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Priority Setting Database (2001)

EPA is proposing to select and screen approximately 50 to 100 chemicals drawn from pesticide active ingredients and HPV chemicals with some pesticidal inert uses (HPV/Inert chemicals) to help EPA further refine the screening and testing program. EPA is not proposing to directly use the Endocrine Disruptor Priority Setting Database (EDPSD) at this time in light of the narrower scope and focus of the initial list; however, for subsequent lists EPA will consider the use of EDPSD. EPA anticipates that it will modify its chemical selection approach for subsequent Tier 1 screening lists based on experience gained from the results of testing chemicals on the initial list, the feasibility of incorporating different categories of chemicals (e.g., non-pesticide substances), additional pathways of exposure, and the availability of new priority setting tools (e.g., HTPS or QSAR models).

EPA developed an automated priority setting database to assist in the evaluation of the large number of Tier 1 candidate chemicals. The Endocrine Disruptor Priority Setting Database (EDPSD) utilizes a "compartment-based priority setting strategy" that was recommended by the Endocrine Disruptor Screening and Testing Committee (EDSTAC) and affirmed by EPA in its 1998 Proposed Statement of Policy [PDF file, 28pp., 228KB, About PDF]. The term "compartment" in this context refers to a set of chemicals defined by common exposure and/or effects parameters (e.g., the set of chemicals found in drinking water). For each compartment, a simple ranking algorithm is developed which makes use of the common parameters shared by the chemicals in that compartment. The overall priority list is then obtained by taking the highest ranking chemicals from each compartment.

An alternative approach that was considered but rejected by both EDSTAC and EPA is the development of an algorithm that integrates all exposure and effects information to form a single rank-ordered list. The single algorithm approach was rejected because of technical difficulties due to large discrepancies in the types and quality of available data among chemicals, concerns about the bias against poorly studied chemicals, and concerns about the transparency of such an approach.

EPA held two workshops to discuss EDPSD. Materials related to EDPSD can be accessed through the following links:

You will need the free Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more. If you need help accessing these PDF documents, please contact William Wooge at 202-564-8476 or wooge.william@epa.gov for assistance.

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