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Research on Evaluating Chemicals for Adverse Effects

Current chemical testing is expensive and time consuming. Only a small fraction of chemicals have been fully evaluated for potential adverse environmental and human health effects. EPA researchers are using rapid and efficient methods to evaluate chemicals for potential toxicity and develop new methods to estimate chemical exposure/dose. These methods are being used to evaluate thousands of chemicals found in consumer products, the air we breathe and the water we drink. 

Rapid, Automated Toxicology

  • ToxCast (Toxicity Forecaster): uses rapid chemical screening technologies (called "high-throughput screening assays") to limit the number of required laboratory animal-based toxicity tests while quickly and efficiently screening thousands of chemicals for potential human and environmental effects.
  • Toxicology Testing in the 21st Century: Federal collaboration that is using a high-throughput robotic screening to test a collection of 10,000 environmental chemicals and approved drugs for their potential to disrupt biological pathways that may result in toxicity.
  • Developing New Assays for Developmental Neurotoxicity: EPA is developing and incorporating new approach methods that are fast, economical, and scientifically relevant to provide information to screen and prioritize thousands of chemicals for developmental neurotoxicity hazard. 

Rapid, Automated Exposure and Dose

EPA is developing, applying, and evaluating advanced measurement methods and computational approaches to efficiently characterize the potential for real-world human exposure to chemicals, including those associated with consumer product use.