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Acceptable Substitutes in Industrial Process Refrigeration

Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential. Lists of acceptable and unacceptable substitutes are updated several times each year. A chronological list of SNAP updates is also available.

Unacceptable substitutes

Note: SNAP-related information published in the Federal Register takes precedence over all information on this page.

Acceptable Substitutes for CFCs (class I ODS) in Industrial Process Refrigeration

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
HCFC-22   12, 502 R, N
HCFC-123   11 R, N
HFC-23   13, 13B1, 503 R, N
Ikon A   12 R, N
Ikon B   12 R, N
THR-02   12 R, N
HFC-134a   11, 12, 502 R, N
HFC-227ea   12 N
HFC-236fa   114 R, N
R-401A, R-401B MP-39, MP-66 12 R, N
R-402A, R-402B HP-80, HP-81 502 R, N
R-403B ISCEON 69-L 13, 13B1, 503
Note: R-403B is unacceptable as a substitute for R-502.
R, N
R-404A HP-62 502, 12, 500 R, N
R-406A GHG 12, 500 R
R-407A, R-407B Klea 407A, 407B 502 R, N
R-408A (HCFC Blend Epsilon)   502 R
R-411A, R-411B   12, 500, 502 R, N
R-507 AZ-50 11, 12, 502 R, N
R-508A (PFC Blend Alpha) Klea 5R3 13, 13B1, 503 R, N
R-508B Suva 95 13, 13B1, 503 R, N
Free Zone (HCFC Blend Delta) Free Zone / RB-276 12 R, N
Freeze 12 Freeze 12 12 R, N
FRIGC FR-12 (HCFC Blend Beta) FRIGC FR-12 12, 500 R, N
GHG-X4 GHG-X4, Autofrost, Chill-it 12, 500 R, N
GHG-X5 GHG-X5 12, 500 R, N
GHG-HP (HCFC Blend Lambda) GHG-HP 12 R, N
G2018C G2018C 12, 500, 502 R, N
Hot Shot Hot Shot, Kar Kool 12, 500 R, N
HCFC-22/HCFC-142b   12 R, N
NARM-502   13, 13B1, 503 R, N
R-744 (Carbon Dioxide, CO2)   13, 13B1, 503 R, N
THR-04 THR-04 502 R, N
FOR12A FOR12A 12 R, N
FOR12B FOR12B 12 R, N
HFC-134a/HBr (92/8)   12, 502 N
Ammonia Vapor Compression   12, 502 N
HFE-7100 as a secondary heat transfer fluid in not-in-kind systems   11, 12, 114, 115, 502 N
HFE-7200 as a secondary heat transfer fluid in not-in-kind systems   11, 12, 114, 115, 502 N
Propane, Propylene, Butane, Hydrocarbon Blend A, Hydrocarbon Blend B) HC-12a®, OZ-12®, Duracool 12a CFC-12 R, N
Chlorine   all R, N
Evaporative/Desiccant Cooling   all N
Hydrofluoroether-7000 (C3F7OCH3) HFE-7000 11, 113 R, N
RS-24 (2002 formulation)   12 R, N
ISCEON 39TC ISCEON 39TC 12 R, N
R-407C Suva 407C, Klea 407C 502 R, N
R-420A Choice R-420A 12, 500 R, N
R-421B Choice R421B 12, 502 R, N
R-426A RS-24 12 R, N
R-422C ICOR XLT1 502 R, N
HFC-245fa Genetron® 245fa 114 R, N
KDD6 KDD6 12 R, N
Hot Shot 2   R Hot Shot 2 11, 12, 13B1, 113, 114, 500, 502 R
Key: R = Retrofit Uses, N = New Uses

Acceptable Substitutes for HCFCs (class II ODS) in Industrial Process Refrigeration

Substitute (Name Used in the Federal Register) Trade Name Refrigerant Being Replaced Retrofit/ New
R-410A AZ-20, Suva 9100, Puron 22 and blends containing HCFCs N
R-410B   22, blends containing 22 and/or 142b N
THR-03   22 N
ISCEON 59, NU-22, R-417A ISCEON 59, NU-22 22, blends containing 22 and/or 142b R, N
R-404A HP-62 22 and blends containing HCFCs R, N
R-407C Suva 9000, Klea 66 22 and blends containing HCFCs R, N
R-507, 507A AZ-50 22 and blends containing HCFCs R, N
R-125/134a/600a (28.1/70.0/1.9) NU-22 old composition 22, blends containing 22 and/or 142b R, N
Ammonia Vapor Compression   22, blends containing 22 and/or 142b N
HFE-7100 (HFE-449s1) as a secondary heat transfer fluid in not-in-kind systems   22, blends containing 22 and/or 142b N
HFE-7200 (HFE-569sf2) as a secondary heat transfer fluid in not-in-kind systems   22, blends containing 22 and/or 142b N
Ammonia Absorption   22, blends containing 22 and/or 142b N
RS-44 (2003 formulation) RS-44 22, blends containing 22 and/or 142b R, N
ISCEON 79, R-422A ISCEON 79 22 and blends containing HCFCs R, N
R-421A Choice R421A 22, blends containing 22 and/or 142b R, N
R-421B Choice R421B 22, blends containing 22 and/or 142b R, N
R-422D ISCEON MO29 22, blends containing 22 and/or 142b R, N
R-424A RS-44 22, blends containing 22 and/or 142b R, N
R-426A RS-24 22, blends containing 22 and/or 142b R, N
KDD5, R-438A ISCEON MO99 22, blends containing 22 and/or 142b R, N
R-434A RS-45 22, blends containing 22 and/or 142b R, N
R-428A RS-52 22, blends containing 22 and/or 142b N
R-125/290/134a/600a (55.0/1.0/42.5/1.5) ICOR AT-22 22, blends containing 22 and/or 142b R, N
R-422B XAC1, NU-22B 22, blends containing 22 and/or 142b R, N
R-422C XLT1 22, blends containing 22 and/or 142b R, N
Evaporative Cooling   22, blends containing 22 and/or 142b N
Desiccant Cooling   22, blends containing 22 and/or 142b N
HFE-7000, HFE-347mcc3 HFE-7000 22, blends containing 22 and/or 142b R, N
RS-24 (2002 formulation)   22, blends containing 22 and/or 142b R,N
R-744 (Carbon Dioxide, CO2)   22, blends containing 22 and/or 142b N
R-423A ISCEON 39TC 22, blends containing 22 and/or 142b R, N
HC Blend A OZ-12 22, blends containing 22 and/or 142b R, N
HC Blend B Original formulation of HC-12a 22, blends containing 22 and/or 142b R, N
HFC-134a   22, blends containing 22 and/or 142b R, N
HFC-227ea   22, blends containing 22 and/or 142b N
Nitrogen direct gas expansion   22, blends containing 22 and/or 142b N
R-290 (Propane)   22, blends containing 22 and/or 142b R, N
R-407A   22, blends containing 22 and/or 142b R, N
R-407B   22, blends containing 22 and/or 142b R, N
R-600 (Butane)   22, blends containing 22 and/or 142b R, N
R-1270 (Propylene)   22, blends containing 22 and/or 142b R, N
Stirling cycle   22, blends containing 22 and/or 142b N
Hot Shot 2    Hot Shot 2 22, blends containing 22 and/or 142b R
R-407F   Genetron Performax LT 22, blends containing 22 and/or 142b R, N
Key: R = Retrofit Uses, N = New Uses

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