An official website of the United States government.

We've made some changes to If the information you are looking for is not here, you may be able to find it on the EPA Web Archive or the January 19, 2017 Web Snapshot.

SeqAPASS 4.0 User Guide

The SeqAPASS tool has been developed to predict across species relative intrinsic susceptibility to chemicals with known molecular targets (e.g., pharmaceuticals, pesticides) as well as evaluate conservation of molecular targets from high-throughput screening assays (i.e., U.S. Environmental Protection Agency ToxCast Program) and molecular initiating events (MIEs) and early key events in the adverse outcome pathway framework, as a means to extrapolate such knowledge across species. This guide provides information on how to use SeqAPASS version 4.0.

You may need a PDF reader to view some of the files on this page. See EPA’s About PDF page to learn more.