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Substitutes in Non-Mechanical Heat Transfer Systems

Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.

Unacceptable substitutes

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Acceptable Substitutes for CFCs (class I ODS) in Non-Mechanical Heat Transfer Systems

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
R-744 (Carbon Dioxide, CO2)   all CFCs R, N
Water   all CFCs R, N
Mineral Oil   all CFCs R, N
Volatile Methyl Siloxanes   all CFCs R, N
Galden Fluids   all CFCs R
HFC-236fa   114 R, N
HFE-7100   11, 12, 113, 114, 115 R, N
HFC-4310mee   all CFCs R, N
HFE-7200   11, 12, 113, 114, 115 R, N
Hydrofluoroether 7000 HFE-7000 11, 113 R, N
R-407C Suva 407C, Klea 407C 502 R, N
R-422C ICOR XLT1 502 R, N
HCF-245fa Genetron® 245fa 11, 113 R, N
KDD6 KDD6 12 R, N
C6 perfluoroketone NovecTM 649 113 R, N
HFO-1234ze (E) HFO-1234ze (E) 113 R, N
C7 Fluoroketone Novec™ 774 113 R, N
Trans-1-chloro-3,3,3-trifluoroprop-1-ene Solstice 1233zd(E), Solstice N12   N
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for HCFCs (class II ODS) in Non-Mechanical Heat Transfer Systems

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
HFE-7100   22, blends containing 22 and/or 142b R, N
HFC-4310mee   all HCFCs R, N
ISCEON 59, NU-22, R-417A ISCEON 59, NU-22 22, blends containing 22 and/or 142b R, N
HFE-7200   22, blends containing 22 and/or 142b R, N
R-422D ISCEON MO29 22, blends containing 22 and/or 142b R, N
KDD5, R-438A ISCEON MO99 22, blends containing 22 and/or 142b R, N
HCF-245fa Genetron® 245fa 21, 141b, 22, blends containing 22 and/or 142b R, N
R-125/290/134a/600a (55.0/1.0/42.5/1.5) ICOR AT-22 22, blends containing 22 and/or 142b R, N
R-422B XAC1, NU-22B 22, blends containing 22 and/or 142b R, N
R-422C XLT1 22, blends containing 22 and/or 142b R, N
C6 perfluoroketone NovecTM 649 22, blends containing 22 and/or 142b R, N
HFO-1234ze (E) HFO-1234ze (E) 22, blends containing 22 and/or 142b R, N
Volatile Methyl Siloxanes   22, blends containing 22 and/or 142b R, N
R-744 (Carbon Dioxide, CO2)   22, blends containing 22 and/or 142b R, N
Water   22, blends containing 22 and/or 142b R, N
R-404A   22 and blends containing HCFCs R, N
R-407C   22 and blends containing HCFCs R, N
R-410A   22 and blends containing HCFCs N
HFE-7000   22, blends containing 22 and/or 142b R, N
Trans-1-chloro-3,3,3-trifluoroprop-1-ene Solstice 1233zd(E), Solstice N12   N
Key: R = Retrofit Uses, N = New Uses

Substitutes for CFCs in Non-Mechanical Heat Transfer Systems Acceptable Subject to Narrowed Use Limits

Substitute ODS Being Replaced Narrowed Use Limit Retrofit/ New
PFCs (C3F8, C4F10, C5F12, C5F11NO, C6F14, C6F13NO, C7F16, C7F15NO, C8F18, C8F17NO, C9F21N) all CFCs PFCs are only allowed in new systems where a study has demonstrated that no other alternatives are technically feasible due to safety or performance requirements; this study must be kept available for review. R, N
Key: R = Retrofit Uses, N = New Uses

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