Cancer Guidelines and Supplemental Guidance Implementation

Application of New Cancer Guidelines (PDF) (2 pp, 1.1MB, about PDF)
Communication I: Application of the mode of action framework in mutagenicity determinations for carcinogenicity (PDF) (8 pp, 4.5MB, about PDF)
Communication II: Performing Risk Assessments that include Carcinogens Described in the Supplemental Guidance as having a Mutagenic Mode of Action. (PDF) (4 pp, 1.3MB, about PDF)
Process for Internal Communication of Mutagenic Mode of Action Determinations for Carcinogens (PDF) (2 pp, 667KB, about PDF)
FACT SHEET - Implementation of the Supplemental Guidance in Cancer Risk Assessment (5 pp, 48KB, about PDF)

You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.