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Priority Setting Activities


Priority Setting is one of three major components of the Endocrine Disruptor Screening Program (EDSP) (the other two are Tier 1 and Tier 2 assay development and validation and development of program policies and procedures to require testing). "Priority setting" in EDSP refers to identifying which chemicals will undergo Tier 1 Screening first.

Access information describing EDSP priority setting activities:

Universe of Chemicals

Developed in response to recommendations from the Office of Inspector General, The EDSP Universe of Chemicals and General Validation Principles (17 pp, 197.94K, About PDF) document provides an overview of the general validation principles that will be used to evaluate computational toxicological methods for chemical prioritization. EPA has also presented the List of EDSP Universe of Chemicals (177 pp, 2.54M, About PDF) as a separate document which will be updated as new information becomes available. The List of the EDSP Universe of Chemicals contains approximately 10,000 chemicals as defined under FFDCA and SDWA 1996 amendments, although not all of the chemicals are expected to undergo EDSP Tier 1 screening. The agency plans to prioritize these chemicals for screening by considering physical chemical properties, exposure, and an effect-based approach using advanced computational toxicological methods. These methods and tools will be evaluated using OECD validation principles for their utilization in chemical prioritization and this topic was the focus of a January 29-31, 2013 FIFRA Science Advisory Panel meeting.

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Chemical Selection for the Second List of Chemicals


June 14, 2013 – Revised Second List of Chemicals for Tier 1 Screening. This revised second list consists of 109 identified chemicals, 41 of which are pesticide active ingredients (PAIs) and 68 are chemicals identified under the Safe Drinking Water Act (SDWA). Visit the links below to learn more about the revised second list of chemicals:

November 17, 2010 - Draft Second List of Chemicals for Tier 1 Screening. This list included 134 chemicals and substances that have been listed as priorities within EPA’s drinking water and the pesticides programs.

Visit the links below to learn more about the second list of chemicals:

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Chemical Selection for the Initial List of Chemicals

Visit the links below to learn more about the initial list:

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Early Priority Setting Activities

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