor [PPT file, 44pp., 625KB, About PDF]

Androgen Receptor Binding Assay

Presentation: Androgen Receptor Binding Assay Update by Dr. Vickie Wilson [PPT file, 26pp., 1.3MB, About PDF]

Other Topics

Update on Reference Chemicals [PDF file, 3pp., 437KB, About PDF]

Presentation: Draft EDMVS Work Plan [PPT file, 21pp., 91KB, About PDF]

Public Comments

CLA Intact Adult Male Assay and Male and Female Rat Pubertal Assays Comments [PDF file, 3pp., 144KB, About PDF]

World Wildlife Fund Comments on the December 10-12, 2003 EDMVS Meeting [PDF file, 3pp., 16KB, About PDF]

December 10-12, 2003 EDMVS Meeting Comments - submitted by JW Owens [PDF file, 6pp., 36KB, About PDF]

Comments and/or Response to Questions Received During the December 10-12, 2003 EDMVS Meeting - submitted by Eldridge and Stevens, Wake Forest University [PDF file, 5pp., 40KB, About PDF]

Sample List, Substances Beginning with the Letter A, that should be Devoid of Inherent EAT Endocrine Activity [PDF file, 3pp., 44KB, About PDF]

Time of Vaginal Opening in the Study of Atrazine [PDF file, 4pp., 36KB, About PDF]

Comments on the Pubertals Assays - submitted by Richard Becker, American Chemistry Council [PDF file, 5pp., 3MB, About PDF]

Meeting Summary

Meeting Summary [PDF file, 33pp., 346KB, About PDF]


PLEASE NOTE:

Some of the documents presented may not be accessible using alternative access devices. If you need access to these documents please contact William Wooge at 202-564-8476. We will post accessible documents as soon as possible.

Documents presented on this page may be in Microsoft PowerPoint (PPT), Microsoft Excel (XLS), or Lotus Freelance Format (PRZ). To view or print them you will need to have their associated programs installed on your computer. The programs can be downloaded and used with no charge from the following links.


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