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Acceptable Substitutes for CFC-114 and CFC-11 in Chillers and Other Refrigerants

Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Substitutes for CFC-114 in Centrifugal Chillers
Substitute (Name Used in the Federal Register) Trade Name Retrofit/New
HCFC-22   N
HCFC-123   N
HCFC-124   R,N
HFC-134a   N
HFC-227ea   N
HFC-236fa   R,N
Ammonia Vapor Compression   N
Evaporative Cooling   N
Desiccant Cooling   N
Ammonia / Water Absorption   N
Water / Lithium Bromide Absorption   N
HFC-245fa Genetron® 245fa R, N
Hot Shot 2 Hot Shot 2 R
R–450A Solstice N–13 R, N
Key: R = Retrofit Uses, N = New Uses
Acceptable Substitutes for CFC-11 in Centrifugal Chillers
Substitutes (Name Used in the Federal Register) Trade Name Retrofit/New
HCFC-123   R, N
HCFC-22   N
HFC-134a   N
HFC-227ea   N
HFC-245fa   N
Ammonia Vapor Compression   N
Evaporative Cooling   N
Desiccant Cooling   N
Ammonia / Water Absorption   N
Water / Lithium Bromide Absorption   N
Hot Shot 2 Hot Shot 2 R
Trans-1-chloro-3,3,3-trifluoroprop-1-ene Solstice 1233zd(E), Solstice N12 Refrigerant N
HFO-1234ze Solstice 1234ze N
R–450A Solstice N–13 R, N
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for CFCs (class I ODS) in Reciprocating and Screw Chillers

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
HCFC-22   12, 500 N
Ikon B   12 N
THR-02   12 N
HFC-134a   12, 500 R, N
HFC-227ea   12, 500 N
R-401A, R-401B MP-39, MP-66 12, 500 R, N
R-411A, R-411B   12, 500 R, N
Free Zone (HCFC Blend Delta) Free Zone / RB-276 12, 500 R, N
Freeze 12 Freeze 12 12, 500 R, N
FRIGC FR-12 (HCFC Blend Beta) FRIGC FR-12 12, 500 R, N
GHG-X4 GHG-X4, Autofrost, Chill-it 12, 500 R, N
GHG-X5 GHG-X5 12, 500 R, N
G2018C G2018C 12, 500 R, N
Hot Shot Hot Shot, Kar Kool 12, 500 R, N
HCFC-22/HCFC-142b   12 R, N
FOR12A FOR12A 12 R, N
FOR12B FOR12B 12 R, N
SP34E SP34E 12 R, N
Evaporative/Desiccant Cooling   12, 500 N
R-407C Suva 407C, Klea 407C 502 R, N
R-420A Choice R-420A 12, 500 R, N
R-422C ICOR XLT1 502 R, N
KDD6 KDD6 12 R, N
Hot Shot 2 Hot Shot 2   R
HFO-1234ze Solstice 1234ze   N
R-450A Solstice N–13   R, N
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for HCFCs (class II ODS) in Reciprocating and Screw Chillers

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
THR-03   22 N
ISCEON 59, NU-22, R-417A ISCEON 59, NU-22 22, blends containing 22 and/or 142b R, N
R-410A AZ-20, Suva 9100, Puron 22 and blends containing HCFCs N
R-410B   22, blends containing 22 and/or 142b N
R-407C Suva 9000, Klea 66 22 and blends containing HCFCs R, N
R-507, R-507A AZ-50 22 and blends containing HCFCs N
Ammonia Vapor Compression With Secondary Loop   22, blends containing 22 and/or 142b N
Ammonia Absorption   22, blends containing 22 and/or 142b N
Evaporative Cooling   22, blends containing 22 and/or 142b N
Desiccant Cooling   22, blends containing 22 and/or 142b N
R-404A HP62 22 and blends containing HCFCs R, N
R-125/134a/600a (28.1/70.0/1.9) NU-22 old composition 22, blends containing 22 and/or 142b R, N
RS-44 (2003 formulation) RS-44 22, blends containing 22 and/or 142b R, N
R-421A Choice R421A 22, blends containing 22 and/or 142b R, N
R-422D ISCEON MO29 22, blends containing 22 and/or 142b R, N
R-424A RS-44 22, blends containing 22 and/or 142b R, N
KDD5, R-438A ISCEON MO99 22, blends containing 22 and/or 142b R, N
R-434A RS-45 22, blends containing 22 and/or 142b R, N
R-125/290/134a/600a (55.0/1.0/42.5/1.5) ICOR AT-22 22, blends containing 22 and/or 142b R, N
R-422B XAC1, NU22B 22, blends containing 22 and/or 142b R, N
R-422C XLT1 22, blends containing 22 and/or 142b R, N
R-427A Forane 427A 22, blends containing 22 and/or 142b R
HFC-134a   22, blends containing 22 and/or 142b R, N
HFC-227ea   22, blends containing 22 and/or 142b N
SP34E SP34E 22, blends containing 22 and/or 142b R, N
Stirling cycle   22, blends containing 22 and/or 142b N
Hot Shot 2 Hot Shot 2 HCFC-22 and HCFC blends, including those containing HCFC–22 and/or HCFC–142b R
HFO-1234ze Solstice 1234ze 22, blends, containing 22 and/or 142b N
R-450A Solstice N–13   R, N
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for CFC-12 & R-500 (class I ODS) in Centrifugal Chiller

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
HCFC-22   12, 500 N
HCFC-123   12, 500 N
HFC-134a   12, 500 R, N
Ikon A   12 R, N
Ikon B   12 R, N
HFC-227ea   12, 500 N
R-406A GHG 12, 500 R, N (R-500 only)
Free Zone (HCFC Blend Delta) Free Zone / RB-276 12, 500 R, N
Freeze 12 Freeze 12 12, 500 R, N
FRIGC FR-12 (HCFC Blend Beta) FRIGC FR-12 12, 500 R, N
GHG-X4 GHG-X4, Autofrost, Chill-it 12, 500 R, N
GHG-X5 GHG-X5 12, 500 R, N
G2018C G2018C 12, 500 R, N
Hot Shot Hot Shot, Kar Kool 12, 500 R, N
HCFC-22/HCFC-142b   12 R, N
R-420A Choice R-420A 12, 500 R, N
FOR12A FOR12A 12 R, N
FOR12B FOR12B 12 R, N
Ammonia Vapor Compression With Secondary Loop   12, 500 N
Evaporative/Desiccant Cooling   12, 500 N
Ammonia / Water Absorption   12, 500 N
Water / Lithium Bromide Absorption   12, 500 N
THR-02 THR-02 12 N
ISCEON 39TC ISCEON 39TC 12 R, N
Hot Shot 2 Hot Shot 2 12,500 R
HFO-1234ze Solstice 1234ze 12,500 N
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for HCFCs (class II ODS) in Centrifugal Chillers

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
THR-03   22 N
ISCEON 59, NU-22, R-417A ISCEON 59, NU-22 22, blends containing 22 and/or 142b R, N
R-410A AZ-20, Suva 9100, Puron 22 and blends containing HCFCs N
R-410B   22, blends containing 22 and/or 142b N
R-407C Suva 9000, Klea 66 22 and blends containing HCFCs R, N
R-507, R-507A AZ-50 22 and blends containing HCFCs N
Ammonia Vapor Compression With Secondary Loop   22, blends containing 22 and/or 142b N
Ammonia Absorption   22, blends containing 22 and/or 142b N
Evaporative Cooling   22, blends containing 22 and/or 142b N
Desiccant Cooling   22, blends containing 22 and/or 142b N
R-404A HP62 22 and blends containing HCFCs R, N
R-125/134a/600a (28.1/70.0/1.9) NU-22 old composition 22, blends containing 22 and/or 142b R, N
RS-44 (2003 formulation) RS-44 22, blends containing 22 and/or 142b R, N
R-421A Choice R421A 22, blends containing 22 and/or 142b R, N
R-422D ISCEON MO29 22, blends containing 22 and/or 142b R, N
R-424A RS-44 22, blends containing 22 and/or 142b R, N
KDD5, R-438A ISCEON MO99 22, blends containing 22 and/or 142b R, N
R-434A RS-45 22, blends containing 22 and/or 142b R, N
R-125/290/134a/600a (55.0/1.0/42.5/1.5) ICOR AT-22 22, blends containing 22 and/or 142b R, N
HFC-245fa Genetron® 245fa 22, blends containing 22 and/or 142b R, N
R-422B XAC1, NU22B 22, blends containing 22 and/or 142b R, N
R-422C XLT1 22, blends containing 22 and/or 142b R, N
HFC-134a   22, blends containing 22 and/or 142b R, N
HFC-227ea   22, blends containing 22 and/or 142b N
R-423A ISCEON 39TC 22, blends containing 22 and/or 142b R, N
Stirling cycle   22, blends containing 22 and/or 142b N
Hot Shot 2 Hot Shot 2 22, blends containing 22 and/or 142b R
Trans-1-chloro-3,3,3-trifluoroprop-1-ene Solstice 1233zd(E), Solstice N12 Refrigerant 123 N
HFO-1234ze Solstice 1234ze 123 N
Key: R = Retrofit Uses, N = New Uses

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